{"id":"https://openalex.org/W2503933827","doi":null,"title":"Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-Inhibitors","display_name":"Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-Inhibitors","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2503933827","mag":"2503933827"},"language":"en","primary_location":{"id":"mag:2503933827","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2016/7766/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056021502","display_name":"Experimentelle Medizin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Experimentelle Medizin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032409973","display_name":"Georg W. Mayr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georg W. Mayr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9919999837875366},{"id":"https://openalex.org/keywords/dual-inhibition","display_name":"dual inhibition","score":0.6140000224113464},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.7390000224113464},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9570000171661377},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.5429999828338623},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8336130380630493},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.673001766204834},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6517965197563171},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.546497106552124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46304160356521606},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.42226895689964294},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.41132816672325134},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39639487862586975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.285370409488678},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13710090517997742},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.056367307901382446},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2503933827","doi":null,"is_oa":false,"landing_page_url":"https://ediss.sub.uni-hamburg.de/volltexte/2016/7766/pdf/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W189263682","https://openalex.org/W1506285409","https://openalex.org/W1510049477","https://openalex.org/W1556314914","https://openalex.org/W1965626427","https://openalex.org/W1967613899","https://openalex.org/W1972013160","https://openalex.org/W1976752775","https://openalex.org/W1977267072","https://openalex.org/W1986368997","https://openalex.org/W1987359254","https://openalex.org/W1990376228","https://openalex.org/W1998203489","https://openalex.org/W1999211774","https://openalex.org/W1999614615","https://openalex.org/W2001008402","https://openalex.org/W2001999652","https://openalex.org/W2005530962","https://openalex.org/W2007847006","https://openalex.org/W2017187984","https://openalex.org/W2021012077","https://openalex.org/W2029530216","https://openalex.org/W2037519578","https://openalex.org/W2038434969","https://openalex.org/W2041309271","https://openalex.org/W2050980183","https://openalex.org/W2054231318","https://openalex.org/W2058390096","https://openalex.org/W2071525523","https://openalex.org/W2075957912","https://openalex.org/W2077945404","https://openalex.org/W2098584395","https://openalex.org/W2105437003","https://openalex.org/W2108325039","https://openalex.org/W2113491029","https://openalex.org/W2114621192","https://openalex.org/W2117692326","https://openalex.org/W2117933729","https://openalex.org/W2120314156","https://openalex.org/W2126569401","https://openalex.org/W2127063807","https://openalex.org/W2128308297","https://openalex.org/W2128965737","https://openalex.org/W2132342658","https://openalex.org/W2135131549","https://openalex.org/W2141078344","https://openalex.org/W2141750100","https://openalex.org/W2144169031","https://openalex.org/W2144894645","https://openalex.org/W2151650153","https://openalex.org/W2156359059","https://openalex.org/W2156768359","https://openalex.org/W2157232767","https://openalex.org/W2159750196","https://openalex.org/W2162147795","https://openalex.org/W2170138574","https://openalex.org/W2312804644","https://openalex.org/W2388163742"],"related_works":["https://openalex.org/W2565630542","https://openalex.org/W3083345156","https://openalex.org/W4400764740","https://openalex.org/W2048367516","https://openalex.org/W2039924299","https://openalex.org/W2165864070","https://openalex.org/W2921720700","https://openalex.org/W2967093573","https://openalex.org/W7096859572","https://openalex.org/W7099621102"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-08-23T00:00:00"}