{"id":"https://openalex.org/W2503602139","doi":"https://doi.org/10.1007/978-1-349-10047-7_33","title":"Genetic and Toxin-induced Depletion of Striatal Dopamine","display_name":"Genetic and Toxin-induced Depletion of Striatal Dopamine","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2503602139","doi":"https://doi.org/10.1007/978-1-349-10047-7_33","mag":"2503602139"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-349-10047-7_33","doi":"https://doi.org/10.1007/978-1-349-10047-7_33","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-10047-7_33","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology and Functional Regulation of Dopaminergic Neurons","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2037724058","display_name":"Pharmacology and Functional Regulation of Dopaminergic Neurons"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060330868","display_name":"Suzanne K. Roffler-Tarlov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Roffler-Tarlov","raw_affiliation_strings":["Neuroscience Program, Tufts University Medical School, Boston, MA, 02111, USA","Neuroscience Program, Tufts University Medical School, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Program, Tufts University Medical School, Boston, MA, 02111, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Neuroscience Program, Tufts University Medical School, Boston, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081686751","display_name":"Ann M. Graybiel","orcid":"https://orcid.org/0000-0002-4326-7720","observed_orcids":["https://orcid.org/0000-0002-4326-7720"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann M. Graybiel","raw_affiliation_strings":["Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, 02139, USA","Department of Brain and Cognitive Sciences, MIT, Cambridge, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, MIT, Cambridge, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9299,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.82751938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"204","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mptp-induced-parkinsonism","display_name":"MPTP-induced parkinsonism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/weaver-mouse","display_name":"weaver mouse","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.7749999761581421},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9229999780654907},{"id":"https://openalex.org/keywords/environmental-toxicants","display_name":"environmental toxins","score":0.5860000252723694},{"id":"https://openalex.org/keywords/autosomal-recessive-mutation","display_name":"autosomal recessive mutation","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.9441074132919312},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.8802042007446289},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6789585947990417},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.6025065779685974},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6008092761039734},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5937210917472839},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5028488039970398},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.4735742509365082},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4078443944454193},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3917226791381836},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.3184361159801483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.263050377368927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-349-10047-7_33","doi":"https://doi.org/10.1007/978-1-349-10047-7_33","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-10047-7_33","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology and Functional Regulation of Dopaminergic Neurons","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.6600000262260437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1560939011","https://openalex.org/W1805785873","https://openalex.org/W1887527925","https://openalex.org/W1969800514","https://openalex.org/W1971522061","https://openalex.org/W1977303938","https://openalex.org/W1986319043","https://openalex.org/W1986716278","https://openalex.org/W1992026400","https://openalex.org/W1999137262","https://openalex.org/W2005102504","https://openalex.org/W2014444130","https://openalex.org/W2023211111","https://openalex.org/W2031288761","https://openalex.org/W2038557175","https://openalex.org/W2041734419","https://openalex.org/W2058138352","https://openalex.org/W2062609550","https://openalex.org/W2072746981","https://openalex.org/W2076205015","https://openalex.org/W2086208850","https://openalex.org/W2132984058","https://openalex.org/W2136177459","https://openalex.org/W2146889361","https://openalex.org/W2323830726","https://openalex.org/W2401449706"],"related_works":["https://openalex.org/W2008437295","https://openalex.org/W3007084251","https://openalex.org/W2009650138","https://openalex.org/W7101082424","https://openalex.org/W2039248403","https://openalex.org/W1995590349","https://openalex.org/W204648407","https://openalex.org/W190761280","https://openalex.org/W2269161749","https://openalex.org/W2016621535"],"abstract_inverted_index":{"Idiopathic":[0],"Parkinson\u2019s":[1,47,80],"disease":[2,73,94],"is":[3,70,95,130,185,269],"not":[4,254,263],"heritable,":[5],"though":[6],"some":[7],"neurological":[8],"disorders":[9,87],"leading":[10],"to":[11,16,52,79,84,159,168,186,241],"parkinsonian":[12,86,224],"symptoms":[13],"are":[14,41],"known":[15],"have":[17,142,213],"a":[18,76],"genetic":[19,93],"base":[20],"(Agid":[21],"et":[22,120,229,233],"al.":[23,121,230,234],"1986).":[24],"The":[25,127,163,209],"discovery":[26],"of":[27,46,60,108,116,149,182,191,198,211,223,244,247],"MPTP-induced":[28],"parkinsonism":[29],"has":[30],"reinforced":[31],"the":[32,44,66,98,106,113,117,135,147,150,180,188,192,196,199,206,220,242,265,272,278],"view":[33],"that":[34,57,74,203,250],"environmental":[35],"toxins,":[36],"rather":[37],"than":[38],"heritable":[39],"factors,":[40],"involved":[42],"in":[43,54,58,65,97,112,173,216,226],"etiology":[45],"disease.":[48],"We":[49],"nevertheless":[50],"wish":[51],"emphasize":[53],"this":[55,183],"chapter":[56,184],"terms":[59],"its":[61],"neuropathology":[62],"as":[63,101,277],"expressed":[64],"dopamine-containing":[67,114],"systems,":[68],"there":[69],"an":[71,102],"inherited":[72],"displays":[75],"remarkable":[77,144],"resemblance":[78],"disease,":[81],"and":[82,124,153,165,176,262,271],"also":[83],"other":[85],"including":[88],"1-methyl-4-phenyl-1,2,5,6-tetrohydropyridine":[89],"(MPTP)-induced":[90],"parkinsonism.":[91],"This":[92,267],"carried":[96],"weaver":[99,151,207],"mouse":[100],"autosomal":[103],"recessive":[104],"mutation,":[105],"consequences":[107,243],"which":[109,140],"include":[110],"defects":[111],"systems":[115],"brain":[118],"(Schmidt":[119],"1982,":[122],"Roffler-Tarlov":[123],"Graybiel":[125],"1984).":[126],"following":[128,219],"summary":[129],"based":[131],"on":[132],"work":[133],"over":[134],"past":[136],"five":[137],"years,":[138],"during":[139],"we":[141],"noted":[143],"similarities":[145,164],"between":[146],"effects":[148,210,225],"gene":[152],"those":[154],"reported":[155],"for":[156],"MPTP":[157,201,212,245],"administered":[158],"normal":[160],"adult":[161],"mice.":[162],"differences":[166],"need":[167],"be":[169,239,275],"explored":[170],"more":[171],"formally":[172],"parallel":[174],"investigations":[175],"will":[177,238,253],"be.":[178],"However":[179],"purpose":[181],"compare":[187],"key":[189],"features":[190],"damage":[193],"resulting":[194],"from":[195],"administration":[197],"toxin":[200],"with":[202],"induced":[204],"by":[205,260,264],"gene.":[208],"been":[214],"studied":[215],"many":[217],"species":[218,251],"initial":[221],"observations":[222],"man":[227],"(Davis":[228],"1979;":[231],"Langston":[232],"1983).":[235],"Here,":[236],"discussion":[237],"confined":[240],"treatment":[246],"mice":[248],"so":[249],"variations":[252],"intervene.":[255],"These":[256],"keywords":[257,273],"were":[258],"added":[259],"machine":[261],"authors.":[266],"process":[268],"experimental":[270],"may":[274],"updated":[276],"learning":[279],"algorithm":[280],"improves.":[281]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}