{"id":"https://openalex.org/W2503584995","doi":"https://doi.org/10.1002/jcc.24466","title":"Adding energy minimization strategy to peptide\u2010design algorithm enables better search for RNA\u2010binding peptides: Redesigned \u03bb N peptide binds boxB RNA","display_name":"Adding energy minimization strategy to peptide\u2010design algorithm enables better search for RNA\u2010binding peptides: Redesigned \u03bb N peptide binds boxB RNA","publication_year":2016,"publication_date":"2016-08-04","ids":{"openalex":"https://openalex.org/W2503584995","doi":"https://doi.org/10.1002/jcc.24466","mag":"2503584995","pmid":"https://pubmed.ncbi.nlm.nih.gov/27487990"},"language":"en","primary_location":{"id":"doi:10.1002/jcc.24466","doi":"https://doi.org/10.1002/jcc.24466","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcc.24466","pdf_url":null,"source":{"id":"https://openalex.org/S21117631","display_name":"Journal of Computational Chemistry","issn_l":"0192-8651","issn":["0192-8651","1096-987X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5314887","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087997669","display_name":"Xingqing Xiao","orcid":"https://orcid.org/0000-0003-3462-3049","observed_orcids":["https://orcid.org/0000-0003-3462-3049"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xingqing Xiao","raw_affiliation_strings":["Chemical and Biomolecular Engineering Department North Carolina State University Raleigh North Carolina 27695\u20107905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biomolecular Engineering Department North Carolina State University Raleigh North Carolina 27695\u20107905","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019293291","display_name":"Michelle E. Hung","orcid":"https://orcid.org/0000-0002-1909-8162","observed_orcids":["https://orcid.org/0000-0002-1909-8162"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle E. Hung","raw_affiliation_strings":["Chemical and Biological Engineering Department, and Chemistry of Life Processes Institute, Northwestern University Evanston Illinois 60208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering Department, and Chemistry of Life Processes Institute, Northwestern University Evanston Illinois 60208","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057179630","display_name":"Joshua N. Leonard","orcid":"https://orcid.org/0000-0003-4359-6126","observed_orcids":["https://orcid.org/0000-0003-4359-6126"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4405271717","display_name":"Chemistry of Life Processes Institute","ror":"https://ror.org/02x58fh78","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua N. Leonard","raw_affiliation_strings":["Chemical and Biological Engineering Department, and Chemistry of Life Processes Institute, Northwestern University Evanston Illinois 60208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering Department, and Chemistry of Life Processes Institute, Northwestern University Evanston Illinois 60208","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4405271717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057051008","display_name":"Carol K. Hall","orcid":"https://orcid.org/0000-0002-7425-587X","observed_orcids":["https://orcid.org/0000-0002-7425-587X"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carol K. Hall","raw_affiliation_strings":["Chemical and Biomolecular Engineering Department North Carolina State University Raleigh North Carolina 27695\u20107905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biomolecular Engineering Department North Carolina State University Raleigh North Carolina 27695\u20107905","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057051008"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":{"value":4520,"currency":"USD","value_usd":4520},"apc_paid":null,"fwci":0.7525,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.72819728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37","issue":"27","first_page":"2423","last_page":"2435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.2498999983072281,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-binding-peptides","display_name":"RNA-binding peptides","score":0.8370000123977661},{"id":"https://openalex.org/keywords/energy-minimization","display_name":"energy minimization","score":0.9039999842643738},{"id":"https://openalex.org/keywords/peptide-rna-binding","display_name":"peptide-RNA binding","score":0.5929999947547913},{"id":"https://openalex.org/keywords/sequence-evolution","display_name":"sequence evolution","score":0.5389999747276306},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/bacteriophage-lambda","display_name":"bacteriophage lambda","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.693283200263977},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6400650143623352},{"id":"https://openalex.org/C14961307","wikidata":"https://www.wikidata.org/wiki/Q5377176","display_name":"Energy minimization","level":2,"score":0.6340368986129761},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.585094690322876},{"id":"https://openalex.org/C147764199","wikidata":"https://www.wikidata.org/wiki/Q6865248","display_name":"Minification","level":2,"score":0.5774346590042114},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5668506622314453},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4412810206413269},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41082900762557983},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3502364754676819},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3395478427410126},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.258274644613266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25153762102127075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21651491522789001},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.20315644145011902},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.11476603150367737},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/jcc.24466","doi":"https://doi.org/10.1002/jcc.24466","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcc.24466","pdf_url":null,"source":{"id":"https://openalex.org/S21117631","display_name":"Journal of Computational Chemistry","issn_l":"0192-8651","issn":["0192-8651","1096-987X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Chemistry","raw_type":"journal-article"},{"id":"pmid:27487990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27487990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4560862","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5314887","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5314887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5314887","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Comput Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5314887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5314887","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Comput Chem","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Affordable and clean energy","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/7"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1553884989","display_name":null,"funder_award_id":"R01EB006006","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G5037168871","display_name":"SPORE in Prostate Cancer","funder_award_id":"P50CA090386","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891045","display_name":"The Robert H. Lurie Comprehensive Cancer Center","funder_award_id":"P30CA060553","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1492285013","https://openalex.org/W1884295873","https://openalex.org/W1969699475","https://openalex.org/W1980336356","https://openalex.org/W1985231519","https://openalex.org/W1996320633","https://openalex.org/W2005136695","https://openalex.org/W2010987005","https://openalex.org/W2018855934","https://openalex.org/W2019574809","https://openalex.org/W2022447980","https://openalex.org/W2038210983","https://openalex.org/W2044736990","https://openalex.org/W2046994420","https://openalex.org/W2047993019","https://openalex.org/W2052277371","https://openalex.org/W2054392131","https://openalex.org/W2054935927","https://openalex.org/W2062617571","https://openalex.org/W2066906496","https://openalex.org/W2070283771","https://openalex.org/W2073275267","https://openalex.org/W2078409719","https://openalex.org/W2082260955","https://openalex.org/W2089843131","https://openalex.org/W2094785910","https://openalex.org/W2103111465","https://openalex.org/W2103137839","https://openalex.org/W2111113395","https://openalex.org/W2126106623","https://openalex.org/W2132696400","https://openalex.org/W2134759124","https://openalex.org/W2138815806","https://openalex.org/W2140247386","https://openalex.org/W2141248208","https://openalex.org/W2144288821","https://openalex.org/W2144775933","https://openalex.org/W2144794967","https://openalex.org/W2150155770","https://openalex.org/W2168589518","https://openalex.org/W2277171521"],"related_works":["https://openalex.org/W1518796764","https://openalex.org/W347294048","https://openalex.org/W2226908759","https://openalex.org/W1899667806","https://openalex.org/W2118841422","https://openalex.org/W2110536527","https://openalex.org/W1981231660","https://openalex.org/W2351116219","https://openalex.org/W1483822002","https://openalex.org/W2061881449"],"abstract_inverted_index":{"Our":[0],"previously":[1],"developed":[2],"peptide-design":[3],"algorithm":[4,34,144],"was":[5,35],"improved":[6],"by":[7],"adding":[8],"an":[9],"energy":[10,130,136],"minimization":[11,131,137],"strategy":[12],"which":[13,44,66],"allows":[14],"the":[15,32,62,83,86,120,127,142,154],"amino":[16],"acid":[17],"sidechains":[18],"to":[19,37,53,81,100,102,116],"move":[20],"in":[21,51],"a":[22,39],"broad":[23],"configuration":[24],"space":[25],"during":[26],"sequence":[27],"evolution.":[28],"In":[29],"this":[30],"work,":[31],"new":[33,134,143],"used":[36],"generate":[38],"library":[40],"of":[41,65,85],"21-mer":[42],"peptides":[43,58,111,152],"could":[45],"substitute":[46],"for":[47],"\u03bb":[48,87,121],"N":[49,88,122],"peptide":[50,89],"binding":[52,69,115],"boxB":[54,72,103,117],"RNA.":[55,73,104],"Six":[56],"potential":[57],"were":[59,78],"obtained":[60],"from":[61],"algorithm,":[63],"all":[64],"exhibited":[67],"good":[68,150],"capability":[70],"with":[71],"Atomistic":[74],"molecular":[75],"dynamics":[76],"simulations":[77],"then":[79],"conducted":[80],"examine":[82],"ability":[84],"and":[90,98,133],"three":[91],"best":[92],"evolved":[93,110],"peptides,":[94],"viz.":[95],"Pept01,":[96],"Pept26,":[97],"Pept28,":[99],"bind":[101],"Simulation":[105],"results":[106],"demonstrated":[107],"that":[108,141],"our":[109],"are":[112],"better":[113],"at":[114,148],"RNA":[118],"than":[119,153],"peptide.":[123],"Sequence":[124],"searches":[125],"using":[126],"old":[128,155],"(without":[129],"strategy)":[132,138],"(with":[135],"algorithms":[139],"confirm":[140],"is":[145],"more":[146],"effective":[147],"finding":[149],"RNA-binding":[151],"algorithm.":[156],"\u00a9":[157],"2016":[158],"Wiley":[159],"Periodicals,":[160],"Inc.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-08-23T00:00:00"}