{"id":"https://openalex.org/W2503580454","doi":"https://doi.org/10.1136/ejhpharm-2016-000944","title":"Analysis of antiretroviral therapy modification in routine clinical practice in the management of HIV infection","display_name":"Analysis of antiretroviral therapy modification in routine clinical practice in the management of HIV infection","publication_year":2016,"publication_date":"2016-07-21","ids":{"openalex":"https://openalex.org/W2503580454","doi":"https://doi.org/10.1136/ejhpharm-2016-000944","mag":"2503580454","pmid":"https://pubmed.ncbi.nlm.nih.gov/31156912"},"language":"en","primary_location":{"id":"doi:10.1136/ejhpharm-2016-000944","doi":"https://doi.org/10.1136/ejhpharm-2016-000944","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2016-000944","pdf_url":"https://ejhp.bmj.com/content/ejhpharm/24/2/96.full.pdf","source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Hospital Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ejhp.bmj.com/content/ejhpharm/24/2/96.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001918462","display_name":"Carmen Sobrino-Jim\u00e9nez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Carmen Sobrino-Jim\u00e9nez","raw_affiliation_strings":["Pharmacy Department, La Paz University Hospital, Madrid, Spain","Pharmacy Department, La Paz University Hospital, Hospital La Paz, Paseo de la Castellana 261, Madrid 28046, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, La Paz University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]},{"raw_affiliation_string":"Pharmacy Department, La Paz University Hospital, Hospital La Paz, Paseo de la Castellana 261, Madrid 28046, Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105935726","display_name":"Inmaculada Jim\u00e9nez\u2010N\u00e1cher","orcid":"https://orcid.org/0000-0002-0680-5534","observed_orcids":["https://orcid.org/0000-0002-0680-5534"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Inmaculada Jim\u00e9nez-N\u00e1cher","raw_affiliation_strings":["Pharmacy Department, La Paz University Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, La Paz University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031507219","display_name":"Francisco Moreno-Ramos","orcid":"https://orcid.org/0000-0002-6870-8174","observed_orcids":["https://orcid.org/0000-0002-6870-8174"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Moreno-Ramos","raw_affiliation_strings":["Pharmacy Department, La Paz University Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, La Paz University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077342799","display_name":"Mar\u00eda \u00c1ngeles Gonz\u00e1lez-Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-3919-4274","observed_orcids":["https://orcid.org/0000-0002-3919-4274"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda \u00c1ngeles Gonz\u00e1lez-Fern\u00e1ndez","raw_affiliation_strings":["Pharmacy Department, La Paz University Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, La Paz University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040446864","display_name":"Mercedes Freire-Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mercedes Freire-Gonz\u00e1lez","raw_affiliation_strings":["Pharmacy Department, La Paz University Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, La Paz University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084032137","display_name":"Juan Gonz\u00e1lez\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-3652-002X","observed_orcids":["https://orcid.org/0000-0002-3652-002X"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Gonz\u00e1lez-Garc\u00eda","raw_affiliation_strings":["Internal Medicine Department, La Paz University Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, La Paz University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015926024","display_name":"Alicia Herrero-Ambrosio","orcid":"https://orcid.org/0000-0003-1375-5165","observed_orcids":["https://orcid.org/0000-0003-1375-5165"]},"institutions":[{"id":"https://openalex.org/I2800562746","display_name":"Hospital Universitario La Paz","ror":"https://ror.org/01s1q0w69","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800562746"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alicia Herrero-Ambrosio","raw_affiliation_strings":["Pharmacy Department, La Paz University Hospital, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Department, La Paz University Hospital, Madrid, Spain","institution_ids":["https://openalex.org/I2800562746"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001918462"],"corresponding_institution_ids":["https://openalex.org/I2800562746"],"apc_list":null,"apc_paid":null,"fwci":0.2804,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.66800635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"24","issue":"2","first_page":"96","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.7620000243186951},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9319999814033508},{"id":"https://openalex.org/keywords/treatment-modification","display_name":"treatment modification","score":0.6679999828338623},{"id":"https://openalex.org/keywords/antiretroviral-drug-costs","display_name":"antiretroviral drug costs","score":0.7820000052452087},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6769999861717224},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7540000081062317},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.7009999752044678},{"id":"https://openalex.org/keywords/integrase-strand-transfer-inhibitors","display_name":"integrase strand transfer inhibitors","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8629999756813049},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/economic-impact","display_name":"economic impact","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.764655590057373},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6936144232749939},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6717098951339722},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6541364789009094},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.5651248693466187},{"id":"https://openalex.org/C129930760","wikidata":"https://www.wikidata.org/wiki/Q1702613","display_name":"Pharmaceutical care","level":3,"score":0.5554505586624146},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5146206617355347},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.5125730037689209},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4092424809932709},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.40197527408599854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38847780227661133},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.21607565879821777},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1802721917629242},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.10025697946548462}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1136/ejhpharm-2016-000944","doi":"https://doi.org/10.1136/ejhpharm-2016-000944","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2016-000944","pdf_url":"https://ejhp.bmj.com/content/ejhpharm/24/2/96.full.pdf","source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Hospital Pharmacy","raw_type":"journal-article"},{"id":"pmid:31156912","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31156912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of hospital pharmacy : science and practice","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6451621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6451621","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Hosp Pharm","raw_type":"Text"},{"id":"pmh:oai:dnet:ricscm______::9757b1e376afdd84dd5d960de4c1a555","doi":null,"is_oa":true,"landing_page_url":"https://repositoriosaludmadrid.es/handle/20.500.12530/23942","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:ejhpharm:24/2/96","doi":null,"is_oa":false,"landing_page_url":"http://ejhp.bmj.com/cgi/content/short/24/2/96","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/ejhpharm-2016-000944","doi":"https://doi.org/10.1136/ejhpharm-2016-000944","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ejhpharm-2016-000944","pdf_url":"https://ejhp.bmj.com/content/ejhpharm/24/2/96.full.pdf","source":{"id":"https://openalex.org/S3012707348","display_name":"European Journal of Hospital Pharmacy","issn_l":"2047-9956","issn":["2047-9956","2047-9964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Hospital Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2503580454.pdf","grobid_xml":"https://content.openalex.org/works/W2503580454.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W3388409","https://openalex.org/W15915457","https://openalex.org/W123944382","https://openalex.org/W1946367640","https://openalex.org/W1948830331","https://openalex.org/W1964932796","https://openalex.org/W1966462610","https://openalex.org/W1973416779","https://openalex.org/W1981343287","https://openalex.org/W1985796937","https://openalex.org/W1993062623","https://openalex.org/W2031656836","https://openalex.org/W2033679867","https://openalex.org/W2034425909","https://openalex.org/W2040417861","https://openalex.org/W2057784452","https://openalex.org/W2076584472","https://openalex.org/W2081131403","https://openalex.org/W2083387456","https://openalex.org/W2087258915","https://openalex.org/W2096880151","https://openalex.org/W2104079629","https://openalex.org/W2118188765","https://openalex.org/W2118370392","https://openalex.org/W2119772888","https://openalex.org/W2134537454","https://openalex.org/W2152715494","https://openalex.org/W2186389098","https://openalex.org/W2318289184","https://openalex.org/W2415620702","https://openalex.org/W2416037454","https://openalex.org/W2428196197","https://openalex.org/W2765240446","https://openalex.org/W6600635936","https://openalex.org/W6687072420","https://openalex.org/W6716554437","https://openalex.org/W7074061212"],"related_works":["https://openalex.org/W36216555","https://openalex.org/W2567016073","https://openalex.org/W4238271440","https://openalex.org/W1911798899","https://openalex.org/W2259751832","https://openalex.org/W2034470753","https://openalex.org/W2340329989","https://openalex.org/W2063234751","https://openalex.org/W2169218167","https://openalex.org/W2981115044"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,26,119,131],"main":[2],"goal":[3],"was":[4,32,126,137,157],"to":[5,208,257],"assess":[6,73],"the":[7,67,74,81,84,109,123,151,218,228],"reasons":[8,65],"for":[9,66,99,232],"antiretroviral":[10,77],"therapy":[11,62,125,135,180,215],"(ART)":[12],"change":[13,69],"in":[14,18,22,235,239,243],"patients":[15,94,113,236],"with":[16,37,95,237],"HIV":[17,38,238],"a":[19,90,200,244,267],"hospital":[20,245],"setting":[21],"routine":[23,240],"clinical":[24,241],"practice.":[25],"economic":[27,75,273],"impact":[28],"of":[29,53,57,83,92,122,171,179,185,192,202,220],"ART":[30,42,58,68,117,196,233,264],"modification":[31,156,216,265],"also":[33],"analysed.":[34,71],"METHODS:":[35],"Patients":[36],"who":[39],"changed":[40],"their":[41,116],"between":[43],"24":[44,47],"November":[45],"and":[46,60,64,150,173,189,224,260],"December":[48],"2014":[49],"were":[50,70,86,168,227],"registered.":[51],"Length":[52],"initial":[54,134],"therapy,":[55],"type":[56],"before":[59],"after":[61,155,214],"modification,":[63],"To":[72],"impact,":[76],"drug":[78],"costs":[79,197],"at":[80,103,217],"time":[82,219],"study":[85,110],"recorded.":[87],"RESULTS:":[88],"Of":[89],"cohort":[91],"3850":[93],"HIV,":[96],"1976":[97],"attended":[98],"pharmaceutical":[100],"care":[101],"consultation":[102],"Hospital":[104],"Universitario":[105],"La":[106],"Paz":[107],"during":[108],"period.":[111],"Ninety-two":[112],"(4.7%)":[114],"had":[115,266],"modified.":[118],"median":[120],"length":[121],"previous":[124],"26":[127],"months":[128],"(range":[129],"1-144).":[130],"most":[132,152,229],"common":[133,153,230],"regimen":[136],"2":[138,158],"nucleoside":[139],"reverse":[140,145],"transcriptase":[141,146],"inhibitors":[142],"(NRTI)+1":[143],"non-nucleoside":[144],"inhibitor":[147,163],"(NNRTI)":[148],"(29.4%),":[149],"one":[154],"NRTI+1":[159],"integrase":[160],"strand":[161],"transfer":[162],"(INSTI)":[164],"(40.2%).":[165],"Forty-three":[166],"modifications":[167],"made":[169],"because":[170,178,184,191],"toxicity":[172,259],"adverse":[174,225],"effects":[175,226],"(46.7%),":[176],"25":[177],"simplification":[181],"(27.2%),":[182],"16":[183],"treatment":[186,262],"failure":[187],"(17.4%),":[188],"8":[190],"drug-drug":[193],"interactions":[194],"(8.7%).":[195],"increased":[198,261],"by":[199],"mean":[201],"\u20ac14":[203],"(SD":[204],"\u20ac216;":[205],"range":[206],"-\u20ac528":[207],"+\u20ac831)":[209],"per":[210,212],"month":[211],"patient":[213],"study.":[221],"CONCLUSIONS:":[222],"Toxicity":[223],"reason":[231],"alteration":[234],"practice":[242],"setting.":[246],"Better":[247],"knowledge":[248],"about":[249],"factors":[250],"that":[251],"motivate":[252],"these":[253],"changes":[254],"may":[255],"contribute":[256],"decreased":[258],"success.":[263],"variable":[268],"but":[269],"not":[270],"very":[271],"substantial":[272],"impact.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}