{"id":"https://openalex.org/W2503560848","doi":"https://doi.org/10.1007/978-1-349-06118-1_5","title":"Phenol Sulfotransferase: Purification and Characterization of the Rat Brain Enzyme","display_name":"Phenol Sulfotransferase: Purification and Characterization of the Rat Brain Enzyme","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2503560848","doi":"https://doi.org/10.1007/978-1-349-06118-1_5","mag":"2503560848"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-349-06118-1_5","doi":"https://doi.org/10.1007/978-1-349-06118-1_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-06118-1_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phenolsulfotransferase in Mental Health Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2480858979","display_name":"Phenolsulfotransferase in Mental Health Research"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035495717","display_name":"Anna Bara\u0144czyk\u2010Ku\u017ama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Baranczyk-Kuzma","raw_affiliation_strings":["Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105421264","display_name":"Ronald T. Borchardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald T. Borchardt","raw_affiliation_strings":["Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113482352","display_name":"Charles S. Schasteen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles S. Schasteen","raw_affiliation_strings":["Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001295390","display_name":"Carol L. Pinnick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol L. Pinnick","raw_affiliation_strings":["Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kansas, Lawrence, Kansas, 66044, USA","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I146416000"],"apc_list":null,"apc_paid":null,"fwci":3.922,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.925,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"55","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenol-sulfotransferase","display_name":"phenol sulfotransferase","score":1.0},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.671999990940094},{"id":"https://openalex.org/keywords/enzyme-characterization","display_name":"enzyme characterization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.8619999885559082},{"id":"https://openalex.org/keywords/3-phosphoadenosine-5-phosphosulfate","display_name":"3'-phosphoadenosine 5'-phosphosulfate","score":0.9200000166893005},{"id":"https://openalex.org/keywords/sulfate-conjugation","display_name":"sulfate conjugation","score":0.921999990940094},{"id":"https://openalex.org/keywords/detoxification","display_name":"detoxification","score":0.703000009059906},{"id":"https://openalex.org/keywords/catecholamine-metabolism","display_name":"catecholamine metabolism","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5519999861717224},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.699999988079071},{"id":"https://openalex.org/keywords/salicylamide","display_name":"salicylamide","score":0.9169999957084656},{"id":"https://openalex.org/keywords/methyldopa","display_name":"methyldopa","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8234322667121887},{"id":"https://openalex.org/C2777611233","wikidata":"https://www.wikidata.org/wiki/Q2496906","display_name":"Salicylamide","level":2,"score":0.7494367361068726},{"id":"https://openalex.org/C2775904581","wikidata":"https://www.wikidata.org/wiki/Q106916699","display_name":"Sulfotransferase","level":3,"score":0.6653625965118408},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5990926027297974},{"id":"https://openalex.org/C2777702071","wikidata":"https://www.wikidata.org/wiki/Q130336","display_name":"Phenol","level":2,"score":0.5660229921340942},{"id":"https://openalex.org/C2778343803","wikidata":"https://www.wikidata.org/wiki/Q172290","display_name":"Sulfate","level":2,"score":0.5602524280548096},{"id":"https://openalex.org/C155138218","wikidata":"https://www.wikidata.org/wiki/Q994559","display_name":"Sulfation","level":2,"score":0.5563859343528748},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5532799363136292},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5162153840065002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49768975377082825},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4864311218261719},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4122147262096405},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.41177690029144287},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.22951549291610718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07193684577941895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.063519686460495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-349-06118-1_5","doi":"https://doi.org/10.1007/978-1-349-06118-1_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-06118-1_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phenolsulfotransferase in Mental Health Research","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1569162071","https://openalex.org/W1775749144","https://openalex.org/W1984505053","https://openalex.org/W1992791081","https://openalex.org/W2002845377","https://openalex.org/W2009868953","https://openalex.org/W2035713904","https://openalex.org/W2051693667","https://openalex.org/W2053981148","https://openalex.org/W2077536537","https://openalex.org/W2081387601","https://openalex.org/W2085226169","https://openalex.org/W2111301002","https://openalex.org/W2128635872","https://openalex.org/W2144760969","https://openalex.org/W2171094357","https://openalex.org/W2218341122","https://openalex.org/W2339424650","https://openalex.org/W2345179618","https://openalex.org/W2401075191","https://openalex.org/W2409407735","https://openalex.org/W2894075739","https://openalex.org/W3021406739","https://openalex.org/W4233019772","https://openalex.org/W4251769577"],"related_works":["https://openalex.org/W4206214304","https://openalex.org/W1982093343","https://openalex.org/W2475963996","https://openalex.org/W1978120043","https://openalex.org/W93725671","https://openalex.org/W1974060576","https://openalex.org/W2050409908","https://openalex.org/W2415572035","https://openalex.org/W223252672","https://openalex.org/W1984505053"],"abstract_inverted_index":{"Phenol":[0],"sulfotransferase":[1],"(PST,":[2],"E.C.2.8.2.1)":[3],"catalyzes":[4],"the":[5,22,25,74,111,118,124],"transfer":[6],"of":[7,24,41,79,95],"a":[8,16,36,90],"sulfate":[9,27],"group":[10],"from":[11],"3\u2032-phosphoadenosine":[12],"5\u2032-phosphosulfate":[13],"(PAPS)":[14],"to":[15,34],"phenolic":[17,47],"acceptor":[18],"substrate":[19],"resulting":[20],"in":[21],"formation":[23],"corresponding":[26],"ester.":[28],"This":[29,113],"PST":[30],"catalyzed":[31],"reaction":[32],"appears":[33],"represent":[35],"major":[37,91],"mechanism":[38],"for":[39,93],"detoxification":[40],"endogenous":[42],"and":[43,51,68,108,117],"exogenous":[44],"compounds":[45],"bearing":[46],"functional":[48],"groups":[49],"(Roy":[50],"Trudinger,":[52],"1970;":[53],"DeMeio,":[54],"1975;":[55],"Jakoby,":[56],"et":[57,83],"al.,":[58,84],"1980).":[59],"Endogenou":[60],"substrates":[61],"include":[62],"catecholamine":[63],"neurotransmitters,":[64],"e.g.,":[65,97],"dopamine":[66],"(Rutledge":[67],"Hoehn,":[69],"1973),":[70],"as":[71,73,123],"well":[72],"deaminated":[75],"and/or":[76],"O-methylated":[77],"metabolites":[78],"catecholamines,e.g.,":[80],"3-methoxy-4-hydroxyphenylglycol":[81],"(Schanberg,":[82],"1968).":[85],"Sulfate":[86],"conjugation":[87],"also":[88],"represents":[89],"pathway":[92],"metabolism":[94],"drugs,":[96],"salicylamide,":[98],"\u03b1-methyldopa":[99],"(Williams,":[100],"1979).":[101],"These":[102],"keywords":[103,119],"were":[104],"added":[105],"by":[106,110],"machine":[107],"not":[109],"authors.":[112],"process":[114],"is":[115],"experimental":[116],"may":[120],"be":[121],"updated":[122],"learning":[125],"algorithm":[126],"improves.":[127]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-08-23T00:00:00"}