{"id":"https://openalex.org/W2503370883","doi":"https://doi.org/10.1158/1538-7445.am2016-sy08-02","title":"Abstract SY08-02: Normal and neoplastic stem cells","display_name":"Abstract SY08-02: Normal and neoplastic stem cells","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2503370883","doi":"https://doi.org/10.1158/1538-7445.am2016-sy08-02","mag":"2503370883"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-sy08-02","doi":"https://doi.org/10.1158/1538-7445.am2016-sy08-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-sy08-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082894731","display_name":"Irving L. Weissman","orcid":"https://orcid.org/0000-0002-9077-7467","observed_orcids":["https://orcid.org/0000-0002-9077-7467"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irving L. Weissman","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082894731"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"SY08","last_page":"02"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7602999806404114,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.1242000013589859,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.7870000004768372},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8270000219345093},{"id":"https://openalex.org/keywords/stem-cell-competition","display_name":"stem cell competition","score":0.8429999947547913},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.7080000042915344},{"id":"https://openalex.org/keywords/germline-stem-cells","display_name":"germline stem cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.9120000004768372},{"id":"https://openalex.org/keywords/myeloid-blast-crisis","display_name":"myeloid blast crisis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":0.7990000247955322},{"id":"https://openalex.org/keywords/sirpalpha","display_name":"SIRP\u03b1","score":0.949999988079071},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/calreticulin","display_name":"calreticulin","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8651860952377319},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.7664483785629272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7065209746360779},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.618150532245636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.615086019039154},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5745530724525452},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.5552548170089722},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5210439562797546},{"id":"https://openalex.org/C143441281","wikidata":"https://www.wikidata.org/wiki/Q5133858","display_name":"Clinical uses of mesenchymal stem cells","level":5,"score":0.47467684745788574},{"id":"https://openalex.org/C18414845","wikidata":"https://www.wikidata.org/wiki/Q15107837","display_name":"Induced stem cells","level":5,"score":0.4572136402130127},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4516836106777191},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.4329795837402344},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.41973134875297546},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.3587748408317566},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3423531651496887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3340993821620941},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23706862330436707},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13817358016967773},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-sy08-02","doi":"https://doi.org/10.1158/1538-7445.am2016-sy08-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-sy08-02","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2537650211","https://openalex.org/W2810661720","https://openalex.org/W2141582526","https://openalex.org/W2749410559","https://openalex.org/W2419302581","https://openalex.org/W2170350160","https://openalex.org/W2676069324","https://openalex.org/W2187263303","https://openalex.org/W2025364309","https://openalex.org/W7096916555"],"abstract_inverted_index":{"Abstract":[0],"The":[1,16,62,179,263],"transition":[2,264],"from":[3,57,70,186,265],"single":[4],"cell":[5,115,126,130,142,219,235,239,294,308,313],"species":[6,133],"to":[7,11,83,113,164,191,269,291,300,305,330,371],"multicellular":[8,23],"organisms":[9,24],"led":[10],"organ":[12],"and":[13,18,52,88,111,127,139,144,155,237,296,348,356,364,368,386],"tissue":[14],"development.":[15],"development":[17],"maintenance":[19],"of":[20,30,49,167,206,224,249,311,333,350,376,393,398],"organs/tissues":[21],"in":[22,27,132,175,259,274,280,354,357,373],"has":[25,182,232],"resulted":[26],"the":[28,96,147,165,171,176,184,198,204,216,247,260,266,275,281,312,320,343,351,374,394,399],"emergence":[29],"specialized":[31],"cells":[32,41,69,73,78,85,99,107,174,189,278,353],"that":[33,65,197,231,341],"self-renew":[34],"as":[35,37,134,136,338],"well":[36],"differentiate;":[38],"these":[39],"rare":[40],"are":[42,54,288,369],"stem":[43,60,68,77,84,98,106,114,125,129,169,188,218,277,388],"cells.":[44,61,389],"Following":[45],"embryonic":[46],"development,":[47],"most":[48,93],"our":[50],"tissues":[51,94],"organs":[53],"continuously":[55],"regenerated":[56],"tissue/organ":[58],"specific":[59],"principal":[63],"property":[64],"distinguishes":[66],"such":[67,337],"their":[71,118],"daughter":[72],"is":[74,146,153,220],"self-renewal;":[75],"when":[76],"divide":[79],"they":[80,209],"give":[81],"rise":[82],"(by":[86,90],"self-renewal)":[87],"progenitors":[89],"differentiation).":[91],"In":[92,246],"only":[95,172],"primitive":[97],"self-renew.":[100],"Even":[101],"within":[102],"a":[103,222,225],"particular":[104],"tissue,":[105],"may":[108],"be":[109,301],"diverse,":[110],"subject":[112],"competition":[116,131],"for":[117,149,322,402],"niche.":[119],"We":[120],"have":[121,195],"documented":[122],"both":[123],"germline":[124],"somatic":[128],"diverse":[135],"colonial":[137],"protochordates":[138],"humans.":[140],"Stem":[141],"isolation":[143],"transplantation":[145],"basis":[148],"regenerative":[150],"medicine.":[151],"Self-renewal":[152],"dangerous,":[154],"therefore":[156],"strictly":[157],"regulated.":[158],"Poorly":[159],"regulated":[160],"self-renewal":[161],"can":[162],"lead":[163],"genesis":[166],"cancer":[168,200],"cells,":[170],"self-renewing":[173],"cancerous":[177],"tumor.":[178],"Weissman":[180],"lab":[181],"followed":[183],"progression":[185],"hematopoietic":[187],"(HSCs)":[190],"myelogenous":[192],"leukemias.":[193],"They":[194],"found":[196],"developing":[199],"clones":[201,255],"progress":[202],"at":[203,221],"stage":[205,223],"HSCs,":[207],"until":[208],"become":[210],"fully":[211],"malignant.":[212],"At":[213],"this":[214],"point,":[215],"\u201cleukemia\u201d":[217],"downstream":[226],"oligolineage":[227],"or":[228,243],"multilineage":[229],"progenitor":[230,283],"evaded":[233],"programmed":[234,238,293,307],"death":[236,295],"removal,":[240],"while":[241],"acquiring":[242],"keeping":[244],"self-renewal.":[245],"case":[248],"chronic":[250,261,267],"myeloid":[251,270],"leukemia,":[252],"bcr-abl+":[253],"HSC":[254],"outcompete":[256],"normal":[257],"HSCs":[258],"phase.":[262],"phase":[268],"blast":[271],"crisis":[272],"results":[273],"leukemia":[276],"appearing":[279],"granulocyte-macrophage":[282],"(GMP)":[284],"stage.":[285],"While":[286],"there":[287,298],"many":[289],"ways":[290],"defeat":[292],"senescence,":[297],"appears":[299],"one":[302],"dominant":[303],"method":[304],"avoid":[306],"removal\u2014the":[309],"expression":[310,332],"surface":[314],"\u201cdon't":[315],"eat":[316],"me\u201d":[317,335],"protein":[318],"CD47,":[319],"ligand":[321],"macrophage":[323],"SIRP\u03b1.":[324],"All":[325,359],"cancers":[326],"tested":[327,360],"express":[328,366],"CD47":[329,367],"overcome":[331],"\u201ceat":[334],"signals":[336],"calreticulin.":[339],"Antibodies":[340],"block":[342],"CD47-SIRP\u03b1":[344],"interaction":[345],"enable":[346],"phagocytosis":[347,372],"killing":[349],"tumor":[352],"vitro":[355],"vivo.":[358],"human":[361],"solid":[362],"tumors":[363],"lymphomas/leukemias/myelomas":[365],"susceptible":[370],"presence":[375],"anti-CD47":[377],"blocking":[378],"antibodies.":[379],"Citation":[380],"Format:":[381],"Irving":[382],"L.":[383],"Weissman.":[384],"Normal":[385],"neoplastic":[387],"[abstract].":[390],"In:":[391],"Proceedings":[392],"107th":[395],"Annual":[396],"Meeting":[397],"American":[400],"Association":[401],"Cancer":[403,414],"Research;":[404],"2016":[405],"Apr":[406],"16-20;":[407],"New":[408],"Orleans,":[409],"LA.":[410],"Philadelphia":[411],"(PA):":[412],"AACR;":[413],"Res":[415],"2016;76(14":[416],"Suppl):Abstract":[417],"nr":[418],"SY08-02.":[419]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-08-23T00:00:00"}
