{"id":"https://openalex.org/W25018822","doi":null,"title":"Circadian rhythm of salivary serotonin in patients with major depressive disorder.","display_name":"Circadian rhythm of salivary serotonin in patients with major depressive disorder.","publication_year":2007,"publication_date":"2007-08-01","ids":{"openalex":"https://openalex.org/W25018822","mag":"25018822","pmid":"https://pubmed.ncbi.nlm.nih.gov/17693970"},"language":"en","primary_location":{"id":"pmid:17693970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17693970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088200644","display_name":"Zhonglin Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong-Lin Tan","raw_affiliation_strings":["Hefei National Laboratory for Physical Sciences at Microscale, and Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei Jinzhai Road 96, Anhui 230026, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hefei National Laboratory for Physical Sciences at Microscale, and Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei Jinzhai Road 96, Anhui 230026, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026108717","display_name":"Ai\u2010Min Bao","orcid":"https://orcid.org/0000-0002-8755-1950","observed_orcids":["https://orcid.org/0000-0002-8755-1950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ai-Min Bao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009771110","display_name":"Ming Tao","orcid":"https://orcid.org/0000-0003-1175-5380","observed_orcids":["https://orcid.org/0000-0003-1175-5380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Tao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059783175","display_name":"Ya-Jing Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ya-Jing Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017448934","display_name":"Jiang\u2010Ning Zhou","orcid":"https://orcid.org/0000-0003-1225-2873","observed_orcids":["https://orcid.org/0000-0003-1225-2873"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang-Ning Zhou","raw_affiliation_strings":["University of Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Science and Technology of China","institution_ids":["https://openalex.org/I126520041"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6331,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.69792783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"28","issue":"4","first_page":"395","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.21410000324249268,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.16249999403953552,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9300000071525574},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.8880000114440918},{"id":"https://openalex.org/keywords/circadian-amplitude","display_name":"circadian amplitude","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cosinor-analysis","display_name":"cosinor analysis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/zung-self-rating-depression-scale","display_name":"Zung Self-Rating Depression Scale","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8938381671905518},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.806660532951355},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.7874172925949097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7041782140731812},{"id":"https://openalex.org/C136792703","wikidata":"https://www.wikidata.org/wiki/Q377893","display_name":"Ultradian rhythm","level":3,"score":0.702657163143158},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6195856928825378},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.5857598781585693},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.5489762425422668},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5145930051803589},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5019404888153076},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.4885633885860443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3696216940879822},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17693970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17693970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:25018822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17693970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W57749977","https://openalex.org/W193585346","https://openalex.org/W1607171655","https://openalex.org/W1965378324","https://openalex.org/W1981427133","https://openalex.org/W1982921548","https://openalex.org/W2009033131","https://openalex.org/W2013548020","https://openalex.org/W2021541254","https://openalex.org/W2044358375","https://openalex.org/W2048242753","https://openalex.org/W2060957014","https://openalex.org/W2061378977","https://openalex.org/W2067509437","https://openalex.org/W2071370008","https://openalex.org/W2073686160","https://openalex.org/W2073944769","https://openalex.org/W2075298455","https://openalex.org/W2080191708","https://openalex.org/W2085516730","https://openalex.org/W2109946624","https://openalex.org/W2111641784","https://openalex.org/W2112834634","https://openalex.org/W2133037699","https://openalex.org/W2140628276","https://openalex.org/W2159011576","https://openalex.org/W2160240946","https://openalex.org/W2172147562","https://openalex.org/W2397555345","https://openalex.org/W2413637759","https://openalex.org/W2424930425","https://openalex.org/W2540571613","https://openalex.org/W4238079920"],"related_works":["https://openalex.org/W3174212142","https://openalex.org/W2051308476","https://openalex.org/W2096998389","https://openalex.org/W2342237972","https://openalex.org/W4308640791","https://openalex.org/W2098490330","https://openalex.org/W1979881132","https://openalex.org/W3210723551","https://openalex.org/W2594559415","https://openalex.org/W2412744690"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,135,198],"present":[2],"study":[3,34],"aimed":[4],"to":[5,87,100,120],"explore":[6],"the":[7,79,89,131,146,172,201],"circadian":[8,107,137,196],"rhythm":[9,108],"of":[10,71,148,174,203],"salivary":[11,36,74,204],"serotonin":[12,37,75,104,136,187,205],"in":[13,38,94,109,126,171,188],"patients":[14,52,112,189],"with":[15,23,28,41,145,190],"major":[16,42,191],"depressive":[17,43,192],"disorder":[18,44,193],"before":[19,63],"and":[20,25,45,47,64,113,178,207],"after":[21,67,123],"treatment":[22,57,125],"fluoxetine":[24,56,124],"its":[26],"relationship":[27,199],"clinical":[29,208],"therapeutic":[30],"effect.":[31],"METHODS:":[32],"This":[33],"investigated":[35],"13":[39],"outpatients":[40],"age-":[46],"sex-matched":[48],"healthy":[49,115],"controls.":[50],"Depressed":[51],"received":[53],"six":[54],"weeks":[55,66],"(20":[58],"mg/day),":[59],"saliva":[60,95],"was":[61,76,85,142,159,167],"collected":[62],"four":[65],"treatment.":[68],"A":[69],"total":[70],"8":[72],"time-point":[73],"measured":[77],"across":[78],"whole":[80],"day.":[81],"Multi-oscillator":[82],"cosinor":[83],"model":[84],"used":[86],"fit":[88],"rhythms.":[90],"RESULTS:":[91],"Serotonin":[92],"concentration":[93],"ranged":[96],"from":[97],"0.32":[98],"ng/ml":[99],"9.62":[101],"ng/ml.":[102],"Salivary":[103,186],"showed":[105,194],"prominent":[106],"91%":[110],"depressed":[111,127],"92%":[114],"subjects.":[116],"Circadian":[117],"amplitude":[118,138,206],"tend":[119],"be":[121],"higher":[122],"patients,":[128],"so":[129],"as":[130],"ultradian":[132],"cycle":[133],"amplitude.":[134],"(After":[139],"minus":[140],"Before)":[141],"positively":[143],"correlated":[144],"decrease":[147],"Zung":[149],"Self-Rating":[150],"Depression":[151],"Scale(SDS)":[152],"scores":[153],"at":[154,163],"day":[155,164],"42":[156],"whereas":[157],"there":[158],"no":[160,168],"such":[161],"correlation":[162],"28.":[165],"There":[166],"significant":[169],"difference":[170],"parameters":[173],"mesor,":[175],"acrophase,":[176],"harmonic":[177],"area":[179],"under":[180],"curve":[181],"among":[182],"three":[183],"groups.":[184],"CONCLUSIONS:":[185],"clear":[195],"rhythm.":[197],"between":[200],"increase":[202],"response":[209],"deserve":[210],"further":[211],"study.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
