{"id":"https://openalex.org/W2501487520","doi":"https://doi.org/10.1038/srep30617","title":"Evaluation of QuantiFERON-TB Gold Plus for Detection of Mycobacterium tuberculosis infection in Japan","display_name":"Evaluation of QuantiFERON-TB Gold Plus for Detection of Mycobacterium tuberculosis infection in Japan","publication_year":2016,"publication_date":"2016-07-29","ids":{"openalex":"https://openalex.org/W2501487520","doi":"https://doi.org/10.1038/srep30617","mag":"2501487520","pmid":"https://pubmed.ncbi.nlm.nih.gov/27470684","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4965764"},"language":"en","primary_location":{"id":"doi:10.1038/srep30617","doi":"https://doi.org/10.1038/srep30617","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep30617","pdf_url":"https://www.nature.com/articles/srep30617.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep30617.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lina Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]},{"id":"https://openalex.org/I4210152755","display_name":"Fukujuji Hospital","ror":"https://ror.org/0422nk691","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152755"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Lina Yi","raw_affiliation_strings":["Department of Basic Mycobacteriology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan","Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Mycobacteriology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133","https://openalex.org/I4210152755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101757103","display_name":"Yuka Sasaki","orcid":"https://orcid.org/0000-0001-8322-5878","observed_orcids":["https://orcid.org/0000-0001-8322-5878","https://orcid.org/0000-0002-6293-3987"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]},{"id":"https://openalex.org/I4210152755","display_name":"Fukujuji Hospital","ror":"https://ror.org/0422nk691","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210152755"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Sasaki","raw_affiliation_strings":["Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133","https://openalex.org/I4210152755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114022056","display_name":"Hideaki Nagai","orcid":"https://orcid.org/0000-0002-7112-6124","observed_orcids":["https://orcid.org/0000-0002-7112-6124","https://orcid.org/0009-0005-1698-2648"]},"institutions":[{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Nagai","raw_affiliation_strings":["Department of Respiratory Medicine, National Hospital Organization Tokyo National Hospital, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, National Hospital Organization Tokyo National Hospital, Kiyose, Japan","institution_ids":["https://openalex.org/I4210156366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101469727","display_name":"Satoru Ishikawa","orcid":"https://orcid.org/0000-0002-5778-8869","observed_orcids":["https://orcid.org/0000-0002-5778-8869"]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Ishikawa","raw_affiliation_strings":["Department of Respiratory Medicine, National Hospital Organization Chiba Higashi National Hospital, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, National Hospital Organization Chiba Higashi National Hospital, Chiba, Japan","institution_ids":["https://openalex.org/I4210137409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014193607","display_name":"Mikio Takamori","orcid":"https://orcid.org/0000-0002-6786-5370","observed_orcids":["https://orcid.org/0000-0002-6786-5370"]},"institutions":[{"id":"https://openalex.org/I4210151172","display_name":"Tokyo Metropolitan Tama Medical Center","ror":"https://ror.org/04c3ebg91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151172"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikio Takamori","raw_affiliation_strings":["Department of Respiratory Medicine, Tokyo Metropolitan Tama Medical Centre, Fuchu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Tokyo Metropolitan Tama Medical Centre, Fuchu, Japan","institution_ids":["https://openalex.org/I4210151172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069917253","display_name":"Kentaro Sakashita","orcid":"https://orcid.org/0000-0002-3948-5557","observed_orcids":["https://orcid.org/0000-0002-3948-5557"]},"institutions":[{"id":"https://openalex.org/I4210151172","display_name":"Tokyo Metropolitan Tama Medical Center","ror":"https://ror.org/04c3ebg91","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210151172"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Sakashita","raw_affiliation_strings":["Department of Basic Mycobacteriology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan","Department of Respiratory Medicine, Tokyo Metropolitan Tama Medical Centre, Fuchu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Mycobacteriology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Tokyo Metropolitan Tama Medical Centre, Fuchu, Japan","institution_ids":["https://openalex.org/I4210151172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002731286","display_name":"Takefumi Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137409","display_name":"National Hospital Organization","ror":"https://ror.org/03ntccx93","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210137409"]},{"id":"https://openalex.org/I4210141661","display_name":"Ibarakihigashi National Hospital","ror":"https://ror.org/040xmsv41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210141661"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takefumi Saito","raw_affiliation_strings":["Department of Respiratory Medicine, National Hospital Organization Ibaraki Higashi National Hospital, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, National Hospital Organization Ibaraki Higashi National Hospital, Ibaraki, Japan","institution_ids":["https://openalex.org/I4210137409","https://openalex.org/I4210141661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072019826","display_name":"Kiyoyasu Fukushima","orcid":"https://orcid.org/0000-0002-1833-7723","observed_orcids":["https://orcid.org/0000-0002-1833-7723"]},"institutions":[{"id":"https://openalex.org/I4405284780","display_name":"Japanese Red Cross Nagasaki Genbaku Isahaya Hospital","ror":"https://ror.org/046e73s49","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4405284780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoyasu Fukushima","raw_affiliation_strings":["Department of Respiratory Medicine, Nagasaki Genbaku Isahaya Hospital, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Nagasaki Genbaku Isahaya Hospital, Nagasaki, Japan","institution_ids":["https://openalex.org/I4405284780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102727239","display_name":"Yuriko Igarashi","orcid":"https://orcid.org/0000-0002-3695-7926","observed_orcids":["https://orcid.org/0000-0002-3695-7926"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuriko Igarashi","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074060649","display_name":"Akio Aono","orcid":"https://orcid.org/0000-0003-3478-6892","observed_orcids":["https://orcid.org/0000-0003-3478-6892"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Aono","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072217209","display_name":"Kinuyo Chikamatsu","orcid":"https://orcid.org/0000-0002-5398-9399","observed_orcids":["https://orcid.org/0000-0002-5398-9399"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kinuyo Chikamatsu","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034002948","display_name":"Hiroyuki Yamada","orcid":"https://orcid.org/0000-0002-2720-9125","observed_orcids":["https://orcid.org/0000-0002-2720-9125"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yamada","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035564080","display_name":"Akiko Takaki","orcid":"https://orcid.org/0000-0002-0592-5737","observed_orcids":["https://orcid.org/0000-0002-0592-5737"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Takaki","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110425405","display_name":"Toru Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Mori","raw_affiliation_strings":["Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033788592","display_name":"Satoshi Mitarai","orcid":"https://orcid.org/0000-0002-2288-077X","observed_orcids":["https://orcid.org/0000-0002-2288-077X"]},"institutions":[{"id":"https://openalex.org/I4210100133","display_name":"Japan Anti Tuberculosis Association","ror":"https://ror.org/012daep68","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210100133"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Mitarai","raw_affiliation_strings":["Department of Basic Mycobacteriology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan","Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Mycobacteriology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan","institution_ids":["https://openalex.org/I43777268"]},{"raw_affiliation_string":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan","institution_ids":["https://openalex.org/I4210100133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210100133","https://openalex.org/I4210152755","https://openalex.org/I43777268"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":6.9998,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.97778392,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"30617","last_page":"30617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantiferon-tb-gold-plus","display_name":"QuantiFERON-TB Gold Plus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/quantiferon-tb-gold-in-tube","display_name":"QuantiFERON-TB Gold In-Tube","score":0.9890000224113464},{"id":"https://openalex.org/keywords/interferon-gamma-release-assay","display_name":"interferon-gamma release assay","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis-infection","display_name":"Mycobacterium tuberculosis infection","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tuberculosis-diagnosis","display_name":"tuberculosis diagnosis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cutoff-values","display_name":"cut-off values","score":0.7620000243186951},{"id":"https://openalex.org/keywords/japan","display_name":"Japan","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2776763545","wikidata":"https://www.wikidata.org/wiki/Q2893466","display_name":"QuantiFERON","level":5,"score":0.7010047435760498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6973046660423279},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6721236705780029},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6553786396980286},{"id":"https://openalex.org/C3020380090","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon \u03b3","level":4,"score":0.5396011471748352},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.4650128483772278},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.44179975986480713},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36904704570770264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34546077251434326},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.30648043751716614},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14566445350646973},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11355537176132202},{"id":"https://openalex.org/C2779806340","wikidata":"https://www.wikidata.org/wiki/Q4254929","display_name":"Latent tuberculosis","level":4,"score":0.10887506604194641}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059425","descriptor_name":"Interferon-gamma Release Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/srep30617","doi":"https://doi.org/10.1038/srep30617","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep30617","pdf_url":"https://www.nature.com/articles/srep30617.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3939448","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4965764","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27470684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27470684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:4965764","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4965764/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/srep30617","doi":"https://doi.org/10.1038/srep30617","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep30617","pdf_url":"https://www.nature.com/articles/srep30617.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2501487520.pdf","grobid_xml":"https://content.openalex.org/works/W2501487520.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1483831487","https://openalex.org/W1498589284","https://openalex.org/W1597086056","https://openalex.org/W1622036515","https://openalex.org/W1929054583","https://openalex.org/W1966145424","https://openalex.org/W2011943102","https://openalex.org/W2061188088","https://openalex.org/W2068034634","https://openalex.org/W2068331751","https://openalex.org/W2084074381","https://openalex.org/W2105420101","https://openalex.org/W2106945255","https://openalex.org/W2110903459","https://openalex.org/W2120595701","https://openalex.org/W2123846481","https://openalex.org/W2125345900","https://openalex.org/W2125774942","https://openalex.org/W2127062586","https://openalex.org/W2133562534","https://openalex.org/W2133936335","https://openalex.org/W2134821207","https://openalex.org/W2143141045","https://openalex.org/W2145176302","https://openalex.org/W2146593359","https://openalex.org/W2166120132","https://openalex.org/W2167382856","https://openalex.org/W2276120671","https://openalex.org/W2410897379","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2977452765","https://openalex.org/W2800076529","https://openalex.org/W3162044028","https://openalex.org/W2998191478","https://openalex.org/W2968906477","https://openalex.org/W2995388449","https://openalex.org/W2767073710","https://openalex.org/W3002580739","https://openalex.org/W3043403968","https://openalex.org/W3133524031"],"abstract_inverted_index":{"Performance":[0],"of":[1,16,23,34,40,73,79,123,161,168,173,195],"interferon-\u03b3":[2],"(IFN-\u03b3)":[3],"release":[4],"assays":[5,98],"still":[6],"needs":[7],"to":[8,38,126,197],"be":[9,190],"improved.":[10],"The":[11,70,158],"data":[12],"on":[13],"the":[14,31,102,111,138,178,184,199],"performance":[15,33,160],"QuantiFERON-TB":[17,41],"Gold":[18,42],"Plus":[19],"(QFT-Plus),":[20],"a":[21,120,171],"new-generation":[22],"QFT":[24],"assay":[25],"are":[26],"limited.":[27],"This":[28],"study":[29],"evaluated":[30],"diagnostic":[32,159],"QFT-Plus,":[35],"and":[36,56,68,95,176],"compared":[37,92,125],"that":[39,78,167,194],"In-Tube":[43],"(QFT-GIT).":[44],"Blood":[45],"samples":[46,62],"were":[47,63,91,144],"collected":[48],"from":[49,193],"162":[50],"bacteriologically":[51],"confirmed":[52],"tuberculosis":[53],"(TB)":[54],"patients":[55,83],"212":[57],"Mycobacterium":[58],"tuberculosis-uninfected":[59],"volunteers;":[60],"these":[61],"then":[64],"tested":[65],"with":[66,137,147],"QFT-GIT":[67,80,94,150,169,196],"QFT-Plus.":[69,96,157],"IFN-\u03b3":[71,142],"concentration":[72],"QFT-Plus":[74,118,162,188],"was":[75,163],"lower":[76,121],"than":[77],"in":[81,149,156,180],"TB":[82],"(p":[84,128,151],"<":[85],"0.001).":[86],"Receiver":[87],"operating":[88],"characteristic":[89],"curves":[90],"between":[93],"Both":[97],"showed":[99],"area":[100],"under":[101],"curve":[103],"values":[104,143],"over":[105],"0.99":[106],"without":[107,202],"significant":[108],"difference.":[109],"Using":[110],"conventional":[112],"cut-off":[113,134,185],"(0.35":[114],"IU/mL)":[115,136],"for":[116,187],"QFT-GIT,":[117],"had":[119],"sensitivity":[122,201],"91.1%":[124],"96.2%":[127],"=":[129,152],"0.008)":[130],"at":[131],"its":[132],"optimum":[133],"(0.168":[135],"same":[139],"specificity.":[140,204],"Moreover,":[141],"significantly":[145],"reduced":[146],"age":[148],"0.035)":[153],"but":[154],"not":[155],"as":[164,166],"accurate":[165],"despite":[170,177],"lack":[172],"TB7.7":[174],"antigen":[175],"decrease":[179],"quantitative":[181],"values.":[182],"However,":[183],"value":[186],"should":[189],"considered":[191],"independently":[192],"obtain":[198],"best":[200],"compromising":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-08-23T00:00:00"}
