{"id":"https://openalex.org/W2501460948","doi":null,"title":"MCP-1 IN THE PERIOSTEUM AND THE ENDOSTEUM AT THE EARLY INFLAMMATORY PHASE IS AN ESSENTIAL COMPONENT FOR SUCCESSFUL FRACTURE HEALING","display_name":"MCP-1 IN THE PERIOSTEUM AND THE ENDOSTEUM AT THE EARLY INFLAMMATORY PHASE IS AN ESSENTIAL COMPONENT FOR SUCCESSFUL FRACTURE HEALING","publication_year":2018,"publication_date":"2018-02-21","ids":{"openalex":"https://openalex.org/W2501460948","mag":"2501460948"},"language":"en","primary_location":{"id":"mag:2790143547","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.96BSUPP_11.CORS2013-209","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001727346","display_name":"Masahiro Ishikawa","orcid":"https://orcid.org/0000-0003-1628-3116","observed_orcids":["https://orcid.org/0000-0003-1628-3116"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Ishikawa","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":"https://orcid.org/0000-0003-1628-3116","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074384098","display_name":"Hiromu Ito","orcid":"https://orcid.org/0000-0002-1827-382X","observed_orcids":["https://orcid.org/0000-0002-1827-382X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromu Ito","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074152292","display_name":"Hiroyuki Yoshitomi","orcid":"https://orcid.org/0000-0001-7339-9030","observed_orcids":["https://orcid.org/0000-0001-7339-9030"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Yoshitomi","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055194718","display_name":"Koichi Murata","orcid":"https://orcid.org/0000-0002-7896-3937","observed_orcids":["https://orcid.org/0000-0002-7896-3937"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Murata","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":"https://orcid.org/0000-0002-7896-3937","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068391117","display_name":"Hideyuki Shibuya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Shibuya","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Moritoshi Furu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Moritoshi Furu","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089397803","display_name":"Toshiyuki Kitaori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Kitaori","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000730403","display_name":"Tatsuo Nakamura","orcid":"https://orcid.org/0009-0003-8736-1123","observed_orcids":["https://orcid.org/0009-0003-8736-1123"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Nakamura","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":"https://orcid.org/0009-0003-8736-1123","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shuichi Matsuda","orcid":"https://orcid.org/0000-0003-0802-1255","observed_orcids":["https://orcid.org/0000-0003-0802-1255"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Matsuda","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan"],"raw_orcid":"https://orcid.org/0000-0003-0802-1255","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto - Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00961797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8849999904632568},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8769999742507935},{"id":"https://openalex.org/keywords/periosteum","display_name":"periosteum","score":0.8320000171661377},{"id":"https://openalex.org/keywords/endosteum","display_name":"endosteum","score":1.0},{"id":"https://openalex.org/keywords/rib-fractures","display_name":"rib fractures","score":0.7319999933242798},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7250000238418579},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5210000276565552},{"id":"https://openalex.org/keywords/monocyte-chemotactic-protein-3","display_name":"MCP-3","score":0.6899999976158142},{"id":"https://openalex.org/keywords/bone-grafting","display_name":"bone grafting","score":0.39500001072883606},{"id":"https://openalex.org/keywords/callus-formation","display_name":"callus formation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/chemoattraction","display_name":"chemoattraction","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.7739768028259277},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.7676956653594971},{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.6637770533561707},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5903424620628357},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5142245292663574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5102488994598389},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.43283629417419434},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.38789230585098267},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3817238509654999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3168816566467285},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21484825015068054}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2790143547","doi":null,"is_oa":false,"landing_page_url":"https://online.boneandjoint.org.uk/doi/abs/10.1302/1358-992X.96BSUPP_11.CORS2013-209","pdf_url":null,"source":{"id":"https://openalex.org/S4387287184","display_name":"Orthopaedic Proceedings","issn_l":"1358-992X","issn":["1358-992X","2049-4416"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Orthopaedic Proceedings","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982753152","https://openalex.org/W2049290532","https://openalex.org/W2164178045","https://openalex.org/W2400354936","https://openalex.org/W2053686222","https://openalex.org/W1952650604","https://openalex.org/W2030164378","https://openalex.org/W2990408500","https://openalex.org/W3025983508","https://openalex.org/W2983599887"],"abstract_inverted_index":{"Summary":[0],"Statement":[1],"MCP-1/":[3,468],"CCR2":[4,171,469],"axis":[5,67,79,157,470],"at":[6,137,254,471,511],"the":[7,15,63,75,107,115,122,138,141,161,185,190,197,202,210,219,222,235,240,250,255,258,261,297,345,378,381,384,390,472,476,485,488,491,506,509,512],"early":[8,162,473,513],"phase":[9,163,474,515],"plays":[10,19],"a":[11,20,48,266,320,325,331,356,404,432,448,456],"pivotal":[12,21],"role":[13,22],"in":[14,23,32,68,106,184,201,209,217,234,239,318,355,377,389,447,484,495,505],"fracture":[16,24,69,109,127,165,182,262,300,408,477,492,522],"healing.":[17,25,110,128,478,523],"Inflammation":[18],"Among":[26],"them,":[27],"chemokines":[28],"play":[29],"key":[30],"roles":[31,251],"inflammation.":[33],"Monocyte":[34],"chemotactic":[35],"protein-1":[36],"(MCP-1),":[37],"via":[38],"its":[39],"receptor":[40,43],"C-C":[41],"chemokine":[42,406],"2":[44,101],"(CCR2),":[45],"acts":[46],"as":[47],"potent":[49],"chemoattractant":[50],"for":[51,407,520],"various":[52],"cells":[53],"to":[54,59,282,296,340],"promote":[55],"migration":[56],"from":[57,277,324],"circulation":[58],"inflammation":[60],"site.":[61],"Thus,":[62,498],"importance":[64],"of":[65,77,93,117,133,164,232,246,252,299,347,359,374,397,441,451],"MCP-1/CCR2":[66,78,156],"healing":[70,183,301,493],"has":[71],"been":[72],"suggested.":[73],"However,":[74],"involvement":[76],"tofracture":[80],"site":[81],"is":[82,158,403,516],"not":[83],"fully":[84],"elucidated.":[85],"Results":[87],"PCR":[89],"Array:":[90],"The":[91,272],"expression":[92,132,376],"MCP-1":[94,118,134,253,278,284,312,333,375,392,402,483,504],"and":[95,135,140,192,221,257,315,371,380,413,487,508],"MCP-3":[96,136],"had":[97],"increased":[98],"on":[99,143,242,302,363,435,455],"day":[100,145,195,227,243,303,364,436],"than":[102,207],"0":[103],"or":[104,174],"7":[105],"rib":[108,126,176],"Immunohistochemistry":[111],"Staining:":[112],"To":[113,153,248,399],"verify":[114],"localization":[116],"expression,":[119],"we":[120,167,264,306,410,465,480],"examined":[121],"Wild":[123],"type":[124],"(WT)-mouse":[125],"We":[129],"observed":[130,238,388,430],"high":[131],"periosteum":[139,256,379,486,507],"endosteum":[142,259,382,489,510],"post-fracture":[144],"3.":[146],"In":[148,229,338,438,462],"vivo":[149,496],"Antagonist":[151],"Study:":[152],"elucidate":[154],"whether":[155,401],"involved":[159],"during":[160,260],"healing,":[166,263,409],"continuously":[168],"administered":[169],"RS102895,":[170],"antagonist,":[172],"before":[173],"after":[175],"fracture.":[177],"Micro-CT":[178,289],"analysis":[179,213,290,367],"showed":[180,214,291,481],"delayed":[181],"before-group":[186,203,241],"compared":[187],"with":[188],"both":[189,218],"control":[191,220],"after-group.":[193],"On":[194],"21,":[196],"hard":[198],"callus":[199,236],"volume":[200],"was":[204,237,328,387,421,429],"significantly":[205],"smaller":[206],"that":[208,215,292,369,467,482,503],"control-group.":[211],"Histological":[212,366],"fractures":[216],"after-groups":[223],"were":[224,275],"healed":[225],"by":[226],"21.":[228,304,365,437],"contrast,":[230,439],"less":[231],"cartilage":[233],"7.":[244],"Gain":[245],"Function:":[247,398],"examine":[249],"created":[265,307,411],"segmental":[267,321],"bone":[268,273,322,342,361,415,427,453],"graft":[269,309,343,349,386,416,420,434,443],"exchanging":[270],"model.":[271],"grafts":[274],"transplanted":[276,329,422],"\u2212/\u2212":[279,285,313,334,393],"mice":[281,287],"another":[283],"(KO-to-KO).":[288],"KO-to-KO":[293,341],"transplantation":[294,346,440],"led":[295],"delay":[298],"Next,":[305],"exchanging-bone":[308],"models":[310],"between":[311],"WT":[316,326],"mice,":[317],"which":[319],"derived":[323],"mouse":[327,336,353],"into":[330,350,423,444],"host":[332,351,391],"(WT-to-KO).":[337],"contrast":[339],"transplantation,":[344],"WT-derived":[348,385,433],"KO":[352],"resulted":[354,446],"significant":[357],"increase":[358],"new":[360,426],"formation":[362,428,454],"revealed":[368],"marked":[370,449],"localised":[372],"induction":[373],"around":[383,431],"mouse.":[395],"Loss":[396],"validate":[400],"crucial":[405],"WT-to-WT":[412],"KO-to-WT":[414],"models.":[417],"When":[418],"WT-donor":[419],"WT-host,":[424],"abundant":[425],"KO-derived":[442],"WT-host":[445],"reduction":[450],"periosteal":[452],"donor":[457],"graft.":[458],"Discussion":[460],"this":[463],"study,":[464],"demonstrated":[466],"modulates":[475],"Furthermore,":[479],"promotes":[490],".":[497],"these":[499],"results":[500],"clearly":[501],"suggest":[502],"inflammatory":[514],"an":[517],"essential":[518],"component":[519],"successful":[521]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
