{"id":"https://openalex.org/W2500892174","doi":"https://doi.org/10.1016/j.biocel.2016.07.027","title":"Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinoma","display_name":"Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinoma","publication_year":2016,"publication_date":"2016-07-30","ids":{"openalex":"https://openalex.org/W2500892174","doi":"https://doi.org/10.1016/j.biocel.2016.07.027","mag":"2500892174","pmid":"https://pubmed.ncbi.nlm.nih.gov/27477312"},"language":"en","primary_location":{"id":"doi:10.1016/j.biocel.2016.07.027","doi":"https://doi.org/10.1016/j.biocel.2016.07.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2016.07.027","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011591358","display_name":"Ioanna Vallianou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioanna Vallianou","raw_affiliation_strings":["Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073210502","display_name":"Dimitra Dafou","orcid":"https://orcid.org/0000-0003-4170-0612","observed_orcids":["https://orcid.org/0000-0003-4170-0612"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitra Dafou","raw_affiliation_strings":["Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044505779","display_name":"Niki Vassilaki","orcid":"https://orcid.org/0000-0001-7992-3438","observed_orcids":["https://orcid.org/0000-0001-7992-3438"]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Niki Vassilaki","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059174311","display_name":"Penelope Mavromara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Penelope Mavromara","raw_affiliation_strings":["Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Virology Laboratory, Hellenic Pasteur Institute, Athens, Greece","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050864482","display_name":"Margarita Hadzopoulou\u2010Cladaras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Margarita Hadzopoulou-Cladaras","raw_affiliation_strings":["Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: cladaras@bio.auth.gr","Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece. Electronic address: cladaras@bio.auth.gr","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050864482"],"corresponding_institution_ids":["https://openalex.org/I21370196"],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":1.9738,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85488234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"78","issue":null,"first_page":"315","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.04399999976158142,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hnf4a","display_name":"HNF4\u03b1","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mir-24","display_name":"miR-24","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mir-124","display_name":"miR-124","score":1.0},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.7490000128746033},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hnf1a","display_name":"HNF1A","score":0.9169999957084656},{"id":"https://openalex.org/keywords/microsomal-triglyceride-transfer-protein","display_name":"microsomal triglyceride transfer protein","score":0.8679999709129333},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C72699923","wikidata":"https://www.wikidata.org/wiki/Q3064192","display_name":"Hepatocyte nuclear factor 4","level":5,"score":0.8401107788085938},{"id":"https://openalex.org/C99535661","wikidata":"https://www.wikidata.org/wiki/Q5731779","display_name":"Hepatocyte nuclear factors","level":4,"score":0.7451362013816833},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6594222784042358},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5827125310897827},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49803805351257324},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4933890402317047},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.463337779045105},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4403689205646515},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.4105263948440552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40513497591018677},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24953347444534302},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2425762116909027},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.24107074737548828},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17428386211395264},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.167483389377594},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.14037004113197327},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06611275672912598}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051538","descriptor_name":"Hepatocyte Nuclear Factor 1-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051557","descriptor_name":"Hepatocyte Nuclear Factor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051557","descriptor_name":"Hepatocyte Nuclear Factor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biocel.2016.07.027","doi":"https://doi.org/10.1016/j.biocel.2016.07.027","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2016.07.027","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},{"id":"pmid:27477312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27477312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of biochemistry & cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W36139658","https://openalex.org/W173455951","https://openalex.org/W1963494649","https://openalex.org/W1967917274","https://openalex.org/W1973027060","https://openalex.org/W1975273858","https://openalex.org/W1976648979","https://openalex.org/W1977238306","https://openalex.org/W1977779856","https://openalex.org/W1981307220","https://openalex.org/W1982959726","https://openalex.org/W1989781896","https://openalex.org/W1991600824","https://openalex.org/W1994054099","https://openalex.org/W1995037054","https://openalex.org/W1999602906","https://openalex.org/W2001030705","https://openalex.org/W2003579943","https://openalex.org/W2007722784","https://openalex.org/W2013018952","https://openalex.org/W2013040998","https://openalex.org/W2014290325","https://openalex.org/W2014297339","https://openalex.org/W2016456139","https://openalex.org/W2019825906","https://openalex.org/W2021199098","https://openalex.org/W2023492746","https://openalex.org/W2023645777","https://openalex.org/W2024086482","https://openalex.org/W2026051181","https://openalex.org/W2026338728","https://openalex.org/W2026645719","https://openalex.org/W2027779897","https://openalex.org/W2028538270","https://openalex.org/W2029834382","https://openalex.org/W2031472841","https://openalex.org/W2034804489","https://openalex.org/W2036982788","https://openalex.org/W2041575284","https://openalex.org/W2043758117","https://openalex.org/W2047028523","https://openalex.org/W2048338928","https://openalex.org/W2053978445","https://openalex.org/W2054886492","https://openalex.org/W2059288162","https://openalex.org/W2060209229","https://openalex.org/W2062254269","https://openalex.org/W2063556868","https://openalex.org/W2068910226","https://openalex.org/W2070968956","https://openalex.org/W2079395665","https://openalex.org/W2079643828","https://openalex.org/W2081763165","https://openalex.org/W2082933842","https://openalex.org/W2083282915","https://openalex.org/W2087460294","https://openalex.org/W2088337621","https://openalex.org/W2090832347","https://openalex.org/W2093214540","https://openalex.org/W2094733152","https://openalex.org/W2095546614","https://openalex.org/W2101019123","https://openalex.org/W2109457390","https://openalex.org/W2110525565","https://openalex.org/W2110605071","https://openalex.org/W2111543371","https://openalex.org/W2112293207","https://openalex.org/W2112360308","https://openalex.org/W2116694893","https://openalex.org/W2118604821","https://openalex.org/W2119010298","https://openalex.org/W2120165528","https://openalex.org/W2121549194","https://openalex.org/W2122496801","https://openalex.org/W2123218517","https://openalex.org/W2123511080","https://openalex.org/W2124036003","https://openalex.org/W2126319554","https://openalex.org/W2127274349","https://openalex.org/W2133285158","https://openalex.org/W2138583492","https://openalex.org/W2138872310","https://openalex.org/W2139025111","https://openalex.org/W2139593820","https://openalex.org/W2146277683","https://openalex.org/W2146832341","https://openalex.org/W2147126871","https://openalex.org/W2150368001","https://openalex.org/W2150802339","https://openalex.org/W2151898297","https://openalex.org/W2156938967","https://openalex.org/W2159837185","https://openalex.org/W2160307370","https://openalex.org/W2160889354","https://openalex.org/W2161197995","https://openalex.org/W2161994461","https://openalex.org/W2342727411","https://openalex.org/W2411964236","https://openalex.org/W6601447181","https://openalex.org/W6683536816","https://openalex.org/W6704516653"],"related_works":["https://openalex.org/W2160889354","https://openalex.org/W2120059952","https://openalex.org/W2133285158","https://openalex.org/W4410540823","https://openalex.org/W4399873179","https://openalex.org/W2021339055","https://openalex.org/W1982336500","https://openalex.org/W1592936080","https://openalex.org/W2018136244","https://openalex.org/W3002049958"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-08-23T00:00:00"}