{"id":"https://openalex.org/W2500654996","doi":"https://doi.org/10.1097/yic.0000000000000138","title":"Effects of levomilnacipran extended-release on motivation/energy and functioning in adults with major depressive disorder","display_name":"Effects of levomilnacipran extended-release on motivation/energy and functioning in adults with major depressive disorder","publication_year":2016,"publication_date":"2016-07-23","ids":{"openalex":"https://openalex.org/W2500654996","doi":"https://doi.org/10.1097/yic.0000000000000138","mag":"2500654996","pmid":"https://pubmed.ncbi.nlm.nih.gov/27455513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5049949"},"language":"en","primary_location":{"id":"doi:10.1097/yic.0000000000000138","doi":"https://doi.org/10.1097/yic.0000000000000138","is_oa":true,"landing_page_url":"https://doi.org/10.1097/yic.0000000000000138","pdf_url":null,"source":{"id":"https://openalex.org/S149156103","display_name":"International Clinical Psychopharmacology","issn_l":"0268-1315","issn":["0268-1315","1473-5857"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Clinical Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/yic.0000000000000138","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085107940","display_name":"Michael E. Thase","orcid":"https://orcid.org/0000-0002-6403-0861","observed_orcids":["https://orcid.org/0000-0002-6403-0861","https://orcid.org/0009-0002-3646-845X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael E. Thase","raw_affiliation_strings":["aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania bAllergan, Inc., Jersey City, New Jersey cInstitute for Advanced Medical Research, Atlanta, Georgia, USA","Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania bAllergan, Inc., Jersey City, New Jersey cInstitute for Advanced Medical Research, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002807505","display_name":"Carl Gommoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Gommoll","raw_affiliation_strings":["Allergan, Inc., Jersey City, New Jersey","Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan, Inc., Jersey City, New Jersey","institution_ids":["https://openalex.org/I4210139498"]},{"raw_affiliation_string":"Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Changzheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changzheng Chen","raw_affiliation_strings":["Allergan, Inc., Jersey City, New Jersey","Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan, Inc., Jersey City, New Jersey","institution_ids":["https://openalex.org/I4210139498"]},{"raw_affiliation_string":"Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088403731","display_name":"Kenneth L. Kramer","orcid":"https://orcid.org/0009-0003-0668-7595","observed_orcids":["https://orcid.org/0009-0003-0668-7595","https://orcid.org/0000-0002-5930-1612"]},"institutions":[{"id":"https://openalex.org/I4210139498","display_name":"Allergan (United States)","ror":"https://ror.org/03pfqk412","country_code":"US","type":"company","lineage":["https://openalex.org/I2948728702","https://openalex.org/I4210139498"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Kramer","raw_affiliation_strings":["Allergan, Inc., Jersey City, New Jersey","Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan, Inc., Jersey City, New Jersey","institution_ids":["https://openalex.org/I4210139498"]},{"raw_affiliation_string":"Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078519859","display_name":"Angelo Sambunaris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117918","display_name":"Institute for Advanced Medical Research","ror":"https://ror.org/02ek94012","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117918"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelo Sambunaris","raw_affiliation_strings":["Institute for Advanced Medical Research, Atlanta, Georgia, USA","Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Medical Research, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I4210117918"]},{"raw_affiliation_string":"Accepted June 15, 2016; Received February 12, 2016; This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/; aDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; bAllergan, Inc., Jersey City, New Jersey; cInstitute for Advanced Medical Research, Atlanta, Georgia, USA; e-mail: [email\u00a0protected]; fax: +1 215 573 0759","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085107940"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":2.1606,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85587568,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"6","first_page":"332","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9959999918937683},{"id":"https://openalex.org/keywords/motivation","display_name":"motivation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/energy","display_name":"energy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/functional-disability","display_name":"functional disability","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sheehan-disability-scale","display_name":"Sheehan Disability Scale","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.7463266253471375},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6244859099388123},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6027212738990784},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.5838631987571716},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5790324211120605},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.4927959740161896},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.42154461145401},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.34150853753089905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33621782064437866},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2839847803115845},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.08962291479110718},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.05527406930923462},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078764","descriptor_name":"Milnacipran","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009042","descriptor_name":"Motivation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009042","descriptor_name":"Motivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/yic.0000000000000138","doi":"https://doi.org/10.1097/yic.0000000000000138","is_oa":true,"landing_page_url":"https://doi.org/10.1097/yic.0000000000000138","pdf_url":null,"source":{"id":"https://openalex.org/S149156103","display_name":"International Clinical Psychopharmacology","issn_l":"0268-1315","issn":["0268-1315","1473-5857"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Clinical Psychopharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5049949","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5049949","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int Clin Psychopharmacol","raw_type":"Text"},{"id":"pmid:27455513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27455513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International clinical psychopharmacology","raw_type":"Clinical Trial, Phase III"}],"best_oa_location":{"id":"doi:10.1097/yic.0000000000000138","doi":"https://doi.org/10.1097/yic.0000000000000138","is_oa":true,"landing_page_url":"https://doi.org/10.1097/yic.0000000000000138","pdf_url":null,"source":{"id":"https://openalex.org/S149156103","display_name":"International Clinical Psychopharmacology","issn_l":"0268-1315","issn":["0268-1315","1473-5857"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Clinical Psychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332585","display_name":"Allergan","ror":"https://ror.org/00wthd003"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W279897541","https://openalex.org/W1964860251","https://openalex.org/W1971568036","https://openalex.org/W1973428941","https://openalex.org/W1985060650","https://openalex.org/W1993628347","https://openalex.org/W1995472991","https://openalex.org/W2002235051","https://openalex.org/W2009337441","https://openalex.org/W2029297015","https://openalex.org/W2029846038","https://openalex.org/W2034528843","https://openalex.org/W2063058927","https://openalex.org/W2063225659","https://openalex.org/W2096924058","https://openalex.org/W2111823785","https://openalex.org/W2115714588","https://openalex.org/W2134918392","https://openalex.org/W2150840378","https://openalex.org/W2156923987"],"related_works":["https://openalex.org/W2278731475","https://openalex.org/W2549416108","https://openalex.org/W2008565107","https://openalex.org/W2556108425","https://openalex.org/W2174415556","https://openalex.org/W2774490089","https://openalex.org/W2169834675","https://openalex.org/W1991923023","https://openalex.org/W2128110714","https://openalex.org/W1992574890"],"abstract_inverted_index":{"The":[0,158,201],"objective":[1],"of":[2,31,113,161],"this":[3],"post-hoc":[4],"analysis":[5,203],"was":[6,82,176,191],"to":[7,50,106,194],"investigate":[8],"the":[9,43,75,85,98,108,122,126,142,154,179,186],"relationship":[10],"between":[11,134],"motivation/energy":[12,59,196,222],"and":[13,46,57,68,89,101,110,125,137,147,183],"functional":[14,208],"impairment":[15,209],"in":[16,35,74,84,97,141,153,178,185,197,207,215,218],"patients":[17,219],"with":[18,37,55,199,220],"major":[19],"depressive":[20],"disorder":[21],"(MDD).":[22],"Data":[23],"were":[24,60,94,132,210],"taken":[25],"from":[26,72],"a":[27,102],"phase":[28],"3":[29],"trial":[30],"levomilnacipran":[32,114,135,162],"extended-release":[33],"(ER)":[34],"adults":[36,198],"MDD":[38],"(NCT01034462;":[39],"N=429)":[40],"that":[41,205],"used":[42],"18-item":[44],"Motivation":[45],"Energy":[47],"Inventory":[48],"(MEI)":[49],"assess":[51,107],"motivation/energy.":[52],"Two":[53],"subgroups":[54],"lower":[56,103,127,180,221],"higher":[58,155],"defined":[61],"using":[62],"baseline":[63,73],"MEI":[64,104,128,156,172,181],"total":[65,80,118,144,166,173],"scores":[66],"(\u226428":[67],">28,":[69],"respectively).":[70],"Change":[71],"Sheehan":[76],"Disability":[77],"Scale":[78],"(SDS)":[79],"score":[81,119,145,167,174],"analyzed":[83],"intent-to-treat":[86],"(ITT)":[87],"population":[88,100,124],"both":[90,149],"subgroups.":[91],"Path":[92],"analyses":[93],"carried":[95],"out":[96],"ITT":[99,123,187],"subgroup":[105,182],"direct":[109],"indirect":[111,159],"effects":[112],"ER":[115,136,163,190],"on":[116,164],"SDS":[117,143,165],"change.":[120],"In":[121],"subgroup,":[129],"significant":[130],"differences":[131],"found":[133],"placebo":[138],"for":[139],"changes":[140],"(-2.6":[146],"-3.9,":[148],"P<0.01),":[150],"but":[151],"not":[152],"subgroup.":[157],"effect":[160],"improvement,":[168],"as":[169],"mediated":[170,212],"by":[171,213],"change,":[175],"79.9%":[177],"67.2%":[184],"population.":[188],"Levomilnacipran":[189],"previously":[192],"shown":[193],"improve":[195],"MDD.":[200],"current":[202],"indicates":[204],"improvements":[206,214],"considerably":[211],"motivation/energy,":[216],"particularly":[217],"at":[223],"baseline.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-08-23T00:00:00"}