{"id":"https://openalex.org/W2500482172","doi":"https://doi.org/10.1089/biores.2016.0024","title":"Regeneration of Cartilage in Human Knee Osteoarthritis with Autologous Adipose Tissue-Derived Stem Cells and Autologous Extracellular Matrix","display_name":"Regeneration of Cartilage in Human Knee Osteoarthritis with Autologous Adipose Tissue-Derived Stem Cells and Autologous Extracellular Matrix","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2500482172","doi":"https://doi.org/10.1089/biores.2016.0024","mag":"2500482172","pmid":"https://pubmed.ncbi.nlm.nih.gov/27588219","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4991578"},"language":"en","primary_location":{"id":"doi:10.1089/biores.2016.0024","doi":"https://doi.org/10.1089/biores.2016.0024","is_oa":true,"landing_page_url":"https://doi.org/10.1089/biores.2016.0024","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/biores.2016.0024","source":{"id":"https://openalex.org/S4210180731","display_name":"BioResearch open access","issn_l":"2164-7844","issn":["2164-7844","2164-7860"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioResearch Open Access","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2500482172"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.liebertpub.com/doi/pdf/10.1089/biores.2016.0024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080934346","display_name":"Jaewoo Pak","orcid":"https://orcid.org/0000-0001-6589-7849","observed_orcids":["https://orcid.org/0000-0001-6589-7849"]},"institutions":[{"id":"https://openalex.org/I2803007516","display_name":"Tianjin Economic-Technological Development Area","ror":"https://ror.org/010fbpe82","country_code":"CN","type":"government","lineage":["https://openalex.org/I2803007516"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jaewoo Pak","raw_affiliation_strings":["Life Science Institute, Komplek Permata Senayan, Jalan Tentara Pelajar, Jakarta Selatan, Indonesia","Stems Medical Clinic, Seoul, Republic of Korea","TEDA-Puhua International Hospital, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Science Institute, Komplek Permata Senayan, Jalan Tentara Pelajar, Jakarta Selatan, Indonesia","institution_ids":[]},{"raw_affiliation_string":"Stems Medical Clinic, Seoul, Republic of Korea","institution_ids":[]},{"raw_affiliation_string":"TEDA-Puhua International Hospital, Tianjin, China","institution_ids":["https://openalex.org/I2803007516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089359259","display_name":"Jung Hun Lee","orcid":"https://orcid.org/0000-0001-5504-4033","observed_orcids":["https://orcid.org/0000-0001-5504-4033","https://orcid.org/0000-0002-4799-6277"]},"institutions":[{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Hun Lee","raw_affiliation_strings":["National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea","Stems Medical Clinic, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea","institution_ids":["https://openalex.org/I89440247"]},{"raw_affiliation_string":"Stems Medical Clinic, Seoul, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003218918","display_name":"Kwang Seung Park","orcid":"https://orcid.org/0000-0001-6611-667X","observed_orcids":["https://orcid.org/0000-0001-6611-667X"]},"institutions":[{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang Seung Park","raw_affiliation_strings":["National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea","institution_ids":["https://openalex.org/I89440247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102776719","display_name":"Byeong Chul Jeong","orcid":"https://orcid.org/0009-0004-0628-1752","observed_orcids":["https://orcid.org/0009-0004-0628-1752"]},"institutions":[{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byeong Chul Jeong","raw_affiliation_strings":["National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea","institution_ids":["https://openalex.org/I89440247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100662266","display_name":"Sang Hee Lee","orcid":"https://orcid.org/0000-0002-5660-7122","observed_orcids":["https://orcid.org/0000-0002-5660-7122","https://orcid.org/0000-0002-4397-3027"]},"institutions":[{"id":"https://openalex.org/I89440247","display_name":"Myongji University","ror":"https://ror.org/00s9dpb54","country_code":"KR","type":"education","lineage":["https://openalex.org/I89440247"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sang Hee Lee","raw_affiliation_strings":["National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea","institution_ids":["https://openalex.org/I89440247"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100662266"],"corresponding_institution_ids":["https://openalex.org/I89440247"],"apc_list":null,"apc_paid":null,"fwci":7.7522,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.97934734,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"192","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.9139999747276306},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adipose-stromal-vascular-fraction","display_name":"adipose stromal vascular fraction","score":0.9079999923706055},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.8740000128746033},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.972000002861023},{"id":"https://openalex.org/keywords/percutaneous-injection","display_name":"percutaneous injection","score":0.8849999904632568},{"id":"https://openalex.org/keywords/minimally-invasive-therapy","display_name":"minimally invasive therapy","score":0.7670000195503235},{"id":"https://openalex.org/keywords/range-of-motion","display_name":"range of motion","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7491780519485474},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.6223447918891907},{"id":"https://openalex.org/C2780745355","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Stromal vascular fraction","level":3,"score":0.5750215649604797},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5367923974990845},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5356220006942749},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5195629596710205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5042718648910522},{"id":"https://openalex.org/C2780076745","wikidata":"https://www.wikidata.org/wiki/Q613879","display_name":"Platelet-rich plasma","level":3,"score":0.4838501513004303},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4600100517272949},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4248502850532532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34621530771255493},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3167470693588257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20967411994934082},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.09314906597137451},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1089/biores.2016.0024","doi":"https://doi.org/10.1089/biores.2016.0024","is_oa":true,"landing_page_url":"https://doi.org/10.1089/biores.2016.0024","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/biores.2016.0024","source":{"id":"https://openalex.org/S4210180731","display_name":"BioResearch open access","issn_l":"2164-7844","issn":["2164-7844","2164-7860"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioResearch Open Access","raw_type":"journal-article"},{"id":"pmid:27588219","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27588219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioResearch open access","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4991578","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4991578/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biores Open Access","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1089/biores.2016.0024","doi":"https://doi.org/10.1089/biores.2016.0024","is_oa":true,"landing_page_url":"https://doi.org/10.1089/biores.2016.0024","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/biores.2016.0024","source":{"id":"https://openalex.org/S4210180731","display_name":"BioResearch open access","issn_l":"2164-7844","issn":["2164-7844","2164-7860"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioResearch Open Access","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2521218515","display_name":null,"funder_award_id":"20150581","funder_id":"https://openalex.org/F4320322011","funder_display_name":"Ministry of Oceans and Fisheries"},{"id":"https://openalex.org/G7699156385","display_name":null,"funder_award_id":"2011-0027928","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G992293698","display_name":null,"funder_award_id":"2011-0027928","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322011","display_name":"Ministry of Oceans and Fisheries","ror":"https://ror.org/00c5s4a53"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2500482172.pdf","grobid_xml":"https://content.openalex.org/works/W2500482172.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1974163213","https://openalex.org/W1990401856","https://openalex.org/W1994143652","https://openalex.org/W2042494273","https://openalex.org/W2052203910","https://openalex.org/W2060657670","https://openalex.org/W2078532053","https://openalex.org/W2107503723","https://openalex.org/W2118788475","https://openalex.org/W2145130313","https://openalex.org/W2161096568","https://openalex.org/W2161486286","https://openalex.org/W2173497140","https://openalex.org/W2224501223","https://openalex.org/W2605187236"],"related_works":["https://openalex.org/W4254192655","https://openalex.org/W2597072427","https://openalex.org/W2892580924","https://openalex.org/W2883409856","https://openalex.org/W4413913973","https://openalex.org/W2897900195","https://openalex.org/W2118788475","https://openalex.org/W3209934580","https://openalex.org/W2945813882","https://openalex.org/W2314984227"],"abstract_inverted_index":{"This":[0,181],"clinical":[1],"case":[2],"series":[3],"demonstrates":[4,183],"that":[5,184],"percutaneous":[6,185],"injections":[7],"of":[8,23,59,85,92,107,142,171,187,217],"autologous":[9,193],"adipose":[10,24,57,194],"tissue-derived":[11],"stem":[12],"cells":[13],"(ADSCs)":[14],"and":[15,34,80,87,99,131,145,175,200,209],"homogenized":[16,73],"extracellular":[17],"matrix":[18],"(ECM)":[19],"in":[20,46,89,169,192,196],"the":[21,60,64,70,90,164],"form":[22,91],"stromal":[25],"vascular":[26],"fraction":[27],"(SVF),":[28],"along":[29,96],"with":[30,78,97,111,120,161,189,198],"hyaluronic":[31],"acid":[32],"(HA)":[33],"platelet-rich":[35],"plasma":[36],"(PRP)":[37],"activated":[38,101,123,202],"by":[39,102,124,203],"calcium":[40,103,125,204],"chloride,":[41,104,205],"could":[42],"regenerate":[43],"cartilage-like":[44,157],"tissue":[45,58,158],"human":[47,218],"knee":[48],"osteoarthritis":[49],"(OA)":[50],"patients.":[51],"Autologous":[52],"lipoaspirates":[53,65,74],"were":[54,66,75,117,149,178],"obtained":[55],"from":[56],"abdominal":[61],"origin.":[62],"Afterward,":[63],"minced":[67],"to":[68],"homogenize":[69],"ECM.":[71],"These":[72],"then":[76,150],"mixed":[77],"collagenase":[79],"incubated.":[81],"The":[82,113],"resulting":[83],"mixture":[84],"ADSCs":[86,188],"ECM":[88,190],"SVF":[93],"was":[94],"injected,":[95],"HA":[98,199],"PRP":[100,122,201],"into":[105],"knees":[106,116],"three":[108],"Korean":[109],"patients":[110],"OA.":[112],"same":[114],"affected":[115],"reinjected":[118],"weekly":[119],"additional":[121],"chloride":[126],"for":[127,215],"3":[128],"weeks.":[129],"Pretreatment":[130],"post-treatment":[132],"magnetic":[133],"resonance":[134],"imaging":[135],"(MRI)":[136],"data,":[137],"functional":[138,176],"rating":[139],"index,":[140],"range":[141],"motion":[143],"(ROM),":[144],"pain":[146],"score":[147],"data":[148,155],"analyzed.":[151],"All":[152],"patients'":[153],"MRI":[154,162],"showed":[156],"regeneration.":[159],"Along":[160],"evidence,":[163],"measured":[165],"physical":[166],"therapy":[167,214],"outcomes":[168],"terms":[170],"ROM,":[172],"subjective":[173],"pain,":[174],"status":[177],"all":[179],"improved.":[180],"study":[182],"injection":[186],"contained":[191],"SVF,":[195],"conjunction":[197],"is":[206],"a":[207],"safe":[208],"potentially":[210],"effective":[211],"minimally":[212],"invasive":[213],"OA":[216],"knees.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":9}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-08-23T00:00:00"}