{"id":"https://openalex.org/W2500145168","doi":"https://doi.org/10.1201/9781420006636-34","title":"Nanoscale Drug Delivery Vehicles for Solid Tumors: A New Paradigm for Localized Drug Delivery Using Temperature Sensitive Liposomes","display_name":"Nanoscale Drug Delivery Vehicles for Solid Tumors: A New Paradigm for Localized Drug Delivery Using Temperature Sensitive Liposomes","publication_year":2006,"publication_date":"2006-12-19","ids":{"openalex":"https://openalex.org/W2500145168","doi":"https://doi.org/10.1201/9781420006636-34","mag":"2500145168"},"language":"en","primary_location":{"id":"doi:10.1201/9781420006636-34","doi":"https://doi.org/10.1201/9781420006636-34","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781420006636-34","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotechnology for Cancer Therapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W409362985","display_name":"Nanotechnology for Cancer Therapy"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160597179","display_name":"David Needham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Needham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5160586866","display_name":"Ana Ponce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Ponce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8049,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.8918583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"677","last_page":"719"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.8420000076293945},{"id":"https://openalex.org/keywords/thermosensitive-liposomes","display_name":"thermosensitive liposomes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lysolipids","display_name":"lysolipids","score":0.859000027179718},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tumor-accumulation","display_name":"tumor accumulation","score":0.5170000195503235},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.4869999885559082},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6140000224113464},{"id":"https://openalex.org/keywords/drug-toxicity-reduction","display_name":"drug toxicity reduction","score":0.7409999966621399},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5833322405815125},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.5113062858581543},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4651540219783783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3692966401576996},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36850422620773315},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.33553409576416016},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2888542413711548},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2196134328842163}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1201/9781420006636-34","doi":"https://doi.org/10.1201/9781420006636-34","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781420006636-34","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotechnology for Cancer Therapy","raw_type":"book-chapter"},{"id":"doi:10.1201/9781420006636.ch34","doi":"https://doi.org/10.1201/9781420006636.ch34","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781420006636.ch34","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotechnology for Cancer Therapy","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W111914281","https://openalex.org/W175938947","https://openalex.org/W652317247","https://openalex.org/W1483734912","https://openalex.org/W1498017834","https://openalex.org/W1498293114","https://openalex.org/W1503662436","https://openalex.org/W1518406034","https://openalex.org/W1583480464","https://openalex.org/W1591500609","https://openalex.org/W1762182381","https://openalex.org/W1796518311","https://openalex.org/W1842875237","https://openalex.org/W1869550436","https://openalex.org/W1884652411","https://openalex.org/W1904126651","https://openalex.org/W1936102867","https://openalex.org/W1946720377","https://openalex.org/W1960327677","https://openalex.org/W1963722000","https://openalex.org/W1963914660","https://openalex.org/W1966652107","https://openalex.org/W1966797112","https://openalex.org/W1967660067","https://openalex.org/W1971230694","https://openalex.org/W1975993453","https://openalex.org/W1978728063","https://openalex.org/W1985631236","https://openalex.org/W1985858988","https://openalex.org/W1986618765","https://openalex.org/W1986981812","https://openalex.org/W1989254508","https://openalex.org/W1989575919","https://openalex.org/W1992450643","https://openalex.org/W1992703558","https://openalex.org/W1994215475","https://openalex.org/W1995598571","https://openalex.org/W1998886157","https://openalex.org/W2000121492","https://openalex.org/W2001166524","https://openalex.org/W2001216252","https://openalex.org/W2002516695","https://openalex.org/W2005556449","https://openalex.org/W2007715498","https://openalex.org/W2009144737","https://openalex.org/W2009629825","https://openalex.org/W2013470095","https://openalex.org/W2014605589","https://openalex.org/W2015626183","https://openalex.org/W2016880770","https://openalex.org/W2019995515","https://openalex.org/W2020126305","https://openalex.org/W2022765714","https://openalex.org/W2022776423","https://openalex.org/W2026073350","https://openalex.org/W2026759036","https://openalex.org/W2028065774","https://openalex.org/W2029458457","https://openalex.org/W2029973997","https://openalex.org/W2033228307","https://openalex.org/W2034773569","https://openalex.org/W2035667625","https://openalex.org/W2037563014","https://openalex.org/W2038225831","https://openalex.org/W2039411920","https://openalex.org/W2039884231","https://openalex.org/W2040150720","https://openalex.org/W2040426912","https://openalex.org/W2040742644","https://openalex.org/W2045020855","https://openalex.org/W2045678504","https://openalex.org/W2046625142","https://openalex.org/W2050129480","https://openalex.org/W2050197542","https://openalex.org/W2050715080","https://openalex.org/W2050940968","https://openalex.org/W2051281074","https://openalex.org/W2052500039","https://openalex.org/W2055943659","https://openalex.org/W2058051718","https://openalex.org/W2063560355","https://openalex.org/W2064225223","https://openalex.org/W2065061795","https://openalex.org/W2070825008","https://openalex.org/W2072550957","https://openalex.org/W2075745688","https://openalex.org/W2077223356","https://openalex.org/W2078120653","https://openalex.org/W2080105128","https://openalex.org/W2086591674","https://openalex.org/W2087785106","https://openalex.org/W2088706830","https://openalex.org/W2090524122","https://openalex.org/W2093079792","https://openalex.org/W2096593771","https://openalex.org/W2096814286","https://openalex.org/W2097777938","https://openalex.org/W2098313773","https://openalex.org/W2098448810","https://openalex.org/W2099374439","https://openalex.org/W2102089901","https://openalex.org/W2104013724","https://openalex.org/W2104497627","https://openalex.org/W2104631267","https://openalex.org/W2107466475","https://openalex.org/W2110646221","https://openalex.org/W2116336389","https://openalex.org/W2118878458","https://openalex.org/W2121429936","https://openalex.org/W2121794314","https://openalex.org/W2123912484","https://openalex.org/W2128398215","https://openalex.org/W2128512834","https://openalex.org/W2131821606","https://openalex.org/W2141394481","https://openalex.org/W2141713397","https://openalex.org/W2145010618","https://openalex.org/W2147581636","https://openalex.org/W2150932917","https://openalex.org/W2151312593","https://openalex.org/W2152686312","https://openalex.org/W2158449037","https://openalex.org/W2161580101","https://openalex.org/W2163294691","https://openalex.org/W2166458266","https://openalex.org/W2167144064","https://openalex.org/W2168321305","https://openalex.org/W2168454302","https://openalex.org/W2169229283","https://openalex.org/W2169253572","https://openalex.org/W2170952917","https://openalex.org/W2171946597","https://openalex.org/W2185469212","https://openalex.org/W2207022446","https://openalex.org/W2277312484","https://openalex.org/W2279675890","https://openalex.org/W2286481547","https://openalex.org/W2294043211","https://openalex.org/W2436597657","https://openalex.org/W2501362055","https://openalex.org/W3027693442","https://openalex.org/W4245526834","https://openalex.org/W4388940305"],"related_works":["https://openalex.org/W2480716176","https://openalex.org/W4390976880","https://openalex.org/W2373232328","https://openalex.org/W2485981114","https://openalex.org/W2487444849","https://openalex.org/W2504090978","https://openalex.org/W4416524054","https://openalex.org/W7167022413","https://openalex.org/W4416524064","https://openalex.org/W2479930018"],"abstract_inverted_index":{"This":[0],"chapter":[1,37,95],"compares":[2],"and":[3,32,52,87,121],"contrasts":[4],"a":[5,46,53,76],"number":[6],"of":[7,24,29,56,70,82,99,116],"contemporary":[8],"liposome":[9,74,104],"formulations.":[10],"The":[11,36,94],"new":[12],"capsular":[13],"design":[14],"addresses":[15],"an":[16,111],"unmet":[17],"need":[18],"in":[19,49,58,85,110,122],"liposomal":[20,43],"drug":[21,27,50,57,83],"delivery,":[22],"that":[23,125],"getting":[25],"the":[26,30,40,59,63,68,71,91,97,100,117],"out":[28],"nanocarrier":[31],"thereby":[33],"improving":[34],"bioavailability.":[35],"describes":[38],"how":[39],"currently":[41],"approved":[42],"nanotechnologies":[44],"achieve":[45],"significant":[47],"decrease":[48],"toxicity":[51],"modest":[54],"accumulation":[55],"tumor.":[60],"It":[61],"reviews":[62],"events":[64],"leading":[65],"up":[66],"to":[67,79,108,113],"invention":[69],"temperature":[72,102],"sensitive":[73,103],"(LTSL),":[75],"potential":[77],"solution":[78],"this":[80],"paradox":[81],"retention":[84],"circulation":[86],"rapid":[88],"release":[89],"at":[90],"tumor":[92],"site.":[93],"narrates":[96],"development":[98],"lysolipid-containing":[101],"(LTSL)":[105],"from":[106],"bench":[107],"bedside":[109],"attempt":[112],"highlight":[114],"many":[115],"formulation,":[118],"clinical,":[119],"cellular,":[120],"vivo":[123],"barriers":[124],"must":[126],"be":[127],"overcome":[128],"by":[129],"any":[130],"nanotechnologically":[131],"designed":[132],"cancer":[133],"therapeutic.":[134]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-08-23T00:00:00"}
