{"id":"https://openalex.org/W2498998610","doi":"https://doi.org/10.1093/brain/aww193","title":"Amyloid-\u03b2 deposition and regional grey matter atrophy rates in dementia with Lewy bodies","display_name":"Amyloid-\u03b2 deposition and regional grey matter atrophy rates in dementia with Lewy bodies","publication_year":2016,"publication_date":"2016-07-24","ids":{"openalex":"https://openalex.org/W2498998610","doi":"https://doi.org/10.1093/brain/aww193","mag":"2498998610","pmid":"https://pubmed.ncbi.nlm.nih.gov/27452602","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5035818"},"language":"en","primary_location":{"id":"doi:10.1093/brain/aww193","doi":"https://doi.org/10.1093/brain/aww193","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/aww193","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5035818","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027325023","display_name":"Lidia Sarro","orcid":"https://orcid.org/0009-0004-4394-8093","observed_orcids":["https://orcid.org/0009-0004-4394-8093"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Lidia Sarro","raw_affiliation_strings":["1 Department of Radiology, Mayo Clinic, Rochester, MN, USA 2 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy 3 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Radiology, Mayo Clinic, Rochester, MN, USA 2 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy 3 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I154387261","https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050718938","display_name":"Matthew L. Senjem","orcid":"https://orcid.org/0000-0001-9308-9275","observed_orcids":["https://orcid.org/0000-0001-9308-9275"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Senjem","raw_affiliation_strings":["1 Department of Radiology, Mayo Clinic, Rochester, MN, USA 4 Department of Information Technology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Radiology, Mayo Clinic, Rochester, MN, USA 4 Department of Information Technology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070711729","display_name":"Emily S. Lundt","orcid":"https://orcid.org/0000-0002-4754-8642","observed_orcids":["https://orcid.org/0000-0002-4754-8642"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily S. Lundt","raw_affiliation_strings":["5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026250910","display_name":"Scott A. Przybelski","orcid":"https://orcid.org/0009-0009-3437-3773","observed_orcids":["https://orcid.org/0009-0009-3437-3773"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Przybelski","raw_affiliation_strings":["5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057493616","display_name":"Timothy G. Lesnick","orcid":"https://orcid.org/0000-0002-4126-5924","observed_orcids":["https://orcid.org/0000-0002-4126-5924"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy G. Lesnick","raw_affiliation_strings":["5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005572080","display_name":"Jonathan Graff\u2010Radford","orcid":"https://orcid.org/0000-0003-2770-0691","observed_orcids":["https://orcid.org/0000-0003-2770-0691"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Graff-Radford","raw_affiliation_strings":["6 Department of Neurology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6 Department of Neurology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066352714","display_name":"Bradley F. Boeve","orcid":"https://orcid.org/0000-0002-4153-8187","observed_orcids":["https://orcid.org/0000-0002-4153-8187"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley F. Boeve","raw_affiliation_strings":["6 Department of Neurology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6 Department of Neurology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001313680","display_name":"Val J. Lowe","orcid":"https://orcid.org/0000-0002-5612-1667","observed_orcids":["https://orcid.org/0000-0002-5612-1667"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val J. Lowe","raw_affiliation_strings":["1 Department of Radiology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Radiology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036878959","display_name":"Tanis J. Ferman","orcid":"https://orcid.org/0000-0001-8377-6194","observed_orcids":["https://orcid.org/0000-0001-8377-6194"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanis J. Ferman","raw_affiliation_strings":["7 Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7 Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027860","display_name":"David S. Knopman","orcid":"https://orcid.org/0000-0002-6544-066X","observed_orcids":["https://orcid.org/0000-0002-6544-066X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Knopman","raw_affiliation_strings":["6 Department of Neurology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6 Department of Neurology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043499649","display_name":"G\u0131ancarlo Com\u0131","orcid":"https://orcid.org/0000-0002-6989-1054","observed_orcids":["https://orcid.org/0000-0002-6989-1054"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Comi","raw_affiliation_strings":["3 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003010065","display_name":"Massimo Filippi","orcid":"https://orcid.org/0000-0002-5485-0479","observed_orcids":["https://orcid.org/0000-0002-5485-0479"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Filippi","raw_affiliation_strings":["2 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy 3 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy 3 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy","institution_ids":["https://openalex.org/I154387261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110342810","display_name":"Ronald Carl Petersen","orcid":"https://orcid.org/0000-0002-8178-6601","observed_orcids":["https://orcid.org/0000-0002-8178-6601"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C. Petersen","raw_affiliation_strings":["5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA 6 Department of Neurology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5 Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA 6 Department of Neurology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005099850","display_name":"Clifford R. Jack","orcid":"https://orcid.org/0000-0001-7916-622X","observed_orcids":["https://orcid.org/0000-0001-7916-622X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford R. Jack","raw_affiliation_strings":["1 Department of Radiology, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Radiology, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077933873","display_name":"Kejal Kantarci","orcid":"https://orcid.org/0000-0002-8001-2081","observed_orcids":["https://orcid.org/0000-0002-8001-2081"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kejal Kantarci","raw_affiliation_strings":["1 Department of Radiology, Mayo Clinic, Rochester, MN, USA kantarci.kejal@mayo.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Radiology, Mayo Clinic, Rochester, MN, USA kantarci.kejal@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4224,"currency":"GBP","value_usd":5570},"apc_paid":null,"fwci":6.6683,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.97640276,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"139","issue":"10","first_page":"2740","last_page":"2750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":0.953000009059906},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gray-matter-atrophy","display_name":"gray matter atrophy","score":0.824999988079071},{"id":"https://openalex.org/keywords/11c-pittsburgh-compound-b","display_name":"11C-Pittsburgh compound B","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6330000162124634},{"id":"https://openalex.org/keywords/ventricular-dilation","display_name":"ventriculomegaly","score":0.7860000133514404},{"id":"https://openalex.org/keywords/clinical-deterioration","display_name":"clinical deterioration","score":0.6430000066757202},{"id":"https://openalex.org/keywords/posterior-cingulate-cortex","display_name":"posterior cingulate cortex","score":0.8289999961853027},{"id":"https://openalex.org/keywords/temporal-lobe","display_name":"temporal lobe","score":0.8619999885559082},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8539999723434448},{"id":"https://openalex.org/keywords/disease-progression-biomarkers","display_name":"disease progression biomarkers","score":0.5519999861717224},{"id":"https://openalex.org/keywords/clinical-dementia-rating","display_name":"Clinical Dementia Rating","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.8226845264434814},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.7204848527908325},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6038225293159485},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5909873843193054},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5650100111961365},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.5344744324684143},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.46648624539375305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4423356056213379},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4192102253437042},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4103214740753174},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.38521769642829895},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37346625328063965},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2229379415512085},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.17727792263031006},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14789676666259766}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020961","descriptor_name":"Lewy Body Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D020961","descriptor_name":"Lewy Body Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/brain/aww193","doi":"https://doi.org/10.1093/brain/aww193","is_oa":false,"landing_page_url":"https://doi.org/10.1093/brain/aww193","pdf_url":null,"source":{"id":"https://openalex.org/S118357697","display_name":"Brain","issn_l":"0006-8950","issn":["0006-8950","1460-2156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5035818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5035818","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"Text"},{"id":"pmid:27452602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27452602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain : a journal of neurology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/14767","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/14767","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:open-archive.highwire.org:brain:139/10/2740","doi":null,"is_oa":false,"landing_page_url":"http://brain.oxfordjournals.org/cgi/content/short/139/10/2740","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5035818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5035818","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G142564060","display_name":"Sex-specific Risk for Vascular Dysfunction and Cognitive Decline","funder_award_id":"P50AG044170","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G303290027","display_name":"Pathological basis of MRS and DTI changes in neurodegenerative dementia","funder_award_id":"R01AG040042","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G388381678","display_name":"Alzheimers Disease Patient Registry","funder_award_id":"U01AG006786","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G517245306","display_name":"Evaluating and Extending Our Hypothetical Model of Alzheimer's Biomarkers","funder_award_id":"R01AG011378","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7417559506","display_name":"EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM","funder_award_id":"C06RR018898","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G95754455","display_name":"Mayo Alzheimer's Disease Research Center","funder_award_id":"P50AG016574","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W114737604","https://openalex.org/W1455747069","https://openalex.org/W1530469809","https://openalex.org/W1559001474","https://openalex.org/W1560372750","https://openalex.org/W1564252327","https://openalex.org/W1586231797","https://openalex.org/W1724755584","https://openalex.org/W1970928383","https://openalex.org/W1971216838","https://openalex.org/W1971262833","https://openalex.org/W1973166472","https://openalex.org/W1973584365","https://openalex.org/W1977197096","https://openalex.org/W1981172863","https://openalex.org/W1981881335","https://openalex.org/W1982834182","https://openalex.org/W1984504747","https://openalex.org/W1984766678","https://openalex.org/W1985023593","https://openalex.org/W1985892643","https://openalex.org/W1987064062","https://openalex.org/W1990502495","https://openalex.org/W1990816744","https://openalex.org/W1993571512","https://openalex.org/W1995975413","https://openalex.org/W1996142279","https://openalex.org/W1998633319","https://openalex.org/W2005133023","https://openalex.org/W2014780458","https://openalex.org/W2019145949","https://openalex.org/W2019595740","https://openalex.org/W2028084638","https://openalex.org/W2029164422","https://openalex.org/W2033081968","https://openalex.org/W2036280154","https://openalex.org/W2037024527","https://openalex.org/W2037088901","https://openalex.org/W2039700943","https://openalex.org/W2040670498","https://openalex.org/W2041792754","https://openalex.org/W2042406995","https://openalex.org/W2052742260","https://openalex.org/W2054302986","https://openalex.org/W2057245667","https://openalex.org/W2058046532","https://openalex.org/W2058474765","https://openalex.org/W2064963539","https://openalex.org/W2069043387","https://openalex.org/W2075575934","https://openalex.org/W2086390616","https://openalex.org/W2087598124","https://openalex.org/W2089085990","https://openalex.org/W2093322139","https://openalex.org/W2097880994","https://openalex.org/W2098138468","https://openalex.org/W2101241299","https://openalex.org/W2102572922","https://openalex.org/W2106507629","https://openalex.org/W2110203358","https://openalex.org/W2111399612","https://openalex.org/W2119398499","https://openalex.org/W2122641260","https://openalex.org/W2124681501","https://openalex.org/W2124712545","https://openalex.org/W2126245509","https://openalex.org/W2127117802","https://openalex.org/W2133719476","https://openalex.org/W2134711807","https://openalex.org/W2138011006","https://openalex.org/W2139699215","https://openalex.org/W2144138616","https://openalex.org/W2144646585","https://openalex.org/W2148079076","https://openalex.org/W2154285343","https://openalex.org/W2155352186","https://openalex.org/W2156981569","https://openalex.org/W2161124934","https://openalex.org/W2166263576","https://openalex.org/W2174862691","https://openalex.org/W2178393107","https://openalex.org/W2398530838"],"related_works":["https://openalex.org/W2592366552","https://openalex.org/W1560372750","https://openalex.org/W7145864474","https://openalex.org/W2991439481","https://openalex.org/W3196175436","https://openalex.org/W2997974303","https://openalex.org/W4244322839","https://openalex.org/W4210772063","https://openalex.org/W2897395328","https://openalex.org/W2955821809"],"abstract_inverted_index":{"Alzheimer\u2019s":[0,60,131,400],"disease":[1,8],"pathology":[2],"frequently":[3],"coexists":[4],"with":[5,13,16,24,27,36,78,81,114,116,182,278,308,311,364,367,380,408],"Lewy":[6,17,28,82,117,312,368,381],"body":[7],"at":[9,150,317,353],"autopsy":[10],"in":[11,76,107,205,237,292,306,324,329,362,378,398],"patients":[12,23,77,113,136,307,363],"probable":[14,25,79,309,365],"dementia":[15,26,80,115,310,366,379],"bodies.":[18,83,369],"More":[19],"than":[20],"half":[21],"of":[22,47,59,74,103,110,164,298,321,336],"bodies":[29,118,382],"have":[30],"high":[31,411],"amyloid-\u03b2":[32,48,68,315,351],"deposition":[33,49,69,316,352,392],"as":[34,250,252],"measured":[35],"11":[37,90,138,194,222,267],"C-Pittsburgh":[38,91,139,195,223,268],"compound":[39,92,140,196,224,269],"B":[40,93,141,197,225,270],"binding":[41,94],"on":[42,52,95,174],"positron":[43,96,142],"emission":[44,97,143],"tomography.":[45],"Biomarkers":[46],"precede":[50],"neurodegeneration":[51,323],"magnetic":[53,146,153,179],"resonance":[54,147,154,180],"imaging":[55,148,155,181],"during":[56],"the":[57,86,100,128,183,238,325,330],"progression":[58,73],"disease,":[61],"but":[62],"little":[63],"is":[64,319,334,371],"known":[65,372],"about":[66,373],"how":[67],"relates":[70],"to":[71,127],"longitudinal":[72,101,203],"atrophy":[75,106,397],"We":[84,215],"investigated":[85],"associations":[87,218],"between":[88,192,219],"baseline":[89,193,221,266,318,354,390],"tomography":[98,144],"and":[99,145,202,230,243,247,254,287,327,342,403,410],"rates":[102,282],"grey":[104,169,207,232,395],"matter":[105,170,208,233,396],"a":[108,159,356],"cohort":[109],"clinically":[111],"diagnosed":[112],"(":[119,261,283,300],"n":[120],"=":[121,302],"20),":[122],"who":[123],"were":[124],"consecutively":[125],"recruited":[126],"Mayo":[129],"Clinic":[130],"Disease":[132],"Research":[133],"Centre.":[134],"All":[135],"underwent":[137],"examinations":[149],"baseline.":[151],"Follow-up":[152],"was":[156,172,190,275],"performed":[157,191],"after":[158,257],"mean":[160],"(standard":[161],"deviation)":[162],"interval":[163],"2.5":[165],"(1.1)":[166],"years.":[167],"Regional":[168],"loss":[171,234],"determined":[173],"three-dimensional":[175],"T":[176],"1":[177],"-weighted":[178],"tensor-based":[184],"morphometry-symmetric":[185],"normalization":[186],"technique.":[187],"Linear":[188],"regression":[189],"standard":[198,226,271],"unit":[199,227,272],"value":[200,228,273],"ratio":[201,229,274],"change":[204],"regional":[206],"volumes":[209],"from":[210,415],"an":[211,399],"in-house":[212],"modified":[213],"atlas.":[214],"identified":[216],"significant":[217],"greater":[220,231,279,288],"over":[235,290,360,376],"time":[236,291,361,377],"posterior":[239],"cingulate":[240],"gyrus,":[241],"lateral":[242],"medial":[244],"temporal":[245],"lobe,":[246],"occipital":[248],"lobe":[249],"well":[251],"caudate":[253],"putamen":[255],"nuclei,":[256],"adjusting":[258],"for":[259],"age":[260],"P":[262,284,301],"<":[263,285],"0.05).":[264],"Greater":[265],"also":[276,328],"associated":[277],"ventricular":[280],"expansion":[281],"0.01)":[286],"worsening":[289],"Clinical":[293],"Dementia":[294],"Rating":[295],"Scale,":[296],"sum":[297],"boxes":[299],"0.02).":[303],"In":[304],"conclusion,":[305],"bodies,":[313],"higher":[314,350,389],"predictive":[320],"faster":[322,357,394,404],"cortex":[326],"striatum.":[331],"This":[332],"distribution":[333],"suggestive":[335],"possible":[337],"interactions":[338],"among":[339],"amyloid-\u03b2,":[340],"tau":[341],"\u03b1-synuclein":[343],"aggregates,":[344],"which":[345],"needs":[346],"further":[347],"investigation.":[348],"Furthermore,":[349],"predicts":[355,393],"clinical":[358,405],"decline":[359],"Little":[370],"biomarker":[374],"trajectories":[375],"(DLB).":[383],"Sarro":[384],"et":[385],"al.":[386],"report":[387],"that":[388],"\u03b2-amyloid":[391,412],"disease-like":[401],"pattern":[402],"decline.":[406],"Patients":[407],"DLB":[409],"could":[413],"benefit":[414],"emerging":[416],"anti-amyloid":[417],"agents.":[418]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-08-23T00:00:00"}
