{"id":"https://openalex.org/W2498897929","doi":"https://doi.org/10.1017/cbo9780511546198.077","title":"The Endothelial Cytoskeleton","display_name":"The Endothelial Cytoskeleton","publication_year":2007,"publication_date":"2007-09-03","ids":{"openalex":"https://openalex.org/W2498897929","doi":"https://doi.org/10.1017/cbo9780511546198.077","mag":"2498897929"},"language":"en","primary_location":{"id":"doi:10.1017/cbo9780511546198.077","doi":"https://doi.org/10.1017/cbo9780511546198.077","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511546198.077","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endothelial Biomedicine","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4296584910","display_name":"Endothelial Biomedicine"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010100025","display_name":"Christopher V. Carman","orcid":"https://orcid.org/0000-0001-7358-2548","observed_orcids":["https://orcid.org/0000-0001-7358-2548"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher V. Carman","raw_affiliation_strings":["Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010100025"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.21372328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"696","last_page":"706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-cytoskeleton","display_name":"endothelial cytoskeleton","score":0.9599999785423279},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.890999972820282},{"id":"https://openalex.org/keywords/endothelial-cell-polarity","display_name":"endothelial cell polarity","score":0.800000011920929},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.8989999890327454},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.9179999828338623},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.7630000114440918},{"id":"https://openalex.org/keywords/hydrostatic-pressure","display_name":"hydrostatic pressure","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cyclic-stretch","display_name":"cyclic strain","score":0.8059999942779541},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.8659999966621399},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.6389999985694885},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":1.0},{"id":"https://openalex.org/keywords/intermediate-filaments","display_name":"intermediate filaments","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.7676486968994141},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6775677800178528},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.6636075973510742},{"id":"https://openalex.org/C2910081258","wikidata":"https://www.wikidata.org/wiki/Q177807","display_name":"Hydrostatic pressure","level":2,"score":0.5853238105773926},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4801313579082489},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.43900078535079956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4184499680995941},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3131479024887085},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11382687091827393},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.10878214240074158},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09230202436447144},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07241436839103699},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06380528211593628}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/cbo9780511546198.077","doi":"https://doi.org/10.1017/cbo9780511546198.077","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511546198.077","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endothelial Biomedicine","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087300502","https://openalex.org/W2057602456","https://openalex.org/W6981549847","https://openalex.org/W2916966470","https://openalex.org/W2730972405","https://openalex.org/W3090389770","https://openalex.org/W1654649921","https://openalex.org/W2004027892","https://openalex.org/W2940560793","https://openalex.org/W1985556486"],"abstract_inverted_index":{"The":[0,13,37,98,142,216],"vascular":[1],"endothelium":[2,38,102,122],"represents":[3],"an":[4,126],"enormous":[5],"and":[6,27,45,51,56,63,75,116,135,162,171,179,195,214,219,233,246,250],"heterogeneous":[7],"organ":[8,22],"faced":[9],"with":[10,30,125,156,211],"diverse":[11],"challenges.":[12,109],"individual":[14],"endothelial":[15,130],"cells":[16,80,155],"(ECs)":[17],"that":[18,236,253],"make":[19],"up":[20],"this":[21],"must":[23,39,60,81],"organize":[24],"a":[25,31,228],"polarized":[26],"discrete":[28],"monolayer,":[29],"range":[32],"of":[33,42,95,100,113,118,129,149,176,199,206,209,221,231],"tissue":[34,90],"specific":[35],"specializations.":[36],"be":[40,82],"capable":[41],"carefully":[43],"balancing":[44],"dynamically":[46],"regulating":[47],"both":[48,133],"barrier":[49],"function":[50,131,220],"selective":[52],"permeability":[53],"to":[54,84,105,167,243],"solutes":[55],"immune":[57],"cells.":[58],"ECs":[59],"resist":[61],"significant,":[62],"in":[64,121,132,173],"some":[65],"settings":[66],"extreme,":[67],"mechanical":[68,158],"forces":[69],"including":[70],"fluid":[71],"shear,":[72],"hydrostatic":[73],"pressure,":[74],"cyclical":[76],"stretch.":[77],"Finally,":[78],"these":[79,108,200,222],"able":[83],"efficiently":[85],"migrate":[86],"and,":[87],"indeed,":[88],"invade":[89],"matrices":[91],"during":[92],"the":[93,101,114,177,204,238],"formation":[94],"new":[96],"vessels.":[97],"cytoskeleton":[99,143],"is":[103,144,201],"central":[104],"meeting":[106],"all":[107],"Our":[110],"growing":[111],"knowledge":[112],"roles":[115],"regulation":[117],"cytoskeletal":[119],"components":[120],"provides":[123],"us":[124],"improved":[127],"understanding":[128],"health":[134],"disease.":[136],"AN":[137],"OVERVIEW":[138],"OF":[139],"THE":[140],"CYTOSKELETON":[141],"formed":[145,202],"by":[146,203],"three":[147],"kinds":[148],"protein":[150,169],"filaments,":[151],"which":[152],"together":[153],"provide":[154,181,251],"shape,":[157],"strength,":[159],"spatial":[160],"organization/polarity,":[161],"movement.":[163],"They":[164],"also":[165],"serve":[166],"connect":[168,241],"complexes":[170],"organelles":[172,255],"distinct":[174,212],"parts":[175],"cell,":[178],"can":[180],"tracks":[182],"for":[183],"transport":[184],"between":[185],"them.":[186],"These":[187],"filaments":[188,223,242],"include":[189],"microfilaments":[190],"(or":[191,256],"\u201cactin":[192],"filaments\u201d),":[193],"microtubules,":[194],"intermediate":[196],"filaments.":[197],"Each":[198],"polymerization":[205],"separate":[207],"sets":[208],"proteins":[210,235],"dynamics":[213],"stability.":[215],"dynamics,":[217],"stability,":[218],"are":[224],"highly":[225],"dependent":[226],"on":[227],"large":[229],"repertoire":[230],"accessory":[232],"regulatory":[234],"control":[237],"localized":[239],"assembly,":[240],"each":[244],"other":[245,247,257],"cellular":[248],"components,":[249],"motors":[252],"move":[254],"filaments)":[258],"along":[259],"their":[260],"length.":[261]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}