{"id":"https://openalex.org/W2498568960","doi":"https://doi.org/10.1111/acer.13136","title":"Alcohol Suppresses Tonic GABAAReceptor Currents in Cerebellar Granule Cells in the Prairie Vole: A Neural Signature of High\u2010Alcohol\u2010Consuming Genotypes","display_name":"Alcohol Suppresses Tonic GABAAReceptor Currents in Cerebellar Granule Cells in the Prairie Vole: A Neural Signature of High\u2010Alcohol\u2010Consuming Genotypes","publication_year":2016,"publication_date":"2016-07-18","ids":{"openalex":"https://openalex.org/W2498568960","doi":"https://doi.org/10.1111/acer.13136","mag":"2498568960","pmid":"https://pubmed.ncbi.nlm.nih.gov/27426857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4961518"},"language":"en","primary_location":{"id":"doi:10.1111/acer.13136","doi":"https://doi.org/10.1111/acer.13136","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.13136","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4961518","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054377997","display_name":"Joshua S. Kaplan","orcid":"https://orcid.org/0000-0002-8005-8442","observed_orcids":["https://orcid.org/0000-0002-8005-8442"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua S. Kaplan","raw_affiliation_strings":["Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","VA Portland Health Care System, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"VA Portland Health Care System, Portland, Oregon","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048551229","display_name":"Claudia Mohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Mohr","raw_affiliation_strings":["Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086923797","display_name":"Caroline M. Hostetler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline M. Hostetler","raw_affiliation_strings":["Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","VA Portland Health Care System, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"VA Portland Health Care System, Portland, Oregon","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003072259","display_name":"Andrey E. Ryabinin","orcid":"https://orcid.org/0000-0003-4662-3775","observed_orcids":["https://orcid.org/0000-0003-4662-3775"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrey E. Ryabinin","raw_affiliation_strings":["Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106132528","display_name":"Deborah A. Finn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2803065977","display_name":"Portland VA Medical Center","ror":"https://ror.org/02v3txv81","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2803065977","https://openalex.org/I4210144745"]},{"id":"https://openalex.org/I4210144745","display_name":"VA Portland Health Care System","ror":"https://ror.org/054484h93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A. Finn","raw_affiliation_strings":["Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","VA Portland Health Care System, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"VA Portland Health Care System, Portland, Oregon","institution_ids":["https://openalex.org/I2803065977","https://openalex.org/I4210144745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002707809","display_name":"David J. Rossi","orcid":"https://orcid.org/0000-0002-6703-0330","observed_orcids":["https://orcid.org/0000-0002-6703-0330"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J. Rossi","raw_affiliation_strings":["Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience Oregon Health & Science University Portland Oregon","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002707809"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I72951846"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":0.5607,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67451126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"40","issue":"8","first_page":"1617","last_page":"1626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.5120000243186951},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prairie-voles","display_name":"Microtus ochrogaster","score":0.9490000009536743},{"id":"https://openalex.org/keywords/genetic-predisposition-to-alcoholism","display_name":"genetic predisposition to alcoholism","score":0.7609999775886536},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tetrodotoxin","display_name":"tetrodotoxin","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.9107984304428101},{"id":"https://openalex.org/C127573956","wikidata":"https://www.wikidata.org/wiki/Q7821376","display_name":"Tonic (physiology)","level":2,"score":0.6512863636016846},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.6287331581115723},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5647385716438293},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4727654755115509},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.44727614521980286},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.4362903833389282},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40777507424354553},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38596802949905396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3855215013027191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3522455096244812},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.33533406257629395},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32845771312713623},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32044655084609985},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27587267756462097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22625932097434998},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13931536674499512}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003411","descriptor_name":"Arvicolinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/acer.13136","doi":"https://doi.org/10.1111/acer.13136","is_oa":false,"landing_page_url":"https://doi.org/10.1111/acer.13136","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:27426857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27426857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4961518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4961518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alcohol Clin Exp Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4961518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4961518","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Alcohol Clin Exp Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G146106621","display_name":"Neurosteroid Modulation of Ethanol Withdrawal Severity","funder_award_id":"R01AA012439","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6403583550","display_name":"Cerebellar GABAA receptor contributions to EtOH intoxication and EtOH intake","funder_award_id":"F31AA022267","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7568165960","display_name":"Social affiliation and alcohol drinking in rodents","funder_award_id":"R01AA019793","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320309913","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W66762736","https://openalex.org/W1499733802","https://openalex.org/W1517470090","https://openalex.org/W1546721452","https://openalex.org/W1550227666","https://openalex.org/W1768957097","https://openalex.org/W1807514330","https://openalex.org/W1868158529","https://openalex.org/W1871962537","https://openalex.org/W1964164372","https://openalex.org/W1964631257","https://openalex.org/W1964925312","https://openalex.org/W1970878373","https://openalex.org/W1975619817","https://openalex.org/W1975706895","https://openalex.org/W1982304594","https://openalex.org/W1995495180","https://openalex.org/W1996353639","https://openalex.org/W1997707954","https://openalex.org/W1998383469","https://openalex.org/W1998419939","https://openalex.org/W2004166962","https://openalex.org/W2006024372","https://openalex.org/W2006461738","https://openalex.org/W2016301063","https://openalex.org/W2022881626","https://openalex.org/W2028364166","https://openalex.org/W2030383771","https://openalex.org/W2034083472","https://openalex.org/W2047463569","https://openalex.org/W2048681789","https://openalex.org/W2051178577","https://openalex.org/W2059021380","https://openalex.org/W2064695132","https://openalex.org/W2065692979","https://openalex.org/W2071961991","https://openalex.org/W2072933305","https://openalex.org/W2072962057","https://openalex.org/W2088143216","https://openalex.org/W2117770293","https://openalex.org/W2118490956","https://openalex.org/W2124231060","https://openalex.org/W2134894690","https://openalex.org/W2154490775","https://openalex.org/W2157045453","https://openalex.org/W2160614601","https://openalex.org/W2170172094","https://openalex.org/W2222862558","https://openalex.org/W2288879381","https://openalex.org/W2765334261","https://openalex.org/W4232580191"],"related_works":["https://openalex.org/W4200104948","https://openalex.org/W1975706895","https://openalex.org/W2157045453","https://openalex.org/W2507785324","https://openalex.org/W2605336164","https://openalex.org/W2149702349","https://openalex.org/W2225590753","https://openalex.org/W4301258748","https://openalex.org/W4248684919","https://openalex.org/W1974114400"],"abstract_inverted_index":{"BACKGROUND:":[0],"Evidence":[1],"indicates":[2],"that":[3,35,63,213,248],"the":[4,23,97,119,122,140,164,194,205,252,261,283,293,305],"cerebellum":[5,92,257],"plays":[6],"a":[7,225,311],"role":[8],"in":[9,18,50,55,65,78,87,107,127,134,145,173,251,264,290],"genetic":[10,76],"predilection":[11,28],"to":[12,72,75,95,153,260,272,288,314],"excessive":[13],"alcohol":[14],"(ethanol":[15],"[EtOH])":[16],"consumption":[17,80,300],"rodents":[19],"and":[20,57,61,138,178,201,275,302],"humans,":[21],"but":[22,160],"molecular":[24],"mechanisms":[25],"mediating":[26],"such":[27],"are":[29],"not":[30,191],"understood.":[31],"We":[32],"recently":[33],"determined":[34],"EtOH":[36,73,79,100,115,172,183,242,289,299,316],"has":[37],"opposite":[38],"actions":[39,219],"(enhancement":[40],"or":[41],"suppression)":[42],"on":[43,101,220],"tonic":[44,67,103,123,141,167,186],"GABAA":[45,68,104,124,142,168,187,209,221,285,307],"receptor":[46],"(GABAA":[47],"R)":[48],"currents":[49,106,170,189],"cerebellar":[51],"granule":[52],"cells":[53],"(GCs)":[54],"low-":[56],"high-EtOH-consuming":[58,109,156,294],"rodents,":[59],"respectively,":[60],"proposed":[62],"variation":[64,77],"GC":[66,102,253,284,306],"R":[69,105,125,143,169,188,286,308],"current":[70,126,144],"responses":[71],"contributes":[74],"phenotype.":[81],"METHODS:":[82],"Voltage-clamp":[83],"recordings":[84],"of":[85,91,99,121,129,136,147,166,185,204,207,227,233,244,255],"GCs":[86,154],"acutely":[88],"prepared":[89],"slices":[90],"were":[93],"used":[94],"evaluate":[96],"effect":[98,133],"another":[108,291],"rodent,":[110],"prairie":[111],"voles":[112],"(PVs).":[113],"RESULTS:":[114],"(52":[116],"mM)":[117],"suppressed":[118],"magnitude":[120],"57%":[128],"cells,":[130,137],"had":[131],"no":[132],"38%":[135],"enhanced":[139],"5%":[146],"cells.":[148],"This":[149],"result":[150],"is":[151,215],"similar":[152,259],"from":[155,163],"C57BL/6J":[157],"(B6)":[158],"mice,":[159,266],"it":[161],"differs":[162],"enhancement":[165,243],"by":[171,193,217],"low-EtOH-consuming":[174],"DBA/2J":[175],"(D2)":[176],"mice":[177,274],"Sprague":[179],"Dawley":[180],"(SD)":[181],"rats.":[182,277],"suppression":[184,214],"was":[190,202,258],"affected":[192],"sodium":[195],"channel":[196],"blocker,":[197],"tetrodotoxin":[198],"(500":[199],"nM),":[200],"independent":[203],"frequency":[206],"phasic":[208],"R-mediated":[210],"currents,":[211],"suggesting":[212],"mediated":[216],"postsynaptic":[218],"Rs,":[222],"rather":[223],"than":[224],"reduction":[226],"GABA":[228,245],"release.":[229],"Finally,":[230],"immunohistochemical":[231],"analysis":[232],"neuronal":[234],"nitric":[235],"oxide":[236],"synthase":[237],"(nNOS;":[238],"which":[239,296],"can":[240],"mediate":[241],"release)":[246],"demonstrated":[247],"nNOS":[249],"expression":[250],"layer":[254],"PV":[256],"levels":[262],"seen":[263],"B6":[265],"both":[267],"being":[268],"significantly":[269],"reduced":[270],"relative":[271],"D2":[273],"SD":[276],"CONCLUSIONS:":[278],"Combined,":[279],"these":[280],"data":[281],"highlight":[282],"response":[287],"species,":[292],"PV,":[295],"correlates":[297],"with":[298],"phenotype":[301],"further":[303],"implicates":[304],"system":[309],"as":[310],"contributing":[312],"mechanism":[313],"high":[315],"consumption.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-08-23T00:00:00"}