{"id":"https://openalex.org/W2497785285","doi":"https://doi.org/10.1182/blood.v122.21.334.334","title":"SNP Analysis Of The VWF GENE Identifies Multiple Common Variants THAT Affect VWF Levels and OCCUR At Different Frequencies In Patients With TYPE 1 VWD","display_name":"SNP Analysis Of The VWF GENE Identifies Multiple Common Variants THAT Affect VWF Levels and OCCUR At Different Frequencies In Patients With TYPE 1 VWD","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2497785285","doi":"https://doi.org/10.1182/blood.v122.21.334.334","mag":"2497785285"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.334.334","doi":"https://doi.org/10.1182/blood.v122.21.334.334","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.334.334","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082671443","display_name":"Jesse D. Hinckley","orcid":"https://orcid.org/0000-0003-4524-2049","observed_orcids":["https://orcid.org/0000-0003-4524-2049"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jesse Hinckley","raw_affiliation_strings":["Pediatrics and Human Genetics, University of Colorado Denver, Aurora, CO, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics and Human Genetics, University of Colorado Denver, Aurora, CO, USA,","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063107555","display_name":"Trudy L. Burns","orcid":"https://orcid.org/0000-0001-5639-3059","observed_orcids":["https://orcid.org/0000-0001-5639-3059"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Trudy Burns","raw_affiliation_strings":["Department of Epidemiology, University of Iowa, Iowa City, IA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Iowa, Iowa City, IA, USA,","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Department of Biostatistics, University of Iowa, Iowa City, IA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Iowa, Iowa City, IA, USA,","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012249054","display_name":"Ayse Bilge Ozel","orcid":"https://orcid.org/0000-0002-1112-4258","observed_orcids":["https://orcid.org/0000-0002-1112-4258"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ayse Bilge Ozel","raw_affiliation_strings":["Human Genetics, University of Michigan, Ann Arbor, MI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Genetics, University of Michigan, Ann Arbor, MI, USA,","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061966534","display_name":"Meadow Heiman","orcid":"https://orcid.org/0000-0002-5926-1382","observed_orcids":["https://orcid.org/0000-0002-5926-1382"]},"institutions":[{"id":"https://openalex.org/I4210162902","display_name":"Indiana Hemophilia and Thrombosis Center","ror":"https://ror.org/05j1fg548","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162902"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meadow Heiman","raw_affiliation_strings":["Indiana Hemophilia and Thrombosis Center, Inidanapolis, IN, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Hemophilia and Thrombosis Center, Inidanapolis, IN, USA,","institution_ids":["https://openalex.org/I4210162902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038597185","display_name":"Amy D. Shapiro","orcid":"https://orcid.org/0000-0003-2821-7159","observed_orcids":["https://orcid.org/0000-0003-2821-7159"]},"institutions":[{"id":"https://openalex.org/I4210162902","display_name":"Indiana Hemophilia and Thrombosis Center","ror":"https://ror.org/05j1fg548","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210162902"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Shapiro","raw_affiliation_strings":["Department of Hematology, Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, USA,","institution_ids":["https://openalex.org/I4210162902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062313473","display_name":"Robert R. Montgomery","orcid":"https://orcid.org/0000-0003-2285-4077","observed_orcids":["https://orcid.org/0000-0003-2285-4077"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. Montgomery","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA,","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088033476","display_name":"Lawrence C. Brody","orcid":"https://orcid.org/0000-0001-9435-3592","observed_orcids":["https://orcid.org/0000-0001-9435-3592"]},"institutions":[{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lawrence Brody","raw_affiliation_strings":["Genome Technology Branch, National Human Genome Research Institute, Bethesda, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Technology Branch, National Human Genome Research Institute, Bethesda, USA,","institution_ids":["https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018179300","display_name":"Karl C. Desch","orcid":"https://orcid.org/0000-0003-0392-4033","observed_orcids":["https://orcid.org/0000-0003-0392-4033"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl C. Desch","raw_affiliation_strings":["Pediatrics and Communicable Disease, University of Michigan, Ann Arbor, MI, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics and Communicable Disease, University of Michigan, Ann Arbor, MI, USA,","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001251736","display_name":"Jorge Di Paola","orcid":"https://orcid.org/0000-0002-1461-2871","observed_orcids":["https://orcid.org/0000-0002-1461-2871"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Di Paola","raw_affiliation_strings":["Pediatrics and Genetics, University of Colorado, Denver, School of Medicine PO Box 6511, Aurora, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics and Genetics, University of Colorado, Denver, School of Medicine PO Box 6511, Aurora, CO, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012249054","https://openalex.org/A5061966534","https://openalex.org/A5063107555","https://openalex.org/A5082671443","https://openalex.org/A5088033476"],"corresponding_institution_ids":["https://openalex.org/I126307644","https://openalex.org/I27837315","https://openalex.org/I4210090236","https://openalex.org/I4210162902","https://openalex.org/I921990950"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31479569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"334","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-von-willebrand-disease","display_name":"type 1 von Willebrand disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/vwf-gene","display_name":"VWF gene","score":0.9520000219345093},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9470000267028809},{"id":"https://openalex.org/keywords/modifier-genes","display_name":"genetic modifiers","score":0.6359999775886536},{"id":"https://openalex.org/keywords/abo-blood-group","display_name":"ABO blood group system","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tagging-snps","display_name":"tagging SNPs","score":0.8270000219345093},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5099999904632568},{"id":"https://openalex.org/keywords/incomplete-penetrance","display_name":"incomplete penetrance","score":0.5680000185966492},{"id":"https://openalex.org/keywords/variable-expressivity","display_name":"variable expressivity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.5249999761581421},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7395504713058472},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.6186830401420593},{"id":"https://openalex.org/C2778780528","wikidata":"https://www.wikidata.org/wiki/Q709360","display_name":"Von Willebrand disease","level":4,"score":0.6150038838386536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6122550964355469},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5709362626075745},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.5471235513687134},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5178923606872559},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5158714056015015},{"id":"https://openalex.org/C176080213","wikidata":"https://www.wikidata.org/wiki/Q188010","display_name":"ABO blood group system","level":2,"score":0.5056736469268799},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4845770597457886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.447335809469223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2894311547279358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2662239074707031},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24721723794937134},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.1019899845123291},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.09578478336334229},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.334.334","doi":"https://doi.org/10.1182/blood.v122.21.334.334","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.334.334","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/5","display_name":"Gender equality"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389233993","https://openalex.org/W2785940426","https://openalex.org/W1515078220","https://openalex.org/W7214996620","https://openalex.org/W4385296570","https://openalex.org/W2791348340","https://openalex.org/W2955765644","https://openalex.org/W2027668519","https://openalex.org/W3009585559","https://openalex.org/W2096480091"],"abstract_inverted_index":{"Abstract":[0],"von":[1],"Willebrand":[2],"disease":[3],"(VWD)":[4],"type":[5,44,76,84,127,381,406,430,469,484,555],"1":[6,45,382,407,431,470,556],"is":[7,57,78,87],"characterized":[8],"by":[9],"incomplete":[10],"penetrance":[11],"and":[12,74,117,142,158,163,180,189,197,202,208,212,248,260,266,291,317,327,337,350,403,436,450,464,542],"variable":[13],"expressivity.":[14],"Individuals":[15],"with":[16,50,82,90,146,223,329,342,418,428,454,553],"very":[17],"low":[18],"levels":[19,52,116,179,225,331,541],"of":[20,43,62,70,100,102,125,220,239,251,287,321,345,377,393,415,446,489,496,508,515,576,593,615,629],"VWF":[21,30,51,63,86,113,115,135,147,178,224,330,420,456,533,540],"(<":[22],"20":[23],"IU/dl)":[24],"typically":[25],"have":[26,527,535],"mutations":[27,35],"in":[28,39,80,112,122,136,226,235,301,313,334,356,370,374,426,433,467,532,551],"the":[29,58,71,123,218,243,258,268,302,314,322,357,363,371,388,394,398,404,480,487,493,506,512],"gene.":[31],"However,":[32],"no":[33],"such":[34],"can":[36],"be":[37],"identified":[38,528],"a":[40,120,137,227,375,536],"significant":[41,171,441],"subset":[42],"VWD":[46,83,126,252,380,429,468,483,554],"patients,":[47],"particularly":[48],"those":[49],">":[53],"30":[54],"IU/dL.":[55],"ABO":[56,159],"best-characterized":[59],"genetic":[60,72],"modifier":[61],"levels,":[64],"accounting":[65],"for":[66,246,293,492,511],"up":[67],"to":[68,186,474],"30%":[69],"variability":[73],"blood":[75,288],"O":[77],"overrepresented":[79],"patients":[81,427,552],"1.":[85,128],"highly":[88],"polymorphic":[89],"over":[91,549],"1,100":[92],"reported":[93],"single":[94,151],"nucleotide":[95],"variants":[96,111,325,531],"(SNVs).":[97],"The":[98,412,443],"impact":[99],"many":[101],"these":[103,221],"changes":[104],"remains":[105],"unknown.":[106],"We":[107,129,149,169,360,386],"hypothesize":[108],"that":[109,367,437,534,558],"common":[110,424,460,530],"affect":[114],"may":[118,559],"play":[119],"role":[121],"diagnosis":[124],"genotyped":[130,362],"94":[131],"tagging":[132,182,395],"SNPs":[133,222,366,396],"through":[134],"large":[138],"Amish":[139],"family":[140,373],"(n=445)":[141],"study":[143],"their":[144],"association":[145,153,219,233,276],"levels.":[148],"performed":[150],"SNP":[152,297,309],"tests":[154],"using":[155],"age,":[156,281],"gender":[157],"status":[160],"as":[161],"covariates":[162],"multiple":[164,294],"testing":[165],"corrections":[166],"were":[167,278,299,311,332,458,498,517],"implemented.":[168],"observed":[170],"associations":[172,298,310],"(p":[173],"value":[174],"\u2264":[175],"0.0005)":[176],"between":[177,397],"twelve":[181],"SNPs:":[183],"rs2362479":[184],"(telomeric":[185],"VWF),":[187],"rs10849363":[188],"rs7964554":[190,416,497],"(intron":[191,194,204,210,214],"4);":[192],"rs216308":[193],"24);":[195],"rs216310":[196],"rs216311":[198],"(exon":[199],"28);":[200],"rs11612370":[201],"rs11612384":[203],"33);":[205],"rs216330,":[206],"rs11064003,":[207,449],"rs2239162":[209,328,451,516],"37);":[211],"rs216293":[213],"38).":[215],"To":[216],"replicate":[217],"larger":[228],"Caucasian":[229,379],"population,":[230],"we":[231,526],"conducted":[232],"analyses":[234,277],"three":[236],"population-based":[237],"cohorts":[238,336],"healthy":[240],"individuals:":[241],"1)":[242],"Zimmerman":[244],"Program":[245],"Molecular":[247],"Clinical":[249],"Biology":[250],"(ZPMCB-VWD)":[253],"control":[254,304,316,400],"cohort":[255,264,273,376,401,410],"(n=150),":[256],"2)":[257],"Genes":[259],"Blood-Clotting":[261],"Study":[262,271],"(GABC)":[263],"(n=934)":[265],"3)":[267],"Trinity":[269],"Student":[270],"(TSS)":[272],"(n=2,145).":[274],"All":[275],"modeled":[279],"including":[280],"gender,":[282],"rs687289":[283],"(a":[284],"proxy":[285],"marker":[286],"group":[289],"O)":[290],"adjusted":[292],"testing.":[295],"Three":[296],"replicated":[300,312,333],"ZPMCB-VWD":[303,315,399,405],"cohort.":[305,359],"An":[306],"additional":[307],"four":[308],"TSS":[318,358],"cohorts.":[319],"Associations":[320],"intron":[323],"37":[324],"rs11064003":[326],"all":[335],"reached":[338],"genome":[339],"wide":[340],"significance":[341,369],"p":[343],"values":[344],"1.34":[346],"x":[347,352],"10":[348,353],"-11":[349],"7.35":[351],"-15":[354],"respectively":[355],"then":[361,486],"12":[364],"candidate":[365],"showed":[368],"original":[372],"310":[378],"index":[383,408,471],"cases":[384,472],"(ZPMCB-VWD).":[385],"compared":[387,473],"minor":[389,413,444,494,513],"allele":[390,414,495,514],"frequency":[391],"(MAF)":[392],"(n=150)":[402],"case":[409],"(n=310).":[411],"(associated":[417],"lower":[419],"levels)":[421,457],"was":[422,439],"more":[423,543],"(46.2%)":[425],"than":[432],"controls":[434],"(34.0%),":[435],"difference":[438],"statistically":[440],"(p=0.0005).":[442],"alleles":[445],"rs11612370,":[447],"rs11612384,":[448],"(all":[452],"associated":[453],"higher":[455],"less":[459],"(p=0.018,":[461],"0.009,":[462],"0.012,":[463],"0.0004,":[465],"respectively)":[466],"controls.":[475],"In":[476,524],"this":[477],"population":[478],"if":[479],"subject":[481],"has":[482],"1,":[485],"odds":[488,507],"being":[490,509],"heterozygous":[491,510],"1.47":[499],"(95%":[500,519],"CI:":[501,520],"1.08,":[502],"2.00;":[503],"p=0.014).":[504,523],"Similarly,":[505],"0.64":[518],"0.45,":[521],"0.91;":[522],"summary":[525],"several":[529],"strong":[537],"effect":[538],"on":[539,572,589,611,625],"importantly":[544],"are":[545],"either":[546],"under":[547],"or":[548,578,595,617,631],"represented":[550],"indicating":[557],"influence":[560],"its":[561],"diagnosis.":[562],"Disclosures:":[563],"Shapiro:":[564],"Baxter:":[565],"Consultancy,":[566,587,623],"Global":[567,603,606],"steering":[568,604,607],"committees":[569,608],"Other,":[570,609],"Membership":[571,588,610,624],"an":[573,590,612,626],"entity\u2019s":[574,591,613,627],"Board":[575,592,614,628],"Directors":[577,594,616,630],"advisory":[579,596,618,632],"committees,":[580,597,605,619,633],"Research":[581,598,620,634,638,642],"Funding,":[582,599],"Speakers":[583,600],"Bureau;":[584,601],"Novo":[585],"Nordisk:":[586],"Bayer:":[602],"Funding;":[621,635,639],"Inspiration:":[622],"CSL":[636],"Behring:":[637,646],"Biogen":[640],"Idec:":[641],"Funding.":[643],"Di":[644],"Paola:CSL":[645],"Consultancy;":[647],"Pfizer:":[648],"DSMB,":[649],"DSMB":[650],"Other.":[651]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-08-23T00:00:00"}