{"id":"https://openalex.org/W2497735565","doi":"https://doi.org/10.1016/j.bbr.2016.07.025","title":"Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence","display_name":"Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence","publication_year":2016,"publication_date":"2016-07-18","ids":{"openalex":"https://openalex.org/W2497735565","doi":"https://doi.org/10.1016/j.bbr.2016.07.025","mag":"2497735565","pmid":"https://pubmed.ncbi.nlm.nih.gov/27435421"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbr.2016.07.025","doi":"https://doi.org/10.1016/j.bbr.2016.07.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2016.07.025","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018613105","display_name":"Man Li","orcid":"https://orcid.org/0000-0001-9365-297X","observed_orcids":["https://orcid.org/0000-0001-9365-297X"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man Li","raw_affiliation_strings":["School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899862","display_name":"Wei Du","orcid":"https://orcid.org/0000-0001-7953-2023","observed_orcids":["https://orcid.org/0000-0001-7953-2023"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Du","raw_affiliation_strings":["School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101491790","display_name":"Feng Shao","orcid":"https://orcid.org/0000-0003-3662-4619","observed_orcids":["https://orcid.org/0000-0003-3662-4619"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Shao","raw_affiliation_strings":["School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China. Electronic address: shaof@pku.edu.cn","School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China. Electronic address: shaof@pku.edu.cn","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100748330","display_name":"Weiwen Wang","orcid":"https://orcid.org/0000-0001-9231-6106","observed_orcids":["https://orcid.org/0000-0001-9231-6106"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210131870","display_name":"Institute of Psychology, Chinese Academy of Sciences","ror":"https://ror.org/03j7v5j15","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210131870"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weiwen Wang","raw_affiliation_strings":["Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address: wangww@psych.ac.cn","Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address: wangww@psych.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210131870"]},{"raw_affiliation_string":"Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210131870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100748330","https://openalex.org/A5101491790"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I20231570","https://openalex.org/I4210131870"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":3.9638,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.94417077,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"313","issue":null,"first_page":"177","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.32589998841285706,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.32589998841285706,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.13009999692440033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.09740000218153,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/social-isolation","display_name":"social isolation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/early-adolescence","display_name":"early adolescence","score":0.6320000290870667},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7979999780654907},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/histone-h3-acetylation","display_name":"histone H3 acetylation","score":0.859000027179718},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":0.8379999995231628},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":1.0},{"id":"https://openalex.org/keywords/childhood-adversity","display_name":"childhood adversity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.7567760944366455},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7483194470405579},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7167782783508301},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6905509233474731},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6866589784622192},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.604621410369873},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48796314001083374},{"id":"https://openalex.org/C2776893239","wikidata":"https://www.wikidata.org/wiki/Q1778765","display_name":"Social isolation","level":2,"score":0.48130738735198975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.430569589138031},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.40109866857528687},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3988797068595886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29143577814102173},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26283520460128784},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18705233931541443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16933530569076538},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.14249715209007263},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.04575645923614502}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012934","descriptor_name":"Social Isolation","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bbr.2016.07.025","doi":"https://doi.org/10.1016/j.bbr.2016.07.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbr.2016.07.025","pdf_url":null,"source":{"id":"https://openalex.org/S81474683","display_name":"Behavioural Brain Research","issn_l":"0166-4328","issn":["0166-4328","1872-7549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural Brain Research","raw_type":"journal-article"},{"id":"pmid:27435421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27435421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioural brain research","raw_type":"Journal Article"},{"id":"pmh:oai:/ir.psych.ac.cn:311026/20535","doi":null,"is_oa":false,"landing_page_url":"http://ir.psych.ac.cn/handle/311026/20535","pdf_url":null,"source":{"id":"https://openalex.org/S4377196583","display_name":"Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210131870","host_organization_name":"Institute of Psychology, Chinese Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210131870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:/ir.psych.ac.cn:311026/25608","doi":null,"is_oa":false,"landing_page_url":"http://ir.psych.ac.cn/handle/311026/25608","pdf_url":null,"source":{"id":"https://openalex.org/S4377196583","display_name":"Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210131870","host_organization_name":"Institute of Psychology, Chinese Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210131870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"\u671f\u520a\u8bba\u6587"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5013414542","display_name":"\u9752\u5c11\u671f\u793e\u4f1a\u9694\u79bb\u8bf1\u53d1\u5927\u9f20\u62df\u7cbe\u795e\u5206\u88c2\u75c7\u8ba4\u77e5\u529f\u80fd\u969c\u788d\u7684BDNF\u8868\u89c2\u9057\u4f20\u5b66\u673a\u5236\u7814\u7a76","funder_award_id":"31470988","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8112516124","display_name":null,"funder_award_id":"81471122","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W312441591","https://openalex.org/W644686294","https://openalex.org/W777478407","https://openalex.org/W1899099918","https://openalex.org/W1917207504","https://openalex.org/W1921451765","https://openalex.org/W1923860514","https://openalex.org/W1965492302","https://openalex.org/W1966985100","https://openalex.org/W1970882922","https://openalex.org/W1971606760","https://openalex.org/W1975738532","https://openalex.org/W1976143905","https://openalex.org/W1982135114","https://openalex.org/W1985444222","https://openalex.org/W2009582310","https://openalex.org/W2010257108","https://openalex.org/W2012316620","https://openalex.org/W2013245174","https://openalex.org/W2014599831","https://openalex.org/W2016676209","https://openalex.org/W2016836206","https://openalex.org/W2019243277","https://openalex.org/W2020771726","https://openalex.org/W2024285462","https://openalex.org/W2025385931","https://openalex.org/W2028018776","https://openalex.org/W2029002395","https://openalex.org/W2030524313","https://openalex.org/W2031067009","https://openalex.org/W2031240642","https://openalex.org/W2032689830","https://openalex.org/W2033698125","https://openalex.org/W2034658390","https://openalex.org/W2036161685","https://openalex.org/W2040136786","https://openalex.org/W2041144442","https://openalex.org/W2042044062","https://openalex.org/W2046194674","https://openalex.org/W2048601608","https://openalex.org/W2050242372","https://openalex.org/W2071426323","https://openalex.org/W2072175866","https://openalex.org/W2073854421","https://openalex.org/W2076365218","https://openalex.org/W2078163458","https://openalex.org/W2081817618","https://openalex.org/W2082999445","https://openalex.org/W2087000073","https://openalex.org/W2088093030","https://openalex.org/W2089199123","https://openalex.org/W2090280523","https://openalex.org/W2092760738","https://openalex.org/W2100041578","https://openalex.org/W2106201573","https://openalex.org/W2115155925","https://openalex.org/W2117996813","https://openalex.org/W2120708979","https://openalex.org/W2121984222","https://openalex.org/W2129217278","https://openalex.org/W2130417276","https://openalex.org/W2131325969","https://openalex.org/W2133556218","https://openalex.org/W2134169577","https://openalex.org/W2139168702","https://openalex.org/W2160621075","https://openalex.org/W2160748820","https://openalex.org/W2165970680","https://openalex.org/W2168203121"],"related_works":["https://openalex.org/W2088093030","https://openalex.org/W2082867428","https://openalex.org/W4317567845","https://openalex.org/W2922523608","https://openalex.org/W2769661765","https://openalex.org/W1997892512","https://openalex.org/W2113714489","https://openalex.org/W3167204899","https://openalex.org/W2963685479","https://openalex.org/W1978229652"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-08-23T00:00:00"}