{"id":"https://openalex.org/W2497543432","doi":"https://doi.org/10.1016/j.chroma.2016.07.055","title":"Residual on column host cell protein analysis during lifetime studies of protein A chromatography","display_name":"Residual on column host cell protein analysis during lifetime studies of protein A chromatography","publication_year":2016,"publication_date":"2016-07-22","ids":{"openalex":"https://openalex.org/W2497543432","doi":"https://doi.org/10.1016/j.chroma.2016.07.055","mag":"2497543432","pmid":"https://pubmed.ncbi.nlm.nih.gov/27473513"},"language":"en","primary_location":{"id":"doi:10.1016/j.chroma.2016.07.055","doi":"https://doi.org/10.1016/j.chroma.2016.07.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2016.07.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021967316309773/pdf","source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021967316309773/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077903991","display_name":"Katherine Lintern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katherine Lintern","raw_affiliation_strings":["Department of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London WC1H 0AH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London WC1H 0AH, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050862781","display_name":"Mili Pathak","orcid":"https://orcid.org/0000-0002-2384-2468","observed_orcids":["https://orcid.org/0000-0002-2384-2468"]},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mili Pathak","raw_affiliation_strings":["Department of Chemical Engineering, IIT Delhi, Hauz Khas, New Delhi, Delhi 110016, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, IIT Delhi, Hauz Khas, New Delhi, Delhi 110016, India","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017406022","display_name":"Christopher Mark Smales","orcid":"https://orcid.org/0000-0002-2762-4724","observed_orcids":["https://orcid.org/0000-0002-2762-4724"]},"institutions":[{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Mark Smales","raw_affiliation_strings":["Centre for Industrial Biotechnology, School of Biosciences, University of Kent, Canterbury, CT2 7NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Industrial Biotechnology, School of Biosciences, University of Kent, Canterbury, CT2 7NJ, United Kingdom","institution_ids":["https://openalex.org/I20581793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072788703","display_name":"Kevin Howland","orcid":"https://orcid.org/0000-0003-4370-0974","observed_orcids":["https://orcid.org/0000-0003-4370-0974"]},"institutions":[{"id":"https://openalex.org/I20581793","display_name":"University of Kent","ror":"https://ror.org/00xkeyj56","country_code":"GB","type":"education","lineage":["https://openalex.org/I20581793"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Howland","raw_affiliation_strings":["Centre for Industrial Biotechnology, School of Biosciences, University of Kent, Canterbury, CT2 7NJ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Industrial Biotechnology, School of Biosciences, University of Kent, Canterbury, CT2 7NJ, United Kingdom","institution_ids":["https://openalex.org/I20581793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078008569","display_name":"Anurag Singh Rathore","orcid":"https://orcid.org/0000-0002-5913-4244","observed_orcids":["https://orcid.org/0000-0002-5913-4244"]},"institutions":[{"id":"https://openalex.org/I68891433","display_name":"Indian Institute of Technology Delhi","ror":"https://ror.org/049tgcd06","country_code":"IN","type":"education","lineage":["https://openalex.org/I68891433"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anurag Rathore","raw_affiliation_strings":["Department of Chemical Engineering, IIT Delhi, Hauz Khas, New Delhi, Delhi 110016, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, IIT Delhi, Hauz Khas, New Delhi, Delhi 110016, India","institution_ids":["https://openalex.org/I68891433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054772413","display_name":"Daniel G. Bracewell","orcid":"https://orcid.org/0000-0003-3866-3304","observed_orcids":["https://orcid.org/0000-0003-3866-3304"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Daniel G. Bracewell","raw_affiliation_strings":["Department of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London WC1H 0AH, United Kingdom. Electronic address: d.bracewell@ucl.ac.uk","Department of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London WC1H 0AH, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-3866-3304","affiliations":[{"raw_affiliation_string":"Department of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London WC1H 0AH, United Kingdom. Electronic address: d.bracewell@ucl.ac.uk","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Biochemical Engineering, University College London, Bernard Katz Building, Gordon Street, London WC1H 0AH, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054772413"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":{"value":4040,"currency":"USD","value_usd":4040},"fwci":2.3578,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.89311358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"1461","issue":null,"first_page":"70","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-a-affinity-chromatography","display_name":"protein A affinity chromatography","score":0.8889999985694885},{"id":"https://openalex.org/keywords/capacity-reduction","display_name":"capacity reduction","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8234908580780029},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7287483215332031},{"id":"https://openalex.org/C73826308","wikidata":"https://www.wikidata.org/wiki/Q684907","display_name":"Elution","level":2,"score":0.5768369436264038},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.576829731464386},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5158650279045105},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5051749348640442},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.4867544174194336},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.440633088350296},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.4213750958442688},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09091833233833313},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013205","descriptor_name":"Staphylococcal Protein A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.chroma.2016.07.055","doi":"https://doi.org/10.1016/j.chroma.2016.07.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2016.07.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021967316309773/pdf","source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},{"id":"pmid:27473513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27473513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. A","raw_type":"Journal Article"},{"id":"pmh:oai:kar.kent.ac.uk:56828","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2016.07.055>)","pdf_url":"https://kar.kent.ac.uk/56828/1/Residual%20on%20column%20host%20cell%20protein%20analysis.pdf","source":{"id":"https://openalex.org/S4377196264","display_name":"Kent Academic Repository (University of Kent)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20581793","host_organization_name":"University of Kent","host_organization_lineage":["https://openalex.org/I20581793"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1508915","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1508915/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chromatography A , 1461 pp. 70-77. (2016)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.chroma.2016.07.055","doi":"https://doi.org/10.1016/j.chroma.2016.07.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2016.07.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021967316309773/pdf","source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G107833955","display_name":"Tailor-made expression hosts depleted in protease activity for recombinant protein production; PRODuCE (PROtease Depleted CEll line)","funder_award_id":"BB/L002310/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G1852325014","display_name":"Integrating upstream host cell line selection and development with improved downstream bioprocessing","funder_award_id":"BB/G010307/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7500320712","display_name":"Creation of a process understanding of chromatographic performance loss during biotherapeutic manufacture: A UK-India partnership","funder_award_id":"EP/K029053/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2497543432.pdf","grobid_xml":"https://content.openalex.org/works/W2497543432.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1186873909","https://openalex.org/W1841204415","https://openalex.org/W1867707303","https://openalex.org/W1980414015","https://openalex.org/W1980750834","https://openalex.org/W1982222591","https://openalex.org/W1992816819","https://openalex.org/W1996862458","https://openalex.org/W2007469546","https://openalex.org/W2010948143","https://openalex.org/W2015433122","https://openalex.org/W2018033335","https://openalex.org/W2025658157","https://openalex.org/W2046271895","https://openalex.org/W2052902037","https://openalex.org/W2063723930","https://openalex.org/W2076902391","https://openalex.org/W2076971609","https://openalex.org/W2099600971","https://openalex.org/W2104928881","https://openalex.org/W2114191814","https://openalex.org/W2119437697","https://openalex.org/W2121690674","https://openalex.org/W2133776376","https://openalex.org/W2171134514","https://openalex.org/W2341869863","https://openalex.org/W2547266856","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2782558389","https://openalex.org/W2076902391","https://openalex.org/W4391070838","https://openalex.org/W2744178304","https://openalex.org/W2591101949","https://openalex.org/W7140078155","https://openalex.org/W2007469546","https://openalex.org/W2073430339","https://openalex.org/W4377030189","https://openalex.org/W2464036658"],"abstract_inverted_index":{"Capacity":[0],"reduction":[1],"in":[2,39,135,148],"protein":[3,68,160],"A":[4,161],"affinity":[5],"chromatography":[6,55],"with":[7,92,131,137,166],"extended":[8],"cycling":[9],"during":[10,26],"therapeutic":[11],"antibody":[12],"manufacture":[13],"is":[14,33,74,109,146],"well":[15],"documented.":[16],"Identification":[17],"of":[18,29,67,81,97,126,139,151,155],"which":[19],"residual":[20,98],"proteins":[21,101,140],"remain":[22],"from":[23],"previous":[24],"cycles":[25],"the":[27,79,82,88,107,123,127,132,149,152,156],"lifetime":[28],"these":[30],"adsorbent":[31],"materials":[32],"required":[34],"to":[35,61,111],"understand":[36],"their":[37],"role":[38],"this":[40,65,120],"ageing":[41,145],"process,":[42],"but":[43],"represents":[44],"a":[45,75],"significant":[46],"metrological":[47],"challenge.":[48],"Scanning":[49],"electron":[50],"microscopy":[51],"(SEM)":[52],"and":[53,63,116,159],"liquid":[54],"mass":[56],"spectrometry":[57],"(LC-MS/MS)":[58],"are":[59],"combined":[60],"detect":[62],"map":[64],"phenomenon":[66],"carry-over.":[69],"We":[70],"show":[71],"that":[72],"there":[73],"morphological":[76],"change":[77],"at":[78],"surface":[80],"agarose":[83],"resin,":[84],"revealing":[85],"deposits":[86],"on":[87,106],"polymer":[89],"fibres":[90],"increasing":[91,142],"cycle":[93,167],"number.":[94,168],"The":[95],"amount":[96],"host":[99],"cell":[100],"(HCPs)":[102],"by":[103],"LC-MS/MS":[104],"present":[105],"resin":[108,133],"shown":[110],"increase":[112],"10-fold":[113],"between":[114],"50":[115],"100":[117],"cycles.":[118],"During":[119],"same":[121],"period":[122],"functional":[124],"class":[125],"predominant":[128],"HCPs":[129],"associated":[130],"increased":[134],"diversity,":[136],"number":[138],"identified":[141],"5-fold.":[143],"This":[144],"observed":[147],"context":[150],"product":[153],"quality":[154],"eluate":[157],"HCP":[158],"leachate":[162],"concentration":[163],"remaining":[164],"constant":[165]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-08-23T00:00:00"}