{"id":"https://openalex.org/W2497305656","doi":"https://doi.org/10.1158/1538-7445.am2016-1020","title":"Abstract 1020: Autophagy forms part of a metabolic switch during epithelial-to-mesenchymal transition and metastasis in a murine claudin-low breast cancer model","display_name":"Abstract 1020: Autophagy forms part of a metabolic switch during epithelial-to-mesenchymal transition and metastasis in a murine claudin-low breast cancer model","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2497305656","doi":"https://doi.org/10.1158/1538-7445.am2016-1020","mag":"2497305656"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-1020","doi":"https://doi.org/10.1158/1538-7445.am2016-1020","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1020","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022170125","display_name":"Ciara H. O\u2019Flanagan","orcid":"https://orcid.org/0000-0001-9467-1291","observed_orcids":["https://orcid.org/0000-0001-9467-1291"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciara H. O\u2019Flanagan","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054875096","display_name":"Emily L. Rossi","orcid":"https://orcid.org/0000-0002-2312-4239","observed_orcids":["https://orcid.org/0000-0002-2312-4239"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily L. Rossi","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Hursting","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"1020","last_page":"1020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.836899995803833,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/claudin-low-breast-cancer","display_name":"claudin-low breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.875},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.9070000052452087},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":0.8019999861717224},{"id":"https://openalex.org/keywords/rapamycin-resistance","display_name":"rapamycin resistance","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.5690000057220459},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7136709690093994},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7077438831329346},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.677760660648346},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6683293581008911},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5492154359817505},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5466391444206238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5352362394332886},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4969375431537628},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.442813903093338},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.4315420687198639},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.42767542600631714},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4261375963687897},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40269649028778076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37084200978279114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24319297075271606},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1278408169746399},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0777682363986969},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.06040501594543457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-1020","doi":"https://doi.org/10.1158/1538-7445.am2016-1020","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1020","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2407350367","https://openalex.org/W3030349331","https://openalex.org/W4229042404","https://openalex.org/W3084004891","https://openalex.org/W4388511476","https://openalex.org/W2948000964","https://openalex.org/W2560443178","https://openalex.org/W2513393093","https://openalex.org/W4303613777","https://openalex.org/W4200015341"],"abstract_inverted_index":{"Abstract":[0],"Epithelial-to-mesenchymal":[1],"transition":[2,142,421],"(EMT),":[3],"the":[4,31,44,141,241,317,435,440],"process":[5,36,88],"through":[6],"which":[7,90,172,340,395],"epithelial":[8],"cells":[9,27,187,204,233,254,266,274,294,298,327,376],"gain":[10],"mesenchymal":[11],"characteristics":[12],"including":[13,148,345,365],"reduced":[14],"adhesion":[15],"and":[16,81,95,112,131,167,175,177,209,250,260,272,275,289,295,347,370,386,422],"enhanced":[17],"invasion,":[18],"is":[19,43,54,62,85,356],"a":[20,63,86,156,182,197,313,357,391,416,425],"critical":[21],"step":[22],"in":[23,77,89,129,160,196,213,235,239,361,394,424],"progression":[24],"of":[25,46,48,66,79,122,127,150,185,231,258,311,316,338,359,415,434,439],"cancer":[26,49,68,104,375,429],"toward":[28],"metastasis.":[29],"However,":[30],"molecular":[32],"mechanisms":[33],"governing":[34],"this":[35],"remain":[37],"poorly":[38],"understood.":[39],"Furthermore,":[40,270,372],"though":[41],"metastasis":[42,132,144,423],"cause":[45],"90%":[47],"deaths,":[50],"no":[51],"targeted":[52],"therapy":[53],"currently":[55],"available":[56],"for":[57,443],"metastatic":[58,183,236,373,398],"disease.":[59],"Metabolic":[60],"reprogramming":[61],"key":[64,314],"feature":[65,358],"most":[67],"cells,":[69,385],"with":[70,332,335],"oxidative":[71,261,368],"phosphorylation":[72,369],"often":[73],"being":[74],"switched":[75],"off":[76],"favor":[78],"glycolytic":[80],"synthetic":[82],"pathways.":[83],"Autophagy":[84,101,412],"catabolic":[87],"protein":[91,348],"complexes,":[92],"damaged":[93],"organelles":[94],"other":[96],"macromolecules":[97],"are":[98,267],"lysosomally":[99],"degraded.":[100],"can":[102],"promote":[103],"cell":[105,170,220],"survival,":[106],"providing":[107],"protein,":[108],"lipid,":[109],"nucleic":[110],"acid":[111],"membrane":[113],"precursors":[114],"as":[115,117,245,284],"well":[116,136],"auxiliary":[118],"energy":[119,123],"during":[120,419],"periods":[121],"stress.":[124],"The":[125],"role":[126],"metabolism":[128],"EMT":[130,360],"has":[133],"not":[134],"been":[135],"studied.":[137],"We":[138],"hypothesized":[139],"that":[140,264,353],"to":[143,279,292,302,330,396],"involves":[145],"metabolic":[146,343,354,417],"alterations,":[147],"activation":[149,337],"autophagy.":[151,371],"Previously,":[152],"we":[153],"derived":[154],"(from":[155],"spontaneous":[157],"mammary":[158,226],"tumor":[159,237],"an":[161],"MMTV-Wnt":[162],"transgenic":[163],"mouse)":[164],"epithelial-like":[165],"(E-Wnt)":[166],"mesenchymal-like":[168],"(M-Wnt)":[169],"lines,":[171],"recapitulate":[173],"basal-like":[174],"claudin-low":[176,362,427],"breast":[178,363,374,399,428],"tumors,":[179],"respectively.":[180],"Here,":[181],"derivative":[184],"M-Wnt":[186,219,271,321],"was":[188],"generated":[189],"from":[190],"lung":[191],"metastases":[192],"following":[193],"serial":[194],"passages":[195],"severe":[198],"combined":[199],"immunodeficient":[200],"(SCID)":[201],"mouse.":[202],"metM-Wnt":[203,232,253,273,297,326],"were":[205,277,299,328],"more":[206,211,300,379],"proliferative,":[207],"invasive":[208],"formed":[210],"colonies":[212],"soft":[214],"agar":[215],"than":[216,320,383],"their":[217],"parental":[218],"line.":[221],"Tail":[222],"vein":[223],"injection":[224],"or":[225,243,309,322],"fat":[227],"pad":[228],"orthotopic":[229],"implantation":[230],"resulted":[234],"formation":[238],"either":[240],"lungs":[242],"liver":[244],"detected":[246],"by":[247,286],"IVIS":[248],"imaging":[249],"histological":[251],"analysis.":[252],"displayed":[255],"higher":[256],"rates":[257],"glycolysis":[259],"phosphorylation,":[262],"indicating":[263],"these":[265],"highly":[268],"energetic.":[269],"tumors":[276],"found":[278],"have":[280],"increased":[281,366],"autophagic":[282,318],"flux,":[283],"measured":[285],"LC3B":[287],"expression":[288],"cleavage":[290],"compared":[291],"E-Wnt":[293,323],"tumors.":[296],"sensitive":[301],"autophagy":[303,346,382,387],"inhibition":[304],"(either":[305],"via":[306],"chloroquine":[307],"treatment":[308,331],"knockout":[310],"Atg5,":[312],"component":[315],"machinery)":[319],"cells.":[324],"Conversely,":[325],"resistant":[329],"rapamycin,":[333],"concomitant":[334],"sustained":[336],"mTOR,":[339],"controls":[341],"many":[342],"pathways":[344],"synthesis.":[349],"These":[350],"results":[351],"indicate":[352],"alteration":[355],"cancer,":[364],"glycolysis,":[367],"may":[377,388],"be":[378,390],"reliant":[380],"on":[381],"non-metastatic":[384],"therefore":[389],"therapeutic":[392],"target":[393],"treat":[397],"cancers.":[400],"Citation":[401],"Format:":[402],"Ciara":[403],"H.":[404],"O\u2019Flanagan,":[405],"Emily":[406],"L.":[407],"Rossi,":[408],"Stephen":[409],"D.":[410],"Hursting.":[411],"forms":[413],"part":[414],"switch":[418],"epithelial-to-mesenchymal":[420],"murine":[426],"model.":[430],"[abstract].":[431],"In:":[432],"Proceedings":[433],"107th":[436],"Annual":[437],"Meeting":[438],"American":[441],"Association":[442],"Cancer":[444,455],"Research;":[445],"2016":[446],"Apr":[447],"16-20;":[448],"New":[449],"Orleans,":[450],"LA.":[451],"Philadelphia":[452],"(PA):":[453],"AACR;":[454],"Res":[456],"2016;76(14":[457],"Suppl):Abstract":[458],"nr":[459],"1020.":[460]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-08-23T00:00:00"}
