{"id":"https://openalex.org/W2497050408","doi":"https://doi.org/10.1007/978-1-349-05555-5_14","title":"Biosynthesis and turnover of nicotinic acetylcholine receptors","display_name":"Biosynthesis and turnover of nicotinic acetylcholine receptors","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W2497050408","doi":"https://doi.org/10.1007/978-1-349-05555-5_14","mag":"2497050408"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-349-05555-5_14","doi":"https://doi.org/10.1007/978-1-349-05555-5_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-05555-5_14","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Receptors and Their Effectors","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1558178330","display_name":"Drug Receptors and Their Effectors"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109050052","display_name":"Douglas M. Fambrough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196817621","display_name":"Carnegie Institution for Science","ror":"https://ror.org/04jr01610","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I196817621"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas M. Fambrough","raw_affiliation_strings":["Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland, 21210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland, 21210, USA","institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5109050052"],"corresponding_institution_ids":["https://openalex.org/I196817621","https://openalex.org/I4210117844"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32728772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"155","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotinic-acetylcholine-receptors","display_name":"nicotinic acetylcholine receptors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/receptor-biosynthesis","display_name":"receptor biosynthesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/receptor-turnover","display_name":"receptor turnover","score":0.9750000238418579},{"id":"https://openalex.org/keywords/plasma-membrane-structure","display_name":"plasma membrane structure","score":0.878000020980835},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.9160000085830688},{"id":"https://openalex.org/keywords/membrane-protein-dynamics","display_name":"membrane protein dynamics","score":0.6869999766349792},{"id":"https://openalex.org/keywords/membrane-cytoskeleton-interactions","display_name":"membrane-cytoskeleton interactions","score":0.8420000076293945},{"id":"https://openalex.org/keywords/membrane-metabolism","display_name":"membrane metabolism","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C560191","wikidata":"https://www.wikidata.org/wiki/Q417736","display_name":"Peripheral membrane protein","level":5,"score":0.7405855059623718},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6715721487998962},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.6689725518226624},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6312564611434937},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.5871703028678894},{"id":"https://openalex.org/C166311969","wikidata":"https://www.wikidata.org/wiki/Q11036250","display_name":"Protein\u2013lipid interaction","level":5,"score":0.5665331482887268},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5043774843215942},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4784988462924957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43154698610305786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3285389244556427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26444128155708313}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-349-05555-5_14","doi":"https://doi.org/10.1007/978-1-349-05555-5_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-05555-5_14","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Receptors and Their Effectors","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1966507045","https://openalex.org/W1972158260","https://openalex.org/W1972690266","https://openalex.org/W2018252071","https://openalex.org/W2032813616","https://openalex.org/W2042319325","https://openalex.org/W2050237848","https://openalex.org/W2054866862","https://openalex.org/W2056334228","https://openalex.org/W2057780554","https://openalex.org/W2063517878","https://openalex.org/W2087696589","https://openalex.org/W2099703541","https://openalex.org/W2114106898","https://openalex.org/W2125213900","https://openalex.org/W2140767214","https://openalex.org/W2178679344","https://openalex.org/W2325935826"],"related_works":["https://openalex.org/W2046587077","https://openalex.org/W2768759687","https://openalex.org/W4292686407","https://openalex.org/W4297984429","https://openalex.org/W3022086215","https://openalex.org/W2140804130","https://openalex.org/W2785665390","https://openalex.org/W2101983215","https://openalex.org/W7101142227","https://openalex.org/W2077266918"],"abstract_inverted_index":{"In":[0,15],"the":[1,7,16,23,58,62,69,75,84,96,98,107],"past":[2],"decade":[3],"our":[4],"concept":[5],"of":[6,41,47,57,65,72,78,86,88,100,106],"plasma":[8,24,48,73],"membrane":[9,25,49,79,93,108],"has":[10],"changed":[11],"a":[12,18,30,37],"great":[13],"deal.":[14],"1960s":[17],"major":[19],"concern":[20],"was":[21],"whether":[22],"should":[26],"be":[27],"considered":[28],"as":[29],"lipid":[31,59,80],"bilayer":[32],"with":[33,95],"associated":[34],"proteins":[35,94],"or":[36],"two-dimensional":[38],"micellar":[39],"array":[40],"ordered":[42],"units.":[43],"Today":[44],"most":[45],"students":[46],"structure":[50],"consider":[51],"this":[52],"matter":[53],"settled":[54],"in":[55],"favour":[56],"bilayer,":[60],"and":[61,81,91,103],"overall":[63],"focus":[64],"today":[66],"is":[67],"on":[68],"dynamic":[70],"aspects":[71],"membrane;":[74],"thermal":[76],"motions":[77],"protein":[82],"molecules,":[83],"mechanisms":[85],"association":[87],"some":[89],"integral":[90],"peripheral":[92],"membrane,":[97],"importance":[99],"cytoskeleton-membrane":[101],"interactions,":[102],"metabolic":[104],"studies":[105],"constituents.":[109]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}