{"id":"https://openalex.org/W2496899853","doi":"https://doi.org/10.1158/1538-7445.am2016-4710","title":"Abstract 4710: BRD4 degradation by PROTACs represents a more effective therapeutic strategy than BRD4 inhibitors in ovarian cancer","display_name":"Abstract 4710: BRD4 degradation by PROTACs represents a more effective therapeutic strategy than BRD4 inhibitors in ovarian cancer","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2496899853","doi":"https://doi.org/10.1158/1538-7445.am2016-4710","mag":"2496899853"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-4710","doi":"https://doi.org/10.1158/1538-7445.am2016-4710","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4710","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038644541","display_name":"Kanak Raina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanak Raina","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035267982","display_name":"Jing L\u00fc","orcid":"https://orcid.org/0000-0001-5766-2775","observed_orcids":["https://orcid.org/0000-0001-5766-2775"]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Lu","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021167157","display_name":"Yimin Qian","orcid":"https://orcid.org/0000-0003-2377-7931","observed_orcids":["https://orcid.org/0000-0003-2377-7931"]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yimin Qian","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027479711","display_name":"Martha Altieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Altieri","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102098376","display_name":"Hanqing Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanqing Dong","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378537","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0000-0001-5412-9860"]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101432732","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-0930-0750","observed_orcids":["https://orcid.org/0000-0002-0930-0750"]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007702221","display_name":"Andrew P. A. Crew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Crew","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109504130","display_name":"Kevin G. Coleman","orcid":"https://orcid.org/0009-0009-6445-2931","observed_orcids":["https://orcid.org/0009-0009-6445-2931"]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Coleman","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016866989","display_name":"Craig M. Crews","orcid":"https://orcid.org/0000-0002-8456-2005","observed_orcids":["https://orcid.org/0000-0002-8456-2005"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Crews","raw_affiliation_strings":["2Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103703982","display_name":"James D. Winkler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142342","display_name":"Arvinas (United States)","ror":"https://ror.org/045jkfr03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210142342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Winkler","raw_affiliation_strings":["1Arvinas, New Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Arvinas, New Haven, CT;","institution_ids":["https://openalex.org/I4210142342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"4710","last_page":"4710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.7390000224113464},{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.9330000281333923},{"id":"https://openalex.org/keywords/brd4-degradation","display_name":"BRD4 degradation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/bet-proteins","display_name":"BET proteins","score":0.5429999828338623},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.6460000276565552},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vhl-e3-ubiquitin-ligase","display_name":"VHL E3 ubiquitin ligase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/proteasomal-degradation","display_name":"proteasomal degradation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/brd4-inhibitors","display_name":"BRD4 inhibitors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.6330000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/super-enhancers","display_name":"super-enhancers","score":0.5270000100135803},{"id":"https://openalex.org/keywords/chromatin-reader","display_name":"chromatin reader","score":0.5600000023841858},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cell-lines","display_name":"cell lines","score":0.3370000123977661},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2779634854","wikidata":"https://www.wikidata.org/wiki/Q18037206","display_name":"BRD4","level":5,"score":0.950365424156189},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6708565950393677},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.6606969833374023},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.5528970956802368},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.48616334795951843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4588800370693207},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.42743033170700073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3822256624698639},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.37846875190734863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3723411560058594},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30044305324554443},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2091130018234253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13810914754867554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1275697648525238},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12199869751930237},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-4710","doi":"https://doi.org/10.1158/1538-7445.am2016-4710","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4710","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2567158520","https://openalex.org/W1997087919","https://openalex.org/W3213943900","https://openalex.org/W2886540393","https://openalex.org/W4412418433","https://openalex.org/W2595924030","https://openalex.org/W4282936336","https://openalex.org/W3163076021","https://openalex.org/W4365511511","https://openalex.org/W2166502164"],"abstract_inverted_index":{"Abstract":[0],"BRD4,":[1],"a":[2,27,38,43,74,81,167,177,182,201,214,263,303,402,434,475],"member":[3],"of":[4,12,19,26,29,45,69,108,114,124,139,169,193,203,265,268,322,333,347,361,374,418,489,494],"the":[5,24,96,111,122,131,140,220,223,247,286,292,319,331,358,362,407,444,490,495],"bromodomain":[6],"and":[7,21,47,73,105,130,162,300,365,377,400,424],"extraterminal":[8],"domain":[9],"(BET)":[10],"family":[11],"chromatin":[13],"readers,":[14],"localizes":[15],"to":[16,54,99,133,181,197,278,350,355,387,420],"super-enhancer":[17],"regions":[18],"DNA,":[20],"turns":[22],"on":[23,155,330],"expression":[25,427],"number":[28,202],"oncogenes.":[30],"Therefore,":[31],"it":[32,79],"has":[33,117],"attracted":[34],"considerable":[35],"interest":[36],"as":[37,80,438],"potential":[39],"drug":[40,115,141],"target":[41,84,126,388],"in":[42,66,85,95,102,200,213,219,285,302,343,353,380,396,406,483],"variety":[44],"cancers,":[46],"several":[48,118,266],"inhibitors":[49,92,235,284,379,482],"that":[50,318,370],"block":[51,134],"its":[52],"binding":[53,187],"acetylated":[55],"histones":[56],"have":[57,148,315,337,366],"been":[58],"discovered.":[59],"The":[60,410],"BRD4":[61,91,152,174,178,194,210,234,245,274,283,298,310,323,351,375,378,389,422,439,470,481],"genomic":[62],"region":[63],"is":[64,325],"amplified":[65],"approximately":[67],"17%":[68],"ovarian":[70,88,170,204,397,484],"serous":[71,87],"adenocarcinomas,":[72],"recent":[75],"shRNA":[76],"screen":[77],"identified":[78,367],"bona":[82],"fide":[83],"high-grade":[86],"carcinoma":[89,171],"(HGSOC).":[90],"were":[93],"shown":[94,317],"same":[97,408],"study":[98],"be":[100,413],"efficacious":[101],"cell":[103,172,206,224,248,289,345],"culture":[104],"PDX":[106],"models":[107],"HGSOC.":[109],"However,":[110],"inhibitor":[112],"paradigm":[113],"discovery":[116],"limitations,":[119,146],"for":[120,128,390,498],"example,":[121],"requirement":[123],"high":[125],"occupancy":[127],"activity,":[129],"inability":[132],"potentially":[135],"critical":[136],"scaffolding":[137],"functions":[138],"target.":[142],"To":[143],"circumvent":[144],"these":[145,381],"we":[147,314,336,430],"designed":[149,386],"small":[150],"molecule":[151],"degraders":[153],"based":[154],"our":[156],"PROTAC":[157],"(PROteolysis":[158],"TArgeting":[159],"Chimera)":[160],"platform,":[161],"assessed":[163],"their":[164,328,416],"activity":[165],"across":[166],"panel":[168],"lines.":[173,207,290],"PROTACs,":[175],"containing":[176],"ligand":[179],"connected":[180],"VHL":[183],"E3":[184],"ubiquitin":[185],"ligase":[186],"moiety,":[188],"successfully":[189],"promote":[190],"proteasome-mediated":[191],"degradation":[192,211,392,471],"at":[195],"sub-":[196],"low-nM":[198],"concentrations":[199],"cancer":[205,398],"Furthermore,":[208],"this":[209],"results":[212],"very":[215],"potent":[216,281,395],"anti-proliferative":[217,229,320],"effect":[218,321,329],"cells.":[221,382],"All":[222],"lines":[225,249,346],"tested":[226],"showed":[227],"modest":[228],"effects":[230],"when":[231,242],"treated":[232,243],"with":[233,244,262,297,372],"(ED50":[236,270],"\u223c":[237,271],"0.5":[238],"\u03bcM-1\u03bcM).":[239],"In":[240,312,383],"contrast,":[241],"PROTACs":[246,275,324,352,376,385,440,473],"separated":[250],"into":[251,443],"three":[252],"profoundly":[253],"different":[254],"groups":[255],"(most":[256],"sensitive,":[257,259],"moderately":[258],"least":[260],"sensitive),":[261],"difference":[264],"orders":[267],"magnitude":[269],"0.03nM-500nM).":[272],"Thus":[273],"are":[276,393,441],"up":[277],"10,000-fold":[279],"more":[280,305,476],"than":[282,309,480],"most":[287],"sensitive":[288],"Moreover,":[291],"ED50":[293],"curves":[294],"closely":[295],"track":[296],"degradation,":[299,423],"result":[301],"much":[304],"profound":[306],"apoptotic":[307],"response":[308,405],"inhibition.":[311],"addition,":[313],"also":[316],"decoupled":[326],"from":[327],"levels":[332],"cMYC.":[334],"Finally,":[335],"carried":[338],"out":[339],"deep":[340],"RNA":[341],"sequencing":[342],"five":[344],"variable":[348],"sensitivity":[349,419],"order":[354],"thoroughly":[356],"define":[357],"molecular":[359],"subtype":[360],"malignancies":[363],"represented":[364],"gene":[368,426],"signatures":[369],"correlate":[371],"efficacy":[373],"summary,":[384],"proteasomal":[391],"highly":[394],"cells,":[399],"elicit":[401],"powerful":[403],"pro-apoptotic":[404],"setting.":[409],"cells":[411],"can":[412],"grouped":[414],"by":[415,472],"level":[417],"PROTAC-mediated":[421],"carry":[425],"biomarkers":[428],"which":[429],"hope":[431],"will":[432],"enable":[433],"patient":[435],"selection":[436],"strategy":[437,479],"advanced":[442],"clinic.":[445],"Citation":[446],"Format:":[447],"Kanak":[448],"Raina,":[449],"Jing":[450,458],"Lu,":[451],"Yimin":[452],"Qian,":[453],"Martha":[454],"Altieri,":[455],"Hanqing":[456],"Dong,":[457],"Wang,":[459],"Xin":[460],"Chen,":[461],"Andrew":[462],"Crew,":[463],"Kevin":[464],"Coleman,":[465],"Craig":[466],"Crews,":[467],"James":[468],"Winkler.":[469],"represents":[474],"effective":[477],"therapeutic":[478],"cancer.":[485],"[abstract].":[486],"In:":[487],"Proceedings":[488],"107th":[491],"Annual":[492],"Meeting":[493],"American":[496],"Association":[497],"Cancer":[499,510],"Research;":[500],"2016":[501],"Apr":[502],"16-20;":[503],"New":[504],"Orleans,":[505],"LA.":[506],"Philadelphia":[507],"(PA):":[508],"AACR;":[509],"Res":[511],"2016;76(14":[512],"Suppl):Abstract":[513],"nr":[514],"4710.":[515]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-08-23T00:00:00"}