{"id":"https://openalex.org/W2496791585","doi":"https://doi.org/10.1158/1538-7445.am2016-3682","title":"Abstract 3682: Phosphorylation mediated conformational changes defines nuclear role of phosphatase and tensin homology (PTEN) in tumor suppression","display_name":"Abstract 3682: Phosphorylation mediated conformational changes defines nuclear role of phosphatase and tensin homology (PTEN) in tumor suppression","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2496791585","doi":"https://doi.org/10.1158/1538-7445.am2016-3682","mag":"2496791585"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-3682","doi":"https://doi.org/10.1158/1538-7445.am2016-3682","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-3682","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036557946","display_name":"Prerna Malaney","orcid":"https://orcid.org/0000-0002-4667-4823","observed_orcids":["https://orcid.org/0000-0002-4667-4823"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prerna Malaney","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064475529","display_name":"Jonathan Semidey-Hurtado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Semidey-Hurtado","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033743203","display_name":"Jamaal Hardee","orcid":"https://orcid.org/0000-0002-8400-1160","observed_orcids":["https://orcid.org/0000-0002-8400-1160"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamaal Hardee","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040982029","display_name":"Deepal Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepal Patel","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043286164","display_name":"Daniel Hennessey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Hennessey","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090578794","display_name":"Kate Stanford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Stanford","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004550280","display_name":"Emily Palumbo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Palumbo","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079649997","display_name":"Zhi Tian","orcid":"https://orcid.org/0000-0003-2558-3268","observed_orcids":["https://orcid.org/0000-0003-2558-3268"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi Tian","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027830353","display_name":"Diane Allen\u2010Gipson","orcid":"https://orcid.org/0000-0001-6976-3960","observed_orcids":["https://orcid.org/0000-0001-6976-3960"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Allen-Gipson","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103499391","display_name":"Vrushank Dav\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vrushank Dav\u00e9.","raw_affiliation_strings":["University of South Florida, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"3682","last_page":"3682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9980000257492065},{"id":"https://openalex.org/keywords/c-terminal-phosphorylation","display_name":"C-terminal phosphorylation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6039999723434448},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.7760000228881836},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/c2-domain","display_name":"C2 domain","score":0.8309999704360962},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.765999972820282},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/serine-threonine-phosphorylation","display_name":"serine/threonine phosphorylation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.5350000262260437},{"id":"https://openalex.org/keywords/adjunctive-cancer-therapy","display_name":"adjunctive cancer therapy","score":0.8489999771118164},{"id":"https://openalex.org/keywords/phosphatase-activity","display_name":"phosphatase activity","score":0.6970000267028809},{"id":"https://openalex.org/keywords/oncogenic-mutations","display_name":"oncogenic mutations","score":0.625},{"id":"https://openalex.org/keywords/cell-proliferation-and-migration","display_name":"cell proliferation and migration","score":0.7720000147819519},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.6290000081062317},{"id":"https://openalex.org/keywords/phosphatase-and-tensin-homolog","display_name":"phosphatase and tensin homolog","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9900315999984741},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.9591213464736938},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6672868132591248},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6556153297424316},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6017574071884155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.499431848526001},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4821486175060272},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4773164689540863},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.4170016050338745},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.41170644760131836},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3435152769088745},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.33834248781204224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3315778374671936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.263507217168808},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23363038897514343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2226385772228241},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2126748263835907}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-3682","doi":"https://doi.org/10.1158/1538-7445.am2016-3682","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-3682","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2767453880","https://openalex.org/W2595527169","https://openalex.org/W2264094926","https://openalex.org/W3098393367","https://openalex.org/W2064220189","https://openalex.org/W1525517767","https://openalex.org/W4287617891","https://openalex.org/W2487118300","https://openalex.org/W4318484481","https://openalex.org/W4389018914"],"abstract_inverted_index":{"Abstract":[0],"Loss":[1],"of":[2,4,44,81,92,124,135,169,181,216,258,303,315,320],"function":[3,244],"tumor":[5,77,219,310],"suppressor":[6,78],"PTEN":[7,17,55,60,93,147,236,242],"(Phosphatase":[8],"and":[9,70,103,119,132,261,305],"tensin":[10,306],"homolog)":[11],"causes":[12],"cancer":[13,229],"in":[14,208,218,245,271,309],"various":[15],"tissues.":[16],"C-terminal":[18,61],"phosphorylation":[19,56,62,237],"(pPTEN)":[20],"inactivates":[21,73],"PTEN,":[22,74],"leading":[23],"to":[24,48,105,111,116,196,240,254],"multiple":[25],"malignancies":[26],"with":[27,85,150],"increased":[28],"severity.":[29],"However,":[30],"little":[31],"is":[32,47,96,137,177],"known":[33],"about":[34],"the":[35,42,50,117,121,151,174,201,316,321],"molecular":[36,51],"mechanisms":[37,52],"underlying":[38],"such":[39],"inactivation.":[40],"Therefore,":[41],"objective":[43],"our":[45],"work":[46],"ascertain":[49],"by":[53],"which":[54,95],"drives":[57],"lung":[58],"cancer.":[59],"at":[63],"a":[64,106,155,251],"serine-threonine":[65],"cluster":[66],"(Ser380,":[67],"Thr382,":[68],"Thr383":[69],"Ser385)":[71],"conformationally":[72],"abrogating":[75],"its":[76,159],"function.":[79],"Replacement":[80],"these":[82,204],"serine/threonine":[83],"residues":[84],"alanine":[86],"generated":[87],"an":[88],"artificial":[89],"phosphorylation-deficient":[90],"mutant":[91],"(PTEN-4A),":[94],"constitutively":[97],"active.":[98],"PTEN-4A":[99,113,136,170,217],"suppressed":[100,120],"cell":[101,125],"proliferation":[102],"migration":[104],"greater":[107],"extent":[108],"as":[109],"compared":[110],"PTEN-WT.":[112],"preferentially":[114],"localized":[115],"nucleus":[118],"E2F-mediated":[122,198],"transcription":[123,152],"cycle":[126],"genes.":[127,165,183],"The":[128],"nuclear":[129,214,243,301],"localization":[130],"sequence":[131],"phosphatase":[133,304],"activity":[134],"critical":[138],"for":[139,158,179,226,324],"this":[140],"transcriptional":[141,185],"suppression.":[142,311],"Immuno-precipitation":[143],"assays":[144,186],"show":[145],"that":[146,173,192,203,221,234,267],"physically":[148],"associates":[149],"factor":[153],"E2F1,":[154],"likely":[156],"mechanism":[157],"suppressive":[160],"effect":[161],"on":[162],"E2F1":[163],"related":[164],"Further,":[166],"deletion":[167],"analysis":[168],"protein":[171],"revealed":[172],"C2":[175,189],"domain":[176,190],"indispensable":[178],"suppression":[180,220],"E2F-related":[182],"Systematic":[184],"identify":[187],"disease-associated":[188],"mutations":[191,205],"lose":[193],"their":[194],"ability":[195],"suppress":[197],"transcription,":[199],"supporting":[200],"concept":[202],"are":[206,268],"oncogenic":[207],"patients.":[209],"Taken":[210],"together,":[211],"we":[212],"reveal":[213],"functions":[215],"can":[222],"be":[223],"therapeutically":[224],"leveraged":[225],"developing":[227],"adjunctive":[228,248],"therapies.":[230],"Small":[231],"molecule":[232],"inhibitors":[233,266],"hinder":[235],"maybe":[238],"utilized":[239],"activate":[241],"tumors.":[246],"Such":[247],"therapy":[249],"has":[250],"high":[252],"likelihood":[253],"reduce":[255],"toxic":[256],"doses":[257],"chemotherapeutic":[259],"agents":[260],"targeted":[262],"inhibitors,":[263],"including":[264],"kinase":[265],"being":[269],"used":[270],"clinical":[272],"settings.":[273],"Citation":[274],"Format:":[275],"Prerna":[276],"Malaney,":[277],"Jonathan":[278],"Semidey-Hurtado,":[279],"Jamaal":[280],"Hardee,":[281],"Deepal":[282],"Patel,":[283],"Daniel":[284],"Hennessey,":[285],"Kate":[286],"Stanford,":[287],"Emily":[288],"Palumbo,":[289],"Zhi":[290],"Tian,":[291],"Diane":[292],"Allen-Gipson,":[293],"Vrushank":[294],"Dav\u00e9.":[295],"Phosphorylation":[296],"mediated":[297],"conformational":[298],"changes":[299],"defines":[300],"role":[302],"homology":[307],"(PTEN)":[308],"[abstract].":[312],"In:":[313],"Proceedings":[314],"107th":[317],"Annual":[318],"Meeting":[319],"American":[322],"Association":[323],"Cancer":[325,336],"Research;":[326],"2016":[327],"Apr":[328],"16-20;":[329],"New":[330],"Orleans,":[331],"LA.":[332],"Philadelphia":[333],"(PA):":[334],"AACR;":[335],"Res":[337],"2016;76(14":[338],"Suppl):Abstract":[339],"nr":[340],"3682.":[341]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-08-23T00:00:00"}