{"id":"https://openalex.org/W2496770907","doi":"https://doi.org/10.1007/s11888-016-0335-4","title":"Organoids as a Model for Colorectal Cancer","display_name":"Organoids as a Model for Colorectal Cancer","publication_year":2016,"publication_date":"2016-08-05","ids":{"openalex":"https://openalex.org/W2496770907","doi":"https://doi.org/10.1007/s11888-016-0335-4","mag":"2496770907","pmid":"https://pubmed.ncbi.nlm.nih.gov/27656116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5016547"},"language":"en","primary_location":{"id":"doi:10.1007/s11888-016-0335-4","doi":"https://doi.org/10.1007/s11888-016-0335-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11888-016-0335-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11888-016-0335-4.pdf","source":{"id":"https://openalex.org/S69903676","display_name":"Current Colorectal Cancer Reports","issn_l":"1556-3790","issn":["1556-3790","1556-3804","2153-5833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Colorectal Cancer Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11888-016-0335-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035431425","display_name":"Madeleine A. Young","orcid":"https://orcid.org/0000-0002-1487-0694","observed_orcids":["https://orcid.org/0000-0002-1487-0694"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Madeleine Young","raw_affiliation_strings":["European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059252165","display_name":"Karen R. Reed","orcid":"https://orcid.org/0000-0002-7467-1718","observed_orcids":["https://orcid.org/0000-0002-7467-1718"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen R. Reed","raw_affiliation_strings":["European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035431425"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":0.6268,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.61199407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"5","first_page":"281","last_page":"287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.02590000070631504,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.6930000185966492},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.9800000190734863},{"id":"https://openalex.org/keywords/in-vitro-disease-model","display_name":"in vitro disease model","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7070000171661377},{"id":"https://openalex.org/keywords/high-throughput-assay","display_name":"high-throughput assay","score":0.9449999928474426},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.8960000276565552}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.7967098355293274},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6865705847740173},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5246317982673645},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.49832630157470703},{"id":"https://openalex.org/C2988540567","wikidata":"https://www.wikidata.org/wiki/Q12070446","display_name":"Model system","level":2,"score":0.496900349855423},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49330082535743713},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4322548508644104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4258939027786255},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4118833839893341},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3255048394203186},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24059179425239563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23581057786941528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20537447929382324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11790663003921509},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1007/s11888-016-0335-4","doi":"https://doi.org/10.1007/s11888-016-0335-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11888-016-0335-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11888-016-0335-4.pdf","source":{"id":"https://openalex.org/S69903676","display_name":"Current Colorectal Cancer Reports","issn_l":"1556-3790","issn":["1556-3790","1556-3804","2153-5833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Colorectal Cancer Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3984867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5016547","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27656116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27656116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current colorectal cancer reports","raw_type":"Review"},{"id":"pmh:oai:pubmedcentral.nih.gov:5016547","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5016547/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Colorectal Cancer Rep","raw_type":"Text"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:94999","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/94999/1/organoids.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/94999/1/organoids.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1007/s11888-016-0335-4","doi":"https://doi.org/10.1007/s11888-016-0335-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11888-016-0335-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11888-016-0335-4.pdf","source":{"id":"https://openalex.org/S69903676","display_name":"Current Colorectal Cancer Reports","issn_l":"1556-3790","issn":["1556-3790","1556-3804","2153-5833"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Colorectal Cancer Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5620567772","display_name":null,"funder_award_id":"15937","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320350","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2496770907.pdf","grobid_xml":"https://content.openalex.org/works/W2496770907.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1483496013","https://openalex.org/W1692777765","https://openalex.org/W1741548448","https://openalex.org/W1872893154","https://openalex.org/W1965157206","https://openalex.org/W1974343902","https://openalex.org/W1983762572","https://openalex.org/W1988075836","https://openalex.org/W1991941572","https://openalex.org/W1997362383","https://openalex.org/W2002513358","https://openalex.org/W2027873459","https://openalex.org/W2036414872","https://openalex.org/W2038714514","https://openalex.org/W2041259207","https://openalex.org/W2043398720","https://openalex.org/W2052721366","https://openalex.org/W2057280155","https://openalex.org/W2062909560","https://openalex.org/W2069026988","https://openalex.org/W2071108036","https://openalex.org/W2079356804","https://openalex.org/W2080157242","https://openalex.org/W2090562908","https://openalex.org/W2091723114","https://openalex.org/W2094535938","https://openalex.org/W2097757674","https://openalex.org/W2098278242","https://openalex.org/W2114881954","https://openalex.org/W2119411167","https://openalex.org/W2121188788","https://openalex.org/W2121998033","https://openalex.org/W2126432370","https://openalex.org/W2137006231","https://openalex.org/W2138224451","https://openalex.org/W2141310245","https://openalex.org/W2143296478","https://openalex.org/W2168623286","https://openalex.org/W2171977041","https://openalex.org/W2253511475","https://openalex.org/W2287258646","https://openalex.org/W2403475582","https://openalex.org/W2463835565"],"related_works":["https://openalex.org/W4308414184","https://openalex.org/W2606467294","https://openalex.org/W4407228761","https://openalex.org/W3165033032","https://openalex.org/W3177291578","https://openalex.org/W4403891851","https://openalex.org/W4411623610","https://openalex.org/W4210662889","https://openalex.org/W4387456905","https://openalex.org/W4213004740"],"abstract_inverted_index":{"Modelling":[0],"human":[1],"diseases":[2],"in":[3,4],"vitro":[5],"systems":[6],"is":[7,111],"undisputedly":[8],"an":[9,40,87],"invaluable":[10,88],"research":[11,37],"tool,":[12],"yet":[13],"there":[14],"are":[15,102,115],"many":[16],"limitations.":[17],"Some":[18],"of":[19,28,42,57,73,80,99,119,132],"those":[20],"limitations":[21,98,131],"have":[22,33],"been":[23],"overcome":[24,104],"through":[25],"the":[26,50,58,78,97,128,137],"introduction":[27],"organoid":[29],"culture":[30],"systems,":[31],"which":[32],"revolutionised":[34],"colorectal":[35,120],"cancer":[36,82,121],"and":[38,54,64,93,130,135],"enabled":[39,140],"array":[41],"new":[43],"experimental":[44],"techniques.":[45],"This":[46,123],"3D":[47],"system":[48,101,134],"models":[49],"physiology,":[51],"shape,":[52],"dynamics":[53],"cell":[55,83],"make-up":[56],"intestinal":[59],"epithelium":[60],"producing":[61],"a":[62,117],"relevant":[63],"highly":[65],"adaptable":[66],"model":[67,75],"system.":[68],"The":[69],"increased":[70],"functional":[71],"relevance":[72],"this":[74,100,133,142],"compared":[76],"to":[77,105,126],"use":[79],"2D":[81],"lines":[84],"makes":[85],"it":[86,110],"tool":[89],"for":[90],"both":[91],"basic":[92],"translational":[94],"research.":[95,122],"As":[96],"being":[103],"make":[106],"high-throughput":[107],"assays":[108],"possible,":[109],"clear":[112],"that":[113],"organoids":[114],"becoming":[116],"mainstay":[118],"review":[124],"aims":[125],"explore":[127],"advantages":[129],"discusses":[136],"future":[138],"directions":[139],"by":[141],"model.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-08-23T00:00:00"}
