{"id":"https://openalex.org/W2496599488","doi":null,"title":"Increased plasma LCAT activity and hyperglycemia contribute to decreased anti-oxidative functionality of HDL in type 2 diabetes mellitus","display_name":"Increased plasma LCAT activity and hyperglycemia contribute to decreased anti-oxidative functionality of HDL in type 2 diabetes mellitus","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2496599488","mag":"2496599488"},"language":"en","primary_location":{"id":"pmh:rug:oai:pure.rug.nl:publications/44388798-c9ca-43d0-b00b-8a6df1de8065","doi":null,"is_oa":false,"landing_page_url":"https://www.rug.nl/research/portal/en/publications/increased-plasma-lcat-activity-and-hyperglycemia-contribute-to-decreased-antioxidative-functionality-of-hdl-in-type-2-diabetes-mellitus(44388798-c9ca-43d0-b00b-8a6df1de8065).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Clinical Investigation, 41, 62 - 62","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111779866","display_name":"Paul J.W.H. Kappelle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul J.W.H. Kappelle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079886197","display_name":"de Jan Freark Boer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"de Jan Freark Boer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074490685","display_name":"Frank G. Perton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank G. Perton","raw_affiliation_strings":["Faculty of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032978074","display_name":"Wijtske Annema","orcid":"https://orcid.org/0000-0002-1300-994X","observed_orcids":["https://orcid.org/0000-0002-1300-994X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wijtske Annema","raw_affiliation_strings":["Faculty of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert de Vries","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert de Vries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113966217","display_name":"Uwe J. Tietge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uwe J. Tietge","raw_affiliation_strings":["Faculty of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medical Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041851398","display_name":"Robin P. F. Dullaart","orcid":"https://orcid.org/0000-0002-3844-5254","observed_orcids":["https://orcid.org/0000-0002-3844-5254","https://orcid.org/0000-0003-4520-1239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin P.F. Dullaart","raw_affiliation_strings":["Lifestyle Medicine (LM)"],"raw_orcid":"https://orcid.org/0000-0003-4520-1239","affiliations":[{"raw_affiliation_string":"Lifestyle Medicine (LM)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":null,"first_page":"62","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.1891999989748001,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-associated-phospholipase-a2","display_name":"lipoprotein-associated phospholipase A2","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lcat","display_name":"lecithin:cholesterol acyltransferase","score":0.6830000281333923},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.6019999980926514},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antioxidant-function","display_name":"antioxidant function","score":0.6639999747276306},{"id":"https://openalex.org/keywords/hdl-dysfunction","display_name":"HDL dysfunction","score":0.6570000052452087},{"id":"https://openalex.org/keywords/plasma-enzyme-activity","display_name":"plasma enzyme activity","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.7119971513748169},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7019607424736023},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6945956945419312},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6141291856765747},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5839477777481079},{"id":"https://openalex.org/C964641","wikidata":"https://www.wikidata.org/wiki/Q424716","display_name":"Lecithin\u2014cholesterol acyltransferase","level":4,"score":0.5376580357551575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5196948647499084},{"id":"https://openalex.org/C3020574416","wikidata":"https://www.wikidata.org/wiki/Q275157","display_name":"Plasma glucose","level":3,"score":0.42388859391212463},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.41328567266464233},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.41246891021728516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3085407018661499},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.26700836420059204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16071191430091858},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.11315098404884338}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:rug:oai:pure.rug.nl:publications/44388798-c9ca-43d0-b00b-8a6df1de8065","doi":null,"is_oa":false,"landing_page_url":"https://www.rug.nl/research/portal/en/publications/increased-plasma-lcat-activity-and-hyperglycemia-contribute-to-decreased-antioxidative-functionality-of-hdl-in-type-2-diabetes-mellitus(44388798-c9ca-43d0-b00b-8a6df1de8065).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Clinical Investigation, 41, 62 - 62","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2496599488","doi":null,"is_oa":false,"landing_page_url":"https://www.rug.nl/research/portal/en/publications/increased-plasma-lcat-activity-and-hyperglycemia-contribute-to-decreased-antioxidative-functionality-of-hdl-in-type-2-diabetes-mellitus(44388798-c9ca-43d0-b00b-8a6df1de8065).html","pdf_url":null,"source":{"id":"https://openalex.org/S153084679","display_name":"European Journal of Clinical Investigation","issn_l":"0014-2972","issn":["0014-2972","1365-2362"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Clinical Investigation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1892706622","https://openalex.org/W2040483926","https://openalex.org/W2270492001","https://openalex.org/W2129947352","https://openalex.org/W2116875799","https://openalex.org/W7027759937","https://openalex.org/W4390348182","https://openalex.org/W2002242057","https://openalex.org/W1674759447","https://openalex.org/W2037069230"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-08-23T00:00:00"}