{"id":"https://openalex.org/W2496355695","doi":"https://doi.org/10.1021/bk-2008-0989.ch012","title":"Synthetic Carbohydrate-Based Antitumor Vaccines","display_name":"Synthetic Carbohydrate-Based Antitumor Vaccines","publication_year":2008,"publication_date":"2008-07-02","ids":{"openalex":"https://openalex.org/W2496355695","doi":"https://doi.org/10.1021/bk-2008-0989.ch012","mag":"2496355695"},"language":"en","primary_location":{"id":"doi:10.1021/bk-2008-0989.ch012","doi":"https://doi.org/10.1021/bk-2008-0989.ch012","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-2008-0989.ch012","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W436170202","display_name":"Carbohydrate-Based Vaccines"},"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055273994","display_name":"Rebecca M. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca M. Wilson","raw_affiliation_strings":["Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014524464","display_name":"J. David Warren","orcid":"https://orcid.org/0000-0002-2833-2248","observed_orcids":["https://orcid.org/0000-0002-2833-2248"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. David Warren","raw_affiliation_strings":["Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049208970","display_name":"Ouathek Ouerfelli","orcid":"https://orcid.org/0000-0002-7038-0219","observed_orcids":["https://orcid.org/0000-0002-7038-0219"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ouathek Ouerfelli","raw_affiliation_strings":["Organic Synthesis Core Laboratory, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organic Synthesis Core Laboratory, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080191966","display_name":"Samuel J. Danishefsky","orcid":"https://orcid.org/0000-0002-7010-8434","observed_orcids":["https://orcid.org/0000-0002-7010-8434"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel J. Danishefsky","raw_affiliation_strings":["Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027","Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021","Organic Synthesis Core Laboratory, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Organic Synthesis Core Laboratory, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.0746,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.97658481,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"258","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.9449999928474426},{"id":"https://openalex.org/keywords/breast-cancer-antigens","display_name":"breast cancer antigens","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C137610392","wikidata":"https://www.wikidata.org/wiki/Q2425020","display_name":"Glycopeptide","level":3,"score":0.7436084151268005},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6083979606628418},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.5752792954444885},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.4492191970348358},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36484673619270325},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3323631286621094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28440868854522705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28390103578567505},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/bk-2008-0989.ch012","doi":"https://doi.org/10.1021/bk-2008-0989.ch012","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bk-2008-0989.ch012","pdf_url":null,"source":{"id":"https://openalex.org/S205053445","display_name":"ACS symposium series","issn_l":"0097-6156","issn":["0097-6156","1947-5918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Symposium Series","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069936145","https://openalex.org/W2066460321","https://openalex.org/W1997064007","https://openalex.org/W1975025931","https://openalex.org/W1972473601","https://openalex.org/W2051341573","https://openalex.org/W2000824502","https://openalex.org/W2506654110","https://openalex.org/W4206533168","https://openalex.org/W1979462837"],"abstract_inverted_index":{"Our":[0],"laboratory":[1],"has":[2],"a":[3,23,81,100],"longstanding":[4],"program":[5],"devoted":[6],"to":[7],"the":[8,28,39,42,62,78],"preparation":[9],"and":[10,34,55,92],"immunological":[11],"evaluation":[12],"of":[13,27,30,41,64,80],"fully":[14],"synthetic":[15],"carbohydrate-based":[16],"antitumor":[17],"vaccine":[18,69,86],"constructs.":[19,70],"We":[20],"present":[21],"herein":[22],"brief":[24],"historical":[25],"account":[26],"evolution":[29],"this":[31,72],"research":[32],"program,":[33],"describe":[35],"key":[36],"achievements,":[37],"including":[38],"synthesis":[40,63,79],"Globo-H-KLH":[43],"construct,":[44,87],"which":[45,89],"is":[46],"currently":[47],"in":[48,53,88],"clinical":[49],"trials.":[50],"Remarkable":[51],"advances":[52],"carbohydrate":[54,95],"glycopeptide":[56],"assembly":[57],"techniques":[58],"have":[59,75],"allowed":[60],"for":[61],"increasingly":[65],"sophisticated,":[66],"structurally":[67],"complex":[68,83],"In":[71],"setting,":[73],"we":[74],"successfully":[76],"accomplished":[77],"highly":[82],"unimolecular":[84],"pentavalent":[85],"five":[90],"prostate":[91],"breast":[93],"cancer-associated":[94],"antigens":[96],"are":[97],"displayed":[98],"on":[99],"single":[101],"polypeptide":[102],"backbone.":[103]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}
