{"id":"https://openalex.org/W2495978755","doi":"https://doi.org/10.1158/1538-7445.am2016-2213","title":"Abstract 2213: Comparison of infusion devices for hepatic artery delivery of CAR-T","display_name":"Abstract 2213: Comparison of infusion devices for hepatic artery delivery of CAR-T","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2495978755","doi":"https://doi.org/10.1158/1538-7445.am2016-2213","mag":"2495978755"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-2213","doi":"https://doi.org/10.1158/1538-7445.am2016-2213","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-2213","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015234233","display_name":"J. Kebbeh Darpolor","orcid":"https://orcid.org/0000-0003-1606-8600","observed_orcids":["https://orcid.org/0000-0003-1606-8600"]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josephine K. Darpolor","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075360618","display_name":"Marissa Cunetta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Cunetta","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039081763","display_name":"Matthew Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Lima","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052081207","display_name":"Jillian Gardell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jillian Gardell","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069399653","display_name":"Gary R. Point","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Point","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100382247","display_name":"Zhi Liu","orcid":"https://orcid.org/0000-0001-9785-9150","observed_orcids":["https://orcid.org/0000-0001-9785-9150"]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi Liu","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112759390","display_name":"N. Joseph Espat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N J. Espat","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059006831","display_name":"Prajna Guha","orcid":"https://orcid.org/0000-0001-6831-9374","observed_orcids":["https://orcid.org/0000-0001-6831-9374"]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prajna Guha","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040099847","display_name":"Steven C. Katz","orcid":"https://orcid.org/0000-0002-6030-9312","observed_orcids":["https://orcid.org/0000-0002-6030-9312"]},"institutions":[{"id":"https://openalex.org/I1336196053","display_name":"Roger Williams Medical Center","ror":"https://ror.org/0478ng049","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336196053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Katz","raw_affiliation_strings":["Roger Williams Medical Center, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Williams Medical Center, Providence, RI","institution_ids":["https://openalex.org/I1336196053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1336196053"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"2213","last_page":"2213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion","display_name":"hepatic artery infusion","score":0.9860000014305115},{"id":"https://openalex.org/keywords/infusion-systems","display_name":"infusion devices","score":0.7329999804496765},{"id":"https://openalex.org/keywords/transcatheter-arterial-embolization","display_name":"transcatheter arterial embolization","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.746999979019165},{"id":"https://openalex.org/keywords/intraperitoneal-tumor","display_name":"intraperitoneal tumor","score":0.7210000157356262},{"id":"https://openalex.org/keywords/microcatheter","display_name":"microcatheter","score":0.671999990940094},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5680000185966492},{"id":"https://openalex.org/keywords/off-target-toxicity","display_name":"off-target toxicity","score":0.5180000066757202},{"id":"https://openalex.org/keywords/tumor-lysis-syndrome","display_name":"tumor lysis syndrome","score":0.36399999260902405},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6568532586097717},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6116470694541931},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5384447574615479},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.46034693717956543},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4270648658275604},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3129984140396118},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28458377718925476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17617803812026978},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-2213","doi":"https://doi.org/10.1158/1538-7445.am2016-2213","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-2213","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W166886671","https://openalex.org/W1994110712","https://openalex.org/W2583111022","https://openalex.org/W2311076054","https://openalex.org/W2295911768","https://openalex.org/W135778288","https://openalex.org/W170620723","https://openalex.org/W2312908696","https://openalex.org/W2060100007","https://openalex.org/W2026792009"],"abstract_inverted_index":{"Abstract":[0],"We":[1,92,161,224],"previously":[2],"tested":[3,148],"the":[4,110,189,192,207,217,252,261,272,282,480,485],"efficacy":[5],"of":[6,87,123,191,206,467,474,479,484],"chimeric":[7],"antigen":[8],"receptor":[9],"T":[10],"cell":[11],"(CAR-T)":[12],"treatment":[13],"via":[14,149],"hepatic":[15,33,72,471],"artery":[16,73,472],"infusion":[17,74,145,468],"in":[18,42,94,97,100,227,230,251,271],"a":[19,62,77,103,133,165],"phase":[20,104],"I":[21],"clinical":[22],"trial.":[23],"Though":[24],"these":[25,309],"results":[26],"were":[27,147,182,286],"promising,":[28],"our":[29],"current":[30],"protocol":[31],"for":[32,35,102,315,470,488],"immunotherapy":[34],"metastasis":[36],"(HITM)":[37],"includes":[38],"transcatheter":[39],"arterial":[40],"embolization":[41],"order":[43],"to":[44,51,84,107,184],"reduce":[45],"off-target":[46],"toxicity":[47],"from":[48],"CAR-T":[49,116,124,152,193,199,279,284,302,320],"delivery":[50,86,473],"gastric,":[52],"enteric,":[53],"or":[54,141,239,305],"pancreatic":[55],"tissues.":[56],"Surefire":[57,137,142],"Infusion":[58,138],"System":[59,139],"devices":[60,297,469],"employ":[61],"soft":[63],"fabric":[64],"one":[65],"way":[66],"valve":[67],"that":[68,109,308],"prevents":[69],"back-flow":[70],"during":[71],"and":[75,96,120,129,174,179,187,221,260,281,295,318],"generates":[76],"pressure":[78],"gradient,":[79],"which":[80],"is":[81],"clinically":[82],"shown":[83],"increase":[85],"therapeutic":[88],"agents":[89],"into":[90],"tumor.":[91,197],"performed":[93,226],"vitro":[95],"vivo":[98,228],"testing":[99,229],"preparation":[101],"Ib":[105],"trial":[106],"ensure":[108],"SIS":[111,240,262,278,294],"does":[112],"not":[113,163,213,287,299],"adversely":[114,300],"affect":[115],"performance.":[117],"Viability,":[118],"phenotype":[119,167],"activation":[121],"status":[122],"with":[125,232,236],"no":[126],"catheter":[127,208],"(NC)":[128],"following":[130],"passage":[131],"through":[132],"standard":[134],"microcatheter":[135],"(STD),":[136],"(SIS),":[140],"Precision":[143],"(SP)":[144],"system":[146],"flow":[150],"cytometry.":[151],"viability":[153],"was":[154,212,246],"preserved":[155],"as":[156],"measured":[157],"by":[158,196],"Zombie":[159],"NIR.":[160],"did":[162,298],"detect":[164],"significant":[166],"shift":[168],"when":[169,194],"examining":[170],"CD4,":[171],"CD8,":[172],"CD25,":[173],"CD69.":[175],"A":[176],"CFSE":[177],"assay":[178],"an":[180],"LDH":[181],"done":[183],"track":[185],"proliferation":[186,203],"measure":[188],"cytotoxicity":[190],"stimulated":[195],"NC":[198,238,253,283],"had":[200],"significantly":[201,214,247,288],"more":[202,316],"than":[204,270],"each":[205],"groups.":[209,223],"Specific":[210],"Lysis":[211],"different":[215,289],"between":[216],"NC,":[218],"STD,":[219],"SIS,":[220],"SP":[222,296],"also":[225],"mice":[231],"intraperitoneal":[233],"(IP)":[234],"tumor":[235,249,273],"IP":[237],"CAR-T.":[241,475],"By":[242],"Day":[243],"10,":[244],"there":[245],"less":[248],"present":[250],"(5.7-":[254],"fold":[255,264],"reduction,":[256,265],"p":[257,266,332,337,342,348,353,358,364,369,374,380,385,390,396,401,406,412,417,422,429,434,439],"=":[258,267,291,333,338,343,349,354,359,365,370,375,381,386,391,397,402,407,413,418,423,430,435,440],"0.02)":[259],"(44-":[263],"0.04)":[268],"groups":[269],"only":[274],"control":[275],"group.":[276],"The":[277,293],"group":[280,285],"(p":[290],"0.38).":[292],"impact":[301],"viability,":[303],"phenotype,":[304],"performance":[306],"implying":[307],"catheters":[310],"could":[311],"be":[312],"interchangeably":[313],"used":[314],"efficient":[317],"targeted":[319],"dose":[321],"delivery.":[322],"In":[323],"Vitro":[324],"Experimental":[325],"Data":[326],"ExperimentNC":[327],"(Control)STD":[328],"(Control)SISPSViability":[329],"(Zombie":[330],"NIR)6%7.9%":[331],"0.7":[334,344,376,392,436],"vs":[335,345,351,356,361,367,372,377,383,388,393,399,404,409,415,420,425,432,437,442],"NC7.4%":[336],"0.9":[339,350,355,366,371,382,387,398,441],"vs.":[340],"STD9.9%":[341],"STDPhenotype":[346,362],"(CD3+CD4+)33.1%30.6%":[347],"NC33.3%":[352],"STD21.3%":[357],"0.8":[360,419],"(CD3+CD8+)68.8%69.5%":[363],"NC69.1%":[368],"STD66.7%":[373],"STDActivation":[378],"(CD69+)34.93%32.3%":[379],"NC33%":[384],"STD25.6%":[389],"STDTreg":[394],"(CD25+)35.2%36.2%":[395],"NC36.8%":[400],"0.6":[403,408],"STD40.5%":[405],"STDProliferation":[410],"(CFSE)41.7%26.7%":[411],"0.005":[414],"NC27.3%":[416],"STD24.2%":[421],"0.4":[424],"STDCytotoxicity":[426],"(LDH":[427],"Assay)51.2%42.1%":[428],"0.1":[431],"NC44%":[433],"STD41.1%":[438],"STD":[443],"Citation":[444],"Format:":[445],"Josephine":[446],"K.":[447],"Darpolor,":[448],"Marissa":[449],"Cunetta,":[450],"Matthew":[451],"Lima,":[452],"Jillian":[453],"Gardell,":[454],"Gary":[455],"Point,":[456],"Zhi":[457],"Liu,":[458],"N":[459],"J.":[460],"Espat,":[461],"Prajna":[462],"Guha,":[463],"Steven":[464],"Katz.":[465],"Comparison":[466],"[abstract].":[476],"In:":[477],"Proceedings":[478],"107th":[481],"Annual":[482],"Meeting":[483],"American":[486],"Association":[487],"Cancer":[489,500],"Research;":[490],"2016":[491],"Apr":[492],"16-20;":[493],"New":[494],"Orleans,":[495],"LA.":[496],"Philadelphia":[497],"(PA):":[498],"AACR;":[499],"Res":[501],"2016;76(14":[502],"Suppl):Abstract":[503],"nr":[504],"2213.":[505]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-08-23T00:00:00"}
