{"id":"https://openalex.org/W2495947776","doi":"https://doi.org/10.3389/fnins.2016.00351","title":"The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery","display_name":"The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery","publication_year":2016,"publication_date":"2016-08-03","ids":{"openalex":"https://openalex.org/W2495947776","doi":"https://doi.org/10.3389/fnins.2016.00351","mag":"2495947776","pmid":"https://pubmed.ncbi.nlm.nih.gov/27536211","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4971013"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2016.00351","doi":"https://doi.org/10.3389/fnins.2016.00351","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2016.00351","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2016.00351/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2016.00351/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091074537","display_name":"Marianthi Georgitsi","orcid":"https://orcid.org/0000-0002-0354-0913","observed_orcids":["https://orcid.org/0000-0002-0354-0913"]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]},{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Marianthi Georgitsi","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Democritus University of ThraceAlexandroupoli, Greece; Department of Medicine, Aristotle University of ThessalonikiThessaloniki, Greece","Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece","Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Democritus University of ThraceAlexandroupoli, Greece; Department of Medicine, Aristotle University of ThessalonikiThessaloniki, Greece","institution_ids":["https://openalex.org/I147962203","https://openalex.org/I21370196"]},{"raw_affiliation_string":"Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece","institution_ids":["https://openalex.org/I147962203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086857587","display_name":"Arthur Jeremy Willsey","orcid":"https://orcid.org/0000-0002-9922-3612","observed_orcids":["https://orcid.org/0000-0002-9922-3612"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Jeremy Willsey","raw_affiliation_strings":["Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085647098","display_name":"Carol A. Mathews","orcid":"https://orcid.org/0000-0003-2208-7058","observed_orcids":["https://orcid.org/0000-0003-2208-7058"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol A. Mathews","raw_affiliation_strings":["Department of Psychiatry, University of Florida School of Medicine, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Florida School of Medicine, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010207238","display_name":"Matthew W. State","orcid":"https://orcid.org/0000-0003-1624-8302","observed_orcids":["https://orcid.org/0000-0003-1624-8302"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew State","raw_affiliation_strings":["Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079732116","display_name":"Jeremiah M. Scharf","orcid":"https://orcid.org/0000-0002-4742-5896","observed_orcids":["https://orcid.org/0000-0002-4742-5896"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremiah M. Scharf","raw_affiliation_strings":["Departments of Neurology and Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039262584","display_name":"Peristera Paschou","orcid":"https://orcid.org/0000-0002-9783-1024","observed_orcids":["https://orcid.org/0000-0002-9783-1024"]},"institutions":[{"id":"https://openalex.org/I147962203","display_name":"Democritus University of Thrace","ror":"https://ror.org/03bfqnx40","country_code":"GR","type":"education","lineage":["https://openalex.org/I147962203"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Peristera Paschou","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece","institution_ids":["https://openalex.org/I147962203"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5010207238","https://openalex.org/A5039262584","https://openalex.org/A5079732116"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I147962203","https://openalex.org/I180670191","https://openalex.org/I4210087915"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":11.0657,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.98488672,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"351","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":1.0},{"id":"https://openalex.org/keywords/genetic-etiology","display_name":"genetic etiology","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tics","display_name":"tics","score":0.7089999914169312},{"id":"https://openalex.org/keywords/multifactorial-inheritance","display_name":"multifactorial inheritance","score":0.621999979019165},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.6970000267028809},{"id":"https://openalex.org/keywords/susceptibility-genes","display_name":"susceptibility genes","score":0.6050000190734863},{"id":"https://openalex.org/keywords/simplex-families","display_name":"simplex families","score":0.5649999976158142},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.8289999961853027},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.8500000238418579},{"id":"https://openalex.org/keywords/genome-sequencing","display_name":"genome sequencing","score":0.6200000047683716},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7072635293006897},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.5879195332527161},{"id":"https://openalex.org/C188997412","wikidata":"https://www.wikidata.org/wiki/Q1640386","display_name":"Proband","level":4,"score":0.5288333296775818},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.5134435892105103},{"id":"https://openalex.org/C2777200579","wikidata":"https://www.wikidata.org/wiki/Q738538","display_name":"Tics","level":2,"score":0.48683303594589233},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.4320889115333557},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4033609628677368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36837974190711975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32744377851486206},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30104732513427734},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.29630914330482483},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.188848614692688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17191103100776672},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1379905343055725},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1176968514919281},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3389/fnins.2016.00351","doi":"https://doi.org/10.3389/fnins.2016.00351","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2016.00351","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2016.00351/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4971013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4971013","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:27536211","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27536211","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt39m2525b","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/39m2525b","pdf_url":"https://escholarship.org/content/qt39m2525b/qt39m2525b.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, vol 10, iss AUG","raw_type":"article"},{"id":"pmh:oai:dash.harvard.edu:1/29002533","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002533","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d8417ad447644c4abb289b8303c5d85b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d8417ad447644c4abb289b8303c5d85b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 10 (2016)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt39m2525b","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/39m2525b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2016.00351","doi":"https://doi.org/10.3389/fnins.2016.00351","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2016.00351","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2016.00351/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G121778103","display_name":"Translational phenomics and genomics of Gilles de la Tourette Syndrome","funder_award_id":"K23MH085057","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2025141141","display_name":"1/8-Collaborative genomic studies of Tourette Disorder","funder_award_id":"R01MH092293","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2255044488","display_name":"European Multicentre Tics in Children Studies","funder_award_id":"278367","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2880196128","display_name":"Advancing Tourette Syndrome genetics using bioinformatics and genome biology","funder_award_id":"K02NS085048","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2973790809","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3825394209","display_name":"2/8-Collaborative genomic studies of Tourette Disorder","funder_award_id":"R01MH092289","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4024554781","display_name":"1st World Congress on Tourette Syndrome and Tic Disorders","funder_award_id":"R13NS095344","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4052664962","display_name":"4/8-Collaborative genomic studies of Tourette Disorder","funder_award_id":"R01MH092520","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4053127980","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"},{"id":"https://openalex.org/G4570346565","display_name":"Interdisciplinary training network for Tourette Syndrome; structuring European Training capacities for neurodevelopmental disorders","funder_award_id":"316978","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4626508987","display_name":null,"funder_award_id":"FP7- PEOPLE-2012-ITN","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4939802854","display_name":"A Genetic Linkage Study of GTS","funder_award_id":"U01NS040024","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5748614774","display_name":"Refining the Tourette Syndrome phenotype across diagnoses to aid gene discovery","funder_award_id":"R01MH096767","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6343321671","display_name":null,"funder_award_id":"316978","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"},{"id":"https://openalex.org/G682275100","display_name":null,"funder_award_id":"FP7/2007\u20102013/","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"},{"id":"https://openalex.org/G7401113806","display_name":null,"funder_award_id":"2012-ITN","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"}],"funders":[{"id":"https://openalex.org/F4320310796","display_name":"Tourette Association of America","ror":"https://ror.org/00x2ve368"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320338368","display_name":"FP7 People: Marie-Curie Actions","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2495947776.pdf","grobid_xml":"https://content.openalex.org/works/W2495947776.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W203587423","https://openalex.org/W1485320007","https://openalex.org/W1499453506","https://openalex.org/W1555439787","https://openalex.org/W1727644174","https://openalex.org/W1825210022","https://openalex.org/W1902269141","https://openalex.org/W1942296832","https://openalex.org/W1967237555","https://openalex.org/W1968042434","https://openalex.org/W1968106380","https://openalex.org/W1969012438","https://openalex.org/W1970582599","https://openalex.org/W1971250615","https://openalex.org/W1975594636","https://openalex.org/W1981390338","https://openalex.org/W1984772239","https://openalex.org/W1986531447","https://openalex.org/W1988308774","https://openalex.org/W1990107367","https://openalex.org/W1994498762","https://openalex.org/W1995515744","https://openalex.org/W1997003258","https://openalex.org/W2002182743","https://openalex.org/W2002924293","https://openalex.org/W2007698371","https://openalex.org/W2009742334","https://openalex.org/W2016864963","https://openalex.org/W2018397294","https://openalex.org/W2021194895","https://openalex.org/W2022575794","https://openalex.org/W2024796679","https://openalex.org/W2030123107","https://openalex.org/W2031134758","https://openalex.org/W2031959540","https://openalex.org/W2034542353","https://openalex.org/W2036916657","https://openalex.org/W2041237576","https://openalex.org/W2045218812","https://openalex.org/W2052747134","https://openalex.org/W2055799496","https://openalex.org/W2056628373","https://openalex.org/W2058082712","https://openalex.org/W2059923496","https://openalex.org/W2069105469","https://openalex.org/W2072624089","https://openalex.org/W2075825728","https://openalex.org/W2078084267","https://openalex.org/W2080845329","https://openalex.org/W2081668545","https://openalex.org/W2092188955","https://openalex.org/W2092825250","https://openalex.org/W2094287065","https://openalex.org/W2094366691","https://openalex.org/W2095395630","https://openalex.org/W2098258490","https://openalex.org/W2102710248","https://openalex.org/W2108710427","https://openalex.org/W2110395878","https://openalex.org/W2111453841","https://openalex.org/W2112157019","https://openalex.org/W2112696084","https://openalex.org/W2114409847","https://openalex.org/W2119688292","https://openalex.org/W2121045992","https://openalex.org/W2122074197","https://openalex.org/W2127117371","https://openalex.org/W2132716107","https://openalex.org/W2138198688","https://openalex.org/W2145709699","https://openalex.org/W2148683100","https://openalex.org/W2153773863","https://openalex.org/W2155276106","https://openalex.org/W2165673024","https://openalex.org/W2166444316","https://openalex.org/W2170644025","https://openalex.org/W2171629666","https://openalex.org/W2286847962","https://openalex.org/W2294329210","https://openalex.org/W2499863146","https://openalex.org/W4255232544","https://openalex.org/W4290203949","https://openalex.org/W6628888878","https://openalex.org/W6633425470","https://openalex.org/W6663674198","https://openalex.org/W6841383397"],"related_works":["https://openalex.org/W2924792514","https://openalex.org/W7127045658","https://openalex.org/W2132716107","https://openalex.org/W2924276064","https://openalex.org/W7049193818","https://openalex.org/W4206349086","https://openalex.org/W7097679132","https://openalex.org/W2516058058","https://openalex.org/W4290974870","https://openalex.org/W2048725710"],"abstract_inverted_index":{"Gilles":[0],"de":[1],"la":[2],"Tourette":[3,97],"Syndrome":[4,98],"(TS)":[5],"is":[6,12],"a":[7,22,58,83,172,182],"childhood-onset":[8],"neurodevelopmental":[9],"disorder":[10,45],"that":[11],"characterized":[13],"by":[14],"multiple":[15,26,49],"motor":[16],"and":[17,51,64,81,112,129,143,164,191,215,230],"phonic":[18],"tics.":[19],"It":[20],"has":[21,105],"complex":[23,94,235],"etiology":[24],"with":[25,30,93],"genes":[27,229],"likely":[28],"interacting":[29],"environmental":[31,216],"factors":[32,218],"to":[33,35,88,155,179,184,192,207],"lead":[34],"the":[36,44,62,68,89,160,189,194,209,234],"onset":[37],"of":[38,43,70,85,91,162,197,212,237],"symptoms.":[39],"The":[40,72,96,146],"genetic":[41,213],"basis":[42],"remains":[46],"elusive.":[47],"However,":[48],"resources":[50],"large-scale":[52,73,186,202],"projects":[53,187],"are":[54,79,204],"coming":[55],"together,":[56],"launching":[57],"new":[59],"era":[60],"in":[61,76,140,150,167,188],"field":[63,190],"bringing":[65],"us":[66],"on":[67,107],"verge":[69],"discovery.":[71],"efforts":[74,203],"outlined":[75],"this":[77,238],"report":[78],"complementary":[80,201],"represent":[82],"range":[84,211],"different":[86],"approaches":[87],"study":[90],"disorders":[92],"inheritance.":[95],"Association":[99],"International":[100],"Consortium":[101],"for":[102,114,219,224],"Genetics":[103,133],"(TSAICG)":[104],"focused":[106],"large":[108,115,136],"families,":[109],"parent-proband":[110],"trios":[111],"cases":[113],"case-control":[116],"designs":[117],"such":[118],"as":[119,181],"genomewide":[120],"association":[121],"studies":[122],"(GWAS),":[123],"copy":[124],"number":[125],"variation":[126,214],"(CNV)":[127],"scans,":[128],"exome/genome":[130],"sequencing.":[131],"TIC":[132],"targets":[134],"rare,":[135],"effect":[137],"size":[138],"mutations":[139],"simplex":[141],"trios,":[142],"multigenerational":[144],"families.":[145],"European":[147],"Multicentre":[148],"Tics":[149],"Children":[151],"Study":[152],"(EMTICS)":[153],"seeks":[154],"elucidate":[156],"gene-environment":[157],"interactions":[158],"including":[159],"involvement":[161],"infection":[163],"immune":[165],"mechanisms":[166],"TS":[168,227],"etiology.":[169],"Finally,":[170],"TS-EUROTRAIN,":[171],"Marie":[173],"Curie":[174],"Initial":[175],"Training":[176],"Network,":[177],"aims":[178],"act":[180],"platform":[183],"unify":[185],"educate":[193],"next":[195],"generation":[196],"experts.":[198],"Importantly,":[199],"these":[200],"joining":[205],"forces":[206],"uncover":[208],"full":[210],"risk":[217],"TS,":[220],"holding":[221],"great":[222],"promise":[223],"identifying":[225],"definitive":[226],"susceptibility":[228],"shedding":[231],"light":[232],"into":[233],"pathophysiology":[236],"disorder.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-08-23T00:00:00"}