{"id":"https://openalex.org/W2495500873","doi":"https://doi.org/10.1530/erc-16-0171","title":"Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study","display_name":"Genetic associations with neuroendocrine tumor risk: results from a genome-wide association study","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2495500873","doi":"https://doi.org/10.1530/erc-16-0171","mag":"2495500873","pmid":"https://pubmed.ncbi.nlm.nih.gov/27492634","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6151867"},"language":"en","primary_location":{"id":"doi:10.1530/erc-16-0171","doi":"https://doi.org/10.1530/erc-16-0171","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-16-0171","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/23/8/587.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/23/8/587.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044368486","display_name":"Yeting Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeting Du","raw_affiliation_strings":["Harvard School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028280842","display_name":"Monica Ter\u2010Minassian","orcid":"https://orcid.org/0000-0002-9497-2585","observed_orcids":["https://orcid.org/0000-0002-9497-2585"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica Ter-Minassian","raw_affiliation_strings":["Harvard School of Public HealthBoston, Massachusetts, USA Dana-Farber Cancer InstituteBoston, Massachusetts, USA","Dana-Farber Cancer Institute, Boston, Massachusetts, USA","Harvard School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public HealthBoston, Massachusetts, USA Dana-Farber Cancer InstituteBoston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028547202","display_name":"Lauren K. Brais","orcid":"https://orcid.org/0000-0003-1069-0407","observed_orcids":["https://orcid.org/0000-0003-1069-0407"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Brais","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028521869","display_name":"Nichole V. Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nichole Brooks","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055769586","display_name":"Amanda Waldron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Waldron","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114950423","display_name":"Jennifer Ang Chan","orcid":"https://orcid.org/0000-0003-2523-9598","observed_orcids":["https://orcid.org/0000-0003-2523-9598"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A Chan","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030660111","display_name":"Xihong Lin","orcid":"https://orcid.org/0000-0001-7067-7752","observed_orcids":["https://orcid.org/0000-0001-7067-7752"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xihong Lin","raw_affiliation_strings":["Harvard School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056487867","display_name":"Peter Kraft","orcid":"https://orcid.org/0000-0002-4472-8103","observed_orcids":["https://orcid.org/0000-0002-4472-8103"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kraft","raw_affiliation_strings":["Harvard School of Public Health, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091331939","display_name":"David C. Christiani","orcid":"https://orcid.org/0000-0002-0301-0242","observed_orcids":["https://orcid.org/0000-0002-0301-0242"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C Christiani","raw_affiliation_strings":["Harvard School of Public HealthBoston, Massachusetts, USA Massachusetts General HospitalBoston, Massachusetts, USA","Harvard School of Public Health, Boston, Massachusetts, USA","Massachusetts General Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard School of Public HealthBoston, Massachusetts, USA Massachusetts General HospitalBoston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard School of Public Health, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017947396","display_name":"Matthew H. Kulke","orcid":"https://orcid.org/0000-0001-8556-3977","observed_orcids":["https://orcid.org/0000-0001-8556-3977"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew H Kulke","raw_affiliation_strings":["Dana-Farber Cancer InstituteBoston, Massachusetts, USA matthew_kulke@dfci.harvard.edu","Dana-Farber Cancer Institute, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer InstituteBoston, Massachusetts, USA matthew_kulke@dfci.harvard.edu","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017947396"],"corresponding_institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":null,"apc_paid":null,"fwci":1.8286,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84674533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"8","first_page":"587","last_page":"594"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/small-intestinal-neuroendocrine-tumors","display_name":"small bowel neuroendocrine tumors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/elk3","display_name":"ELK3","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chromosome-12","display_name":"chromosome 12","score":0.9190000295639038},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.984000027179718},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6010000109672546},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bronchial-neuroendocrine-tumors","display_name":"bronchial neuroendocrine tumors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7148044109344482},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.6134061813354492},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5163606405258179},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5019872188568115},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49826836585998535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4472879469394684},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.43685266375541687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4348217248916626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4311593770980835},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.43041667342185974},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3657577335834503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2878669500350952},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.260392963886261},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1740647554397583}],"mesh":[{"descriptor_ui":"D001984","descriptor_name":"Bronchial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1530/erc-16-0171","doi":"https://doi.org/10.1530/erc-16-0171","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-16-0171","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/23/8/587.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},{"id":"pmid:27492634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27492634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-related cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5098577","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6151867","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6151867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6151867","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Endocr Relat Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1530/erc-16-0171","doi":"https://doi.org/10.1530/erc-16-0171","is_oa":true,"landing_page_url":"https://doi.org/10.1530/erc-16-0171","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/23/8/587.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1119066253","display_name":"Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer","funder_award_id":"P50CA127003","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4656134595","display_name":"Molecular and Genetic Analysis of Neuroendocrine Tumor Risk and Survival","funder_award_id":"R01CA151532","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000918361","display_name":"Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research","funder_award_id":"R35CA197449","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307205","display_name":"Caring for Carcinoid Foundation","ror":"https://ror.org/026t1zr39"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2495500873.pdf","grobid_xml":"https://content.openalex.org/works/W2495500873.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1503273596","https://openalex.org/W1921512153","https://openalex.org/W1964082229","https://openalex.org/W1975686877","https://openalex.org/W1991912136","https://openalex.org/W1995622522","https://openalex.org/W2005250386","https://openalex.org/W2010704999","https://openalex.org/W2031084325","https://openalex.org/W2053027458","https://openalex.org/W2067398230","https://openalex.org/W2073866552","https://openalex.org/W2098482546","https://openalex.org/W2098785387","https://openalex.org/W2100734221","https://openalex.org/W2102079513","https://openalex.org/W2106944276","https://openalex.org/W2120960711","https://openalex.org/W2130608121","https://openalex.org/W2130811802","https://openalex.org/W2133139757","https://openalex.org/W2140968934","https://openalex.org/W2142033642","https://openalex.org/W2143578264","https://openalex.org/W2143827882","https://openalex.org/W2147572908","https://openalex.org/W2149214723","https://openalex.org/W2157752701","https://openalex.org/W2161633633","https://openalex.org/W2168909456","https://openalex.org/W2173270555","https://openalex.org/W2283550226","https://openalex.org/W2299168734","https://openalex.org/W4233636985"],"related_works":["https://openalex.org/W2166441850","https://openalex.org/W2074815103","https://openalex.org/W2130608121","https://openalex.org/W2174353708","https://openalex.org/W4415743074","https://openalex.org/W3023981770","https://openalex.org/W4384157642","https://openalex.org/W4286640333","https://openalex.org/W2112454006","https://openalex.org/W2776556156"],"abstract_inverted_index":{"The":[0,24,152],"etiology":[1],"of":[2,26,89,158,208],"neuroendocrine":[3,9,27,49,71,115,132,178,191,236],"tumors":[4,10,28,192,237],"remains":[5],"poorly":[6],"defined.":[7],"Although":[8],"are":[11,22,29,155,238],"in":[12,66,109,114,124,149,164,173,211],"some":[13],"cases":[14,73],"associated":[15],"with":[16,142],"inherited":[17],"genetic":[18,44,196,228],"syndromes,":[19],"such":[20],"syndromes":[21],"rare.":[23],"majority":[25],"thought":[30],"to":[31,41,218,225],"be":[32],"sporadic.":[33],"We":[34,105,118,166],"performed":[35],"a":[36,67,160,195,201],"genome-wide":[37],"association":[38],"study":[39,182],"(GWAS)":[40],"identify":[42,169],"potential":[43,121,227],"risk":[45,107,122,140,171,229],"factors":[46,230],"for":[47,102,203,215,231],"sporadic":[48,188,232],"tumors.":[50],"Using":[51],"germline":[52],"DNA":[53],"from":[54,74,85,96],"blood":[55],"specimens,":[56],"we":[57,138],"genotyped":[58],"909,622":[59],"SNPs":[60,144,154],"using":[61],"the":[62,86,110,125,129,174,206,220],"Affymetrix":[63],"6.0":[64],"GeneChip,":[65],"cohort":[68,126],"comprising":[69,135],"832":[70],"tumor":[72,116,133],"Dana-Farber":[75,97],"Cancer":[76,98],"Institute":[77,99],"and":[78,82,113,214,234],"Massachusetts":[79],"General":[80],"Hospital":[81],"4542":[83],"controls":[84,95],"Harvard":[87],"School":[88],"Public":[90],"Health.":[91],"An":[92],"additional":[93],"241":[94],"were":[100],"used":[101],"quality":[103],"control.":[104],"assessed":[106],"associations":[108,123,141,172],"overall":[111],"cohort,":[112],"subgroups.":[117,179],"identified":[119,139],"no":[120],"overall.":[127],"In":[128],"small":[130,189],"intestine":[131,190],"subgroup,":[134],"293":[136],"cases,":[137],"three":[143,153],"on":[145],"chromosome":[146],"12,":[147],"all":[148],"strong":[150],"LD.":[151],"located":[156],"upstream":[157],"ELK3,":[159],"transcription":[161],"factor":[162],"implicated":[163,210],"angiogenesis.":[165],"did":[167],"not":[168],"clear":[170],"bronchial":[175,235],"or":[176],"pancreatic":[177,233],"This":[180],"large-scale":[181],"provides":[183],"initial":[184],"evidence":[185],"that":[186],"presumed":[187],"may":[193],"have":[194],"etiology.":[197],"Our":[198],"results":[199],"provide":[200],"basis":[202],"further":[204],"exploring":[205],"role":[207],"genes":[209],"this":[212],"analysis,":[213],"replication":[216],"studies":[217,224],"confirm":[219],"observed":[221],"associations.":[222],"Additional":[223],"evaluate":[226],"warranted.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}