{"id":"https://openalex.org/W2495368148","doi":null,"title":"Genetic analysis of cellulose crystallization in Gluconacetobacter xylinus","display_name":"Genetic analysis of cellulose crystallization in Gluconacetobacter xylinus","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2495368148","mag":"2495368148"},"language":"en","primary_location":{"id":"pmh:oai:ir.library.dc-uoit.ca:10155/551","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10155/551","pdf_url":"http://hdl.handle.net/10155/551","source":{"id":"https://openalex.org/S4306401586","display_name":"e-scholar@UOIT (University of Ontario Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39470171","host_organization_name":"Ontario Tech University","host_organization_lineage":["https://openalex.org/I39470171"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10155/551","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103704430","display_name":"Luis Fernando Salgado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Luis Fernando Salgado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103704430"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10610","display_name":"Advanced Cellulose Research Studies","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10610","display_name":"Advanced Cellulose Research Studies","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.2996000051498413,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellulose-crystallization","display_name":"cellulose crystallization","score":0.9649999737739563},{"id":"https://openalex.org/keywords/acetobacter-xylinum","display_name":"Acetobacter xylinum","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cellulose-biosynthesis","display_name":"cellulose biosynthesis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cellulose-i","display_name":"cellulose I","score":0.6700000166893005},{"id":"https://openalex.org/keywords/forward-genetics","display_name":"forward genetics","score":0.6869999766349792},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cellulose-producing-bacteria","display_name":"cellulose-producing bacteria","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.6085283756256104},{"id":"https://openalex.org/C2779477270","wikidata":"https://www.wikidata.org/wiki/Q4839982","display_name":"Bacterial cellulose","level":3,"score":0.5750001072883606},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.5454987287521362},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.45936885476112366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36623328924179077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3335227072238922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14842045307159424},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07999467849731445}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ir.library.dc-uoit.ca:10155/551","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10155/551","pdf_url":"http://hdl.handle.net/10155/551","source":{"id":"https://openalex.org/S4306401586","display_name":"e-scholar@UOIT (University of Ontario Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39470171","host_organization_name":"Ontario Tech University","host_organization_lineage":["https://openalex.org/I39470171"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:ontariotechu.scholaris.ca:10155/551","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10155/551","pdf_url":null,"source":{"id":"https://openalex.org/S4306401586","display_name":"e-scholar@UOIT (University of Ontario Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39470171","host_organization_name":"Ontario Tech University","host_organization_lineage":["https://openalex.org/I39470171"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2495368148","doi":null,"is_oa":false,"landing_page_url":"https://ir.library.dc-uoit.ca/bitstream/10155/551/1/Salgado_Luis_Fernando.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ir.library.dc-uoit.ca:10155/551","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10155/551","pdf_url":"http://hdl.handle.net/10155/551","source":{"id":"https://openalex.org/S4306401586","display_name":"e-scholar@UOIT (University of Ontario Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39470171","host_organization_name":"Ontario Tech University","host_organization_lineage":["https://openalex.org/I39470171"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2495368148.pdf","grobid_xml":"https://content.openalex.org/works/W2495368148.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W133640418","https://openalex.org/W181765173","https://openalex.org/W305559593","https://openalex.org/W619682892","https://openalex.org/W1507415332","https://openalex.org/W1531191653","https://openalex.org/W1576751539","https://openalex.org/W1675454309","https://openalex.org/W1803102843","https://openalex.org/W1836101194","https://openalex.org/W1911657064","https://openalex.org/W1912762964","https://openalex.org/W1934886907","https://openalex.org/W1964915062","https://openalex.org/W1965443629","https://openalex.org/W1967525631","https://openalex.org/W1971133394","https://openalex.org/W1971912308","https://openalex.org/W1977906605","https://openalex.org/W1980167694","https://openalex.org/W1983940374","https://openalex.org/W1984235867","https://openalex.org/W1985909720","https://openalex.org/W1986180302","https://openalex.org/W1986743182","https://openalex.org/W1987510214","https://openalex.org/W1991394444","https://openalex.org/W1991923066","https://openalex.org/W1992718766","https://openalex.org/W1996442036","https://openalex.org/W1999083038","https://openalex.org/W2002254535","https://openalex.org/W2003413932","https://openalex.org/W2004451874","https://openalex.org/W2005291574","https://openalex.org/W2007237010","https://openalex.org/W2009619936","https://openalex.org/W2011556569","https://openalex.org/W2014637766","https://openalex.org/W2016195587","https://openalex.org/W2016518326","https://openalex.org/W2016965453","https://openalex.org/W2018175473","https://openalex.org/W2021439590","https://openalex.org/W2023011190","https://openalex.org/W2023566399","https://openalex.org/W2026552146","https://openalex.org/W2028072637","https://openalex.org/W2035923499","https://openalex.org/W2036145289","https://openalex.org/W2037365513","https://openalex.org/W2041752034","https://openalex.org/W2042210230","https://openalex.org/W2049375165","https://openalex.org/W2049731555","https://openalex.org/W2054404254","https://openalex.org/W2057321728","https://openalex.org/W2062816529","https://openalex.org/W2078607868","https://openalex.org/W2079776803","https://openalex.org/W2080119168","https://openalex.org/W2082091267","https://openalex.org/W2082561535","https://openalex.org/W2083202409","https://openalex.org/W2084617901","https://openalex.org/W2087017025","https://openalex.org/W2087637802","https://openalex.org/W2098839738","https://openalex.org/W2099567869","https://openalex.org/W2106498910","https://openalex.org/W2108489943","https://openalex.org/W2111480278","https://openalex.org/W2112289062","https://openalex.org/W2113273019","https://openalex.org/W2114220158","https://openalex.org/W2116015581","https://openalex.org/W2120154084","https://openalex.org/W2120548956","https://openalex.org/W2120684616","https://openalex.org/W2120770718","https://openalex.org/W2126302756","https://openalex.org/W2132890636","https://openalex.org/W2133045323","https://openalex.org/W2137808217","https://openalex.org/W2145792008","https://openalex.org/W2145839489","https://openalex.org/W2148285527","https://openalex.org/W2149725925","https://openalex.org/W2151957625","https://openalex.org/W2154977216","https://openalex.org/W2159270176","https://openalex.org/W2160295639","https://openalex.org/W2163798300","https://openalex.org/W2165322702","https://openalex.org/W2165490685","https://openalex.org/W2166636340","https://openalex.org/W2169615907","https://openalex.org/W2252296167","https://openalex.org/W2328597410","https://openalex.org/W2770983033","https://openalex.org/W2912166057"],"related_works":["https://openalex.org/W2972922274","https://openalex.org/W2022855620","https://openalex.org/W2972031687","https://openalex.org/W1967525631","https://openalex.org/W7098304425","https://openalex.org/W2131761542","https://openalex.org/W3115689720","https://openalex.org/W2620790821","https://openalex.org/W1912762964","https://openalex.org/W4205937788"],"abstract_inverted_index":{"In":[0,86],"nature,":[1],"polysaccharides,":[2],"such":[3],"as":[4,122],"cellulose,":[5],"are":[6,69,77,184],"important":[7,148],"biopolymers":[8],"involved":[9,186],"in":[10,108,138,187,198],"numerous":[11],"biological":[12,31],"functions":[13],"including":[14],"prevention":[15],"of":[16,74,94,104,117,127,153,158,192,205,216,232],"cellular":[17],"desiccation,":[18],"energy":[19],"storage,":[20],"osmoregulation,":[21],"and":[22,49,52,83,99,130,136,162,202,209],"cell":[23],"wall":[24],"formation.":[25],"Apart":[26],"from":[27],"having":[28],"a":[29,36,58,91,114],"relevant":[30],"role,":[32],"cellulose":[33,42,67,81,96,105,118,188,224],"also":[34],"has":[35],"great":[37],"economic":[38],"importance.":[39],"For":[40],"instance,":[41],"provides":[43],"the":[44,95,102,125,133,139,159,176,193,199,207,210,229,233,236],"raw":[45],"material":[46],"for":[47,61,79],"paper":[48],"textile":[50],"production,":[51],"it":[53],"is":[54],"predicted":[55],"to":[56,89,113,146,149,175],"become":[57],"key":[59],"precursor":[60],"glucose-derived":[62],"ethanol.":[63],"The":[64,190],"mechanisms":[65,76],"underlying":[66],"biosynthesis":[68,97],"not":[70,167],"completely":[71],"understood.":[72],"Elucidation":[73],"these":[75,182],"essential":[78],"efficient":[80],"production":[82],"industrial":[84],"applications.":[85],"an":[87],"effort":[88],"gain":[90],"better":[92],"understanding":[93],"process":[98,231],"its":[100],"regulation,":[101],"crystallization":[103,225],"was":[106],"investigated":[107],"Gluconacetobacter":[109],"xylinus":[110,141],"mutants":[111,165],"resistant":[112],"novel":[115],"inhibitor":[116],"I":[119],"formation":[120],"known":[121],"pellicin.":[123],"Through":[124],"use":[126],"forward":[128],"genetics":[129],"site-directed":[131],"mutagenesis,":[132],"mutations":[134,183],"A449T":[135,161],"A449V":[137,164],"G.":[140],"BcsA":[142,160,163,200,212,237],"protein":[143,201,238],"were":[144],"found":[145],"be":[147],"confer":[150],"high":[151],"levels":[152],"pellicin":[154,221],"resistance.":[155],"Phenotypic":[156],"analysis":[157,204],"did":[166],"reveal":[168],"other":[169],"apparent":[170],"phenotypic":[171],"alterations":[172],"when":[173],"compared":[174],"wild":[177],"type.":[178],"This":[179],"suggests":[180],"that":[181,220],"exclusively":[185],"crystallization.":[189],"localization":[191],"A449":[194],"amino":[195],"acid":[196],"residue":[197],"structural":[203],"both":[206],"native":[208],"mutant":[211],"proteins,":[213],"by":[214,227,240],"means":[215],"3D":[217],"modelling,":[218],"suggest":[219],"may":[222],"inhibit":[223],"either":[226],"affecting":[228],"translocation":[230],"glucan":[234],"within":[235],"or":[239],"allosterically":[241],"altering":[242],"protein-protein":[243],"interactions.":[244]},"counts_by_year":[],"updated_date":"2026-09-02T18:50:13.731487","created_date":"2016-08-23T00:00:00"}