{"id":"https://openalex.org/W2494965995","doi":"https://doi.org/10.1093/med/9780199783113.003.0032","title":"Clinical Trial Designs in Amyotrophic Lateral Sclerosis","display_name":"Clinical Trial Designs in Amyotrophic Lateral Sclerosis","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2494965995","doi":"https://doi.org/10.1093/med/9780199783113.003.0032","mag":"2494965995"},"language":"en","primary_location":{"id":"doi:10.1093/med/9780199783113.003.0032","doi":"https://doi.org/10.1093/med/9780199783113.003.0032","is_oa":false,"landing_page_url":"https://doi.org/10.1093/med/9780199783113.003.0032","pdf_url":null,"source":{"id":"https://openalex.org/S4306463708","display_name":"Oxford University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Motor Neuron Disease in Adults","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W614409869","display_name":"Motor Neuron Disease in Adults"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059617881","display_name":"Dan H. Moore","orcid":"https://orcid.org/0000-0002-5860-0127","observed_orcids":["https://orcid.org/0000-0002-5860-0127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan H. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110332015","display_name":"Mark B. Bromberg","orcid":"https://orcid.org/0000-0003-3230-7130","observed_orcids":["https://orcid.org/0000-0003-3230-7130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark B. Bromberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26896368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"298","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.4616999924182892,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.9909999966621399},{"id":"https://openalex.org/keywords/clinical-trial-endpoints","display_name":"clinical trial endpoints","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drug-efficacy-evaluation","display_name":"drug efficacy evaluation","score":0.746999979019165},{"id":"https://openalex.org/keywords/functional-outcome-measures","display_name":"functional outcome measures","score":0.7110000252723694},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9231073260307312},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5592032670974731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5493823289871216},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43577301502227783},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37541794776916504},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22391554713249207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17337387800216675},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09940019249916077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/med/9780199783113.003.0032","doi":"https://doi.org/10.1093/med/9780199783113.003.0032","is_oa":false,"landing_page_url":"https://doi.org/10.1093/med/9780199783113.003.0032","pdf_url":null,"source":{"id":"https://openalex.org/S4306463708","display_name":"Oxford University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Motor Neuron Disease in Adults","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1977549880","https://openalex.org/W2970689169","https://openalex.org/W4281746369","https://openalex.org/W2028688903","https://openalex.org/W2103326717","https://openalex.org/W3211109458","https://openalex.org/W4214675211","https://openalex.org/W2098791278","https://openalex.org/W2996442517","https://openalex.org/W2030932792"],"abstract_inverted_index":{"Abstract":[0],"Assessing":[1],"drug":[2,29,42],"or":[3,30],"intervention":[4,31],"efficacy":[5,32],"is":[6,15],"difficult":[7],"with":[8],"amyotrophic":[9],"lateral":[10],"sclerosis":[11],"(ALS)":[12],"because":[13],"there":[14],"a":[16,60],"wide":[17],"spectrum":[18],"of":[19,21,25,41,62],"regions":[20],"involvement":[22],"and":[23],"rates":[24],"progression.":[26],"In":[27],"addition,":[28],"does":[33],"not":[34],"result":[35],"in":[36,52],"functional":[37],"improvements.":[38],"A":[39],"variety":[40],"trial":[43],"endpoint":[44],"measures":[45],"have":[46],"been":[47,56],"developed,":[48],"but":[49],"their":[50],"sensitivity":[51],"clinical":[53],"trials":[54],"has":[55],"hampered":[57],"due":[58],"to":[59,69],"lack":[61],"effective":[63],"drugs.":[64],"This":[65],"chapter":[66],"reviews":[67],"efforts":[68],"design":[70],"efficient":[71],"trials.":[72]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}
