{"id":"https://openalex.org/W2494664255","doi":"https://doi.org/10.1158/1538-7445.am2016-1487","title":"Abstract 1487: Gene expression and linkage analysis implicates CBLB as a mediator of rituximab resistance","display_name":"Abstract 1487: Gene expression and linkage analysis implicates CBLB as a mediator of rituximab resistance","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2494664255","doi":"https://doi.org/10.1158/1538-7445.am2016-1487","mag":"2494664255"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-1487","doi":"https://doi.org/10.1158/1538-7445.am2016-1487","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1487","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"John Jack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Jack","raw_affiliation_strings":["1North Carolina State, Raleigh, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Carolina State, Raleigh, NC;","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005605346","display_name":"George W. Small","orcid":"https://orcid.org/0000-0002-7585-7258","observed_orcids":["https://orcid.org/0000-0002-7585-7258"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Small","raw_affiliation_strings":["2University of North Carolina - Chapel Hill, Chapel Hill, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina - Chapel Hill, Chapel Hill, NC;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014237654","display_name":"Tammy M. Havener","orcid":"https://orcid.org/0000-0002-4613-0498","observed_orcids":["https://orcid.org/0000-0002-4613-0498"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy Havener","raw_affiliation_strings":["2University of North Carolina - Chapel Hill, Chapel Hill, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of North Carolina - Chapel Hill, Chapel Hill, NC;","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111485617","display_name":"Chad Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad Brown","raw_affiliation_strings":["1North Carolina State, Raleigh, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Carolina State, Raleigh, NC;","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011034688","display_name":"Howard L. McLeod","orcid":"https://orcid.org/0000-0002-9004-9232","observed_orcids":["https://orcid.org/0000-0002-9004-9232"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard McLeod","raw_affiliation_strings":["3Moffitt Cancer Center, Tampa, FL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Moffitt Cancer Center, Tampa, FL;","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055785853","display_name":"Alison A. Motsinger\u2010Reif","orcid":"https://orcid.org/0000-0003-1346-2493","observed_orcids":["https://orcid.org/0000-0003-1346-2493"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Motsinger","raw_affiliation_strings":["1North Carolina State, Raleigh, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1North Carolina State, Raleigh, NC;","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054381821","display_name":"Kristy L. Richards","orcid":"https://orcid.org/0000-0001-5765-6631","observed_orcids":["https://orcid.org/0000-0001-5765-6631"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy L. Richards","raw_affiliation_strings":["4Cornell University, Ithaca, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cornell University, Ithaca, NY","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"1487","last_page":"1487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rituximab-resistance","display_name":"rituximab resistance","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cbl-b","display_name":"Cbl-b","score":0.8420000076293945},{"id":"https://openalex.org/keywords/monoclonal-antibody-resistance","display_name":"monoclonal antibody resistance","score":0.8539999723434448},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.4659999907016754},{"id":"https://openalex.org/keywords/smoc2","display_name":"SMOC2","score":0.7599999904632568},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.671999990940094},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7549999952316284},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.5820000171661377},{"id":"https://openalex.org/keywords/complement-dependent-cytotoxicity","display_name":"complement-dependent cytotoxicity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/bcl11a","display_name":"BCL11A","score":0.4650000035762787},{"id":"https://openalex.org/keywords/bcl11b","display_name":"BCL11B","score":0.5649999976158142},{"id":"https://openalex.org/keywords/bcl11c","display_name":"BCL11C","score":0.6430000066757202},{"id":"https://openalex.org/keywords/bcl11d","display_name":"BCL11D","score":0.6700000166893005},{"id":"https://openalex.org/keywords/bcl11e","display_name":"BCL11E","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.5498964786529541},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45386385917663574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43953707814216614},{"id":"https://openalex.org/C2778714382","wikidata":"https://www.wikidata.org/wiki/Q410656","display_name":"Ofatumumab","level":4,"score":0.43778735399246216},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.436504989862442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42085665464401245},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18798309564590454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-1487","doi":"https://doi.org/10.1158/1538-7445.am2016-1487","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-1487","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2775715487","https://openalex.org/W6987321417","https://openalex.org/W2066823421","https://openalex.org/W4379793150","https://openalex.org/W4386019587","https://openalex.org/W1721657566","https://openalex.org/W2119661337","https://openalex.org/W2992877157","https://openalex.org/W2527842532","https://openalex.org/W2068907607"],"abstract_inverted_index":{"Abstract":[0],"Drug":[1],"resistance":[2,22,415],"remains":[3],"one":[4,185,212],"of":[5,13,19,44,65,98,178,245,254,328,335,391,401,413,449,455,460],"the":[6,10,17,42,72,85,94,164,176,200,207,243,287,295,326,379,389,411,456,461],"largest":[7],"challenges":[8],"in":[9,23,25,93,293,316,337,357,365],"curative":[11],"treatment":[12,104],"cancer.":[14],"We":[15,312],"investigated":[16],"problem":[18],"monoclonal":[20],"antibody":[21,383],"vitro":[24],"a":[26,63,397,447],"high":[27],"throughput,":[28],"complement-dependent":[29],"cytotoxic":[30],"(CDC)":[31],"assay":[32],"using":[33,51,107,112,116],"immortalized":[34],"as":[35,37,416,418,446],"well":[36,417],"cancerous":[38,321],"cell":[39,57,318,338],"lines.":[40],"First,":[41],"heritability":[43],"rituximab":[45,100,128,169,196,220,247,264,332,350,450],"and":[46,78,122,129,137,147,156,174,221,230,266,320,342,351,386,441],"ofatumumab":[47,103,172,249,274],"sensitivity":[48,265,275],"was":[49,105,110,140,184,240,261,271,286,291,306,363],"explored":[50],"Epstein":[52],"Barr":[53],"Virus-immortalized":[54],"human":[55],"lymphoblastoid":[56],"lines":[58],"from":[59,71,84],"two":[60,222],"independent":[61],"sources:":[62],"collection":[64,81],"trios":[66],"(95":[67],"samples,":[68],"13":[69,257],"trios)":[70],"Centre":[73],"d\u2019Etude":[74],"du":[75],"Polymorphisme":[76],"Humain":[77],"an":[79],"unrelated":[80,166],"(486":[82],"samples)":[83],"Children's":[86],"Hospital":[87],"Oakland":[88],"Research":[89],"Initiative.":[90],"Cell":[91],"viability":[92],"presence":[95],"or":[96,101,248,298],"absence":[97],"10ug/ml":[99,102],"quantitated":[106],"AlamarBlue.":[108],"Heritability":[109],"estimated":[111],"variance":[113],"component":[114],"analysis":[115,205,443],"MERLIN:":[117],"H2":[118,123],"=":[119,124],"33.11%":[120],"(p<0.001)":[121,126],"31.11%":[125],"for":[127,195,219,225,308,464],"ofatumumab,":[130,226],"resp.":[131],"Next,":[132,203],"public":[133],"information":[134],"on":[135,163,206,216,227,282,331],"genotype":[136],"gene":[138,157,284,289],"expression":[139,158,238,260,270,330,440],"used":[141,313],"to":[142,323,345,348,395,408],"analyze":[143],"associations":[144],"between":[145,381],"loci/genes":[146],"drug":[148],"response":[149,197],"with":[150,242,263,273,367],"three":[151,191],"methods:":[152],"genome-wide":[153],"association,":[154],"linkage,":[155],"analysis.":[159],"GWAS":[160],"were":[161],"performed":[162,355],"486":[165],"samples:":[167],"(a)":[168],"responses,":[170,173],"(b)":[171],"(c)":[175],"vector":[177],"both":[179,283,340,349],"responses":[180],"modeled":[181],"jointly.":[182],"There":[183],"suggestive":[186],"(-log10(P)>6)":[187],"result":[188,194],"across":[189],"all":[190],"analyses;":[192],"this":[193],"occurred":[198],"within":[199],"gene,":[201],"SMOC2.":[202],"linkage":[204,214,301,442],"95":[208],"related":[209],"samples":[210],"revealed":[211,256],"significant":[213,223],"peak":[215],"chromosome":[217,228,296,299],"12":[218,229,300],"peaks":[224],"3.":[231],"Also,":[232],"we":[233,354],"identified":[234],"genes":[235,258,268],"whose":[236,259,269],"mRNA":[237],"level":[239],"correlated":[241,262,272],"degree":[244],"either":[246,294],"sensitivity.":[250],"Quantitative":[251],"Significance":[252],"Analysis":[253],"Microarrays":[255],"25":[267],"(false":[276],"discovery":[277],"rate":[278],"cutoff<0.001%).":[279],"CBLB,":[280,385],"present":[281],"lists,":[285],"only":[288],"that":[290],"located":[292],"3":[297],"peak.":[302],"As":[303],"such,":[304],"CBLB":[305,329,336,358,368,445],"chosen":[307],"further":[309,409],"functional":[310],"validation.":[311],"RNA":[314],"silencing":[315],"several":[317],"line":[319],"models":[322],"functionally":[324],"validate":[325],"role":[327],"resistance.":[333,451],"Knockdown":[334],"lines,":[339],"LCLs":[341],"lymphoma,":[343],"led":[344],"increased":[346],"resistant":[347],"ofatumumab.":[352],"Additionally,":[353],"immunofluorescence":[356],"knockdown":[359],"cells.":[360],"CD20":[361],"localization":[362],"altered":[364],"cells":[366],"knockdown.":[369],"Our":[370],"current":[371],"work":[372],"has":[373],"uncovered":[374],"new":[375],"mechanistic":[376],"insight":[377],"into":[378],"relationship":[380],"anti-CD20":[382],"susceptibility,":[384],"CD20,":[387],"illustrating":[388],"power":[390],"comprehensive":[392],"genetic":[393],"analyses":[394],"discover":[396],"previously":[398],"unknown":[399],"mediator":[400,448],"rituxumab":[402],"response.":[403],"Additional":[404],"studies":[405],"are":[406],"ongoing":[407],"elucidate":[410],"mechanisms":[412],"CBLB-mediated":[414],"its":[419],"clinical":[420],"relevance.":[421],"Citation":[422],"Format:":[423],"John":[424],"Jack,":[425],"George":[426],"Small,":[427],"Tammy":[428],"Havener,":[429],"Chad":[430],"Brown,":[431],"Howard":[432],"McLeod,":[433],"Alison":[434],"Motsinger,":[435],"Kristy":[436],"L.":[437],"Richards.":[438],"Gene":[439],"implicates":[444],"[abstract].":[452],"In:":[453],"Proceedings":[454],"107th":[457],"Annual":[458],"Meeting":[459],"American":[462],"Association":[463],"Cancer":[465,476],"Research;":[466],"2016":[467],"Apr":[468],"16-20;":[469],"New":[470],"Orleans,":[471],"LA.":[472],"Philadelphia":[473],"(PA):":[474],"AACR;":[475],"Res":[477],"2016;76(14":[478],"Suppl):Abstract":[479],"nr":[480],"1487.":[481]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-08-23T00:00:00"}
