{"id":"https://openalex.org/W2494220133","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e20661","title":"Comparison of eight commonly used regimens as first-line treatment of metastatic non-small lung cancer.","display_name":"Comparison of eight commonly used regimens as first-line treatment of metastatic non-small lung cancer.","publication_year":2016,"publication_date":"2016-05-20","ids":{"openalex":"https://openalex.org/W2494220133","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e20661","mag":"2494220133"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.15_suppl.e20661","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e20661","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e20661","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063772573","display_name":"Ahmed Ashour Badawy","orcid":"https://orcid.org/0000-0001-9567-3598","observed_orcids":["https://orcid.org/0000-0001-9567-3598"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG","US"],"is_corresponding":false,"raw_author_name":"Ahmed Ashour Badawy","raw_affiliation_strings":["Alexandria University and University of Alabama at Birmingham, Alexandria, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexandria University and University of Alabama at Birmingham, Alexandria, Egypt;","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003418175","display_name":"Waleed O. Arafat","orcid":"https://orcid.org/0000-0002-6617-5992","observed_orcids":["https://orcid.org/0000-0002-6617-5992"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Waleed O. Arafat","raw_affiliation_strings":["University Of Alexandria Egypt, Alexandria, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Of Alexandria Egypt, Alexandria, Egypt;","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608570","display_name":"Sejong Bae","orcid":"https://orcid.org/0000-0001-9982-3223","observed_orcids":["https://orcid.org/0000-0001-9982-3223"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sejong Bae","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL;","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103818675","display_name":"Abbas Omar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abbas Omar","raw_affiliation_strings":["Alexandria University Hospital, Alexandria, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexandria University Hospital, Alexandria, Egypt;","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004229337","display_name":"Gehan Abd Elatti Khedr","orcid":"https://orcid.org/0000-0003-3634-3956","observed_orcids":["https://orcid.org/0000-0003-3634-3956"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Gehan Abd Elatti Khedr","raw_affiliation_strings":["Alexandria School of Medicine, Alexandria, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alexandria School of Medicine, Alexandria, Egypt;","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062978212","display_name":"Stefan C. Grant","orcid":"https://orcid.org/0000-0001-9053-3852","observed_orcids":["https://orcid.org/0000-0001-9053-3852"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan C. Grant","raw_affiliation_strings":["Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC;","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"15_suppl","first_page":"e20661","last_page":"e20661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-nsclc","display_name":"metastatic non-small cell lung cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/treatment-regimen-comparison","display_name":"treatment regimen comparison","score":0.7940000295639038},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7260000109672546},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.843999981880188},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9290000200271606},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.859000027179718},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9023721218109131},{"id":"https://openalex.org/C2777240266","wikidata":"https://www.wikidata.org/wiki/Q415220","display_name":"Pemetrexed","level":4,"score":0.8381330966949463},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.7328908443450928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7274969816207886},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7052129507064819},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.6885197758674622},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6588326096534729},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6197697520256042},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6032652854919434},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.4536549150943756},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4478800296783447},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.44395729899406433},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3935942053794861},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3385831117630005},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.094370037317276},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.08612528443336487}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.15_suppl.e20661","doi":"https://doi.org/10.1200/jco.2016.34.15_suppl.e20661","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.15_suppl.e20661","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2580188001","https://openalex.org/W2658569466","https://openalex.org/W2134122287","https://openalex.org/W2026410269","https://openalex.org/W2011954462","https://openalex.org/W4301728004","https://openalex.org/W2414249691","https://openalex.org/W2342231480","https://openalex.org/W2940905346","https://openalex.org/W2046107487"],"abstract_inverted_index":{"e20661":[0],"Background:":[1],"Despite":[2],"the":[3,11,34,63,131,193,198],"wide":[4],"availability":[5],"of":[6,13,47,65,106],"many":[7],"chemotherapeutic":[8],"regimens":[9,39,50,103,217],"for":[10,109,127,139],"treatment":[12,27,38,49,75,95],"advanced":[14],"non-small":[15],"cell":[16,230],"lung":[17],"cancer":[18],"(NSCLC),":[19],"by":[20,72,87,157,164],"design":[21],"most":[22],"clinical":[23],"trials":[24],"compare":[25],"a":[26,29,44],"to":[28,52,69],"single":[30,293,301],"standard":[31],"regimen,":[32],"making":[33],"choice":[35],"between":[36,58,96],"various":[37],"challenging.":[40],"Methods:":[41],"We":[42],"undertook":[43],"retrospective":[45],"comparison":[46],"common":[48],"given":[51],"patients":[53,92,107,183,194,205,225],"with":[54,104,115,145,149,159,184,190,221,226],"stage":[55],"IV":[56],"NSCLC":[57],"2002":[59,97],"and":[60,85,98,119,124,214,228],"2012":[61],"at":[62,67],"University":[64],"Alabama":[66],"Birmingham":[68],"explore":[70],"outcomes":[71],"first":[73,132],"line":[74,133],"regimen.":[76,129],"Statistical":[77],"analysis":[78,110],"was":[79,155,201],"performed":[80],"using":[81],"SPSS":[82],"22":[83],"software":[84],"calculated":[86],"log-rank":[88],"testing":[89],"Results:":[90],"409":[91],"received":[93],"systemic":[94],"2012.":[99],"The":[100],"commonly":[101],"used":[102],"numbers":[105],"sufficient":[108],"are":[111],"summarized":[112],"in":[113,170,203,210,224],"table,":[114],"median":[116,120,152,160],"overall":[117,147,171],"survival":[118,123,161,172,200],"progression":[121],"free":[122],"histological":[125],"subtype":[126],"each":[128],"In":[130],"setting":[134],"tyrosine":[135],"kinase":[136,248],"inhibitors":[137],"(TKI)":[138],"EGFR":[140,186,196],"driven":[141],"mutations":[142,187],"were":[143,219],"associated":[144,220],"best":[146,189],"survival,":[148],"19.11":[150,250],"months":[151,237,241],"survival.":[153],"This":[154,168],"followed":[156,163],"paclitaxel/carboplatin/bevacizumab":[158],"18.3,":[162],"pemetrexed":[165,286,292],"containing":[166,216],"regimens.":[167],"difference":[169],"is":[173],"statistically":[174],"significant":[175],"(p":[176],"=":[177],"0.012).":[178],"Conclusions:":[179],"As":[180],"well":[181],"documented,":[182],"targetable":[185],"do":[188],"TKIs.":[191],"Of":[192],"without":[195],"mutations,":[197],"longest":[199],"observed":[202],"those":[204],"receiving":[206],"frontline":[207],"carboplatin/paclitaxel/bevacizumab":[208],"mainly":[209],"non-squama":[211],"histology.":[212],"Pemetrexed":[213],"gemcitabine":[215],"also":[218],"long":[222],"survivals":[223],"adenocarcinoma":[227],"squamous":[229],"histology":[231],"tumors,":[232],"respectively.":[233],"Regimens":[234],"Overall":[235],"Survival":[236,240],"Progression":[238],"Free":[239],"Histological":[242],"percentage":[243],"Adenocarcinoma":[244],"SCC":[245],"Other":[246],"Tyrosine":[247],"inhibitor":[249],"8.03":[251],"57.1":[252],"11.9":[253],"31":[254],"paclitaxel+":[255,263],"Carboplatin+":[256,278,285],"bevacizumab":[257],"18.03":[258],"7.11":[259],"67.9":[260],"10.7":[261],"21.4":[262],"carboplatin":[264],"11.31":[265],"4.50":[266],"40.6":[267],"23.6":[268],"35.8":[269],"Docetaxel":[270],"+":[271],"platinum":[272],"9.97":[273],"4.13":[274],"33.3":[275],"16.7":[276],"50":[277],"Gemcitabine":[279,300],"11.64":[280],"4.44":[281],"28.6":[282],"22.9":[283],"48.6":[284],"15.31":[287],"6.08":[288],"88":[289],"0":[290,305,307],"1":[291],"agent":[294,302],"16.92":[295],"5.77":[296],"59.3":[297],"25.9":[298],"14.8":[299],"15.15":[303],"4.95":[304],"100":[306]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-08-23T00:00:00"}