{"id":"https://openalex.org/W2494092147","doi":"https://doi.org/10.1111/tbj.12668","title":"Polymorphism of Metastasis Suppressor GenesMKK4andNME1in Kashmiri Patients with Breast Cancer","display_name":"Polymorphism of Metastasis Suppressor GenesMKK4andNME1in Kashmiri Patients with Breast Cancer","publication_year":2016,"publication_date":"2016-08-10","ids":{"openalex":"https://openalex.org/W2494092147","doi":"https://doi.org/10.1111/tbj.12668","mag":"2494092147","pmid":"https://pubmed.ncbi.nlm.nih.gov/27509166"},"language":"en","primary_location":{"id":"doi:10.1111/tbj.12668","doi":"https://doi.org/10.1111/tbj.12668","is_oa":true,"landing_page_url":"https://doi.org/10.1111/tbj.12668","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbj.12668","source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbj.12668","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014984386","display_name":"Beenish Iqbal","orcid":"https://orcid.org/0009-0008-9796-766X","observed_orcids":["https://orcid.org/0009-0008-9796-766X"]},"institutions":[{"id":"https://openalex.org/I135388327","display_name":"University of Kashmir","ror":"https://ror.org/032xfst36","country_code":"IN","type":"education","lineage":["https://openalex.org/I135388327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Beenish Iqbal","raw_affiliation_strings":["Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India","institution_ids":["https://openalex.org/I135388327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102020254","display_name":"Akbar Masood","orcid":"https://orcid.org/0000-0002-7288-1308","observed_orcids":["https://orcid.org/0000-0002-7288-1308"]},"institutions":[{"id":"https://openalex.org/I135388327","display_name":"University of Kashmir","ror":"https://ror.org/032xfst36","country_code":"IN","type":"education","lineage":["https://openalex.org/I135388327"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akbar Masood","raw_affiliation_strings":["Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India","institution_ids":["https://openalex.org/I135388327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057324682","display_name":"Mohd Maqbool Lone","orcid":"https://orcid.org/0000-0003-4605-8622","observed_orcids":["https://orcid.org/0000-0003-4605-8622"]},"institutions":[{"id":"https://openalex.org/I206040828","display_name":"Sher-i-Kashmir Institute of Medical Sciences","ror":"https://ror.org/03gd3wz76","country_code":"IN","type":"education","lineage":["https://openalex.org/I206040828"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohd Maqbool Lone","raw_affiliation_strings":["Department of Radiation Oncology, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India","institution_ids":["https://openalex.org/I206040828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108541145","display_name":"Abdul Rashid Lone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I206040828","display_name":"Sher-i-Kashmir Institute of Medical Sciences","ror":"https://ror.org/03gd3wz76","country_code":"IN","type":"education","lineage":["https://openalex.org/I206040828"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abdul Rashid Lone","raw_affiliation_strings":["Department of Medical Oncology, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, SK Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India","institution_ids":["https://openalex.org/I206040828"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004775875","display_name":"Nazir Ahmad Dar","orcid":"https://orcid.org/0000-0002-9517-9458","observed_orcids":["https://orcid.org/0000-0002-9517-9458"]},"institutions":[{"id":"https://openalex.org/I135388327","display_name":"University of Kashmir","ror":"https://ror.org/032xfst36","country_code":"IN","type":"education","lineage":["https://openalex.org/I135388327"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Nazir Ahmad Dar","raw_affiliation_strings":["Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir, India","institution_ids":["https://openalex.org/I135388327"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004775875"],"corresponding_institution_ids":["https://openalex.org/I135388327"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":null,"fwci":0.3464,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.66276143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"22","issue":"6","first_page":"673","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mkk4","display_name":"MKK4","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nm23","display_name":"nm23","score":0.9909999966621399},{"id":"https://openalex.org/keywords/metastasis-suppressor-gene","display_name":"metastasis suppressor gene","score":0.984000027179718},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9010000228881836},{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.9620000123977661},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6669999957084656},{"id":"https://openalex.org/keywords/lymph-node-involvement","display_name":"lymph node involvement","score":0.7730000019073486},{"id":"https://openalex.org/keywords/kashmiri-population","display_name":"Kashmiri population","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.8678971529006958},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8390660881996155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.647254228591919},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.6018383502960205},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.48877212405204773},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4706748425960541},{"id":"https://openalex.org/C2778025950","wikidata":"https://www.wikidata.org/wiki/Q6823243","display_name":"Metastasis suppressor","level":4,"score":0.4563522934913635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4141373932361603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3572142422199249},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.338482528924942},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31645116209983826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24367952346801758}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054778","descriptor_name":"NM23 Nucleoside Diphosphate Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/tbj.12668","doi":"https://doi.org/10.1111/tbj.12668","is_oa":true,"landing_page_url":"https://doi.org/10.1111/tbj.12668","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbj.12668","source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},{"id":"pmid:27509166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27509166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The breast journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/tbj.12668","doi":"https://doi.org/10.1111/tbj.12668","is_oa":true,"landing_page_url":"https://doi.org/10.1111/tbj.12668","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tbj.12668","source":{"id":"https://openalex.org/S169520197","display_name":"The Breast Journal","issn_l":"1075-122X","issn":["1075-122X","1524-4741"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Breast Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2494092147.pdf","grobid_xml":"https://content.openalex.org/works/W2494092147.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1531977757","https://openalex.org/W1553651506","https://openalex.org/W1979793976","https://openalex.org/W1981989535","https://openalex.org/W2006261729","https://openalex.org/W2006423274","https://openalex.org/W2007599495","https://openalex.org/W2017767253","https://openalex.org/W2018875909","https://openalex.org/W2022233074","https://openalex.org/W2036907820","https://openalex.org/W2039697985","https://openalex.org/W2055133484","https://openalex.org/W2070303204","https://openalex.org/W2080327105","https://openalex.org/W2089397084","https://openalex.org/W2099939399","https://openalex.org/W2117289493","https://openalex.org/W2118855824","https://openalex.org/W2127999360","https://openalex.org/W2147570487","https://openalex.org/W2155890719","https://openalex.org/W2804007336","https://openalex.org/W2916161913","https://openalex.org/W6631780823","https://openalex.org/W6632908295","https://openalex.org/W6675018125","https://openalex.org/W6681427686"],"related_works":["https://openalex.org/W2883156031","https://openalex.org/W3031533140","https://openalex.org/W2127999360","https://openalex.org/W1989688663","https://openalex.org/W4416574284","https://openalex.org/W4412730701","https://openalex.org/W4387611767","https://openalex.org/W2324512722","https://openalex.org/W1996951844","https://openalex.org/W7135404674"],"abstract_inverted_index":{"Genetic":[0],"polymorphisms":[1,26],"in":[2,14,31,53],"metastatic":[3],"suppressor":[4],"genes":[5,41],"like":[6],"MKK4":[7,23,40,89],"and":[8,24,27,39,48,58,61,92,113,153],"NME1":[9,25,38,144],"are":[10],"not":[11],"well":[12],"studied":[13],"breast":[15,28,55,78,93,127,154],"cancer.":[16,79,128],"Hence,":[17],"we":[18,83],"analyzed":[19,43],"the":[20,72,134],"relationship":[21],"between":[22,88,143],"cancer":[29,56,94,155],"risk":[30,125],"Kashmir,":[32],"India.":[33],"The":[34],"different":[35],"genotypes":[36,76,122],"of":[37,74,126,136],"were":[42,68,131],"by":[44],"polymerase":[45],"chain":[46],"reaction":[47],"restriction":[49],"fragment":[50],"length":[51],"polymorphism":[52,91],"130":[54],"cases":[57],"200":[59],"age-":[60],"sex-matched":[62],"controls.":[63],"Conditional":[64],"logistic":[65],"regression":[66],"models":[67],"used":[69],"to":[70,98],"assess":[71],"association":[73,87,142],"various":[75],"with":[77,103],"In":[80],"this":[81],"study,":[82],"found":[84],"an":[85],"inverse":[86],"promoter":[90],"risk.":[95],"As":[96],"compared":[97],"TT":[99],"(wild)":[100],"genotype,":[101],"individuals":[102],"TG":[104],"(heterozygous)":[105],"(OR":[106,116,147],"=":[107,111,117,120,148,151],"0.32;":[108],"95%":[109],"CI":[110,119,150],"(0.17-0.58)":[112],"GG":[114],"(mutant)":[115],"0.13;":[118],"0.04-0.40)":[121],"showed":[123],"decreased":[124],"When":[129],"participants":[130],"classified":[132],"on":[133],"basis":[135],"lymph":[137],"node":[138],"involvement,":[139],"a":[140],"strong":[141],"heterozygous":[145],"genotype":[146],"3.82;":[149],"(1.54-9.44)":[152],"was":[156],"found.":[157]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-08-23T00:00:00"}