{"id":"https://openalex.org/W2494001035","doi":"https://doi.org/10.2174/1381612822666160719110618","title":"Approaches to Improve Efficiency of Dendritic Cell-based Therapy of High Grade Gliomas","display_name":"Approaches to Improve Efficiency of Dendritic Cell-based Therapy of High Grade Gliomas","publication_year":2016,"publication_date":"2016-07-24","ids":{"openalex":"https://openalex.org/W2494001035","doi":"https://doi.org/10.2174/1381612822666160719110618","mag":"2494001035","pmid":"https://pubmed.ncbi.nlm.nih.gov/27510476"},"language":"en","primary_location":{"id":"doi:10.2174/1381612822666160719110618","doi":"https://doi.org/10.2174/1381612822666160719110618","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612822666160719110618","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043145631","display_name":"Dimitry A. Chistiakov","orcid":"https://orcid.org/0000-0001-9869-3607","observed_orcids":["https://orcid.org/0000-0001-9869-3607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dimitry Chistiakov","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006009957","display_name":"Ivan Vladimirovich Chekhonin","orcid":"https://orcid.org/0000-0002-6652-2472","observed_orcids":["https://orcid.org/0000-0002-6652-2472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Chekhonin","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012866812","display_name":"Olga Ivanovna Gurina","orcid":"https://orcid.org/0000-0001-6942-5531","observed_orcids":["https://orcid.org/0000-0001-6942-5531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga Gurina","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075043020","display_name":"Yuri Veniaminovich Bobryshev","orcid":"https://orcid.org/0000-0002-3745-321X","observed_orcids":["https://orcid.org/0000-0002-3745-321X"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yuri Bobryshev","raw_affiliation_strings":["Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia","Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.,Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086018071","display_name":"Vladimir Pavlovich Chekhonin","orcid":"https://orcid.org/0000-0003-4386-7897","observed_orcids":["https://orcid.org/0000-0003-4386-7897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir Chekhonin","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.43,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.58373791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"22","issue":"37","first_page":"5738","last_page":"5751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7383000254631042,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.26100000739097595,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.8289999961853027},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.8259999752044678},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-specific-antigens","display_name":"tumor-specific antigens","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.8551945686340332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7195172309875488},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.692632794380188},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6449100375175476},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6390625238418579},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5922332406044006},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.572956383228302},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5640928745269775},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5348832607269287},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5251338481903076},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5182756781578064},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.49776673316955566},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4409838318824768},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4184381365776062},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41833603382110596},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37379950284957886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24861988425254822},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17688438296318054}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612822666160719110618","doi":"https://doi.org/10.2174/1381612822666160719110618","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612822666160719110618","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:27510476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27510476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3208865630","https://openalex.org/W3203366820","https://openalex.org/W4311142312","https://openalex.org/W4386751186","https://openalex.org/W2883891816","https://openalex.org/W1525911437","https://openalex.org/W2328548638","https://openalex.org/W1965696789","https://openalex.org/W7063751054","https://openalex.org/W2292411590"],"abstract_inverted_index":{"High":[0],"grade":[1],"gliomas":[2],"(HGGs)":[3],"are":[4,138],"the":[5,26,99,196],"most":[6],"frequent":[7],"and":[8,28,46,92,105,120,146,159,176,201],"highly":[9,103],"invasive":[10],"type":[11],"of":[12,56,164],"brain":[13],"tumors,":[14],"which":[15],"arise":[16],"from":[17],"glial":[18],"cells.":[19,96],"Among":[20],"HGGs,":[21],"glioblastoma":[22],"multiforme":[23],"(GBM)":[24],"is":[25,79,102],"commonest":[27],"deadliest":[29],"tumor":[30,37,100,199],"type.":[31],"Standard":[32],"HGG":[33,133,181],"therapy":[34,166],"that":[35,190],"involves":[36],"resection":[38],"followed":[39],"by":[40,149],"concomitant":[41],"treatment":[42,134,182],"with":[43,67,73,156,167],"radiation":[44],"exposure":[45],"temozolomide":[47],"(TMZ)":[48],"cannot":[49],"prevent":[50],"recurrent":[51],"tumor.":[52],"The":[53],"median":[54],"survival":[55],"treated":[57],"patients":[58],"after":[59],"surgery":[60],"does":[61],"not":[62],"exceed":[63],"1.5":[64],"years.":[65],"Vaccination":[66],"autologous":[68],"dendritic":[69],"cells":[70],"(DCs)":[71],"pulsed":[72],"tumor-specific":[74],"peptides,":[75],"antigens,":[76],"or":[77,137],"lysates":[78],"considered":[80],"as":[81],"a":[82,87],"promising":[83],"option":[84,193],"to":[85,112,194],"induce":[86],"potent":[88],"anti-tumor":[89,152],"immune":[90,153,197,206],"response":[91],"cytotoxicity":[93],"against":[94,116],"GBM":[95],"However,":[97],"since":[98],"microenvironment":[101,200],"immunosuppressive":[104],"immunotolerant,":[106],"specialized":[107],"approaches":[108,178],"should":[109,179],"be":[110],"applied":[111],"protect":[113],"DC":[114,130,142,165,203],"transplants":[115],"tumor-induced":[117],"functional":[118],"impairment":[119],"inhibition.":[121],"So":[122],"far,":[123],"many":[124],"phase":[125],"I-III":[126],"clinical":[127],"trials":[128],"utilizing":[129],"vaccines":[131],"for":[132],"were":[135],"completed":[136],"underway.":[139],"In":[140,184],"summary,":[141],"vaccination":[143],"was":[144],"safe":[145],"well":[147],"tolerated":[148],"patients.":[150],"DC-induced":[151],"responses":[154],"correlated":[155],"prolonged":[157],"overall":[158],"progression-":[160],"free":[161],"survival.":[162],"Combination":[163],"other":[168],"interventional":[169],"strategies":[170,189],"(i.e.,":[171],"radiotherapy,":[172],"chemotherapy,":[173],"antibodies,":[174],"etc.)":[175],"multimodal":[177],"improve":[180],"outcomes.":[183],"this":[185],"review,":[186],"we":[187],"consider":[188],"provide":[191],"an":[192],"override":[195],"inhibitory":[198],"boost":[202],"vaccine-based":[204],"antitumor":[205],"response.":[207]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-08-23T00:00:00"}