{"id":"https://openalex.org/W249374603","doi":null,"title":"Effects of spinal TLR3 activation in non-neuronal cells of rats on pain processing","display_name":"Effects of spinal TLR3 activation in non-neuronal cells of rats on pain processing","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W249374603","mag":"249374603"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt3pv3h123","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3pv3h123","pdf_url":"https://escholarship.org/uc/item/3pv3h123","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/3pv3h123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064309597","display_name":"Hamid Ehsani-Nia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hamid Ehsani-Nia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064309597"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.9620000123977661},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.796999990940094},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8669999837875366},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":1.0},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.7279999852180481},{"id":"https://openalex.org/keywords/polyinosinic-polycytidylic-acid","display_name":"polyinosinic-polycytidylic acid","score":0.8330000042915344},{"id":"https://openalex.org/keywords/intrathecal-administration","display_name":"intrathecal administration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pentoxifylline","display_name":"pentoxifylline","score":1.0},{"id":"https://openalex.org/keywords/ketorolac","display_name":"ketorolac","score":0.9900000095367432},{"id":"https://openalex.org/keywords/valdecoxib","display_name":"valdecoxib","score":1.0},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.875},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.6320000290870667},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6694798469543457},{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.6157047152519226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6143395304679871},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5920704007148743},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5809441804885864},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.5443112850189209},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5220698714256287},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5157740116119385},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.4850234389305115},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37608009576797485},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37493643164634705},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3743244409561157},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3264460861682892},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.3239659368991852},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3155946731567383},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2823103666305542},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17382991313934326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15124410390853882},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07909765839576721},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt3pv3h123","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3pv3h123","pdf_url":"https://escholarship.org/uc/item/3pv3h123","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:249374603","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt3pv3h123/qt3pv3h123.pdf?t=n229gq","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt3pv3h123","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3pv3h123","pdf_url":"https://escholarship.org/uc/item/3pv3h123","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W249374603.pdf","grobid_xml":"https://content.openalex.org/works/W249374603.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W69042384","https://openalex.org/W1502048985","https://openalex.org/W1503511302","https://openalex.org/W1526689294","https://openalex.org/W1535641516","https://openalex.org/W1537626170","https://openalex.org/W1542136448","https://openalex.org/W1548862642","https://openalex.org/W1555940993","https://openalex.org/W1612226764","https://openalex.org/W1979859079","https://openalex.org/W1980538131","https://openalex.org/W1986178107","https://openalex.org/W1989124419","https://openalex.org/W1990378054","https://openalex.org/W1990445317","https://openalex.org/W1991550485","https://openalex.org/W1996016174","https://openalex.org/W1996639413","https://openalex.org/W1998028366","https://openalex.org/W2000787206","https://openalex.org/W2002212851","https://openalex.org/W2003646312","https://openalex.org/W2003674452","https://openalex.org/W2003830841","https://openalex.org/W2005384145","https://openalex.org/W2006785548","https://openalex.org/W2007415551","https://openalex.org/W2008820260","https://openalex.org/W2009182920","https://openalex.org/W2010067410","https://openalex.org/W2015173171","https://openalex.org/W2016754754","https://openalex.org/W2017523469","https://openalex.org/W2033634651","https://openalex.org/W2036693151","https://openalex.org/W2036717742","https://openalex.org/W2038994511","https://openalex.org/W2040725197","https://openalex.org/W2041008164","https://openalex.org/W2044639383","https://openalex.org/W2047391267","https://openalex.org/W2048434698","https://openalex.org/W2049449151","https://openalex.org/W2049593742","https://openalex.org/W2061188274","https://openalex.org/W2062957919","https://openalex.org/W2064441562","https://openalex.org/W2070312747","https://openalex.org/W2077179568","https://openalex.org/W2077486035","https://openalex.org/W2078736915","https://openalex.org/W2080436444","https://openalex.org/W2081130105","https://openalex.org/W2086214436","https://openalex.org/W2089633836","https://openalex.org/W2090285876","https://openalex.org/W2090640877","https://openalex.org/W2092413554","https://openalex.org/W2095461860","https://openalex.org/W2097331976","https://openalex.org/W2100530619","https://openalex.org/W2107182434","https://openalex.org/W2113617025","https://openalex.org/W2113723285","https://openalex.org/W2117558614","https://openalex.org/W2118295691","https://openalex.org/W2120229762","https://openalex.org/W2121761530","https://openalex.org/W2126112217","https://openalex.org/W2127269510","https://openalex.org/W2134940821","https://openalex.org/W2135247591","https://openalex.org/W2137590150","https://openalex.org/W2140441724","https://openalex.org/W2147457499","https://openalex.org/W2151825728","https://openalex.org/W2159017711","https://openalex.org/W2160316566","https://openalex.org/W2162730620","https://openalex.org/W2164320307","https://openalex.org/W2170019750","https://openalex.org/W2172201406","https://openalex.org/W7096831481"],"related_works":["https://openalex.org/W2561437065","https://openalex.org/W2067491197","https://openalex.org/W1139140741","https://openalex.org/W1970047152","https://openalex.org/W4297905480","https://openalex.org/W4301385380","https://openalex.org/W4381681814","https://openalex.org/W1521689093","https://openalex.org/W2157715974","https://openalex.org/W2015196837"],"abstract_inverted_index":{"Toll-Like":[0],"Receptor":[1],"3":[2],"(TLR3)":[3],"is":[4],"a":[5,75,234,247],"receptor":[6],"of":[7,35,149,162,175,211,230,237],"the":[8,62,78,120,143,150,157,212],"innate":[9],"immune":[10],"system.":[11],"TLR3":[12,38,231],"exists":[13],"within":[14],"spinal":[15,28,37],"glial":[16,41,176],"cells":[17],"which":[18],"are":[19],"known":[20],"to":[21,48,112,192],"play":[22],"an":[23,45,209],"important":[24],"role":[25],"in":[26,74,77,88,119,137,142,156,222,244],"facilitating":[27],"pain":[29,122,239],"processing.":[30],"We":[31],"hypothesized":[32],"that":[33,228],"activation":[34,42,141,229],"these":[36,59],"would":[39],"cause":[40],"and":[43,109,130,139,146,164,180,189,196,205],"initiate":[44,233],"enhanced":[46],"response":[47],"noxious":[49],"stimuli.":[50],"Using":[51],"rats":[52],"with":[53,85],"chronic":[54],"lumbar":[55],"intrathecal":[56,173,193],"(IT)":[57],"catheters":[58],"studies":[60],"demonstrated":[61],"following":[63],"observations.":[64],"1)":[65],"IT":[66,105,113,127,216],"Polyinosine":[67],"-polycytidylic":[68],"acid":[69],"(Poly":[70],"I:C,":[71],"100[mu]g)":[72],"resulted":[73],"fall":[76],"tactile":[79],"threshold":[80],"(tactile":[81],"allodynia":[82],":":[83],"TA)":[84],"no":[86,220],"change":[87,221],"thermal":[89],"escape":[90],"by":[91,246],"24":[92],"hrs.":[93],"The":[94],"TA":[95],"lasted":[96],"at":[97,132,167,198,242],"least":[98,243],"though":[99],"4":[100],"days.":[101],"2)":[102],"Rats":[103,125,171],"receiving":[104,126,172],"minocycline,":[106],"pentoxifylline,":[107],"ketorolac":[108],"valdecoxib":[110],"prior":[111,191],"Poly":[114,128,194,217],"I:C":[115,129,195,218],"showed":[116,135,201],"significant":[117],"decreases":[118],"persistent":[121,235],"state.":[123],"3)":[124],"sacrificed":[131,197],"day":[133,168,199],"1":[134,200],"increases":[136],"astrocyte":[138,204],"microglia":[140,165,206],"superficial":[144],"lamina":[145,148],"deep":[147],"dorsal":[151],"horn":[152],"as":[153,155,182,184],"well":[154,183],"ventral":[158],"horn.":[159],"4)":[160],"Activation":[161],"astrocytes":[163],"diminished":[166],"4.":[169],"5)":[170],"pretreatments":[174],"inhibiting":[177],"drugs":[178,187],"(minocycline":[179],"pentoxifylline)":[181],"COX":[185],"blocking":[186],"(ketorolac":[188],"valdecoxib)":[190],"normal":[202],"levels":[203],"activation,":[207],"indicating":[208],"inhibition":[210],"nociceptive":[213],"cascade.":[214],"6)":[215],"produced":[219],"nocturnal":[223],"behavior.":[224],"These":[225],"results":[226],"indicate":[227],"can":[232],"cascade":[236,250],"facilitated":[238],"processing,":[240],"mediated":[241],"part":[245],"glially":[248],"related":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}