{"id":"https://openalex.org/W249325067","doi":"https://doi.org/10.2527/1993.71171x","title":"Influence of repeated restraint and isolation stress and electrolyte administration on pituitary-adrenal secretions, electrolytes, and other blood constituents of sheep1","display_name":"Influence of repeated restraint and isolation stress and electrolyte administration on pituitary-adrenal secretions, electrolytes, and other blood constituents of sheep1","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W249325067","doi":"https://doi.org/10.2527/1993.71171x","mag":"249325067","pmid":"https://pubmed.ncbi.nlm.nih.gov/8384198"},"language":"en","primary_location":{"id":"doi:10.2527/1993.71171x","doi":"https://doi.org/10.2527/1993.71171x","is_oa":false,"landing_page_url":"https://doi.org/10.2527/1993.71171x","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091008525","display_name":"JASON K. APPLE","orcid":"https://orcid.org/0000-0001-5318-1093","observed_orcids":["https://orcid.org/0000-0001-5318-1093"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. K. Apple","raw_affiliation_strings":["Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114003816","display_name":"J. E. Minton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. E. Minton","raw_affiliation_strings":["Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109397927","display_name":"K. M. Parsons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. M. Parsons","raw_affiliation_strings":["Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103353124","display_name":"John A. Unruh","orcid":"https://orcid.org/0000-0002-4660-1421","observed_orcids":["https://orcid.org/0000-0002-4660-1421"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Unruh","raw_affiliation_strings":["Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201","institution_ids":["https://openalex.org/I189590672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5114003816"],"corresponding_institution_ids":["https://openalex.org/I189590672"],"apc_list":{"value":4368,"currency":"USD","value_usd":4368},"apc_paid":null,"fwci":4.3393,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.92889123,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"71","issue":"1","first_page":"71","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10838","display_name":"Animal Behavior and Welfare Studies","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10838","display_name":"Animal Behavior and Welfare Studies","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.13019999861717224,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12365","display_name":"Effects of Environmental Stressors on Livestock","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.9039999842643738},{"id":"https://openalex.org/keywords/isolation-stress","display_name":"isolation stress","score":0.921999990940094},{"id":"https://openalex.org/keywords/pituitary-adrenal-axis","display_name":"pituitary-adrenal axis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/serum-electrolytes","display_name":"serum electrolytes","score":0.824999988079071},{"id":"https://openalex.org/keywords/serum-calcium","display_name":"serum calcium","score":0.8389999866485596},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/electrolyte-supplementation","display_name":"electrolyte supplementation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.46000000834465027},{"id":"https://openalex.org/keywords/lambs","display_name":"lambs","score":0.9010000228881836},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7099317908287048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.688030481338501},{"id":"https://openalex.org/C2776877979","wikidata":"https://www.wikidata.org/wiki/Q424288","display_name":"Transaminase","level":3,"score":0.6556521654129028},{"id":"https://openalex.org/C68801617","wikidata":"https://www.wikidata.org/wiki/Q162908","display_name":"Electrolyte","level":3,"score":0.5642684698104858},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.4878375828266144},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4694485366344452},{"id":"https://openalex.org/C2779429693","wikidata":"https://www.wikidata.org/wiki/Q274959","display_name":"Distilled water","level":2,"score":0.4496293365955353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36135661602020264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1652761697769165},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1534270942211151},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12453123927116394},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010913","descriptor_name":"Pituitary-Adrenal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012149","descriptor_name":"Restraint, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012757","descriptor_name":"Sheep Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2527/1993.71171x","doi":"https://doi.org/10.2527/1993.71171x","is_oa":false,"landing_page_url":"https://doi.org/10.2527/1993.71171x","pdf_url":null,"source":{"id":"https://openalex.org/S72684844","display_name":"Journal of Animal Science","issn_l":"0021-8812","issn":["0021-8812","1525-3015","1525-3163","1544-7847"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Animal Science","raw_type":"journal-article"},{"id":"pmid:8384198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8384198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of animal science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1482266597","https://openalex.org/W1540547397","https://openalex.org/W1569325250","https://openalex.org/W1585159514","https://openalex.org/W1972562473","https://openalex.org/W2058227278","https://openalex.org/W2079403859","https://openalex.org/W2085305905","https://openalex.org/W2110775244","https://openalex.org/W2162027308","https://openalex.org/W2308011384","https://openalex.org/W2398073145","https://openalex.org/W2411775612","https://openalex.org/W2412445524","https://openalex.org/W2417004268","https://openalex.org/W2417671381","https://openalex.org/W2439980479","https://openalex.org/W2473936225","https://openalex.org/W4297914956"],"related_works":["https://openalex.org/W2414281391","https://openalex.org/W2166975263","https://openalex.org/W2084847918","https://openalex.org/W1733948103","https://openalex.org/W2606608226","https://openalex.org/W2413257925","https://openalex.org/W2014502674","https://openalex.org/W2067176793","https://openalex.org/W2411775612","https://openalex.org/W4243452360"],"abstract_inverted_index":{"Crossbred":[0],"lambs":[1,183,191],"(n":[2],"=":[3],"24)":[4],"were":[5,118],"blocked":[6],"by":[7],"weight":[8],"and":[9,39,43,73,79,133,143,159,172,181,199,223,236],"assigned":[10],"within":[11],"blocks":[12],"to":[13,67,154,166,217],"four":[14],"treatments":[15],"applied":[16],"in":[17,56,219,229],"two":[18],"replications":[19],"of":[20,37,99,103,109,113,128,130,149,169,232,261],"a":[21],"2":[22,24],"x":[23],"factorial":[25],"arrangement.":[26],"Main":[27],"effects":[28,243],"included":[29],"no":[30,250],"stress":[31,41,225],"(NS)":[32],"or":[33,49,93,256],"three":[34,85],"consecutive":[35,86],"days":[36],"restraint":[38],"isolation":[40,224],"(RIS)":[42],"treatment":[44,59,151,248],"with":[45,76],"either":[46,90],"water":[47],"(W)":[48],"an":[50],"electrolyte":[51,157],"(E)":[52],"solution.":[53],"Each":[54],"lamb":[55],"the":[57,100,107,110,140,147,185],"RIS":[58,180,220],"group":[60],"was":[61,137,211],"moved":[62],"from":[63,71],"its":[64],"home":[65],"stanchion":[66],"another":[68],"room,":[69],"isolated":[70],"visual":[72],"tactile":[74],"contact":[75],"other":[77,160,258],"lambs,":[78],"restrained":[80],"for":[81,123,126],"6":[82,124],"h":[83,125,145],"on":[84,97,244,253],"days.":[87],"Lambs":[88],"received":[89],"distilled":[91],"W":[92],"E":[94],"(320":[95],"mL)":[96],"each":[98],"3":[101],"d":[102,112],"stressor":[104,114,150,188],"treatment.":[105],"On":[106],"morning":[108],"3rd":[111],"treatment,":[115],"blood":[116,136,161],"samples":[117],"collected":[119,138],"at":[120,139],"1-h":[121],"intervals":[122],"determination":[127],"concentrations":[129,158,168,202,231],"ACTH,":[131,170,233],"cortisol,":[132,171,234],"lactate.":[134],"Also,":[135],"conclusion":[141],"of,":[142],"18":[144],"after,":[146],"termination":[148],"(at":[152],"slaughter)":[153],"measure":[155],"serum":[156,197,245],"constituents.":[162],"Polynomial":[163],"curves":[164],"fit":[165],"plasma":[167,230],"lactate":[173],"data":[174],"differed":[175],"(P":[176,194,213],"<":[177,195,214],".005)":[178],"between":[179],"NS":[182,205],"during":[184],"last":[186],"6-h":[187],"bout.":[189],"Stressed":[190],"had":[192,241,249],"lower":[193],".05)":[196,215],"calcium":[198],"alkaline":[200],"phosphatase":[201],"than":[203],"did":[204],"lambs.":[206,221],"Serum":[207],"glutamic":[208,237],"oxaloacetic":[209,238],"transaminase":[210,239],"increased":[212],"20-":[216],"30-fold":[218],"Restraint":[222],"caused":[226],"clear":[227],"increases":[228],"lactate,":[235],"but":[240],"minimal":[242],"electrolytes.":[246],"Electrolyte":[247],"appreciable":[251],"effect":[252],"pituitary-adrenal":[254],"secretions":[255],"any":[257],"measured":[259],"component":[260],"blood.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}