{"id":"https://openalex.org/W2493219106","doi":"https://doi.org/10.1093/annonc/mdw289","title":"Temporal and spatial discordance of programmed cell death-ligand 1 expression and lymphocyte tumor infiltration between paired primary lesions and brain metastases in lung cancer","display_name":"Temporal and spatial discordance of programmed cell death-ligand 1 expression and lymphocyte tumor infiltration between paired primary lesions and brain metastases in lung cancer","publication_year":2016,"publication_date":"2016-08-08","ids":{"openalex":"https://openalex.org/W2493219106","doi":"https://doi.org/10.1093/annonc/mdw289","mag":"2493219106","pmid":"https://pubmed.ncbi.nlm.nih.gov/27502709","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5035793"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdw289","doi":"https://doi.org/10.1093/annonc/mdw289","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdw289","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/annonc/mdw289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A.S. Mansfield","raw_affiliation_strings":["Division of Medical Oncology, Departments of Oncology mansfield.aaron@mayo.edu","Division of Medical Oncology, Departments of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Departments of Oncology mansfield.aaron@mayo.edu","institution_ids":[]},{"raw_affiliation_string":"Division of Medical Oncology, Departments of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029041878","display_name":"MC Aubry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.C. Aubry","raw_affiliation_strings":["Laboratory Medicine and Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine and Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082674870","display_name":"Justin C. Moser","orcid":"https://orcid.org/0000-0002-0643-6759","observed_orcids":["https://orcid.org/0000-0002-0643-6759"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.C. Moser","raw_affiliation_strings":["Internal Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001422801","display_name":"Susan M. Harrington","orcid":"https://orcid.org/0000-0001-8112-0896","observed_orcids":["https://orcid.org/0000-0001-8112-0896"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.M. Harrington","raw_affiliation_strings":["Urology Immunology","Immunology","Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Immunology","institution_ids":[]},{"raw_affiliation_string":"Immunology","institution_ids":[]},{"raw_affiliation_string":"Urology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027176998","display_name":"Roxana Stefania Dronca","orcid":"https://orcid.org/0000-0002-5345-2268","observed_orcids":["https://orcid.org/0000-0002-5345-2268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.S. Dronca","raw_affiliation_strings":["Division of Medical Oncology, Departments of Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Departments of Oncology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043967516","display_name":"S. S. Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.S. Park","raw_affiliation_strings":["Radiation Oncology, Mayo Clinic, Rochester, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Mayo Clinic, Rochester, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038413156","display_name":"Haidong Dong","orcid":"https://orcid.org/0000-0002-5782-2983","observed_orcids":["https://orcid.org/0000-0002-5782-2983","https://orcid.org/0000-0001-8543-661X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Dong","raw_affiliation_strings":["Urology Immunology","Immunology","Urology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Immunology","institution_ids":[]},{"raw_affiliation_string":"Immunology","institution_ids":[]},{"raw_affiliation_string":"Urology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071440718"],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":{"value":5080,"currency":"USD","value_usd":5080},"fwci":17.5008,"has_fulltext":false,"cited_by_count":338,"citation_normalized_percentile":{"value":0.99508433,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"27","issue":"10","first_page":"1953","last_page":"1958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6669999957084656},{"id":"https://openalex.org/keywords/spatiotemporal-heterogeneity","display_name":"spatiotemporal heterogeneity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.843999981880188},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8896905183792114},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7231821417808533},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.7228765487670898},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5929520130157471},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5022563934326172},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.43117085099220276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23726102709770203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11924117803573608},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000066491","descriptor_name":"Clinical Decision-Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/annonc/mdw289","doi":"https://doi.org/10.1093/annonc/mdw289","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdw289","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5035793","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5035793","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Oncol","raw_type":"Text"},{"id":"pmid:27502709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27502709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:annonc:27/10/1953","doi":null,"is_oa":false,"landing_page_url":"http://annonc.oxfordjournals.org/cgi/content/short/27/10/1953","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdw289","doi":"https://doi.org/10.1093/annonc/mdw289","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdw289","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000866180","display_name":"Mayo Clinic Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA015083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000881388","display_name":"Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic","funder_award_id":"K12CA090628","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W155985006","https://openalex.org/W1568317937","https://openalex.org/W1889335134","https://openalex.org/W1977381583","https://openalex.org/W1990779902","https://openalex.org/W2013090484","https://openalex.org/W2016983859","https://openalex.org/W2050302729","https://openalex.org/W2057893793","https://openalex.org/W2062952095","https://openalex.org/W2066671159","https://openalex.org/W2088270805","https://openalex.org/W2096027620","https://openalex.org/W2101670384","https://openalex.org/W2103277177","https://openalex.org/W2104347254","https://openalex.org/W2123918574","https://openalex.org/W2156353875","https://openalex.org/W2158804744","https://openalex.org/W2165623281","https://openalex.org/W2165625761","https://openalex.org/W2175480754","https://openalex.org/W2181211402","https://openalex.org/W2198093519","https://openalex.org/W2205987892","https://openalex.org/W2210073947","https://openalex.org/W2282352166","https://openalex.org/W2346198650","https://openalex.org/W2560367415","https://openalex.org/W2572174216"],"related_works":["https://openalex.org/W3213903455","https://openalex.org/W4296342867","https://openalex.org/W2885270262","https://openalex.org/W2946818852","https://openalex.org/W2997018338","https://openalex.org/W2892374454","https://openalex.org/W2981789309","https://openalex.org/W3191083304","https://openalex.org/W2793974615","https://openalex.org/W4391160865"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"dynamics":[2,23],"of":[3,21,24,93,107,126,161,200,230,236],"PD-L1":[4,25,52,63,96,109,127,148,167,221],"expression":[5,26,55,64,97,110,125,149],"may":[6],"limit":[7],"its":[8],"use":[9],"as":[10],"a":[11,140,218],"tissue-based":[12],"predictive":[13],"biomarker.":[14],"We":[15,82,189],"sought":[16],"to":[17,211],"expand":[18],"our":[19],"understanding":[20],"the":[22,71,157,162,180,197,228,231,237],"and":[27,44,49,53,70,105,150,205,233],"tumor-infiltrating":[28],"lymphocytes":[29],"(TILs)":[30],"in":[31,98,111,156,179,227],"patients":[32,213],"with":[33,59,121,214,217],"lung":[34,42,182,203,215],"cancer-related":[35],"brain":[36,45,163,206],"metastases.":[37,207],"EXPERIMENTAL":[38],"DESIGN:":[39],"Paired":[40],"primary":[41,181,202],"cancers":[43,204],"metastases":[46,164],"were":[47,65,77,128,137,153,177],"identified":[48,190],"assessed":[50],"for":[51,79],"CD3":[54],"by":[56],"immunohistochemistry.":[57],"Lesions":[58],"5%":[60],"or":[61,73,131,172,220],"greater":[62],"considered":[66],"positive.":[67],"Agreement":[68],"statistics":[69],"\u03c7(2)":[72],"Fisher's":[74],"exact":[75],"test":[76],"used":[78],"analysis.":[80],"RESULTS:":[81],"analyzed":[83],"146":[84],"paired":[85,119,201],"lesions":[86,120],"from":[87],"73":[88],"cases.":[89],"There":[90],"was":[91],"disagreement":[92,106],"tumor":[94,123,142,169,198,238],"cell":[95,124],"10":[99],"cases":[100,113],"(14%,":[101],"\u03ba":[102,115],"=":[103,116,186],"0.71),":[104],"TIL":[108],"19":[112],"(26%,":[114],"0.38).":[117],"Most":[118],"discordant":[122],"obtained":[129],"6":[130],"more":[132],"months":[133],"apart.":[134],"When":[135,208],"specimens":[136,184],"categorized":[138],"using":[139],"proposed":[141],"microenvironment":[143,199],"categorization":[144],"scheme":[145],"based":[146],"on":[147],"TILs,":[151],"there":[152,192],"significant":[154,194],"changes":[155],"classifications":[158],"because":[159],"many":[160],"lacked":[165],"either":[166],"expression,":[168],"lymphocyte":[170],"infiltration":[171],"both":[173],"even":[174],"when":[175],"they":[176,223],"present":[178],"cancer":[183,216],"(P":[185],"0.009).":[187],"CONCLUSIONS:":[188],"that":[191],"are":[193],"differences":[195],"between":[196],"physicians":[209],"decide":[210],"treat":[212],"PD-1":[219],"inhibitor,":[222],"must":[224],"do":[225],"so":[226],"context":[229],"spatial":[232],"temporal":[234],"heterogeneity":[235],"microenvironment.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":35},{"year":2022,"cited_by_count":43},{"year":2021,"cited_by_count":45},{"year":2020,"cited_by_count":41},{"year":2019,"cited_by_count":40},{"year":2018,"cited_by_count":40},{"year":2017,"cited_by_count":33},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-08-23T00:00:00"}