{"id":"https://openalex.org/W2493087768","doi":"https://doi.org/10.3109/9780849375965-2","title":"Background for Nonchemists","display_name":"Background for Nonchemists","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2493087768","doi":"https://doi.org/10.3109/9780849375965-2","mag":"2493087768"},"language":"en","primary_location":{"id":"doi:10.3109/9780849375965-2","doi":"https://doi.org/10.3109/9780849375965-2","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9780849375965-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4251941377","display_name":"Drug Metabolism"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039008828","display_name":"Jack Uetrecht","orcid":"https://orcid.org/0000-0003-1024-1302","observed_orcids":["https://orcid.org/0000-0003-1024-1302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack P. Uetrecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111461042","display_name":"William F. Trager","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Trager","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18790497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.4480000138282776,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.4480000138282776,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.15780000388622284,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.12049999833106995,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-properties","display_name":"drug properties","score":0.8579999804496765},{"id":"https://openalex.org/keywords/drug-receptor-interactions","display_name":"drug-receptor interactions","score":0.7319999933242798},{"id":"https://openalex.org/keywords/enzyme-interaction","display_name":"enzyme interaction","score":0.7279999852180481},{"id":"https://openalex.org/keywords/water-solubility","display_name":"water solubility","score":0.9750000238418579},{"id":"https://openalex.org/keywords/molecular-charge","display_name":"molecular charge","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.675000011920929},{"id":"https://openalex.org/keywords/drug-distribution","display_name":"drug distribution","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-excretion","display_name":"drug excretion","score":0.8610000014305115},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ion-dipole-interactions","display_name":"ion-dipole interactions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acids-and-bases","display_name":"acids and bases","score":0.9110000133514404},{"id":"https://openalex.org/keywords/conjugate-acid-base-pairs","display_name":"conjugate acid-base pairs","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3529232144355774},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.33200937509536743}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3109/9780849375965-2","doi":"https://doi.org/10.3109/9780849375965-2","is_oa":false,"landing_page_url":"https://doi.org/10.3109/9780849375965-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2032747912","https://openalex.org/W4244806755"],"related_works":["https://openalex.org/W3004259121","https://openalex.org/W1626565280","https://openalex.org/W2947196032","https://openalex.org/W57989646","https://openalex.org/W4234146299","https://openalex.org/W2321465493","https://openalex.org/W2496623717","https://openalex.org/W2086806820","https://openalex.org/W2921370831","https://openalex.org/W7219053095"],"abstract_inverted_index":{"The":[0,48,135],"properties":[1,44],"and":[2,18,68,70,123,146],"pharmacological":[3],"effects":[4],"of":[5,28,45,50,138,150],"drugs":[6],"are":[7],"due":[8],"to":[9,82],"their":[10],"interactions":[11,34,96],"with":[12,35,107],"other":[13,110],"molecules":[14],"such":[15,102],"as":[16],"enzymes":[17],"receptors.":[19],"Water":[20],"solubility,":[21,57],"which":[22],"is":[23,31,114,126,142,154],"a":[24,29,39,46,51,61,75,78,121,124,133,139,143,151,155],"very":[25],"important":[26],"property":[27],"drug,":[30],"based":[32],"on":[33,42,64],"water.":[36],"Charge":[37],"has":[38,60],"major":[40,62],"effect":[41,63],"the":[43,100,147],"drug.":[47],"presence":[49],"charge":[52,76],"not":[53],"only":[54],"increases":[55],"water":[56,108],"but":[58],"also":[59],"its":[65],"absorption,":[66],"distribution,":[67],"excretion,":[69,84],"many":[71],"metabolic":[72],"pathways":[73],"introduce":[74],"onto":[77],"drug":[79],"in":[80],"order":[81],"increase":[83],"especially":[85],"renal":[86],"excretion.":[87],"In":[88],"larger":[89],"molecules,":[90],"hydrogen":[91],"bonds":[92],"or":[93,109],"even":[94],"iondipole":[95],"can":[97,119,131],"occur":[98],"within":[99],"molecule":[101],"that":[103,118,130],"they":[104],"interact":[105],"less":[106],"molecules.":[111],"An":[112],"acid":[113,137,145,149],"any":[115,127],"chemical":[116,128],"entity":[117,129],"donate":[120],"proton":[122],"base":[125,141,153],"accept":[132],"proton.":[134],"conjugate":[136,148],"weak":[140,156],"strong":[144,152],"acid.":[157]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}