{"id":"https://openalex.org/W2492790556","doi":"https://doi.org/10.1016/b978-0-12-374145-5.00257-6","title":"Complexity of Stress Signaling","display_name":"Complexity of Stress Signaling","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2492790556","doi":"https://doi.org/10.1016/b978-0-12-374145-5.00257-6","mag":"2492790556"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-374145-5.00257-6","doi":"https://doi.org/10.1016/b978-0-12-374145-5.00257-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-374145-5.00257-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Cell Signaling","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2560320833","display_name":"Handbook of Cell Signaling"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044507284","display_name":"Daniel R. Hyduke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Hyduke","raw_affiliation_strings":["Department of Bioengineering, University of California-San Diego, La Jolla, California","John B. Little Center for the Radiation Sciences and Environmental Health, Harvard School of Public Health, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California-San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"John B. Little Center for the Radiation Sciences and Environmental Health, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039752024","display_name":"Sally A. Amundson","orcid":"https://orcid.org/0000-0001-9992-8818","observed_orcids":["https://orcid.org/0000-0001-9992-8818"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally A. Amundson","raw_affiliation_strings":["Center for Radiological Research, Columbia University Medical Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Radiological Research, Columbia University Medical Center, New York","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076492425","display_name":"Albert J. Fornace","orcid":"https://orcid.org/0000-0001-9695-085X","observed_orcids":["https://orcid.org/0000-0001-9695-085X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert J. Fornace","raw_affiliation_strings":["John B. Little Center for the Radiation Sciences and Environmental Health, Harvard School of Public Health, Boston, Massachusetts","Lombardi Comprehensive Cancer Center, and Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John B. Little Center for the Radiation Sciences and Environmental Health, Harvard School of Public Health, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, and Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3858,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.68903704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"2107","last_page":"2125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.27079999446868896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.27079999446868896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.21660000085830688,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.19130000472068787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress-signaling","display_name":"stress signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.7900000214576721},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9440000057220459},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9430000185966492},{"id":"https://openalex.org/keywords/electron-leakage","display_name":"electron leakage","score":0.527999997138977},{"id":"https://openalex.org/keywords/complex-i","display_name":"complex I","score":0.6610000133514404},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9430000185966492},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8420000076293945},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.9589999914169312},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8410000205039978},{"id":"https://openalex.org/keywords/phosphorelay","display_name":"phosphorelay","score":0.8679999709129333},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7699999809265137},{"id":"https://openalex.org/keywords/acetylation","display_name":"acetylation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/isgylation","display_name":"ISGylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/nitrosylation","display_name":"nitrosylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6936177015304565},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6847479939460754},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6825350522994995},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6548237800598145},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5462446212768555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44495853781700134},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4153675138950348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40799641609191895},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3749934136867523},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21056002378463745}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-12-374145-5.00257-6","doi":"https://doi.org/10.1016/b978-0-12-374145-5.00257-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-374145-5.00257-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Cell Signaling","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":271,"referenced_works":["https://openalex.org/W142337791","https://openalex.org/W144423133","https://openalex.org/W151786846","https://openalex.org/W1494567425","https://openalex.org/W1527632333","https://openalex.org/W1532078988","https://openalex.org/W1542272425","https://openalex.org/W1546139069","https://openalex.org/W1577834403","https://openalex.org/W1581582023","https://openalex.org/W1590514634","https://openalex.org/W1594833373","https://openalex.org/W1616121322","https://openalex.org/W1650754258","https://openalex.org/W1675626679","https://openalex.org/W1787381913","https://openalex.org/W1909048318","https://openalex.org/W1964803257","https://openalex.org/W1966115284","https://openalex.org/W1967630574","https://openalex.org/W1967686012","https://openalex.org/W1969883652","https://openalex.org/W1970090817","https://openalex.org/W1970136142","https://openalex.org/W1970140396","https://openalex.org/W1970156673","https://openalex.org/W1970579593","https://openalex.org/W1972482541","https://openalex.org/W1972831673","https://openalex.org/W1974888722","https://openalex.org/W1975644211","https://openalex.org/W1979319210","https://openalex.org/W1980438612","https://openalex.org/W1981317342","https://openalex.org/W1982085892","https://openalex.org/W1985289402","https://openalex.org/W1985372480","https://openalex.org/W1985652307","https://openalex.org/W1987091328","https://openalex.org/W1988163167","https://openalex.org/W1988377311","https://openalex.org/W1989076816","https://openalex.org/W1989454102","https://openalex.org/W1992686564","https://openalex.org/W1996264210","https://openalex.org/W1998129814","https://openalex.org/W1998464042","https://openalex.org/W2004547943","https://openalex.org/W2004724154","https://openalex.org/W2004932721","https://openalex.org/W2005236007","https://openalex.org/W2005281324","https://openalex.org/W2006173503","https://openalex.org/W2008374869","https://openalex.org/W2008656776","https://openalex.org/W2008743975","https://openalex.org/W2010711320","https://openalex.org/W2014323289","https://openalex.org/W2014895432","https://openalex.org/W2016066165","https://openalex.org/W2016492849","https://openalex.org/W2017489364","https://openalex.org/W2018201204","https://openalex.org/W2018843280","https://openalex.org/W2019736640","https://openalex.org/W2021727296","https://openalex.org/W2022417639","https://openalex.org/W2022811243","https://openalex.org/W2022957486","https://openalex.org/W2023735966","https://openalex.org/W2024994588","https://openalex.org/W2025638498","https://openalex.org/W2026297232","https://openalex.org/W2027821655","https://openalex.org/W2027844138","https://openalex.org/W2028019289","https://openalex.org/W2029395237","https://openalex.org/W2029793430","https://openalex.org/W2029796493","https://openalex.org/W2029934673","https://openalex.org/W2030098073","https://openalex.org/W2030570585","https://openalex.org/W2031414445","https://openalex.org/W2033525264","https://openalex.org/W2033536968","https://openalex.org/W2034405939","https://openalex.org/W2036421201","https://openalex.org/W2036546456","https://openalex.org/W2038049104","https://openalex.org/W2038252034","https://openalex.org/W2038563918","https://openalex.org/W2039408641","https://openalex.org/W2040640278","https://openalex.org/W2040852689","https://openalex.org/W2041075518","https://openalex.org/W2041193942","https://openalex.org/W2045289095","https://openalex.org/W2045687954","https://openalex.org/W2046106802","https://openalex.org/W2048254922","https://openalex.org/W2048674295","https://openalex.org/W2049108649","https://openalex.org/W2050306073","https://openalex.org/W2050994990","https://openalex.org/W2050996284","https://openalex.org/W2051690544","https://openalex.org/W2052447164","https://openalex.org/W2053279361","https://openalex.org/W2054060734","https://openalex.org/W2054307806","https://openalex.org/W2055303628","https://openalex.org/W2055364097","https://openalex.org/W2057744474","https://openalex.org/W2057949133","https://openalex.org/W2059073003","https://openalex.org/W2060004514","https://openalex.org/W2061060103","https://openalex.org/W2061298521","https://openalex.org/W2061587634","https://openalex.org/W2065566217","https://openalex.org/W2065773243","https://openalex.org/W2066765509","https://openalex.org/W2067913768","https://openalex.org/W2068206902","https://openalex.org/W2068513294","https://openalex.org/W2069055534","https://openalex.org/W2069628816","https://openalex.org/W2069645361","https://openalex.org/W2071442537","https://openalex.org/W2071468228","https://openalex.org/W2072249943","https://openalex.org/W2073207327","https://openalex.org/W2074114480","https://openalex.org/W2075497030","https://openalex.org/W2077033733","https://openalex.org/W2077479630","https://openalex.org/W2077953882","https://openalex.org/W2078850445","https://openalex.org/W2079115295","https://openalex.org/W2079472722","https://openalex.org/W2084104357","https://openalex.org/W2084299666","https://openalex.org/W2084459589","https://openalex.org/W2084586873","https://openalex.org/W2084908610","https://openalex.org/W2086472100","https://openalex.org/W2086939601","https://openalex.org/W2087106147","https://openalex.org/W2087312216","https://openalex.org/W2087790613","https://openalex.org/W2088308108","https://openalex.org/W2089574530","https://openalex.org/W2092758029","https://openalex.org/W2092915443","https://openalex.org/W2094478098","https://openalex.org/W2094908106","https://openalex.org/W2095752149","https://openalex.org/W2098132781","https://openalex.org/W2098761151","https://openalex.org/W2099113454","https://openalex.org/W2102304447","https://openalex.org/W2102435984","https://openalex.org/W2103709309","https://openalex.org/W2105462242","https://openalex.org/W2105657039","https://openalex.org/W2105804516","https://openalex.org/W2107067315","https://openalex.org/W2108547322","https://openalex.org/W2109271488","https://openalex.org/W2109748156","https://openalex.org/W2109893157","https://openalex.org/W2111446846","https://openalex.org/W2111476798","https://openalex.org/W2111900629","https://openalex.org/W2111984347","https://openalex.org/W2112651905","https://openalex.org/W2113791211","https://openalex.org/W2114069643","https://openalex.org/W2116000203","https://openalex.org/W2118001641","https://openalex.org/W2118567506","https://openalex.org/W2118733942","https://openalex.org/W2120100970","https://openalex.org/W2121604817","https://openalex.org/W2121619203","https://openalex.org/W2122128696","https://openalex.org/W2123775239","https://openalex.org/W2125775877","https://openalex.org/W2126760155","https://openalex.org/W2126918333","https://openalex.org/W2127230663","https://openalex.org/W2127322546","https://openalex.org/W2127639686","https://openalex.org/W2127848114","https://openalex.org/W2128032802","https://openalex.org/W2128680272","https://openalex.org/W2129903518","https://openalex.org/W2130410032","https://openalex.org/W2130979840","https://openalex.org/W2131632095","https://openalex.org/W2131970968","https://openalex.org/W2132305988","https://openalex.org/W2134650984","https://openalex.org/W2135453449","https://openalex.org/W2138268741","https://openalex.org/W2138297556","https://openalex.org/W2140781522","https://openalex.org/W2140948740","https://openalex.org/W2141326128","https://openalex.org/W2142026383","https://openalex.org/W2143629217","https://openalex.org/W2143996615","https://openalex.org/W2144065739","https://openalex.org/W2144154026","https://openalex.org/W2144318283","https://openalex.org/W2144665159","https://openalex.org/W2145355816","https://openalex.org/W2145545235","https://openalex.org/W2146355613","https://openalex.org/W2149991291","https://openalex.org/W2150562727","https://openalex.org/W2152653671","https://openalex.org/W2153080177","https://openalex.org/W2155208683","https://openalex.org/W2155229070","https://openalex.org/W2155640249","https://openalex.org/W2156990953","https://openalex.org/W2158507854","https://openalex.org/W2159099751","https://openalex.org/W2159212221","https://openalex.org/W2160637452","https://openalex.org/W2161045918","https://openalex.org/W2161409973","https://openalex.org/W2162298790","https://openalex.org/W2163199119","https://openalex.org/W2163235555","https://openalex.org/W2163296115","https://openalex.org/W2163386603","https://openalex.org/W2163394323","https://openalex.org/W2164786703","https://openalex.org/W2165582828","https://openalex.org/W2166078611","https://openalex.org/W2166522896","https://openalex.org/W2166785715","https://openalex.org/W2167804446","https://openalex.org/W2168065678","https://openalex.org/W2168459422","https://openalex.org/W2168841715","https://openalex.org/W2168846334","https://openalex.org/W2168909179","https://openalex.org/W2170033314","https://openalex.org/W2171322586","https://openalex.org/W2171407623","https://openalex.org/W2172114433","https://openalex.org/W2175416669","https://openalex.org/W2245834004","https://openalex.org/W2316716290","https://openalex.org/W2334459459","https://openalex.org/W2409614837","https://openalex.org/W2410208266","https://openalex.org/W2539646193","https://openalex.org/W2961146810","https://openalex.org/W3099289621","https://openalex.org/W4212962560","https://openalex.org/W4234219391","https://openalex.org/W4238261567","https://openalex.org/W4246939468","https://openalex.org/W4292140522","https://openalex.org/W6637067916","https://openalex.org/W6676792355","https://openalex.org/W7096869818"],"related_works":["https://openalex.org/W1980445160","https://openalex.org/W2107601804","https://openalex.org/W3170684510","https://openalex.org/W3009610935","https://openalex.org/W1978423374","https://openalex.org/W70313559","https://openalex.org/W2597447268","https://openalex.org/W3111329531","https://openalex.org/W4383371785","https://openalex.org/W2906799341"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}