{"id":"https://openalex.org/W2492777075","doi":"https://doi.org/10.1158/1538-7445.am2016-2174","title":"Abstract 2174: A high-throughput, high-content assay for the discovery of new inhibitors of DNA double-strand break repair","display_name":"Abstract 2174: A high-throughput, high-content assay for the discovery of new inhibitors of DNA double-strand break repair","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2492777075","doi":"https://doi.org/10.1158/1538-7445.am2016-2174","mag":"2492777075"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-2174","doi":"https://doi.org/10.1158/1538-7445.am2016-2174","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-2174","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005079725","display_name":"Yulia V. Surovtseva","orcid":"https://orcid.org/0000-0001-6079-9246","observed_orcids":["https://orcid.org/0000-0001-6079-9246"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yulia Surovtseva","raw_affiliation_strings":["1Yale University, West Haven, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Yale University, West Haven, CT;","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077056042","display_name":"Vikram Jairam","orcid":"https://orcid.org/0000-0001-6602-7204","observed_orcids":["https://orcid.org/0000-0001-6602-7204"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Jairam","raw_affiliation_strings":["2Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016318219","display_name":"Ranjini K. Sundaram","orcid":"https://orcid.org/0000-0002-5725-0284","observed_orcids":["https://orcid.org/0000-0002-5725-0284"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjini Sundaram","raw_affiliation_strings":["2Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040738951","display_name":"Ranjit S. Bindra","orcid":"https://orcid.org/0000-0002-3255-0467","observed_orcids":["https://orcid.org/0000-0002-3255-0467"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ranjit Bindra","raw_affiliation_strings":["2Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055878366","display_name":"Seth B. Herzon","orcid":"https://orcid.org/0000-0001-5940-9853","observed_orcids":["https://orcid.org/0000-0001-5940-9853"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Herzon","raw_affiliation_strings":["2Yale University, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yale University, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"2174","last_page":"2174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dna-repair-inhibitors","display_name":"DNA repair inhibitors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"high-content screening","score":0.5809999704360962},{"id":"https://openalex.org/keywords/high-throughput-assay","display_name":"high-throughput assay","score":0.7149999737739563},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9860000014305115},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cardiac-glycosides","display_name":"cardiac glycosides","score":0.9290000200271606},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.8949999809265137},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6313377618789673},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6297608017921448},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6281550526618958},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5267505049705505},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.52154541015625},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.4912235140800476},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.4595029056072235},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4315233826637268},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4221956729888916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38830652832984924},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32012414932250977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2512630224227905}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-2174","doi":"https://doi.org/10.1158/1538-7445.am2016-2174","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-2174","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2595775277","https://openalex.org/W759905330","https://openalex.org/W4389881830","https://openalex.org/W2164419505","https://openalex.org/W3083062515","https://openalex.org/W2106057323","https://openalex.org/W4317391498","https://openalex.org/W2604404138","https://openalex.org/W2086210951","https://openalex.org/W2296744697"],"abstract_inverted_index":{"Abstract":[0],"DNA":[1,27,65,74,95,192,261,360],"repair":[2,28,57,75,148],"pathways":[3,62],"are":[4,171,318,328],"being":[5],"intensively":[6],"investigated":[7],"as":[8,150,152,257,333],"targets":[9],"for":[10,23,41,142,155,248,292,321,331,353,376],"chemotherapeutic":[11],"interventions.":[12],"Despite":[13],"the":[14,24,42,48,59,79,112,201,224,227,233,238,249,269,273,277,354,368,373],"immense":[15],"interest":[16],"in":[17,223,245,323],"this":[18,198,280,293,300],"area,":[19],"few":[20],"whole-cell":[21],"screens":[22],"discovery":[25,44,355],"of":[26,45,47,73,81,107,114,123,133,158,181,203,229,240,251,260,272,279,312,356,359,367,372],"inhibitors":[29,46,259,358],"have":[30,34,102,267],"been":[31],"described.":[32],"We":[33,100,183],"developed":[35,103],"an":[36,290],"automated,":[37],"whole-cell,":[38],"high-throughput":[39,153,186],"assay":[40,69,187,352],"unbiased":[43],"non-homologous":[49],"end":[50],"joining":[51],"(NHEJ)":[52],"and":[53,83,93,117,130,146,161,168,173,191,196,212,254,297,335],"homologous":[54],"recombination":[55],"HR)":[56],"pathways,":[58],"two":[60],"primary":[61,167],"that":[63,299],"ameliorate":[64],"double-strand":[66,262,361],"breaks.":[67],"Our":[68,287],"enables":[70],"indirect":[71],"measurement":[72],"activity":[76,281,301],"by":[77],"monitoring":[78],"kinetics":[80],"\u03b3H2AX":[82],"53BP1":[84],"foci":[85],"resolution":[86],"after":[87],"treatment":[88,250],"with":[89,208],"ionizing":[90],"radiation":[91],"(IR)":[92],"candidate":[94],"damage":[96,193],"response":[97],"(DDR)":[98],"inhibitor.":[99],"also":[101,235],"a":[104,284],"unique":[105],"platform":[106,138],"secondary":[108,169],"assays":[109,141,154,170],"to":[110,127,177,216,237],"rank-order":[111],"potency":[113],"lead":[115,236],"compounds":[116,214,317],"gain":[118],"insights":[119],"into":[120,305],"their":[121],"mechanism":[122],"action.":[124],"In":[125],"addition":[126],"hit":[128],"validation":[129],"rigorous":[131],"exclusion":[132],"false-positive":[134],"hits,":[135],"our":[136,166,185,230],"follow-up":[137],"includes":[139],"orthogonal":[140],"measuring":[143],"mutagenic":[144],"NHEJ":[145],"HR":[147],"activity,":[149,220],"well":[151],"quantitative":[156],"analysis":[157],"cell":[159,162],"viability":[160],"cycle.":[163],"Notably,":[164,232],"both":[165],"fully-automated":[172],"may":[174],"be":[175,303],"applied":[176,197],"screen":[178,199,234],"large":[179],"libraries":[180],"compounds.":[182],"validated":[184],"using":[188],"known":[189,209,215],"DDR":[190,218],"checkpoint":[194],"inhibitors,":[195],"toward":[200],"evaluation":[202],"2,366":[204],"structurally-diverse":[205],"small":[206],"molecules":[207],"bioactivity.":[210],"Vorinostat":[211],"quercetin,":[213],"possess":[217],"inhibitory":[219],"were":[221],"identified":[222],"screen,":[225],"supporting":[226],"sensitivity":[228],"approach.":[231],"identification":[239],"cardiac":[241,274],"glycosides,":[242,275],"natural":[243],"products":[244],"clinical":[246,310],"use":[247,322],"heart":[252],"failure":[253],"atrial":[255],"arrhythmia,":[256],"potent":[258],"break":[263,362],"repair.":[264,363],"Many":[265],"studies":[266],"noted":[268],"anticancer":[270],"properties":[271],"but":[276],"basis":[278],"has":[282],"remained":[283],"\u201cblack":[285],"box\u201d.":[286],"data":[288],"suggest":[289],"explanation":[291],"long-standing":[294],"unsolved":[295],"problem,":[296],"argue":[298],"should":[302],"taken":[304],"consideration":[306],"when":[307],"evaluating":[308],"other":[309],"applications":[311],"these":[313,316],"agents.":[314],"Because":[315],"already":[319],"approved":[320],"humans,":[324],"we":[325],"believe":[326],"they":[327],"excellent":[329],"candidates":[330],"repurposing":[332],"chemo":[334],"radiosensitizers.":[336],"Citation":[337],"Format:":[338],"Yulia":[339],"Surovtseva,":[340],"Vikram":[341],"Jairam,":[342],"Ranjini":[343],"Sundaram,":[344],"Ranjit":[345],"Bindra,":[346],"Seth":[347],"Herzon.":[348],"A":[349],"high-throughput,":[350],"high-content":[351],"new":[357],"[abstract].":[364],"In:":[365],"Proceedings":[366],"107th":[369],"Annual":[370],"Meeting":[371],"American":[374],"Association":[375],"Cancer":[377,388],"Research;":[378],"2016":[379],"Apr":[380],"16-20;":[381],"New":[382],"Orleans,":[383],"LA.":[384],"Philadelphia":[385],"(PA):":[386],"AACR;":[387],"Res":[389],"2016;76(14":[390],"Suppl):Abstract":[391],"nr":[392],"2174.":[393]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-08-23T00:00:00"}
