{"id":"https://openalex.org/W2492634878","doi":"https://doi.org/10.1016/j.aott.2016.06.007","title":"Efficacy of preoperative administration of single high dose intravenous tranexamic acid in reducing blood loss in total knee arthroplasty: A prospective clinical study","display_name":"Efficacy of preoperative administration of single high dose intravenous tranexamic acid in reducing blood loss in total knee arthroplasty: A prospective clinical study","publication_year":2016,"publication_date":"2016-07-17","ids":{"openalex":"https://openalex.org/W2492634878","doi":"https://doi.org/10.1016/j.aott.2016.06.007","mag":"2492634878","pmid":"https://pubmed.ncbi.nlm.nih.gov/27435332","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6197312"},"language":"en","primary_location":{"id":"doi:10.1016/j.aott.2016.06.007","doi":"https://doi.org/10.1016/j.aott.2016.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aott.2016.06.007","pdf_url":"https://www.aott.org.tr/Content/files/sayilar/385/385-3710.pdf","source":{"id":"https://openalex.org/S104441155","display_name":"Acta Orthopaedica et Traumatologica Turcica","issn_l":"1017-995X","issn":["1017-995X","2589-1294"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Orthopaedica et Traumatologica Turcica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aott.org.tr/Content/files/sayilar/385/385-3710.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028945164","display_name":"Turgut Akg\u00fcl","orcid":"https://orcid.org/0000-0002-0704-3797","observed_orcids":["https://orcid.org/0000-0002-0704-3797"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Turgut Akg\u00fcl","raw_affiliation_strings":["\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey. Electronic address: doktorturgut@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey. Electronic address: doktorturgut@yahoo.com","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031129748","display_name":"Mehmet Ilke Buget","orcid":"https://orcid.org/0000-0002-8321-6346","observed_orcids":["https://orcid.org/0000-0002-8321-6346"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Buget","raw_affiliation_strings":["\u0130stanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130stanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047024309","display_name":"Ahmet Salduz","orcid":"https://orcid.org/0000-0001-9448-6416","observed_orcids":["https://orcid.org/0000-0001-9448-6416"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Salduz","raw_affiliation_strings":["\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey","Istanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey","institution_ids":["https://openalex.org/I67581229"]},{"raw_affiliation_string":"Istanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034712232","display_name":"\u0130pek Saadet Edipo\u011flu","orcid":"https://orcid.org/0000-0002-3510-5991","observed_orcids":["https://orcid.org/0000-0002-3510-5991"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130pek Edipo\u011flu","raw_affiliation_strings":["\u0130stanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130stanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021240986","display_name":"Mehmet Ekinci","orcid":"https://orcid.org/0000-0001-5251-8280","observed_orcids":["https://orcid.org/0000-0001-5251-8280"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Ekinci","raw_affiliation_strings":["\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076066279","display_name":"S\u00fcleyman K\u00fc\u00e7\u00fckay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S\u00fcleyman K\u00fc\u00e7\u00fckay","raw_affiliation_strings":["\u0130stanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130stanbul University, Istanbul Faculty of Medicine, Department of Anaesthesiology, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045718610","display_name":"Cengiz \u015een","orcid":"https://orcid.org/0000-0001-9788-580X","observed_orcids":["https://orcid.org/0000-0001-9788-580X"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cengiz \u015een","raw_affiliation_strings":["\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0130stanbul University, Istanbul Faculty of Medicine, Department of Orthopaedics and Traumatology, Turkey","institution_ids":["https://openalex.org/I67581229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028945164"],"corresponding_institution_ids":["https://openalex.org/I67581229"],"apc_list":{"value":990,"currency":"USD","value_usd":990},"apc_paid":{"value":990,"currency":"USD","value_usd":990},"fwci":3.8347,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.93581606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"50","issue":"4","first_page":"429","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12548","display_name":"Hemostasis and retained surgical items","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":0.9959999918937683},{"id":"https://openalex.org/keywords/perioperative-blood-loss","display_name":"perioperative blood loss","score":0.9120000004768372},{"id":"https://openalex.org/keywords/preoperative-administration","display_name":"preoperative administration","score":0.5709999799728394},{"id":"https://openalex.org/keywords/intravenous-tranexamic-acid","display_name":"intravenous tranexamic acid","score":0.7170000076293945},{"id":"https://openalex.org/keywords/postoperative-drainage","display_name":"postoperative drainage","score":0.8059999942779541},{"id":"https://openalex.org/keywords/red-blood-cell-transfusion","display_name":"red blood cell transfusion","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9844646453857422},{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.9633492231369019},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6402637958526611},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6350723505020142},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.6204978823661804},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.6009742021560669},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5755367279052734},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.558817982673645},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.4871308505535126},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.46522945165634155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1239069402217865}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016063","descriptor_name":"Blood Loss, Surgical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019106","descriptor_name":"Postoperative Hemorrhage","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.aott.2016.06.007","doi":"https://doi.org/10.1016/j.aott.2016.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aott.2016.06.007","pdf_url":"https://www.aott.org.tr/Content/files/sayilar/385/385-3710.pdf","source":{"id":"https://openalex.org/S104441155","display_name":"Acta Orthopaedica et Traumatologica Turcica","issn_l":"1017-995X","issn":["1017-995X","2589-1294"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Orthopaedica et Traumatologica Turcica","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5147669","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6197312","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:27435332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27435332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta orthopaedica et traumatologica turcica","raw_type":"Controlled Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:6197312","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6197312/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Orthop Traumatol Turc","raw_type":"Text"},{"id":"pmh:oai:dnet:scipediaopen::2ea88971adeec0a65ee2880de040e1b2","doi":null,"is_oa":true,"landing_page_url":"https://www.scipedia.com/public/Akgul_et_al_2016a","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f9c204b4558a460c9133a705dd1a5002","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f9c204b4558a460c9133a705dd1a5002","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Orthopaedica et Traumatologica Turcica, Vol 50, Iss 4, Pp 429-431 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.aott.2016.06.007","doi":"https://doi.org/10.1016/j.aott.2016.06.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.aott.2016.06.007","pdf_url":"https://www.aott.org.tr/Content/files/sayilar/385/385-3710.pdf","source":{"id":"https://openalex.org/S104441155","display_name":"Acta Orthopaedica et Traumatologica Turcica","issn_l":"1017-995X","issn":["1017-995X","2589-1294"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Orthopaedica et Traumatologica Turcica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2492634878.pdf","grobid_xml":"https://content.openalex.org/works/W2492634878.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1967836655","https://openalex.org/W1983524750","https://openalex.org/W1983583305","https://openalex.org/W1984164333","https://openalex.org/W1991362539","https://openalex.org/W2004736807","https://openalex.org/W2010416645","https://openalex.org/W2011332416","https://openalex.org/W2017238690","https://openalex.org/W2029217378","https://openalex.org/W2039547663","https://openalex.org/W2039922513","https://openalex.org/W2078966348","https://openalex.org/W2083963404","https://openalex.org/W2093820005","https://openalex.org/W2095413188","https://openalex.org/W2099751180","https://openalex.org/W2140526822","https://openalex.org/W2147572453","https://openalex.org/W2151385646","https://openalex.org/W2409709183"],"related_works":["https://openalex.org/W2406666456","https://openalex.org/W4206217278","https://openalex.org/W2413190427","https://openalex.org/W2883682937","https://openalex.org/W2530428237","https://openalex.org/W4410993054","https://openalex.org/W2981466491","https://openalex.org/W1820124446","https://openalex.org/W2140526822","https://openalex.org/W2909796894"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,52,77,113,162,195],"aim":[2],"of":[3,11,14,84,102,116,226],"this":[4],"study":[5,120,148,178,207],"was":[6,57,73,122,141,167,200],"to":[7,63,230,234],"analyse":[8],"the":[9,23,60,69,90,100,105,110,119,133,147,156,165,173,177,185,189,206,215,231,235,239,242,246,256,260,264],"effectiveness":[10],"single":[12,224],"dose":[13,225],"20":[15,53],"mg/kg":[16,54],"intravenous":[17],"tranexamic":[18],"acid":[19],"(TXA),":[20],"in":[21,26,49,118,132,146,155,176,188,205,214,255],"reducing":[22],"blood":[24],"loss":[25],"patients":[27,37],"undergoing":[28],"total":[29,114],"knee":[30],"arthroplasty":[31],"(TKA).":[32],"MATERIAL":[33],"AND":[34],"METHOD:":[35],"70":[36],"(65.5":[38],"\u00b1":[39,124,129,143,152,169,181,202,211],"8.1":[40],"years":[41],"old)":[42],"that":[43],"have":[44],"undergone":[45],"TKA":[46,72,236],"were":[47,107],"divided":[48],"two":[50],"groups.":[51,111],"IV":[55],"TXA":[56,227],"given":[58,229],"before":[59],"skin":[61],"incision":[62],"one":[64],"group":[65,121,135,149,158,191,208,217],"(study":[66],"group).":[67],"On":[68],"control":[70,134,157,190,216],"group,":[71,179],"performed":[74],"without":[75],"TXA.":[76],"demographic":[78],"data,":[79],"body":[80],"mass":[81],"index,":[82],"amount":[83,101,115,258],"bleeding":[85,117,140,240,257],"and":[86,93,97,127,150,209,244],"erythrocyte":[87],"infusion":[88],"during":[89,241],"operation,":[91],"hemoglobin":[92],"hematocrit":[94],"values":[95],"(preoperative":[96],"48th":[98],"hour),":[99],"drainage":[103,163,196],"after":[104,164,197,259],"operation":[106,166,243],"compared":[108],"between":[109],"RESULTS:":[112],"634.03":[123],"182.88":[125],"ml":[126,131,145,154,171,183,204,213],"1166.42":[128],"295.92":[130],"(p":[136,159,192,218],"<":[137,193],"0.001).":[138,194],"Perioperative":[139],"252.01":[142],"144.13":[144],"431.33":[151],"209.10":[153],"=":[160,219],"0.018).":[161],"311.11":[168],"141.64":[170],"at":[172,184],"24th":[174,186,198,261],"hour":[175,187,199,262],"640.74":[180],"279.43":[182],"97.96":[201],"115.86":[203],"112.96":[210],"64.43":[212],"0.584).":[220],"CONCLUSION:":[221],"A":[222],"high,":[223],"intravenously":[228],"patient":[232],"prior":[233],"significantly":[237],"reduces":[238],"within":[245],"postoperative":[247],"24":[248],"h.":[249],"There":[250],"is":[251],"no":[252],"significant":[253],"change":[254],"following":[263],"operation.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-08-23T00:00:00"}