{"id":"https://openalex.org/W2492483006","doi":"https://doi.org/10.1158/1538-7445.am2016-4425","title":"Abstract 4425: Comprehensive study of TGF-\u03b2 pathway-driven functional molecular characterization of human hepatocellular cancer","display_name":"Abstract 4425: Comprehensive study of TGF-\u03b2 pathway-driven functional molecular characterization of human hepatocellular cancer","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2492483006","doi":"https://doi.org/10.1158/1538-7445.am2016-4425","mag":"2492483006"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-4425","doi":"https://doi.org/10.1158/1538-7445.am2016-4425","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4425","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100727841","display_name":"Jian Chen","orcid":"https://orcid.org/0000-0001-5230-7141","observed_orcids":["https://orcid.org/0000-0001-5230-7141","https://orcid.org/0000-0001-8105-3670","https://orcid.org/0000-0003-1090-5586"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Chen","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083265666","display_name":"Jiun\u2010Sheng Chen","orcid":"https://orcid.org/0000-0002-0708-6498","observed_orcids":["https://orcid.org/0000-0002-0708-6498"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiun-Sheng Chen","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390083","display_name":"Jianping Zhang","orcid":"https://orcid.org/0000-0003-2012-7837","observed_orcids":["https://orcid.org/0000-0003-2012-7837"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianping Zhang","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045940203","display_name":"YoungJin Gi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YoungJin Gi","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000002829","display_name":"Lior Haim Katz","orcid":"https://orcid.org/0000-0003-2885-7279","observed_orcids":["https://orcid.org/0000-0003-2885-7279"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lior Katz","raw_affiliation_strings":["2Sheeba Medical Center, Ramat Gan, Israel;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Sheeba Medical Center, Ramat Gan, Israel;","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012592309","display_name":"Ji\u2010Hyun Shin","orcid":"https://orcid.org/0000-0002-0887-1180","observed_orcids":["https://orcid.org/0000-0002-0887-1180"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Hyun Shin","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003802194","display_name":"Yunseong Jeong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YunSeong Jeong","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019765191","display_name":"Mitchell D. Belkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120022","display_name":"Institute of Clinical Research","ror":"https://ror.org/02gcjrk43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210120022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitch Belkin","raw_affiliation_strings":["3Institute of Clinical Research, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Institute of Clinical Research, Washington, DC;","institution_ids":["https://openalex.org/I4210120022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076758530","display_name":"Wilma SR Jogunoori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120022","display_name":"Institute of Clinical Research","ror":"https://ror.org/02gcjrk43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210120022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilma Jogunoori","raw_affiliation_strings":["3Institute of Clinical Research, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Institute of Clinical Research, Washington, DC;","institution_ids":["https://openalex.org/I4210120022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102477507","display_name":"Bibhuti Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120022","display_name":"Institute of Clinical Research","ror":"https://ror.org/02gcjrk43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210120022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bibhuti Mishra","raw_affiliation_strings":["3Institute of Clinical Research, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Institute of Clinical Research, Washington, DC;","institution_ids":["https://openalex.org/I4210120022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027961631","display_name":"Jon C. White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120022","display_name":"Institute of Clinical Research","ror":"https://ror.org/02gcjrk43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210120022"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon White","raw_affiliation_strings":["3Institute of Clinical Research, Washington, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Institute of Clinical Research, Washington, DC;","institution_ids":["https://openalex.org/I4210120022"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037332686","display_name":"Shoujun Gu","orcid":"https://orcid.org/0000-0003-1041-3813","observed_orcids":["https://orcid.org/0000-0003-1041-3813"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shoujun Gu","raw_affiliation_strings":["4George Washington University, Washington DC, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4George Washington University, Washington DC, DC;","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054771911","display_name":"Milind M. Javle","orcid":"https://orcid.org/0000-0001-9158-0941","observed_orcids":["https://orcid.org/0000-0001-9158-0941"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milind Javle","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072226386","display_name":"Xiaoping Su","orcid":"https://orcid.org/0000-0003-1824-943X","observed_orcids":["https://orcid.org/0000-0003-1824-943X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoping Su","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110270377","display_name":"John Stroehlein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Stroehlein","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112785059","display_name":"Marta L. Davila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Davila","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390604","display_name":"Xuemei Wang","orcid":"https://orcid.org/0000-0001-6882-7774","observed_orcids":["https://orcid.org/0000-0001-6882-7774"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuemei Wang","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001295453","display_name":"Jeffrey S. Morris","orcid":"https://orcid.org/0000-0002-8520-6088","observed_orcids":["https://orcid.org/0000-0002-8520-6088"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Morris","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051190667","display_name":"Patrizia Farci","orcid":"https://orcid.org/0000-0003-0556-7711","observed_orcids":["https://orcid.org/0000-0003-0556-7711"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrizia Farci","raw_affiliation_strings":["5National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056924090","display_name":"Rehan Akbani","orcid":"https://orcid.org/0000-0003-2686-7721","observed_orcids":["https://orcid.org/0000-0003-2686-7721"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rehan Akbani","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091703176","display_name":"Lopa Mishra","orcid":"https://orcid.org/0000-0002-6850-0808","observed_orcids":["https://orcid.org/0000-0002-6850-0808"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lopa Mishra","raw_affiliation_strings":["4George Washington University, Washington DC, DC;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4George Washington University, Washington DC, DC;","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"4425","last_page":"4425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.8199999928474426},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.7699999809265137},{"id":"https://openalex.org/keywords/sptbn1","display_name":"SPTBN1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.6759999990463257},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.9504942893981934},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.788122296333313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6918236017227173},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.601728618144989},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5668431520462036},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5602902173995972},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5030466914176941},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.47034576535224915},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4697606563568115},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.4193945825099945},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3202325105667114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3094370663166046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1461305320262909}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-4425","doi":"https://doi.org/10.1158/1538-7445.am2016-4425","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4425","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.46000000834465027}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992314595","https://openalex.org/W2375390396","https://openalex.org/W4390228625","https://openalex.org/W2188205072","https://openalex.org/W3161864617","https://openalex.org/W2035703032","https://openalex.org/W2117410915","https://openalex.org/W1911027473","https://openalex.org/W4244851463","https://openalex.org/W2042571415"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"TGF-\u03b2":[2,30,54,105,126,146,186,206,220,258,283,364],"plays":[3,260],"a":[4,94,131,167,176,198,228,251,261],"complex":[5],"role":[6,263],"in":[7,72,76,108,115,136,160,209,242,264],"cancer-":[8],"from":[9,79,245],"tumor":[10,16,168,224,288],"suppression":[11],"to":[12,15,22,34,141,306],"immune":[13],"modulation":[14],"promotion":[17],"that":[18,28,235],"are":[19,40,56,239],"unclearly":[20],"defined":[21],"date.":[23],"Recent":[24],"clinical":[25],"studies":[26],"show":[27],"targeting":[29,309],"improves":[31],"survival":[32,134,313],"up":[33],"21":[35],"months,":[36],"yet":[37],"prognostic":[38,275],"significances":[39],"undefined.":[41],"Moreover,":[42],"the":[43,53,62,73,124,144,154,161,185,210,268,299,377,382],"relationships":[44],"between":[45,179,201],"patterns":[46],"of":[47,64,91,97,110,117,157,254,310,314,363,369,376,381],"mutations":[48,71,114,159],"and":[49,68,184,191,205,230,248,267,282],"transcriptomic":[50,190,229],"phenotypes":[51],"for":[52,70,385],"pathway":[55,75,187,207,259,302],"unclear.":[57],"Methods:":[58],"1.":[59,100],"We":[60,152,174,195],"analyzed":[61],"transcriptome":[63],"488":[65],"hepatocellular":[66,111,371],"cancers":[67],"screened":[69],"TGF-b":[74],"202":[77],"HCCs":[78,121,142],"The":[80,257,295],"Cancer":[81,386,397],"Genome":[82],"Atlas":[83],"(TCGA).":[84],"2.":[85,119],"Next":[86],"we":[87,233,271],"correlated":[88],"mouse":[89],"models":[90],"HCC":[92],"with":[93,113,130,143,219,298],"functional":[95,158,231,366],"analysis":[96,232],"drivers.":[98],"Results:":[99],"Transcriptomic":[101],"analyses":[102],"revealed":[103],"aberrant":[104],"superfamily":[106],"profiles":[107],"72%":[109],"cancers,":[112],"38%":[116],"patients.":[118],"Significantly,":[120],"characterized":[122],"by":[123],"\u201cinactivated\u201d":[125],"signature":[127,147],"were":[128],"associated":[129],"significantly":[132],"poorer":[133],"particularly":[135],"early":[137],"stage":[138],"HCCs,":[139],"compared":[140],"\u201cactivated\u201d":[145],"(p":[148],"=":[149],"0.0027).":[150],"3.":[151],"observed":[153,197,234],"greatest":[155],"number":[156],"SPTBN1":[162],"gene":[163],"(6%),":[164],"which":[165],"encodes":[166],"suppressor":[169],"TGF-\u03b2/Smad3":[170],"adaptor":[171],"protein.":[172],"4.":[173],"found":[175],"strong":[177,199],"association":[178,297],"DNA":[180,300],"damage":[181],"response":[182],"genes":[183,204,208],"at":[188],"both":[189],"genomic":[192,212],"levels.":[193],"5.":[194],"also":[196],"correlation":[200],"VD":[202,216,280],"related":[203],"TCGA":[211],"analysis.":[213],"6.":[214],"subsequent":[215],"deprivation":[217],"synergistically":[218,285],"inactivation":[221],"promotes":[222],"liver":[223,243,265,287,315],"development.":[225],"7.":[226],"Through":[227],"TLR7":[236,249,293],"mRNA":[237],"levels":[238],"increased":[240],"4-fold":[241],"tissues":[244],"Smad3+/-":[246],"mice,":[247],"is":[250],"direct":[252],"target":[253],"Smad3.":[255],"Conclusions:":[256],"pivotal":[262],"tumorigenesis":[266],"molecular":[269,367],"signatures":[270],"characterize":[272],"here":[273],"have":[274],"significance.":[276],"In":[277],"specific":[278],"populations,":[279],"deficiency":[281],"disruption":[284],"promote":[286],"growth,":[289],"possibly":[290],"through":[291],"regulating":[292],"expression.":[294],"additional":[296],"repair":[301],"supports":[303],"new":[304],"approaches":[305],"biomarker":[307],"driven":[308],"TGF-\u03b2,":[311],"improving":[312],"cancer.":[316,372],"Citation":[317],"Format:":[318],"Jian":[319],"Chen,":[320,322],"Jiun-Sheng":[321],"Jianping":[323],"Zhang,":[324],"YoungJin":[325],"Gi,":[326],"Lior":[327],"Katz,":[328],"Ji-Hyun":[329],"Shin,":[330],"YunSeong":[331],"Jeong,":[332],"Mitch":[333],"Belkin,":[334],"Wilma":[335],"Jogunoori,":[336],"Bibhuti":[337],"Mishra,":[338],"Jon":[339],"White,":[340],"Shoujun":[341],"Gu,":[342],"Milind":[343],"Javle,":[344],"Xiaoping":[345],"Su,":[346],"John":[347],"Stroehlein,":[348],"Marta":[349],"Davila,":[350],"Xuemei":[351],"Wang,":[352],"Jeffrey":[353],"Morris,":[354],"Patrizia":[355],"Farci,":[356],"Rehan":[357],"Akbani,":[358],"Lopa":[359],"Mishra.":[360],"Comprehensive":[361],"study":[362],"pathway-driven":[365],"characterization":[368],"human":[370],"[abstract].":[373],"In:":[374],"Proceedings":[375],"107th":[378],"Annual":[379],"Meeting":[380],"American":[383],"Association":[384],"Research;":[387],"2016":[388],"Apr":[389],"16-20;":[390],"New":[391],"Orleans,":[392],"LA.":[393],"Philadelphia":[394],"(PA):":[395],"AACR;":[396],"Res":[398],"2016;76(14":[399],"Suppl):Abstract":[400],"nr":[401],"4425.":[402]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
