{"id":"https://openalex.org/W2492425651","doi":"https://doi.org/10.1038/mt.2016.120","title":"Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis","display_name":"Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis","publication_year":2016,"publication_date":"2016-07-19","ids":{"openalex":"https://openalex.org/W2492425651","doi":"https://doi.org/10.1038/mt.2016.120","mag":"2492425651","pmid":"https://pubmed.ncbi.nlm.nih.gov/27434585","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5113099"},"language":"en","primary_location":{"id":"doi:10.1038/mt.2016.120","doi":"https://doi.org/10.1038/mt.2016.120","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2016.120","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2492425651"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/mt.2016.120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032398798","display_name":"Hyun\u2010Kyung Chang","orcid":"https://orcid.org/0000-0002-3490-7597","observed_orcids":["https://orcid.org/0000-0002-3490-7597"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Kyung Chang","raw_affiliation_strings":["Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052302305","display_name":"Pyung\u2010Hwan Kim","orcid":"https://orcid.org/0000-0002-3117-4025","observed_orcids":["https://orcid.org/0000-0002-3117-4025"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I165028127","display_name":"Konyang University","ror":"https://ror.org/02v8yp068","country_code":"KR","type":"education","lineage":["https://openalex.org/I165028127"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Pyung-Hwan Kim","raw_affiliation_strings":["Current address: Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, Daejeon, South Korea","Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, Daejeon, South Korea","institution_ids":["https://openalex.org/I165028127"]},{"raw_affiliation_string":"Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101817483","display_name":"Hyunmin Cho","orcid":"https://orcid.org/0000-0002-4321-0572","observed_orcids":["https://orcid.org/0000-0002-4321-0572","https://orcid.org/0009-0000-4294-9909"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Min Cho","raw_affiliation_strings":["Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059738362","display_name":"Soo\u2010Young Yum","orcid":"https://orcid.org/0000-0002-9922-9168","observed_orcids":["https://orcid.org/0000-0002-9922-9168"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soo-Young Yum","raw_affiliation_strings":["Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089312783","display_name":"Young\u2010Jin Choi","orcid":"https://orcid.org/0000-0002-8466-4132","observed_orcids":["https://orcid.org/0000-0002-8466-4132"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Jin Choi","raw_affiliation_strings":["Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018857201","display_name":"YeonSung Son","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"YeonSung Son","raw_affiliation_strings":["Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003253588","display_name":"Dabin Lee","orcid":"https://orcid.org/0000-0003-3966-0666","observed_orcids":["https://orcid.org/0000-0003-3966-0666"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"DaBin Lee","raw_affiliation_strings":["Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008590783","display_name":"Insung Kang","orcid":"https://orcid.org/0000-0003-1792-5002","observed_orcids":["https://orcid.org/0000-0003-1792-5002"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"InSung Kang","raw_affiliation_strings":["Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013654282","display_name":"Kyung\u2010Sun Kang","orcid":"https://orcid.org/0000-0002-9322-741X","observed_orcids":["https://orcid.org/0000-0002-9322-741X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Sun Kang","raw_affiliation_strings":["Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018791841","display_name":"Goo Jang","orcid":"https://orcid.org/0000-0003-3804-1871","observed_orcids":["https://orcid.org/0000-0003-3804-1871"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Goo Jang","raw_affiliation_strings":["Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024801112","display_name":"Je\u2010Yoel Cho","orcid":"https://orcid.org/0000-0003-1030-3577","observed_orcids":["https://orcid.org/0000-0003-1030-3577"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269553","display_name":"Research Institute for Veterinary Science","ror":"https://ror.org/04h6qvc91","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269553"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Je-Yoel Cho","raw_affiliation_strings":["Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, South Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024801112"],"corresponding_institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269553"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.0841,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.91825321,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"9","first_page":"1644","last_page":"1654"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/talen-genome-editing","display_name":"TALEN genome editing","score":0.8970000147819519},{"id":"https://openalex.org/keywords/inducible-gene-expression","display_name":"inducible gene expression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hindlimb-ischemia","display_name":"hindlimb ischemia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7689999938011169},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.8514896035194397},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8358442783355713},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6986522078514099},{"id":"https://openalex.org/C2781188250","wikidata":"https://www.wikidata.org/wiki/Q4455440","display_name":"Therapeutic angiogenesis","level":4,"score":0.5609484910964966},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5602923631668091},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.49003517627716064},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47561150789260864},{"id":"https://openalex.org/C2776719180","wikidata":"https://www.wikidata.org/wiki/Q14882120","display_name":"Angiogenin","level":3,"score":0.4523008465766907},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41363096237182617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36287569999694824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34874284267425537},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.2842053174972534},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2748456597328186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08300444483757019},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/mt.2016.120","doi":"https://doi.org/10.1038/mt.2016.120","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2016.120","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5113099","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5113099/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5113099/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:4077398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5113099","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27434585","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27434585","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/mt.2016.120","doi":"https://doi.org/10.1038/mt.2016.120","is_oa":true,"landing_page_url":"https://doi.org/10.1038/mt.2016.120","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1525405925","display_name":null,"funder_award_id":"2014M3A9D5A01073598","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G1748768340","display_name":null,"funder_award_id":"2012M3A9C6049716","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G8433116828","display_name":null,"funder_award_id":"2012M3A9C6049716","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2492425651.pdf","grobid_xml":"https://content.openalex.org/works/W2492425651.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W117902596","https://openalex.org/W1242683026","https://openalex.org/W1563129071","https://openalex.org/W1974416220","https://openalex.org/W1999068651","https://openalex.org/W2001811125","https://openalex.org/W2004496950","https://openalex.org/W2012792646","https://openalex.org/W2044114587","https://openalex.org/W2050051758","https://openalex.org/W2052534316","https://openalex.org/W2054042846","https://openalex.org/W2060525515","https://openalex.org/W2070869797","https://openalex.org/W2071001421","https://openalex.org/W2076226559","https://openalex.org/W2078131641","https://openalex.org/W2082515302","https://openalex.org/W2087578260","https://openalex.org/W2091123051","https://openalex.org/W2095132685","https://openalex.org/W2099277272","https://openalex.org/W2124396531","https://openalex.org/W2139973886","https://openalex.org/W2144960281","https://openalex.org/W2152173653","https://openalex.org/W2154502317","https://openalex.org/W2156770263","https://openalex.org/W2166106062","https://openalex.org/W2167271524","https://openalex.org/W2324482901","https://openalex.org/W2345610219"],"related_works":["https://openalex.org/W2360897327","https://openalex.org/W2786188197","https://openalex.org/W2390585785","https://openalex.org/W4321598717","https://openalex.org/W2149428538","https://openalex.org/W3010807086","https://openalex.org/W6976994437","https://openalex.org/W2390124538","https://openalex.org/W2901307774"],"abstract_inverted_index":{"Mesenchymal":[0],"stem":[1],"cells":[2],"(MSCs)":[3],"promote":[4],"therapeutic":[5,55,196],"angiogenesis":[6,156],"to":[7,51,133,150,173],"cure":[8],"serious":[9],"vascular":[10,202],"disorders.":[11],"However,":[12],"their":[13],"survival":[14],"period":[15],"and":[16,136,176],"cytokine-secretory":[17],"capacity":[18],"are":[19,171,193],"limited.":[20],"Although":[21],"hepatocyte":[22],"growth":[23],"factor":[24],"(HGF)":[25],"can":[26],"accelerate":[27],"the":[28,88,93,104,113,126,138,167,184,199],"rate":[29],"of":[30,37,95,103,115,129,201],"angiogenesis,":[31],"recombinant":[32],"HGF":[33,48,67,73,116,152,178,188],"is":[34,49],"limited":[35],"because":[36],"its":[38],"very":[39],"short":[40],"half-life":[41],"(<3-5":[42],"minutes).":[43],"Thus,":[44,183],"continuous":[45],"treatment":[46,200],"with":[47],"required":[50],"obtain":[52],"an":[53,84,190],"effective":[54],"response.":[56],"To":[57],"overcome":[58],"these":[59],"limitations,":[60],"we":[61],"produced":[62],"genome-edited":[63,130],"MSCs":[64,131,185],"that":[65,107,166,186],"secreted":[66],"upon":[68,112],"drug-specific":[69],"induction.":[70],"The":[71],"inducible":[72,168,191],"expression":[74],"cassette":[75],"was":[76],"integrated":[77],"into":[78],"a":[79,158,180,194],"safe":[80],"harbor":[81],"site":[82],"in":[83,92,154,157,179,189],"MSC":[85],"chromosome":[86],"using":[87],"TALEN":[89],"system,":[90],"resulting":[91],"production":[94],"TetOn-HGF/human":[96],"umbilical":[97],"cord":[98],"blood-derived":[99],"(hUCB)-MSCs.":[100],"Functional":[101],"assessment":[102],"TetOn-HGF/hUCB-MSCs":[105,124,142],"showed":[106,165],"they":[108],"had":[109],"enhanced":[110,125],"mobility":[111],"induction":[114],"expression.":[117],"Moreover,":[118],"long-term":[119],"exposure":[120],"by":[121,144],"doxycycline":[122],"(Dox)-treated":[123],"anti-apoptotic":[127],"responses":[128],"subjected":[132],"oxidative":[134],"stress":[135],"improved":[137,153],"tube-formation":[139],"ability.":[140],"Furthermore,":[141],"encapsulated":[143],"arginine-glycine-aspartic":[145],"acid":[146],"(RGD)-alginate":[147],"microgel":[148],"induced":[149],"express":[151,175,187],"vivo":[155],"mouse":[159],"hindlimb":[160],"ischemia":[161],"model.":[162],"This":[163],"study":[164],"HGF-expressing":[169],"hUCB-MSCs":[170],"competent":[172],"continuously":[174],"secrete":[177],"controlled":[181],"manner.":[182],"manner":[192],"useful":[195],"modality":[197],"for":[198],"diseases":[203],"requiring":[204],"angiogenesis.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-08-23T00:00:00"}
