{"id":"https://openalex.org/W2492415836","doi":"https://doi.org/10.1002/cbdv.201600149","title":"Four New Tirucallane Triterpenoids from the Fruits of Melia azedarach and Their Cytotoxic Activities","display_name":"Four New Tirucallane Triterpenoids from the Fruits of Melia azedarach and Their Cytotoxic Activities","publication_year":2016,"publication_date":"2016-07-23","ids":{"openalex":"https://openalex.org/W2492415836","doi":"https://doi.org/10.1002/cbdv.201600149","mag":"2492415836","pmid":"https://pubmed.ncbi.nlm.nih.gov/27449157"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.201600149","doi":"https://doi.org/10.1002/cbdv.201600149","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.201600149","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102174275","display_name":"Fang Zhou","orcid":"https://orcid.org/0009-0002-4119-3075","observed_orcids":["https://orcid.org/0009-0002-4119-3075"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Zhou","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xin\u2010Hua Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin\u2010Hua Ma","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450010","display_name":"Zhijun Li","orcid":"https://orcid.org/0000-0001-5566-3846","observed_orcids":["https://orcid.org/0000-0001-5566-3846"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi\u2010Jun Li","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318444","display_name":"Wei Li","orcid":"https://orcid.org/0000-0003-4143-8597","observed_orcids":["https://orcid.org/0000-0003-4143-8597"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei\u2010Min Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei\u2010Min Zheng","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086874263","display_name":"Zhibiao Wang","orcid":"https://orcid.org/0000-0002-1030-9912","observed_orcids":["https://orcid.org/0000-0002-1030-9912"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi\u2010Biao Wang","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059891057","display_name":"Xian\u2010Ming Zeng","orcid":"https://orcid.org/0009-0000-9445-4318","observed_orcids":["https://orcid.org/0009-0000-9445-4318"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian\u2010Ming Zeng","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035576442","display_name":"Kai\u2010Hui Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai\u2010Hui Sun","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100429053","display_name":"Yonghong Zhang","orcid":"https://orcid.org/0000-0002-7740-9408","observed_orcids":["https://orcid.org/0000-0002-7740-9408"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong\u2010Hong Zhang","raw_affiliation_strings":["Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province School of Pharmacy Fujian Medical University 88 Jiao Tong Road Fuzhou 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]},{"raw_affiliation_string":"Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University, 88 Jiao Tong Road, Fuzhou, 350004 P. R. China","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100429053"],"corresponding_institution_ids":["https://openalex.org/I129708740"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.6027,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.70276445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":"12","first_page":"1738","last_page":"1746"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirucallane-triterpenoids","display_name":"tirucallane triterpenoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melia-azedarach","display_name":"Melia azedarach","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fruits","display_name":"fruits","score":0.7300000190734863},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/sgc-7901-cells","display_name":"SGC-7901 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epoxy-triterpenoids","display_name":"epoxy triterpenoids","score":0.6990000009536743},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.5960000157356262},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7990000247955322},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2780899423","wikidata":"https://www.wikidata.org/wiki/Q162171","display_name":"Melia azedarach","level":2,"score":0.9208707809448242},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7396683692932129},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6152167320251465},{"id":"https://openalex.org/C107585567","wikidata":"https://www.wikidata.org/wiki/Q2915788","display_name":"Triterpenoid","level":2,"score":0.577322244644165},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5756853818893433},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.47257912158966064},{"id":"https://openalex.org/C44937612","wikidata":"https://www.wikidata.org/wiki/Q212364","display_name":"Terpene","level":2,"score":0.4615360200405121},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.41509056091308594},{"id":"https://openalex.org/C2781131524","wikidata":"https://www.wikidata.org/wiki/Q158979","display_name":"Meliaceae","level":2,"score":0.414633572101593},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.30984845757484436},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.27591365575790405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2510429620742798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16138023138046265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1075284481048584},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08683112263679504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031586","descriptor_name":"Melia azedarach","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031586","descriptor_name":"Melia azedarach","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031586","descriptor_name":"Melia azedarach","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbdv.201600149","doi":"https://doi.org/10.1002/cbdv.201600149","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.201600149","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},{"id":"pmid:27449157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27449157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4709839958","display_name":null,"funder_award_id":"2016J01369","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"},{"id":"https://openalex.org/G5679526684","display_name":null,"funder_award_id":"2012Y0035","funder_id":"https://openalex.org/F4320323190","funder_display_name":"Fujian Provincial Department of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320323190","display_name":"Fujian Provincial Department of Science and Technology","ror":"https://ror.org/00rgzpv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1543112032","https://openalex.org/W1968903834","https://openalex.org/W1972852558","https://openalex.org/W1974310574","https://openalex.org/W1976186932","https://openalex.org/W1979341360","https://openalex.org/W1979590183","https://openalex.org/W1986398610","https://openalex.org/W1990847319","https://openalex.org/W1992143833","https://openalex.org/W1999021171","https://openalex.org/W2010079834","https://openalex.org/W2013542281","https://openalex.org/W2016624608","https://openalex.org/W2016804370","https://openalex.org/W2020639141","https://openalex.org/W2025038925","https://openalex.org/W2029263262","https://openalex.org/W2033994669","https://openalex.org/W2037431488","https://openalex.org/W2038769814","https://openalex.org/W2042245712","https://openalex.org/W2052332853","https://openalex.org/W2056708937","https://openalex.org/W2057701353","https://openalex.org/W2058893146","https://openalex.org/W2069343726","https://openalex.org/W2074613164","https://openalex.org/W2078675343","https://openalex.org/W2079001315","https://openalex.org/W2079511231","https://openalex.org/W2109689528","https://openalex.org/W2116102284","https://openalex.org/W2119981356","https://openalex.org/W2123672931","https://openalex.org/W2133468878","https://openalex.org/W2315729535","https://openalex.org/W2327644750","https://openalex.org/W2409014788","https://openalex.org/W2952561815"],"related_works":["https://openalex.org/W1826081306","https://openalex.org/W2183312291","https://openalex.org/W4320488784","https://openalex.org/W3035951186","https://openalex.org/W2075148036","https://openalex.org/W2749181082","https://openalex.org/W1569164569","https://openalex.org/W2142388644","https://openalex.org/W2501111095","https://openalex.org/W3112887204"],"abstract_inverted_index":{"Four":[0],"new":[1],"tirucallane":[2],"triterpenoids,":[3],"(21S,23R,24R)\u201021,23\u2010epoxy\u201021,24\u2010dihydroxy\u201025\u2010methoxytirucall\u20107\u2010en\u20103\u2010one":[4],"(2),":[5],"(3S,21S,23R,24S)\u201021,23\u2010epoxy\u201021,25\u2010dimethoxytirucall\u20107\u2010ene\u20103,24\u2010diol":[6],"(8),":[7],"(21S,23R,24R)\u201021,23\u2010epoxy\u201024\u2010hydroxy\u201021\u2010methoxytirucalla\u20107,25\u2010dien\u20103\u2010one":[8],"(11),":[9],"and":[10,25,46,49,66,79,89],"(21S,23R,24R)\u201021,23\u2010epoxy\u201021,24\u2010dihydroxytirucalla\u20107,25\u2010dien\u20103\u2010one":[11],"(12),":[12],"along":[13],"with":[14,83],"16":[15],"known":[16],"analogues,":[17],"1,":[18],"3":[19],"\u2013":[20,23,27],"7,":[21],"9":[22],"10,":[24],"13":[26],"20,":[28],"were":[29,39,54],"isolated":[30],"from":[31],"the":[32,84],"fruits":[33],"of":[34,87],"Melia":[35],"azedarach.":[36],"Their":[37],"structures":[38],"elucidated":[40],"by":[41],"spectroscopic":[42],"methods":[43],"including":[44],"1D\u2010":[45],"2D\u2010NMR":[47],"techniques":[48],"mass":[50],"spectrometry.":[51],"These":[52],"compounds":[53],"evaluated":[55],"for":[56],"their":[57],"cytotoxicities":[58],"against":[59,77],"HepG2":[60,78],"(liver),":[61],"SGC7901":[62,80],"(stomach),":[63],"K562":[64],"(leukemia),":[65],"HL60":[67],"(leukemia)":[68],"cancer":[69,81],"cell":[70],"lines.":[71],"Compound":[72],"20":[73],"exhibited":[74],"potent":[75],"cytotoxicity":[76],"cells":[82],"IC50":[85],"values":[86],"6.9":[88,90],"\u03bcm,":[91],"respectively.":[92]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-08-23T00:00:00"}