{"id":"https://openalex.org/W2491923045","doi":"https://doi.org/10.1158/1538-7445.am2016-4749","title":"Abstract 4749: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma","display_name":"Abstract 4749: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma","publication_year":2016,"publication_date":"2016-07-15","ids":{"openalex":"https://openalex.org/W2491923045","doi":"https://doi.org/10.1158/1538-7445.am2016-4749","mag":"2491923045"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2016-4749","doi":"https://doi.org/10.1158/1538-7445.am2016-4749","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4749","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023605713","display_name":"Patricia J. Keller","orcid":"https://orcid.org/0000-0002-7252-7843","observed_orcids":["https://orcid.org/0000-0002-7252-7843"]},"institutions":[{"id":"https://openalex.org/I4210146481","display_name":"Constellation Pharmaceuticals (United States)","ror":"https://ror.org/04dxbz091","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia J. Keller","raw_affiliation_strings":["1Constellation Pharmaceuticals, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Constellation Pharmaceuticals, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4210146481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070418940","display_name":"Andrew R. Conery","orcid":"https://orcid.org/0000-0003-3638-7633","observed_orcids":["https://orcid.org/0000-0003-3638-7633"]},"institutions":[{"id":"https://openalex.org/I4210146481","display_name":"Constellation Pharmaceuticals (United States)","ror":"https://ror.org/04dxbz091","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew R. Conery","raw_affiliation_strings":["1Constellation Pharmaceuticals, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Constellation Pharmaceuticals, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4210146481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079460736","display_name":"Richard C. Centore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146481","display_name":"Constellation Pharmaceuticals (United States)","ror":"https://ror.org/04dxbz091","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard C. Centore","raw_affiliation_strings":["1Constellation Pharmaceuticals, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Constellation Pharmaceuticals, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4210146481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086401659","display_name":"Archana Bommi\u2010Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146481","display_name":"Constellation Pharmaceuticals (United States)","ror":"https://ror.org/04dxbz091","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Archana Bommi-Reddy","raw_affiliation_strings":["1Constellation Pharmaceuticals, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Constellation Pharmaceuticals, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4210146481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020375889","display_name":"Karen E. Gascoigne","orcid":"https://orcid.org/0000-0002-9407-2982","observed_orcids":["https://orcid.org/0000-0002-9407-2982"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen E. Gascoigne","raw_affiliation_strings":["2Genentech, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Genentech, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080077602","display_name":"Barbara M. Bryant","orcid":"https://orcid.org/0000-0003-2707-1186","observed_orcids":["https://orcid.org/0000-0003-2707-1186"]},"institutions":[{"id":"https://openalex.org/I4210146481","display_name":"Constellation Pharmaceuticals (United States)","ror":"https://ror.org/04dxbz091","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara M. Bryant","raw_affiliation_strings":["1Constellation Pharmaceuticals, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Constellation Pharmaceuticals, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4210146481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078816311","display_name":"Jennifer A. Mertz","orcid":"https://orcid.org/0000-0002-4716-1077","observed_orcids":["https://orcid.org/0000-0002-4716-1077"]},"institutions":[{"id":"https://openalex.org/I4210146481","display_name":"Constellation Pharmaceuticals (United States)","ror":"https://ror.org/04dxbz091","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Mertz","raw_affiliation_strings":["1Constellation Pharmaceuticals, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Constellation Pharmaceuticals, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4210146481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077841984","display_name":"Robert J. Sims","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146481","display_name":"Constellation Pharmaceuticals (United States)","ror":"https://ror.org/04dxbz091","country_code":"US","type":"company","lineage":["https://openalex.org/I4210146481"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Sims","raw_affiliation_strings":["1Constellation Pharmaceuticals, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Constellation Pharmaceuticals, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4210146481"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"14_Supplement","first_page":"4749","last_page":"4749"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.08910000324249268,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bromodomain-inhibition","display_name":"bromodomain inhibition","score":0.9449999928474426},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/irf4","display_name":"IRF4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9049999713897705},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.9259999990463257},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lymphoid-malignancies","display_name":"lymphoid malignancies","score":0.746999979019165},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.9313539266586304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7058951258659363},{"id":"https://openalex.org/C12652872","wikidata":"https://www.wikidata.org/wiki/Q18027997","display_name":"IRF4","level":4,"score":0.5960944890975952},{"id":"https://openalex.org/C2779634854","wikidata":"https://www.wikidata.org/wiki/Q18037206","display_name":"BRD4","level":5,"score":0.587439775466919},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.53269362449646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5222480893135071},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5023922920227051},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.2280806005001068},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20518344640731812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19860368967056274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13609546422958374}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2016-4749","doi":"https://doi.org/10.1158/1538-7445.am2016-4749","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2016-4749","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2239381098","https://openalex.org/W6981184695","https://openalex.org/W4280606610","https://openalex.org/W4405040216","https://openalex.org/W4393074417","https://openalex.org/W4416290382","https://openalex.org/W4392603736","https://openalex.org/W4393093374","https://openalex.org/W4417006596","https://openalex.org/W2092722989"],"abstract_inverted_index":{"Abstract":[0],"Pharmacological":[1],"inhibition":[2,27,47,116,161],"of":[3,19,32,39,51,55,67,74,82,93,105,108,162,182,187],"chromatin":[4],"co-regulatory":[5],"factors":[6],"represents":[7,117],"a":[8,102,118,168],"clinically":[9],"validated":[10],"strategy":[11,121,170],"to":[12,171],"modulate":[13],"oncogenic":[14],"signaling":[15],"through":[16,44],"selective":[17],"attenuation":[18],"gene":[20,78],"expression.":[21],"We":[22],"demonstrate":[23],"that":[24,113],"CBP/EP300":[25,45,94,114,166],"bromodomain":[26,46,95,115],"preferentially":[28],"abrogates":[29],"the":[30,49,56,65,71,75,88,98,132,163,173,183,188],"viability":[31,66],"multiple":[33,40,124,177],"myeloma":[34,41,68,125],"cell":[35,42],"lines.":[36],"Selective":[37],"targeting":[38,123],"lines":[43],"is":[48,62],"result":[50],"direct":[52],"transcriptional":[53,91,164],"suppression":[54],"lymphocyte-specific":[57],"transcription":[58],"factor":[59],"IRF4,":[60],"which":[61],"essential":[63],"for":[64,122,191],"cells,":[69],"and":[70,90,126],"concomitant":[72],"repression":[73],"IRF4":[76,84,133,174],"target":[77,172],"c-MYC.":[79],"Ectopic":[80],"expression":[81],"either":[83],"or":[85],"MYC":[86],"antagonizes":[87],"phenotypic":[89],"effects":[92],"inhibition,":[96],"highlighting":[97],"IRF4/MYC":[99],"axis":[100],"as":[101,167],"key":[103],"component":[104],"its":[106],"mechanism":[107],"action.":[109],"These":[110],"findings":[111],"suggest":[112],"viable":[119],"therapeutic":[120,169],"other":[127],"lymphoid":[128],"malignancies":[129],"dependent":[130],"on":[131],"network.":[134],"Citation":[135],"Format:":[136],"Patricia":[137],"J.":[138,158],"Keller,":[139],"Andrew":[140],"R.":[141],"Conery,":[142],"Richard":[143],"C.":[144],"Centore,":[145],"Archana":[146],"Bommi-Reddy,":[147],"Karen":[148],"E.":[149],"Gascoigne,":[150],"Barbara":[151],"M.":[152],"Bryant,":[153],"Jennifer":[154],"A.":[155],"Mertz,":[156],"Robert":[157],"Sims.":[159],"Bromodomain":[160],"coactivators":[165],"network":[175],"in":[176],"myeloma.":[178],"[abstract].":[179],"In:":[180],"Proceedings":[181],"107th":[184],"Annual":[185],"Meeting":[186],"American":[189],"Association":[190],"Cancer":[192,203],"Research;":[193],"2016":[194],"Apr":[195],"16-20;":[196],"New":[197],"Orleans,":[198],"LA.":[199],"Philadelphia":[200],"(PA):":[201],"AACR;":[202],"Res":[204],"2016;76(14":[205],"Suppl):Abstract":[206],"nr":[207],"4749.":[208]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-08-23T00:00:00"}