{"id":"https://openalex.org/W2491786104","doi":null,"title":"The role of human serum carnosinase-1 in diabetic nephropathy","display_name":"The role of human serum carnosinase-1 in diabetic nephropathy","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2491786104","mag":"2491786104"},"language":"en","primary_location":{"id":"pmh:oai:pure.rug.nl:openaire/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, S 2016, 'The role of human serum carnosinase-1 in diabetic nephropathy', Doctor of Philosophy, University of Groningen, [Groningen].","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.rug.nl/en/publications/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101913807","display_name":"Shiqi Zhang","orcid":"https://orcid.org/0000-0002-4155-6342","observed_orcids":["https://orcid.org/0000-0002-4155-6342"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shiqi Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4155-6342","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101913807"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13551","display_name":"Biochemical effects in animals","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.29910001158714294,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cndp1","display_name":"CNDP1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/carnosine","display_name":"carnosine","score":0.7710000276565552},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.609000027179718},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9480000138282776},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.6380000114440918},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C27206212","wikidata":"https://www.wikidata.org/wiki/Q34178","display_name":"Theology","level":1,"score":0.6939693689346313},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.5293389558792114},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1938355267047882}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pure.rug.nl:openaire/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, S 2016, 'The role of human serum carnosinase-1 in diabetic nephropathy', Doctor of Philosophy, University of Groningen, [Groningen].","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:rug:oai:pure.rug.nl:publications/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2491786104","doi":null,"is_oa":false,"landing_page_url":"https://pure.rug.nl/ws/files/31621390/Title_and_contents_.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.rug.nl:openaire/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/17dc7c07-d6d9-4bce-97b5-f78d01af03a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhang, S 2016, 'The role of human serum carnosinase-1 in diabetic nephropathy', Doctor of Philosophy, University of Groningen, [Groningen].","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2990131975","display_name":null,"funder_award_id":"GRK 1874-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G537683861","display_name":null,"funder_award_id":"GRK1874","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":223,"referenced_works":["https://openalex.org/W45385785","https://openalex.org/W55539197","https://openalex.org/W78297221","https://openalex.org/W172609984","https://openalex.org/W1041726898","https://openalex.org/W1509366584","https://openalex.org/W1544686198","https://openalex.org/W1565599145","https://openalex.org/W1592519647","https://openalex.org/W1710332479","https://openalex.org/W1731934262","https://openalex.org/W1816365875","https://openalex.org/W1849649569","https://openalex.org/W1904840095","https://openalex.org/W1952120608","https://openalex.org/W1965252324","https://openalex.org/W1966104662","https://openalex.org/W1968071041","https://openalex.org/W1969129502","https://openalex.org/W1970796396","https://openalex.org/W1971860549","https://openalex.org/W1973458478","https://openalex.org/W1974167693","https://openalex.org/W1974311036","https://openalex.org/W1974859319","https://openalex.org/W1978192462","https://openalex.org/W1982159551","https://openalex.org/W1983225545","https://openalex.org/W1983335008","https://openalex.org/W1984218699","https://openalex.org/W1989256798","https://openalex.org/W1989695598","https://openalex.org/W1991153551","https://openalex.org/W1991595901","https://openalex.org/W1991892895","https://openalex.org/W1993920060","https://openalex.org/W1994259668","https://openalex.org/W1994351798","https://openalex.org/W1994445001","https://openalex.org/W1996093689","https://openalex.org/W1997735511","https://openalex.org/W1998064777","https://openalex.org/W2000072194","https://openalex.org/W2001049748","https://openalex.org/W2001118080","https://openalex.org/W2002315912","https://openalex.org/W2002616153","https://openalex.org/W2004043215","https://openalex.org/W2004260430","https://openalex.org/W2004437896","https://openalex.org/W2005479877","https://openalex.org/W2005515485","https://openalex.org/W2006113097","https://openalex.org/W2006984835","https://openalex.org/W2009094537","https://openalex.org/W2009393104","https://openalex.org/W2012024317","https://openalex.org/W2012210623","https://openalex.org/W2014317033","https://openalex.org/W2015584755","https://openalex.org/W2017930303","https://openalex.org/W2020028494","https://openalex.org/W2020234604","https://openalex.org/W2020603589","https://openalex.org/W2021538955","https://openalex.org/W2022061456","https://openalex.org/W2022662760","https://openalex.org/W2023448223","https://openalex.org/W2024322073","https://openalex.org/W2025592728","https://openalex.org/W2025595039","https://openalex.org/W2026294692","https://openalex.org/W2028076666","https://openalex.org/W2029460112","https://openalex.org/W2029981002","https://openalex.org/W2030719457","https://openalex.org/W2030743629","https://openalex.org/W2030820120","https://openalex.org/W2033391106","https://openalex.org/W2034359651","https://openalex.org/W2034696992","https://openalex.org/W2035775064","https://openalex.org/W2036423496","https://openalex.org/W2039240458","https://openalex.org/W2040809050","https://openalex.org/W2041391173","https://openalex.org/W2042270222","https://openalex.org/W2042362553","https://openalex.org/W2043553851","https://openalex.org/W2044276013","https://openalex.org/W2044437167","https://openalex.org/W2044502131","https://openalex.org/W2044534888","https://openalex.org/W2044773944","https://openalex.org/W2045242418","https://openalex.org/W2047199980","https://openalex.org/W2047364204","https://openalex.org/W2047686999","https://openalex.org/W2048321718","https://openalex.org/W2048414885","https://openalex.org/W2048593947","https://openalex.org/W2049833943","https://openalex.org/W2050309355","https://openalex.org/W2051752675","https://openalex.org/W2051754678","https://openalex.org/W2053761394","https://openalex.org/W2055095306","https://openalex.org/W2056075470","https://openalex.org/W2056579542","https://openalex.org/W2056976690","https://openalex.org/W2057239114","https://openalex.org/W2057363122","https://openalex.org/W2057434215","https://openalex.org/W2058013703","https://openalex.org/W2062129613","https://openalex.org/W2063771744","https://openalex.org/W2067006131","https://openalex.org/W2067756232","https://openalex.org/W2069246794","https://openalex.org/W2070236309","https://openalex.org/W2071894938","https://openalex.org/W2072739923","https://openalex.org/W2074054494","https://openalex.org/W2074302096","https://openalex.org/W2075273337","https://openalex.org/W2075475582","https://openalex.org/W2075837574","https://openalex.org/W2076511856","https://openalex.org/W2076619655","https://openalex.org/W2076943504","https://openalex.org/W2077061601","https://openalex.org/W2082083141","https://openalex.org/W2082806735","https://openalex.org/W2082865005","https://openalex.org/W2083074809","https://openalex.org/W2085428819","https://openalex.org/W2085574022","https://openalex.org/W2085577426","https://openalex.org/W2085680051","https://openalex.org/W2086056134","https://openalex.org/W2086204342","https://openalex.org/W2086357384","https://openalex.org/W2088227259","https://openalex.org/W2089502287","https://openalex.org/W2089939599","https://openalex.org/W2090662855","https://openalex.org/W2090795304","https://openalex.org/W2091193302","https://openalex.org/W2091698284","https://openalex.org/W2094270785","https://openalex.org/W2095108793","https://openalex.org/W2095951882","https://openalex.org/W2099411863","https://openalex.org/W2099635791","https://openalex.org/W2099905857","https://openalex.org/W2102108180","https://openalex.org/W2102921247","https://openalex.org/W2103825172","https://openalex.org/W2105739927","https://openalex.org/W2106082597","https://openalex.org/W2106336595","https://openalex.org/W2106426335","https://openalex.org/W2107272824","https://openalex.org/W2107408187","https://openalex.org/W2110664743","https://openalex.org/W2111287126","https://openalex.org/W2111370164","https://openalex.org/W2111675700","https://openalex.org/W2114364609","https://openalex.org/W2119360186","https://openalex.org/W2120220697","https://openalex.org/W2120501091","https://openalex.org/W2120773936","https://openalex.org/W2122981222","https://openalex.org/W2123691955","https://openalex.org/W2124558372","https://openalex.org/W2125112185","https://openalex.org/W2125729787","https://openalex.org/W2126728583","https://openalex.org/W2126834915","https://openalex.org/W2127055718","https://openalex.org/W2127867698","https://openalex.org/W2129578049","https://openalex.org/W2131274976","https://openalex.org/W2133896431","https://openalex.org/W2134794465","https://openalex.org/W2135241248","https://openalex.org/W2135579337","https://openalex.org/W2136490577","https://openalex.org/W2137473606","https://openalex.org/W2139675687","https://openalex.org/W2140228577","https://openalex.org/W2140797812","https://openalex.org/W2144002666","https://openalex.org/W2148048541","https://openalex.org/W2149229545","https://openalex.org/W2151022143","https://openalex.org/W2151780081","https://openalex.org/W2151920020","https://openalex.org/W2152102707","https://openalex.org/W2153673274","https://openalex.org/W2157002396","https://openalex.org/W2157373537","https://openalex.org/W2159099277","https://openalex.org/W2160599171","https://openalex.org/W2161840616","https://openalex.org/W2162196137","https://openalex.org/W2163910874","https://openalex.org/W2164019365","https://openalex.org/W2164287441","https://openalex.org/W2167311408","https://openalex.org/W2167578061","https://openalex.org/W2170271198","https://openalex.org/W2170483116","https://openalex.org/W2189696564","https://openalex.org/W2235557483","https://openalex.org/W2297056277","https://openalex.org/W2312215131","https://openalex.org/W2315370133","https://openalex.org/W2319086716","https://openalex.org/W2337454357","https://openalex.org/W2340171512","https://openalex.org/W4300987630"],"related_works":["https://openalex.org/W2515065998","https://openalex.org/W2033391106","https://openalex.org/W2339932640","https://openalex.org/W7140277542","https://openalex.org/W2106720900","https://openalex.org/W4281767661","https://openalex.org/W2099635791","https://openalex.org/W2071894938","https://openalex.org/W7096940661","https://openalex.org/W2095951882"],"abstract_inverted_index":{"Diabetische":[0],"nephropaty":[1],"(DN),":[2],"een":[3,162,172],"nierziekte":[4],"die":[5,151,183,217,233],"ontstaat":[6],"ten":[7,41],"gevolge":[8],"van":[9,36,49,67,87,94,134,154,165,214,253,258],"diabetes,":[10],"is":[11,22,96,130,137,145,189,229],"de":[12,46,50,65,84,115,132,139,181,201,250],"meest":[13],"voorkomende":[14],"oorzaak":[15],"voor":[16,33,104,220],"nierfalen.":[17],"Uit":[18],"verschillende":[19],"genetische":[20,47],"studies":[21,182,247],"gebleken":[23],"dat":[24,39,149],"niet":[25,127,235],"alle":[26],"patienten":[27,216,232],"met":[28,196],"diabetes":[29],"even":[30],"gevoelig":[31],"zijn":[32,81,187,219,238],"het":[34,97,105,121,125,155,221,256],"ontstaan":[35],"DN,":[37],"maar":[38,224],"dit":[40,185,234],"dele":[42],"wordt":[43,117],"bepaald":[44],"door":[45],"compositie":[48],"betroffen":[51],"person.":[52],"De":[53],"gevoeligheid":[54,140],"om":[55,141,176,249],"DN":[56,89,142,177,226],"te":[57,143,178,194,261],"ontwikkelen":[58],"berust":[59],"hierbij":[60],"op":[61],"zogenaamde":[62,156],"variatie":[63],"in":[64,114,120,167,184,212,242,245],"sequentie":[66],"bepaalde":[68],"genen.":[69],"Deze":[70],"genen":[71],"worden":[72],"ook":[73,241],"wel":[74,109,147],"\u201csusceptibility":[75],"genes\u201d":[76],"genoemd.":[77],"Tot":[78],"nu":[79],"toe":[80],"er":[82,239,240],"uit":[83],"literatuur":[85],"verscheidene":[86],"zulke":[88],"susceptibility":[90],"genes":[91],"bekend,":[92],"\u00e9\u00e9n":[93],"deze":[95,191],"CNDP1":[98,101,135,157],"gen.":[99],"Het":[100],"gen":[102],"codeert":[103],"enzyme":[106],"carnosinase":[107],"(ook":[108],"CN-1":[110,166,210],"genoemd)":[111],"hetgeen":[112],"vooral":[113],"lever":[116],"geproduceerd":[118],"en":[119,170,208,244],"bloed":[122],"uitgescheiden.":[123],"Hoewel":[124],"nog":[126],"geheel":[128],"duidelijk":[129],"waarom":[131],"genvariatie":[133],"betrokken":[136],"bij":[138,204,231,255],"ontwikkelen,":[144,227],"inmiddels":[146],"aangetoond":[148],"personen":[150],"2":[152],"kopieen":[153],"Mannheim":[158,222],"allel":[159,223],"hebben":[160,169,175],"(homozygoot),":[161],"geringere":[163,173],"concentratie":[164],"serum":[168,213],"bovendien":[171],"kans":[174],"ontwikkelen.":[179,236],"In":[180],"proefschrift":[186],"beschreven,":[188],"getracht":[190],"associatie":[192,202],"verder":[193],"onderzoeken":[195,262],"betrekking":[197],"tot":[198],"geslacht":[199],"(is":[200],"sterker":[203],"mannen":[205],"of":[206,209],"vrouwen),":[207],"concentraties":[211],"diabetische":[215],"homozygoot":[218],"toch":[225],"hoger":[228],"als":[230],"Tevens":[237],"vitro":[243],"vivo":[246],"gedaan":[248],"beschermende":[251],"rol":[252],"carnosine":[254],"onstaan":[257],"diabetisch":[259],"complicaties":[260]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}
