{"id":"https://openalex.org/W2491722838","doi":"https://doi.org/10.1097/tp.0000000000001336","title":"Successful Posttransplant Treatment of Hepatitis C With Ledipasvir-Sofosbuvir in HIV+ Kidney Transplant Recipients","display_name":"Successful Posttransplant Treatment of Hepatitis C With Ledipasvir-Sofosbuvir in HIV+ Kidney Transplant Recipients","publication_year":2016,"publication_date":"2016-07-28","ids":{"openalex":"https://openalex.org/W2491722838","doi":"https://doi.org/10.1097/tp.0000000000001336","mag":"2491722838","pmid":"https://pubmed.ncbi.nlm.nih.gov/27467534"},"language":"en","primary_location":{"id":"doi:10.1097/tp.0000000000001336","doi":"https://doi.org/10.1097/tp.0000000000001336","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000001336","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036989582","display_name":"Deirdre L. Sawinski","orcid":"https://orcid.org/0000-0001-7903-8295","observed_orcids":["https://orcid.org/0000-0001-7903-8295"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deirdre Sawinski","raw_affiliation_strings":["1 Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA. 2 Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University, Philadelphia, PA. 3 Division of Nephrology and Hypertension, Department of Medicine, Drexel University, Philadelphia, PA. 4 Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA. 2 Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University, Philadelphia, PA. 3 Division of Nephrology and Hypertension, Department of Medicine, Drexel University, Philadelphia, PA. 4 Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I72816309","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110614064","display_name":"Dong Hyun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong H. Lee","raw_affiliation_strings":["Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University, Philadelphia, PA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064626231","display_name":"Alden Michael Doyle","orcid":"https://orcid.org/0000-0003-3113-571X","observed_orcids":["https://orcid.org/0000-0003-3113-571X"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alden M. Doyle","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Drexel University, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Drexel University, Philadelphia, PA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024826112","display_name":"Emily A. Blumberg","orcid":"https://orcid.org/0000-0002-5193-6170","observed_orcids":["https://orcid.org/0000-0002-5193-6170"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily A. Blumberg","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036989582"],"corresponding_institution_ids":["https://openalex.org/I72816309","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":2.5379,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.8952659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"101","issue":"5","first_page":"974","last_page":"979"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hiv-hcv-coinfection","display_name":"HIV/HCV coinfection","score":0.9340000152587891},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ledipasvir-sofosbuvir","display_name":"ledipasvir/sofosbuvir","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hcv-genotype-1","display_name":"HCV genotype 1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tacrolimus-dose-adjustment","display_name":"tacrolimus dose adjustment","score":0.7549999952316284},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8538433909416199},{"id":"https://openalex.org/C2778390639","wikidata":"https://www.wikidata.org/wiki/Q2502747","display_name":"Sofosbuvir","level":5,"score":0.793949544429779},{"id":"https://openalex.org/C2775999097","wikidata":"https://www.wikidata.org/wiki/Q15409409","display_name":"Ledipasvir","level":5,"score":0.7113696336746216},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5557662844657898},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5511972308158875},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.5172908306121826},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.5120149254798889},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4622950255870819},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37041908502578735},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3431243896484375},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.27573972940444946},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19517970085144043},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.12333202362060547},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069474","descriptor_name":"Sofosbuvir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005449","descriptor_name":"Fluorenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011182","descriptor_name":"Postoperative Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014542","descriptor_name":"Uridine Monophosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014542","descriptor_name":"Uridine Monophosphate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/tp.0000000000001336","doi":"https://doi.org/10.1097/tp.0000000000001336","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000001336","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:27467534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27467534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1526693855","https://openalex.org/W1908153784","https://openalex.org/W1970780901","https://openalex.org/W2030470608","https://openalex.org/W2047156711","https://openalex.org/W2056725789","https://openalex.org/W2078251659","https://openalex.org/W2097405564","https://openalex.org/W2124892937","https://openalex.org/W2154479838","https://openalex.org/W2161578383","https://openalex.org/W2164466220","https://openalex.org/W2178839188","https://openalex.org/W2323367640","https://openalex.org/W2332403844","https://openalex.org/W2462352464","https://openalex.org/W2471789457"],"related_works":["https://openalex.org/W2589654756","https://openalex.org/W2507376318","https://openalex.org/W3039396548","https://openalex.org/W2801232829","https://openalex.org/W2563657857","https://openalex.org/W2554701966","https://openalex.org/W4360816867","https://openalex.org/W2605356469","https://openalex.org/W4254781297","https://openalex.org/W2767513769"],"abstract_inverted_index":{"In":[0],"Brief":[1],"Background":[2],"Ledipasvir-sofosbuvir":[3,110],"is":[4,132,143],"effective":[5],"at":[6,53,88,179],"eradicating":[7],"hepatitis":[8],"C":[9],"virus":[10,76,167],"(HCV)":[11],"infection":[12],"in":[13,18,32,117,129],"the":[14,75,123,135,166],"general":[15],"population":[16,131],"and":[17,63,80,100,134,158,164],"HCV-monoinfected":[19],"kidney":[20,37,48,151],"transplant":[21,38,49,152],"recipients,":[22],"but":[23,104],"there":[24],"are":[25,154,161],"no":[26],"data":[27],"to":[28,145],"guide":[29],"its":[30],"use":[31],"human":[33,44],"immunodeficiency":[34,45],"virus/HCV":[35,46],"coinfected":[36,47,150],"patients.":[39],"Methods":[40],"We":[41],"treated":[42,121,155],"6":[43],"recipients":[50,153],"with":[51,60,156],"ledipasvir-sofosbuvir":[52,102,157],"our":[54,118],"2":[55],"centers.":[56],"All":[57,72,171],"were":[58,120],"infected":[59],"genotype":[61],"1":[62],"66%":[64],"had":[65],"received":[66],"kidneys":[67],"from":[68],"HCV+":[69],"donors.":[70],"Results":[71],"patients":[73,116,160,172],"cleared":[74],"while":[77,168],"on":[78,140,169],"therapy":[79,103,128],"100%":[81],"have":[82,173],"achieved":[83,174],"a":[84,175],"sustained":[85,176],"virologic":[86,177],"response":[87,178],"12":[89,180],"weeks":[90,181],"after":[91,101,182],"completion":[92,183],"of":[93,126,137,184],"ledipasvir-sofosbuvir.":[94,185],"Tacrolimus":[95],"dosing":[96],"required":[97],"adjustment":[98],"during":[99],"antiretroviral":[105],"regimens":[106],"did":[107],"not.":[108],"Conclusions":[109],"was":[111],"well":[112,162],"tolerated.":[113],"Although":[114],"all":[115,159],"series":[119],"posttransplant,":[122],"ideal":[124],"timing":[125],"HCV":[127,138],"this":[130],"unknown,":[133],"impact":[136],"clearance":[139],"posttransplant":[141],"outcomes":[142],"yet":[144],"be":[146],"determined.":[147],"Six":[148],"HIV/HCV":[149],"tolerated":[163],"clear":[165],"therapy.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}
