{"id":"https://openalex.org/W2491706735","doi":"https://doi.org/10.1007/978-1-349-07431-0_59","title":"Repeated Administration with Enkephalin into the A-10 Dopamine Region Produces Supersensitivity of the Mesolimbic Dopamine System","display_name":"Repeated Administration with Enkephalin into the A-10 Dopamine Region Produces Supersensitivity of the Mesolimbic Dopamine System","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2491706735","doi":"https://doi.org/10.1007/978-1-349-07431-0_59","mag":"2491706735"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-349-07431-0_59","doi":"https://doi.org/10.1007/978-1-349-07431-0_59","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-07431-0_59","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dopaminergic Systems and their Regulation","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W627164170","display_name":"Dopaminergic Systems and their Regulation"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078035590","display_name":"Peter W. Kalivas","orcid":"https://orcid.org/0000-0001-9487-0119","observed_orcids":["https://orcid.org/0000-0001-9487-0119"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. W. Kalivas","raw_affiliation_strings":["Department of Pharmacology and Experimental Therapeutics, LSU Medical Center, 1901 Perdido Street, New Orleans, LA, 70112, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Experimental Therapeutics, LSU Medical Center, 1901 Perdido Street, New Orleans, LA, 70112, USA","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078035590"],"corresponding_institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34240363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"441","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enkephalin","display_name":"enkephalin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/d-ala2-met5-enkephalinamide","display_name":"D-Ala2-Met5-enkephalinamide","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mesolimbic-dopamine-system","display_name":"mesolimbic dopamine system","score":0.9169999957084656},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.843999981880188},{"id":"https://openalex.org/keywords/dopamine-receptor-supersensitivity","display_name":"dopamine receptor supersensitivity","score":0.746999979019165},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.8429999947547913},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.6970000267028809},{"id":"https://openalex.org/keywords/spiperone-binding","display_name":"spiperone binding","score":0.7379999756813049},{"id":"https://openalex.org/keywords/repeated-administration","display_name":"repeated administration","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2780948874","wikidata":"https://www.wikidata.org/wiki/Q640562","display_name":"Ventral tegmental area","level":4,"score":0.8805910348892212},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.8776834607124329},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7354318499565125},{"id":"https://openalex.org/C131722271","wikidata":"https://www.wikidata.org/wiki/Q7547759","display_name":"Sniffing","level":2,"score":0.4701768457889557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4642779231071472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4639650583267212},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.45030248165130615},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.44603070616722107},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42260611057281494},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35435429215431213},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3208398222923279},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.24249354004859924},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11439460515975952}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-349-07431-0_59","doi":"https://doi.org/10.1007/978-1-349-07431-0_59","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-349-07431-0_59","pdf_url":null,"source":{"id":"https://openalex.org/S4306463716","display_name":"Palgrave Macmillan UK eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319703","host_organization_name":"Palgrave Macmillan","host_organization_lineage":["https://openalex.org/P4310319703","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Palgrave Macmillan","Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dopaminergic Systems and their Regulation","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2261650087","https://openalex.org/W7100722927","https://openalex.org/W2261581174","https://openalex.org/W7096993773","https://openalex.org/W1975076810","https://openalex.org/W1828393704","https://openalex.org/W1982648534","https://openalex.org/W2163729672","https://openalex.org/W2005980893","https://openalex.org/W2064956571"],"abstract_inverted_index":{"Actue":[0],"injection":[1,49,80],"with":[2,47,64,136,186],"the":[3,13,19,36,40,52,60,71,81,121,125,194,217,224,230],"enkenhalin":[4],"analogue,":[5],"D-Ala":[6],"2":[7,154],"-Met":[8],"5":[9,77,157],"-enkephalinamide":[10],"(DALA),":[11],"into":[12],"ventral":[14],"tegmental":[15],"area":[16],"(VTA)":[17],"of":[18,120,131,159],"rat":[20],"has":[21],"been":[22],"shown":[23],"to":[24,35,110,149,165],"increase":[25,133,188,200],"spontaneous":[26],"motor":[27,90,106],"activity":[28,91,107],"by":[29,128,169,176,212,216],"activating":[30],"mesolimbic":[31],"dopamine":[32],"(DA)":[33],"projections":[34],"nucleus":[37,195],"accumbens.":[38],"In":[39],"present":[41],"study,":[42],"rats":[43,61,82,122],"were":[44,62,83,210],"stereotaxically":[45],"implanted":[46],"chronic":[48],"cannulae":[50],"over":[51],"VTA,":[53],"and":[54,89,214,223],"starting":[55],"one":[56],"week":[57],"after":[58,156],"surgery":[59],"injected":[63],"DALA":[65,100,129,161,166],"(1.0":[66],"\u00b5g/\u00b5l)":[67],"or":[68,143],"saline":[69,115],"in":[70,85,105,108,134,139,189,193,201],"VTA":[72],"once":[73],"a":[74,86,102],"day":[75],"for":[76,94,151],"days.":[78],"Following":[79],"placed":[84],"photocell":[87],"apparatus":[88],"was":[92,147,167,183,205],"measured":[93],"120":[95],"min.":[96],"Rats":[97,112],"receiving":[98,113],"daily":[99,114,160],"showed":[101,116],"progressive":[103],"augmentation":[104,127,146,164,182],"response":[109],"DALA.":[111],"no":[117,137],"change.":[118],"Observation":[119],"indicated":[123],"that":[124,198],"behavioral":[126],"consisted":[130],"an":[132,187,199],"locomotion":[135],"change":[138],"rearing,":[140],"sniffing,":[141],"grooming":[142],"gnawing.":[144],"This":[145,219],"found":[148],"persist":[150],"at":[152],"least":[153],"wks":[155],"days":[158],"injection.":[162],"The":[163,181],"blocked":[168],"naloxone":[170],"(2":[171],"mg/kg,":[172,179],"ip)":[173],"but":[174],"not":[175,184,206,215],"haloperidol":[177],"(0.3":[178],"ip).":[180],"associated":[185],"3":[190],"H-spiperone":[191],"binding":[192],"accumbens":[196],"indicating":[197],"post-synaptic":[202],"DA":[203],"receptors":[204],"involved.":[207],"These":[208],"keywords":[209,225],"added":[211],"machine":[213],"authors.":[218],"process":[220],"is":[221],"experimental":[222],"may":[226],"be":[227],"updated":[228],"as":[229],"learning":[231],"algorithm":[232],"improves.":[233]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-08-23T00:00:00"}