{"id":"https://openalex.org/W2491590985","doi":"https://doi.org/10.1007/s40778-016-0060-6","title":"Adult Versus Pluripotent Stem Cell-Derived Mesenchymal Stem Cells: The Need for More Precise Nomenclature","display_name":"Adult Versus Pluripotent Stem Cell-Derived Mesenchymal Stem Cells: The Need for More Precise Nomenclature","publication_year":2016,"publication_date":"2016-07-28","ids":{"openalex":"https://openalex.org/W2491590985","doi":"https://doi.org/10.1007/s40778-016-0060-6","mag":"2491590985","pmid":"https://pubmed.ncbi.nlm.nih.gov/27547711","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4972883"},"language":"en","primary_location":{"id":"doi:10.1007/s40778-016-0060-6","doi":"https://doi.org/10.1007/s40778-016-0060-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40778-016-0060-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-016-0060-6.pdf","source":{"id":"https://openalex.org/S4210191462","display_name":"Current Stem Cell Reports","issn_l":"2198-7866","issn":["2198-7866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-016-0060-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008580136","display_name":"Michael D. West","orcid":"https://orcid.org/0000-0002-4842-5468","observed_orcids":["https://orcid.org/0000-0002-4842-5468","https://orcid.org/0009-0009-9328-8800"]},"institutions":[{"id":"https://openalex.org/I4210121053","display_name":"Lineage Cell Therapeutics (United States)","ror":"https://ror.org/034y7by63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121053"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael D. West","raw_affiliation_strings":["BioTime, Inc., 1010 Atlantic Ave., Alameda, CA, 94501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTime, Inc., 1010 Atlantic Ave., Alameda, CA, 94501, USA","institution_ids":["https://openalex.org/I4210121053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007910838","display_name":"Igor O. Nasonkin","orcid":"https://orcid.org/0000-0002-9286-2219","observed_orcids":["https://orcid.org/0000-0002-9286-2219"]},"institutions":[{"id":"https://openalex.org/I4210121053","display_name":"Lineage Cell Therapeutics (United States)","ror":"https://ror.org/034y7by63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Nasonkin","raw_affiliation_strings":["BioTime, Inc., 1010 Atlantic Ave., Alameda, CA, 94501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTime, Inc., 1010 Atlantic Ave., Alameda, CA, 94501, USA","institution_ids":["https://openalex.org/I4210121053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039763108","display_name":"David LaRocca","orcid":"https://orcid.org/0000-0001-5863-9833","observed_orcids":["https://orcid.org/0000-0001-5863-9833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Larocca","raw_affiliation_strings":["ReCyte Therapeutics, 1010 Atlantic Ave, Alameda, CA, 94501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ReCyte Therapeutics, 1010 Atlantic Ave, Alameda, CA, 94501, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081019013","display_name":"Karen B. Chapman","orcid":"https://orcid.org/0000-0003-3866-4200","observed_orcids":["https://orcid.org/0000-0003-3866-4200"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen B. Chapman","raw_affiliation_strings":["OncoCyte Corporation, 1010 Atlantic Ave, Alameda, CA, 94501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoCyte Corporation, 1010 Atlantic Ave, Alameda, CA, 94501, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029967722","display_name":"Fran\u00e7ois Binette","orcid":"https://orcid.org/0000-0002-1544-7791","observed_orcids":["https://orcid.org/0000-0002-1544-7791"]},"institutions":[{"id":"https://openalex.org/I4210121053","display_name":"Lineage Cell Therapeutics (United States)","ror":"https://ror.org/034y7by63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francois Binette","raw_affiliation_strings":["BioTime, Inc., 1010 Atlantic Ave., Alameda, CA 94501 USA ; OrthoCyte Corporation, 1010 Atlantic Ave, Alameda, CA 94501 USA","OrthoCyte Corporation, 1010 Atlantic Ave, Alameda, CA, 94501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTime, Inc., 1010 Atlantic Ave., Alameda, CA 94501 USA ; OrthoCyte Corporation, 1010 Atlantic Ave, Alameda, CA 94501 USA","institution_ids":["https://openalex.org/I4210121053"]},{"raw_affiliation_string":"OrthoCyte Corporation, 1010 Atlantic Ave, Alameda, CA, 94501, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060122966","display_name":"Hal Sternberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121053","display_name":"Lineage Cell Therapeutics (United States)","ror":"https://ror.org/034y7by63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121053"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hal Sternberg","raw_affiliation_strings":["BioTime, Inc., 1010 Atlantic Ave., Alameda, CA, 94501, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioTime, Inc., 1010 Atlantic Ave., Alameda, CA, 94501, USA","institution_ids":["https://openalex.org/I4210121053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008580136"],"corresponding_institution_ids":["https://openalex.org/I4210121053"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":0.5695,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.66251606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"3","first_page":"299","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cd-antigens","display_name":"CD antigens","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cell-identity","display_name":"cell identity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cell-purity","display_name":"cell purity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.7289999723434448},{"id":"https://openalex.org/keywords/mesoderm","display_name":"mesoderm","score":0.9269999861717224},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8425599336624146},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.722499668598175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6067036986351013},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.601258397102356},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5922138690948486},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5427156090736389},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5160576701164246},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.44117167592048645},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4384113550186157},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39178356528282166},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3487603962421417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22695893049240112},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s40778-016-0060-6","doi":"https://doi.org/10.1007/s40778-016-0060-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40778-016-0060-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-016-0060-6.pdf","source":{"id":"https://openalex.org/S4210191462","display_name":"Current Stem Cell Reports","issn_l":"2198-7866","issn":["2198-7866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4972883","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4972883","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Stem Cell Rep","raw_type":"Text"},{"id":"pmid:27547711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27547711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current stem cell reports","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.1007/s40778-016-0060-6","doi":"https://doi.org/10.1007/s40778-016-0060-6","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40778-016-0060-6","pdf_url":"https://link.springer.com/content/pdf/10.1007%2Fs40778-016-0060-6.pdf","source":{"id":"https://openalex.org/S4210191462","display_name":"Current Stem Cell Reports","issn_l":"2198-7866","issn":["2198-7866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2491590985.pdf","grobid_xml":"https://content.openalex.org/works/W2491590985.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1579865974","https://openalex.org/W1717743938","https://openalex.org/W1963829828","https://openalex.org/W1968410373","https://openalex.org/W1977383123","https://openalex.org/W1993433963","https://openalex.org/W1998663807","https://openalex.org/W1998863145","https://openalex.org/W2003856278","https://openalex.org/W2022481684","https://openalex.org/W2023485889","https://openalex.org/W2025371271","https://openalex.org/W2029185806","https://openalex.org/W2034630426","https://openalex.org/W2036519060","https://openalex.org/W2047418122","https://openalex.org/W2067716147","https://openalex.org/W2071536607","https://openalex.org/W2078653911","https://openalex.org/W2082586271","https://openalex.org/W2086943348","https://openalex.org/W2112220623","https://openalex.org/W2123769181","https://openalex.org/W2132345567","https://openalex.org/W2144268541","https://openalex.org/W2159999899","https://openalex.org/W2160204201","https://openalex.org/W2192152106","https://openalex.org/W4292330637"],"related_works":["https://openalex.org/W2990493075","https://openalex.org/W2914529147","https://openalex.org/W2109354688","https://openalex.org/W2945052866","https://openalex.org/W2610696761","https://openalex.org/W2781926475","https://openalex.org/W3084392990","https://openalex.org/W2044769151","https://openalex.org/W2591223570","https://openalex.org/W2056392359"],"abstract_inverted_index":{"The":[0],"complexity":[1],"of":[2,41,60,76,86,94,97,117,121],"human":[3],"pluripotent":[4],"stem":[5,79],"cell":[6,18,61],"(hPSC)":[7],"fate":[8],"represents":[9],"both":[10],"opportunity":[11],"and":[12,43,124,133,152,157],"challenge.":[13],"In":[14],"theory,":[15],"all":[16],"somatic":[17],"types":[19],"can":[20],"be":[21],"differentiated":[22],"from":[23],"hPSCs,":[24],"opening":[25],"the":[26,52,58,72],"door":[27],"to":[28,137],"many":[29,47,85],"opportunities":[30],"in":[31,57,101,150],"transplant":[32],"medicine.":[33],"However,":[34],"such":[35,108],"clinical":[36],"applications":[37],"require":[38],"high":[39],"standards":[40],"purity":[42,156],"identity,":[44],"that":[45,84,145],"challenge":[46],"existing":[48],"protocols.":[49],"This":[50],"underscores":[51],"need":[53],"for":[54,159],"increasing":[55],"precision":[56,149],"description":[59],"identity":[62,158],"during":[63],"hPSC":[64],"differentiation.":[65],"We":[66,82,139],"highlight":[67],"one":[68],"salient":[69],"example,":[70],"namely,":[71],"numerous":[73],"published":[74],"reports":[75,88],"hPSC-derived":[77,109],"mesenchymal":[78,110],"cells":[80,111,153],"(MSCs).":[81],"suggest":[83],"these":[87],"likely":[89,113],"represent":[90],"an":[91],"improper":[92],"use":[93],"certain":[95],"cluster":[96],"differentiation":[98,135],"(CD)":[99],"antigens":[100],"defining":[102],"bone":[103],"marrow-derived":[104],"MSCs.":[105],"Instead,":[106],"most":[107],"are":[112],"a":[114,141],"complex":[115],"mixture":[116],"embryonic":[118],"anlagen,":[119],"primarily":[120],"diverse":[122],"mesodermal":[123],"neural":[125],"crest":[126],"origins,":[127],"making":[128],"precise":[129],"identification,":[130],"reproducible":[131],"manufacture,":[132],"uniform":[134],"difficult":[136],"achieve.":[138],"describe":[140],"potential":[142,160],"path":[143],"forward":[144],"may":[146],"provide":[147],"more":[148],"nomenclature,":[151],"with":[154],"higher":[155],"therapeutic":[161],"use.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-08-23T00:00:00"}